Drug & supplement interaction

Green Coffee + Fluphenazine

Fluphenazine brand names: Prolixin, Permitil, Fluphenazine.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Green Coffee has a minor interaction with Fluphenazine. Theoretically, phenothiazines might increase the levels and adverse effects of caffeine.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Green Coffee and Fluphenazine

Here is the interaction we found between these two, with the evidence behind it.

Minor

PHENOTHIAZINES

Why this applies to Fluphenazine

Fluphenazine falls under PHENOTHIAZINES — the group Green Coffee interacts with.

Theoretically, phenothiazines might increase the levels and adverse effects of caffeine.
Green coffee can contain caffeine. Phenothiazines can reduce the metabolism of caffeine by inhibiting cytochrome P450 1A2 (CYP1A2).
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for these two together. Fluphenazine can gently slow down a liver enzyme called CYP1A2, which happens to be the same enzyme your body uses to clear caffeine. Since green coffee carries caffeine, that caffeine may stick around a bit longer than usual. So this is really about the caffeine in the supplement building up, not about your fluphenazine changing.

In practice, you might just notice more of the usual caffeine jitters: a racing heart, feeling wired, trouble sleeping, or some restlessness. The good news is this is rated minor and is based only on lab data, so it's more theoretical than proven. Everyday coffee is usually fine, but concentrated green coffee pills add up faster. If you feel extra jittery, check in with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Wojcikowski, J. and Daniel, W. A. Perazine at therapeutic drug concentrations inhibits human cytochrome P450 isoenzyme 1A2 (CYP1A2) and caffeine metabolism--an in vitro study. Pharmacol Rep. 2009;61(5):851-858. PubMed
  2. Daniel, W. A., Syrek, M., Rylko, Z., and Kot, M. Effects of phenothiazine neuroleptics on the rate of caffeine demethylation and hydroxylation in the rat liver. Pol.J Pharmacol 2001;53(6):615-621.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Green Coffee Also Interacts With Other Medications

Green Coffee has 8 major, 442 moderate, 221 minor known drug interactions in our database — the Fluphenazine one above is one of them. If you take anything else, check it against the full list below.

Major 8 Moderate 442 Minor 221 No known interaction 2,159 (incl. Fluphenazine)
Taking anything else?

Check Another of Your Medications Against Green Coffee

Covers the 2,830 medications we’ve checked against Green Coffee. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Fluphenazine

This page covers Green Coffee only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fluphenazine page lists 148 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Indian Snakeroot (major), Rauvolfia Vomitoria (major) and Scopolia (major).

By severity: 5 major · 109 moderate · 34 minor.

From our pharmacist’s overview on the Fluphenazine page

“Take real care with supplements while on fluphenazine (Prolixin), an antipsychotic used mainly for schizophrenia. Five of the 148 ingredients on file rate major: herbs like henbane that stack anticholinergic side effects (dry mouth, blurred vision, confusion) onto a drug already prone to them, two rauwolfia plants that can intensify it…”

Reviewed by 2 · Jul 18, 2026

Open the Fluphenazine interaction page

One more smart check

Taking Green Coffee as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,716 real supplement products containing Green Coffee, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Green Coffee. Your product may carry other ingredients that interact with Fluphenazine too, on top of Green Coffee — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Green Coffee and Fluphenazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Green Coffee
Steady interest

#900 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fluphenazine
Top half

#1,012 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Green Coffee

What is Green Coffee?

Green Coffee
  • Weight loss
  • High blood pressure
  • Blood sugar control
  • Antioxidant support
  • General energy

Green coffee is the unroasted bean of the coffee plant, prized for its high chlorogenic acid content. Some early studies suggest modest benefits for weight, blood pressure, and blood sugar, but the evidence is limited and far from conclusive. It contains caffeine, so people sensitive to stimulants should use caution and check with a pharmacist or doctor first.

Read the full Green Coffee monograph & all interactions
Medication

About Fluphenazine

What Is Fluphenazine Used For?

Brand names: Prolixin, Permitil, Fluphenazine

Fluphenazine hydrochloride tablets and oral solution are indicated for the management of psychotic disorders. Fluphenazine Hydrochloride Injection is also used for psychotic disorders and can bridge patients to oral therapy.

Fluphenazine Decanoate Injection is a long-acting form specifically intended for patients who need extended antipsychotic treatment — for example, those with chronic schizophrenia who benefit from a single injection that can last up to four weeks or longer. It is not approved for behavioral problems related to intellectual disability, and it is not approved for dementia-related psychosis in elderly patients.

See full Fluphenazine drug information
Keep checking

Other Drugs & Green Coffee

Browse every other medication we’ve checked against Green Coffee — both the ones with a known interaction and the ones without. Select any drug for the full detail.

8Major
442Moderate
221Minor
2,158No known interaction
8 Major 442 Moderate 221 Minor 2,158 No interaction
Major

8 interactions

Moderate

442 interactions

Showing 60 of 442 moderate interactions — see all 442 on the Green Coffee page.

Minor

221 interactions

Showing 60 of 221 minor interactions — see all 221 on the Green Coffee page.

No interaction 2,158 drugs checked — show the list

We also checked Green Coffee against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,158 medications checked with no known interaction — see the full Green Coffee list.

See the full Green Coffee interactions page
See every supplement checked against Fluphenazine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Green Coffee monograph › Uses, safety, and every drug interaction in one place Fluphenazine supplement interactions › Every supplement checked against Fluphenazine, ranked by severity Fluphenazine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Green Coffee and Fluphenazine Together: Common Questions

Can you take Green Coffee with Fluphenazine?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Green Coffee and Fluphenazine interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Fluphenazine and Green Coffee?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.