Drug & supplement interaction

Green Coffee + Levofloxacin

Levofloxacin brand names: Levaquin, Levaquin Injection, Leva-pak.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Green Coffee has a minor interaction with Levofloxacin. Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Green Coffee and Levofloxacin

Here is the interaction we found between these two, with the evidence behind it.

Minor

QUINOLONE ANTIBIOTICS

Why this applies to Levofloxacin

Levofloxacin falls under QUINOLONE ANTIBIOTICS — the group Green Coffee interacts with.

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Green coffee can contain caffeine. Concomitant use of quinolones can decrease caffeine clearance and increase effects and risk of adverse effects.
Severity Minor Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know about pairing green coffee with levofloxacin: it's really the caffeine in green coffee that matters here, not the antibiotic getting changed. Levofloxacin can slow down how fast your body clears caffeine, so that caffeine tends to hang around longer and hit harder.

In plain terms, you might feel more of the usual caffeine effects, like jitteriness, a racing heart, trouble sleeping, or feeling on edge. This is rated as a minor, theoretical interaction, so most people won't run into trouble, especially with small amounts. If you take a concentrated green coffee supplement or you're sensitive to stimulants, it's worth a quick chat with your pharmacist or doctor while you're on this antibiotic.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. PubMed
  2. Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. PubMed
  3. Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. PubMed
  4. Staib, A. H., Stille, W., Dietlein, G., Shah, P. M., Harder, S., Mieke, S., and Beer, C. Interaction between quinolones and caffeine. Drugs 1987;34 Suppl 1:170-174. PubMed
  5. Stille, W., Harder, S., Mieke, S., Beer, C., Shah, P. M., Frech, K., and Staib, A. H. Decrease of caffeine elimination in man during co-administration of 4-quinolones. J.Antimicrob.Chemother. 1987;20(5):729-734. PubMed
  6. Fuhr, U., Strobl, G., Manaut, F., Anders, E. M., Sorgel, F., Lopez-de-Brinas, E., Chu, D. T., Pernet, A. G., Mahr, G., Sanz, F., and . Quinolone antibacterial agents: relationship between structure and in vitro inhibition of the human cytochrome P450 isof
  7. Harder S, Staib AH, Beer C, et al. 4-quinolones inhibit biotransformation of caffeine. Eur J Clin Pharmacol 1988;35:651-6. PubMed
  8. Zhang LL, Zhang JR, Guo K, et al. Effects of fluoroquinolones on CYP4501A and 3A in male broilers. Res Vet Sci 2011;90:99-105. PubMed
  9. Cesana M, Broccali G, Imbimbo BP, Crema A. Effect of single doses of rufloxacin on the disposition of theophylline and caffeine after single administration. Int J Clin Pharmacol Ther Toxicol 1991:29:133-8.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Green Coffee Also Interacts With Other Medications

Green Coffee has 8 major, 442 moderate, 221 minor known drug interactions in our database — the Levofloxacin one above is one of them. If you take anything else, check it against the full list below.

Major 8 Moderate 442 Minor 221 No known interaction 2,159 (incl. Levofloxacin)
Taking anything else?

Check Another of Your Medications Against Green Coffee

Covers the 2,830 medications we’ve checked against Green Coffee. Pick one to open its full report.

From our Q&A

Questions About Green Coffee or Levofloxacin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Green Coffee or Levofloxacin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Levofloxacin

This page covers Green Coffee only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Levofloxacin page lists 155 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Apple (major), Arsenic (major) and Asarabacca (major).

By severity: 13 major · 121 moderate · 21 minor.

From our pharmacist’s overview on the Levofloxacin page

“Levofloxacin (Levaquin) is a potent fluoroquinolone antibiotic, and its supplement list deserves real respect, with 13 of the 155 entries rated major. The most everyday hazards are fruit juices.”

Reviewed by 2 · Jul 18, 2026

Open the Levofloxacin interaction page

One more smart check

Taking Green Coffee as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,716 real supplement products containing Green Coffee, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Green Coffee. Your product may carry other ingredients that interact with Levofloxacin too, on top of Green Coffee — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Green Coffee and Levofloxacin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Green Coffee
Steady interest

#900 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Levofloxacin
Top 25%

#435 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Green Coffee

What is Green Coffee?

Green Coffee
  • Weight loss
  • High blood pressure
  • Blood sugar control
  • Antioxidant support
  • General energy

Green coffee is the unroasted bean of the coffee plant, prized for its high chlorogenic acid content. Some early studies suggest modest benefits for weight, blood pressure, and blood sugar, but the evidence is limited and far from conclusive. It contains caffeine, so people sensitive to stimulants should use caution and check with a pharmacist or doctor first.

Read the full Green Coffee monograph & all interactions
Medication

About Levofloxacin

What Is Levofloxacin Used For?

Brand names: Levaquin, Levaquin Injection, Leva-pak

Levofloxacin treats bacterial infections in adults, including pneumonia (both community-acquired and hospital-acquired), skin infections, urinary tract infections, kidney infections, chronic bacterial prostatitis, and sinus infections. It is also used after exposure to inhalational anthrax and for plague.

Because levofloxacin carries significant risks, it should only be used for uncomplicated urinary tract infections, acute bacterial worsening of chronic bronchitis, and acute bacterial sinusitis when no other treatment option is available. Always use it only for infections confirmed or strongly suspected to be bacterial.

See full Levofloxacin drug information
Keep checking

Other Drugs & Green Coffee

Browse every other medication we’ve checked against Green Coffee — both the ones with a known interaction and the ones without. Select any drug for the full detail.

8Major
442Moderate
221Minor
2,158No known interaction
8 Major 442 Moderate 221 Minor 2,158 No interaction
Major

8 interactions

Moderate

442 interactions

Showing 60 of 442 moderate interactions — see all 442 on the Green Coffee page.

Minor

221 interactions

Showing 60 of 221 minor interactions — see all 221 on the Green Coffee page.

No interaction 2,158 drugs checked — show the list

We also checked Green Coffee against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,158 medications checked with no known interaction — see the full Green Coffee list.

See the full Green Coffee interactions page
See every supplement checked against Levofloxacin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Green Coffee monograph › Uses, safety, and every drug interaction in one place Levofloxacin supplement interactions › Every supplement checked against Levofloxacin, ranked by severity Levofloxacin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Green Coffee and Levofloxacin Together: Common Questions

Can you take Green Coffee with Levofloxacin?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Green Coffee and Levofloxacin interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Levofloxacin and Green Coffee?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.