Can You Take Vitamins With Amoxicillin?

In our latest question and answer, our pharmacist discusses whether or not it is safe to take multivitamins with amoxicillin.

Question

I am taking amoxicillin for a sinus infection. I take a daily multivitamin. Is it okay to take with amoxicillin?

Asked by Mitch On Nov 14, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Nov 14, 2022
Last updated May 01, 2024

Key points

  • There is no interaction between amoxicillin and multivitamins. They are safe to combine.

Answer

While the vitamins and minerals contained in multivitamins can certainly interact with a number of different medications, they are considered safe to take with amoxicillin.

When it comes to antibiotics and multivitamins, we are generally concerned about calcium, aluminum, and magnesium 'chelating' or binding, to antibiotics, which can significantly decrease their absorption. This is a concern with several antibiotic drug classes including:

  • Fluoroquinolones (e.g., ciprofloxacin, levofloxacin)
  • Tetracyclines (e.g., minocycline, tetracycline, doxycycline)

Fortunately, amoxicillin does not chelate with the ingredients in multivitamins and they are safe to combine.

Other Concerns With Multivitamin - Drug Interactions

While we're on the topic, I know you asked about antibiotics, but I think it is an important reminder that you should always check with your doctor or pharmacist before combining drugs and supplements.

Some major interactions between vitamins and drugs include:

  • Vitamin B6 and levodopa
  • Vitamin A and retinoids
  • Potassium and ACE-Inhibitors
  • Vitamin K and warfarin
  • Vitamin E and cyclosporinrine
  • Vitamin B6 and phenytoin
  • Calcium and atazanavir

The above list provides only a small number of drug-vitamin/mineral interactions that can have significant clinical consequences.

Vitamins Are Recommended With Some Drugs

Even though there are concerns with interactions between some combinations, there are certainly cases where vitamins are recommended to take with certain drugs.

One such example is metformin and vitamin B6. Metformin can delete vitamin B6 levels, which can increase the risk of nerve pain in diabetics. Vitamin B6 supplementation can help prevent this.

Diuretics are another great example of a drug (class) that can deplete certain vitamins and minerals.

 Make sure you talk to your doctor or pharmacist for recommendations about what to take with your prescriptions.

Final Words

I hope you found this helpful!

Amoxicillin, as mentioned, is safe with your multivitamin, but always ask your healthcare professional about interactions before combining things!

References

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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