Taking Gabapentin With Lipitor - Pharmacist Analysis

Is There An Interaction?

There is no known interaction between gabapentin and Lipitor (atorvastatin). They are generally considered safe to take together.

Discussion From The Pharmacist

Lipitor and gabapentin have different mechanisms of action that are not known to interfere with one another.

Additionally, neither drug is known to affect the metabolism of the other.

Gabapentin is not metabolized by cytochrome P450 enzymes (it is cleared through the kidneys, with most of the drug being excreted unchanged in the urine), which are responsible for the metabolism of many other medications (including Lipitor). Gabapentin is not known to affect these enzymes, which means that gabapentin is unlikely to interact with other drugs that are metabolized by them.

Lipitor is metabolized via a cytochrome enzyme (CYP3A4), but again, gabapentin does not affect these enzymes.

It is important to note that there are some factors that can affect the metabolism of gabapentin.

For example, individuals with impaired renal function may have slower clearance of the drug, which can lead to higher levels of gabapentin in the body and an increased risk of side effects.

In addition, there is some evidence to suggest that certain medications, such as antacids, can reduce the absorption of gabapentin.

Likewise, there are certainly plenty of drugs that can affect Lipitor metabolism via alterations to CYP metabolizing enzymes. As discussed though, this isn't a concern with gabapentin.

What About Side Effects?

Gabapentin and Lipitor do not share many similar side effects, so the risk of additive effects occurring is unlikely.

Final Words

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