Can You Take NyQuil Long-Term To Help Treat Insomnia?

In our latest question and answer, the pharmacist talks about the safety of taking NyQuil long-term for sleep.

Question

I have chronic trouble with mild sinus congestion and snoring, which makes for a poor night's sleep. Last week, I had painful sinus, upper tooth, and jaw on one side. After three nights of severe cold and flu NyQuil, the pain was gone. I sleep much better and do not snore when I take half a dose of this medication each night. I tried Flonase and allergy medications with no relief. In fact, Flonase is rather irritating. Is it safe to keep using NyQuil for an extended time to sleep well?

Asked by Deb On Jul 17, 2023

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Jul 17, 2023
Last updated Apr 28, 2024

Key points

  • NyQuil can provide temporary relief for sinus congestion and improve sleep quality, but it is not recommended for long-term use as a sleep aid.
  • It is important to consult with a doctor to explore alternative treatments for chronic sleep issues and consider medications specifically approved for long-term use in managing insomnia.

Quick Answer

Thanks for reaching out! While NyQuil Severe can provide temporary relief for sinus congestion and help with sleep troubles, using it as a long-term solution for sleep is not recommended.

NyQuil is not intended for prolonged use, and the FDA-approved labeling only recommends it for the short-term treatment of insomnia (less than 2 weeks).

I certainly recommend speaking with your doctor to explore options for treating your underlying conditions and alternative insomnia medications that have a proven track record of safety and efficacy with long-term use.

I will say that, overall, using NyQuil long-term likely isn't a severe health risk by any means, you just aren't treating the root cause of your problems and there are other medications that have been studied for use over a long period of time.

Detailed Answer

I understand the frustration you must be feeling due to your chronic sinus congestion and related symptoms affecting your sleep quality. While NyQuil may provide temporary relief and improve sleep quality, it is important to note that it is not intended for long-term use as a sleep aid, as there isn't sufficient long-term safety and efficacy data to support its prolonged use.

Safety of Prolonged NyQuil Use

There are several different NyQuil products available, and based on your question, you have been using the 'Severe' version. This version of NyQuil contains the following ingredients:

  • Acetaminophen
  • Doxylamine
  • Dextromethorphan
  • Phenylephrine

All NyQuil products are generally considered non-habit forming, meaning they are unlikely to cause dependence or addiction when used as directed.

However, according to the FDA-approved labeling, NyQuil is only indicated for the short-term treatment of insomnia, typically lasting less than two weeks. The safety and efficacy of prolonged use have not been thoroughly studied, and there may be potential risks associated with extended use, especially related to the doxylamine component of the drug.

Doxylamine is the sedating antihistamine found in NyQuil that can cause drowsiness and aid in sleep.

While some individuals may experience improved sleep quality with the use of doxylamine, scientific evidence suggests limited beneficial effects on sleep, an increased risk of next-day performance impairments, and potential rebound insomnia following discontinuation if used consistently.

Therefore, while short-term use is generally considered safe, long-term use of NyQuil for sleep improvement may carry these potential risks, and other options may be better suited for you.

Consulting a Doctor for Alternative Options

I highly recommend speaking with your doctor to explore alternative treatments that address the underlying causes of your sleep issues and provide more sustainable solutions.

Your doctor can assess your specific needs and recommend appropriate options. Specifically, they should be able to diagnose and treat what is actually causing your sleep issues in the first place.

In regard to alternative medications, there are several options out there:

  • Benzodiazepine Receptor Agonists (BZRAs): This class includes benzodiazepines and nonbenzodiazepine BZRAs like zolpidem (Ambien). They work by enhancing the inhibitory effects of the neurotransmitter GABA in the brain, promoting sedation and sleep.
  • Histamine Receptor Antagonists: Low-dose doxepin acts as a histamine receptor antagonist, reducing wakefulness and promoting sleep.
  • Melatonin Receptor Agonists: Ramelteon is a melatonin receptor agonist that targets the specific receptors involved in regulating the sleep-wake cycle, mimicking the effects of naturally produced melatonin.
  • Dual Orexin Receptor Antagonists: Suvorexant is a medication that works by blocking the activity of orexin, a neurotransmitter involved in promoting wakefulness, helping induce and maintain sleep.
  • Trazodone: Primarily an antidepressant, trazodone has sedating properties and is sometimes used off-label at lower doses specifically for the treatment of insomnia.

Your doctor can provide further information on these medications and determine which option may be most suitable for you.

Final Words

While NyQuil may provide temporary relief for sinus congestion and aid in sleep, relying on it as a long-term solution is not advisable.

Thanks again for reaching out to us! I hope this helped.

References

  • [Effectiveness of reslip (doxylamine) in short-term insomnia: multicenter comparative randomized study], PubMed
  • Sleep complaints: Whenever possible, avoid the use of sleeping pills, PubMed
  • Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient Insomnia: A Systematic Review of Efficacy and Safety, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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