Skip to the answer

Minocycline

Minocycline is a tetracycline-class antibiotic used to treat certain bacterial infections, and in some specific products, inflammatory acne, rosacea, and gum disease (periodontitis).

Brand names DynacinMinocinSolodynMyracXimino +6 more
Drug classes Tetracycline-class Drug
Rx Forms 6
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 80 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 5, 2026 🚨Recall on record
Other forms & routes:
Topical
Minocycline at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Minocycline is a tetracycline-class antibiotic that keeps bacteria from growing by blocking how they make proteins, and depending on the product it treats certain infections, inflammatory acne, rosacea or gum disease (periodontitis); on the U.S. market since about 1971 and available generically, this older standby is probably best known today as an acne medicine. Most people tolerate it reasonably well, though nausea and dizziness or vertigo (a spinning feeling) are what people notice most. Avoid it in pregnancy, and call your prescriber about severe diarrhea (even weeks after finishing), headache with vision changes, rash with fever, or yellow skin or eyes.

Clinical pearls

  • Space it away from antacids containing aluminum, calcium or magnesium, and from iron products, which block its absorption.
  • Swallow capsules and tablets whole with plenty of water; pain on swallowing or chest pain afterward needs prompt attention.
  • Do not combine it with isotretinoin for acne, since both can raise pressure in the head and threaten vision.
  • Use a backup form of contraception, because minocycline may make low-dose birth control pills less effective.
How we write & review this content — our editorial policy →
How you get itPrescription only
Comes asExtended-release tablet, Capsule, Tablet +3
Earliest FDA record1971
Companies listing it with the FDA23
FDA label last updatedApr 11, 2025
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Minocycline, written from its FDA label.

What Minocycline is used for

▾

Minocycline is used for several different conditions depending on the product.

  • Minocycline capsules and tablets, and Minocin IV: infections caused by susceptible bacteria, including rickettsial infections (such as Rocky Mountain spotted fever and typhus), Mycoplasma pneumoniae respiratory infections, chlamydia-related infections, plague, tularemia, cholera and brucellosis (with streptomycin).
  • Gram-negative bacterial infections, when lab testing shows the bacteria are susceptible.
  • Extended-release tablets, including Minolira: inflammatory acne lesions in patients 12 and older.
  • Amzeeq foam: inflammatory acne lesions in patients 9 and older.
  • Zilxi foam: inflammatory rosacea lesions in adults.
  • Emrosi capsules: inflammatory rosacea lesions in adults.
  • Arestin: adult periodontitis, along with scaling and root planing.

How Minocycline works

▾

Minocycline is a tetracycline-class antibiotic. These drugs mostly stop bacteria from multiplying, and they are thought to do so by blocking bacterial protein production. Minocycline is active against a wide range of bacteria.

Bacteria resistant to tetracycline are common. Overusing antibiotics can promote resistance, so use minocycline only as prescribed. For acne, the way the extended-release tablets work is unknown.

Minocycline dosage

▾

Minocycline is taken or used differently depending on the product. Always follow your prescriber and the product label.

  • Capsules and regular tablets: swallowed whole with plenty of fluid, with or without food, usually every 12 hours for infections.
  • Extended-release tablets for acne: once daily for about 12 weeks, with the strength based on body weight.
  • Amzeeq and Zilxi foams: skin use only, once daily at least 1 hour before bedtime, and no bathing, showering or swimming for 1 hour after.
  • Minocin IV: given by a healthcare professional through a vein.
  • Arestin: placed in gum pockets by a dental professional.

Dosing details from the FDA-approved label

From the Minocycline prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Pediatric Patients above 8 years of Age
    • Initial dose of 4 mg/kg, then 2 mg/kg administered over 60 minutes every 12 hours
    • Maximum: not to exceed the usual adult dose
    • Usual pediatric dose; rapid administration is to be avoided
  • Adults
    • Initial dose of 200 mg, then 100 mg administered over 60 minutes every 12 hours
    • Maximum: should not exceed 400 mg in 24 hours
    • Usual adult dose; rapid administration is to be avoided
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION The recommended dosage of minocycline hydrochloride extended-release tablets USP are approximately 1 mg/kg once daily for 12 weeks. ( 2 ) The recommended dosage of minocycline hydrochloride extended-release tablet USP are approximately 1 mg/kg once daily for 12 weeks. Higher doses have not shown to be of additional benefit in the treatment of inflammatory lesions of acne, and may be associated with more acute vestibular side effects. The following table shows tablet strength and body weight to achieve approximately 1 mg/kg. Table 1: Dosing Table for Minocycline Hydrochloride Extended-release Tablets USP Patient's Weight ( lbs .) Patient's Weight ( kg ) Tablet Strength ( mg ) Actual mg / kg Dose 99 - 109 45 - 49 45 1 - 0.92 110 - 131 50 - 59 55 1.10 - 0.93 132 - 157 60 - 71 65 1.08 - 0.92 158 - 186 72 - 84 80 1.11 - 0.95 187 - 212 85 - 96 90 1.06 - 0.94 213 - 243 97 - 110 105 1.08 - 0.95 244 - 276 111 - 125 115 1.04 - 0.92 277 - 300 126 - 136 135 1.07 - 0.99 Minocycline hydrochloride extended-release tablets USP may be taken with or without food [see CLINICAL PHARMACOLOGY (12.3) ]. Ingestion of food along with minocycline hydrochloride extended-release tablets USP may help reduce the risk of esophageal irritation and ulceration. In patients with renal impairment, the total dosage should be decreased by either reducing the recommended individual doses and/or by extending the time intervals between doses [see WARNINGS AND PRECAUTIONS (5.4) ] .

Read the full Dosage and Administration section on DailyMed →

Minocycline side effects

▾

Many people tolerate minocycline well, but these effects can occur:

Common side effects

  • Nausea or vomiting
  • Diarrhea
  • Loss of appetite or indigestion
  • Dizziness, light-headedness or vertigo
  • Headache
  • Skin rash or itching
  • Sun sensitivity (exaggerated sunburn)
  • Mouth or tongue irritation

When to get medical help

  • Severe or ongoing diarrhea, even weeks after finishing treatment (possible C. difficile colitis)
  • Headache with blurred vision, double vision or vision loss (possible raised pressure in the head)
  • Fever, widespread rash, swollen glands or signs of organ involvement (possible DRESS syndrome)
  • Severe skin reactions, hives, facial swelling or trouble breathing (possible severe allergic reaction)
  • Yellow skin or eyes, dark urine or severe tiredness (possible liver injury)
  • Joint pain, fever or rash (possible lupus-like or serum sickness-like reaction)
  • Painful or difficult swallowing, or chest pain after taking a capsule or tablet
  • Ringing in the ears or decreased hearing

Minocycline warnings and precautions

▾
  • Teeth and bones: tetracyclines can permanently discolor developing teeth and slow bone growth during pregnancy, infancy and childhood up to age 8.
  • Liver injury: serious cases, including liver failure, have been reported.
  • Severe allergic and skin reactions: these include anaphylaxis, Stevens-Johnson syndrome and DRESS, some fatal.
  • Raised pressure in the head: symptoms are headache, blurred or double vision, and vision loss. Permanent vision loss is possible.
  • C. difficile diarrhea: this can appear weeks after treatment.
  • Autoimmune reactions: lupus-like syndrome and serum sickness have been reported.
  • Sun sensitivity and dizziness: limit sun exposure, and be careful driving or using machinery.
  • Kidney problems: the drug can build up, so the dose may need adjusting.

Minocycline interactions

▾

Several medicines and products can affect or be affected by minocycline.

  • Blood thinners: the dose may need to be lowered.
  • Penicillin: minocycline may interfere with how penicillin works.
  • Antacids (aluminum, calcium, magnesium) and iron: they reduce absorption.
  • Isotretinoin: both can raise pressure in the head.
  • Methoxyflurane: the combination has been linked to fatal kidney toxicity.
  • Low-dose birth control pills: effectiveness may be reduced, so use another contraceptive method.

Interactions listed in the FDA-approved label

From the Minocycline prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Anticoagulants: Because tetracyclines have been shown to depress plasma prothrombin activity, patients on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.
  • Penicillin: Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. Avoid giving tetracycline-class drugs in conjunction with penicillin.
  • Methoxyflurane: The concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.
  • Antacids and iron preparations: Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium and iron-containing preparations.
  • Low dose oral contraceptives: Minocycline-related changes in estradiol, progestinic hormone, FSH and LH plasma levels, of breakthrough bleeding, or of contraceptive failure, can not be ruled out. To avoid contraceptive failure, female patients are advised to use a second form of contraceptive during treatment with minocycline.
  • Drug/laboratory test (urinary catecholamines): False elevations of urinary catecholamine levels may occur due to interference with the fluorescence test.
Read the label’s full interactions text

7 DRUG INTERACTIONS Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. ( 7.1 ) The concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity. ( 7.3 ) To avoid contraceptive failure, female patients are advised to use a second form of contraceptive during treatment with minocycline. ( 7.5 ) 7.1 Anticoagulants Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. 7.2 Penicillin Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. 7.3 Methoxyflurane The concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity. 7.4 Antacids and Iron Preparations Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium and iron-containing preparations. 7.5 Low Dose Oral Contraceptives In a multi-center study to evaluate the effect of minocycline hydrochloride extended-release tablets on low dose oral contraceptives, hormone levels over one menstrual cycle with and without minocycline hydrochloride extended-release tablets 1 mg/kg once-daily were measured. Based on the results of this trial, minocycline-related changes in estradiol, progestinic hormone, FSH and LH plasma levels, of breakthrough bleeding, or of contraceptive failure, can not be ruled out. To avoid contraceptive failure, female patients are advised to use a second form of contraceptive during treatment with minocycline. 7.6 Drug/Laboratory Test Interactions False elevations of urinary catecholamine levels may occur due to interference with the fluorescence test.

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿331 supplements and herbs with documented Minocycline interactions, ranked by severity Check Minocycline against a supplement or herb →

Before taking Minocycline

▾
  • Do not use if you are allergic to tetracyclines.
  • Tell your doctor if you are pregnant or planning pregnancy. Minocycline can harm the fetus.
  • Breastfeeding is not recommended.
  • Children under 8 are at risk for tooth discoloration and slowed bone growth. Product age limits apply.
  • Tell your doctor about kidney or liver problems.
  • Tell your doctor if you have had raised pressure in the head or vision problems.
  • Older adults may need cautious dose selection.
  • Males trying to conceive should discuss use with their doctor.

Minocycline overdose

▾

Overdose most often causes dizziness, nausea and vomiting. There is no specific antidote. Treatment is to stop the medicine and give supportive care for symptoms. Dialysis does not remove significant amounts of minocycline.

What Minocycline does in the body

▾

For the extended-release tablets used for acne, the drug's effects on the body are unknown. Minocycline is primarily bacteriostatic, meaning it slows or stops bacterial growth.

How your body processes Minocycline

▾

After a dose of minocycline capsules, blood levels peak in about 1 to 4 hours (average about 2 hours). A high-fat meal delays the peak by about an hour but does not change how much is absorbed. The half-life is about 15 hours in healthy adults and can be much longer in people with kidney problems. Minocycline is lipid soluble and spreads into skin and sebum. Emrosi is not bioequivalent to other minocycline products.

How to store Minocycline

▾

Store at 20°C - 25°C (68°F - 77°F); excursions are permitted to 15°C-30°C (59°-86°F) . Protect from light and moisture. Dispense in tight, light-resistant container as defined in USP with child-resistant closure.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

331

Supplements & herbs that interact with Minocycline

331 supplements and herbal products have documented interactions with Minocycline in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 9
  • Moderate · 290
  • Minor · 32
ACTIVATED CHARCOAL Major ASARABACCA Major BEER Major DANSHEN Major OLEANDER Major PIRACETAM Major SIBERIAN COCKLEBUR Major ST. JOHN'S WORT Major +323 more
Every supplement checked against Minocycline — ranked by severity The full interaction hub: 9 major · 290 moderate · 32 minor · every one linked to its full report. Check Minocycline against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

11

Nutrient depletion considerations

Minocycline has been associated with lower levels of 11 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

Evidence & significance mix
  • Higher significance · 10
  • Moderate · 1
BIOTIN Insignificant Depletion CALCIUM Insignificant Depletion FOLIC ACID Insignificant Depletion IRON Insignificant Depletion MAGNESIUM Insignificant Depletion RIBOFLAVIN Insignificant Depletion THIAMINE Insignificant Depletion VITAMIN B12 Insignificant Depletion +3 more
See the full Minocycline nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Minocycline: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Minocycline — the kind of thing our pharmacy team would talk through with you at the counter.

What is minocycline used for?

▾
It depends on the product. Capsules, tablets and IV minocycline treat certain bacterial infections. Extended-release tablets and Amzeeq foam treat inflammatory acne. Zilxi foam and Emrosi capsules treat rosacea lesions in adults, and Arestin is used by dentists for gum pockets in periodontitis.

Do I take it with food?

▾
Minocycline capsules and regular tablets can be taken with or without food. Swallow them whole with a full glass of water. Avoid taking them right before lying down, since that is linked to throat irritation and ulcers.

What side effects should I expect?

▾
Nausea, vomiting, diarrhea, headache and dizziness are possible. You may also sunburn more easily, so limit sun and tanning beds. Call your doctor if you have severe diarrhea, vision changes, a bad rash with fever, or yellowing of your skin or eyes.

Can I take it with antacids or iron?

▾
These products can reduce how much minocycline your body absorbs. Ask me or your prescriber how to space them out. Also tell us if you take blood thinners, penicillin or isotretinoin, because those combinations need attention.

Is it safe in pregnancy or for kids?

▾
Minocycline can harm an unborn baby and can permanently discolor developing teeth, so tell your doctor if you are pregnant or could become pregnant. Breastfeeding is not recommended. It is also not meant for children under 8, and product age limits apply.

Will it affect my birth control?

▾
It may make low-dose birth control pills less reliable. Use a second form of contraception while you take it.

Is Minocycline available over the counter?

▾
No. Minocycline is a prescription medicine: every Minocycline product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Minocycline first available?

▾
The earliest FDA record we hold for Minocycline is from 1971: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Minocycline was first used.

Who makes Minocycline?

▾
23 companies currently list Minocycline products in the FDA's NDC Directory, including Bryant Ranch Prepack, Aurobindo Pharma Limited, PD-Rx Pharmaceuticals, Inc.. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Minocycline on HelloPharmacist

📊Minocycline supplement interactions331 checked — ranked by severity 🌿Drug & Supplement CheckerMinocycline vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Minocycline NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Minocycline Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Minocycline forms and strengths (how it comes)

Minocycline is available in 6 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Extended-release tablet

By mouth
Brands Solodyn
How this form is used
What it may be used for
  • Minocycline hydrochloride extended-release tablets are used for inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 12 and older.
Important instructions
  • Minocycline hydrochloride extended-release tablets are taken once daily for about 12 weeks, with the strength based on body weight.
Available strengths 8 strengths
45 mg 55 mg 65 mg 80 mg 90 mg 105 mg
Show 2 more strengths Show fewer strengths
115 mg 135 mg
135 FDA-listed product records ⓘ

Capsule

By mouth
Brands Emrosi
How this form is used
What it may be used for
  • Minocycline Hydrochloride capsules are used for infections caused by susceptible bacteria.
  • Emrosi is used for inflammatory lesions (papules and pustules) of rosacea in adults.
Important instructions
  • Minocycline Hydrochloride capsules may be taken with or without food and should be swallowed whole with plenty of fluid.
Available strengths 4 strengths
40 mg 50 mg 75 mg 100 mg
107 FDA-listed product records ⓘ

Tablet

By mouth
Brands Minolira Extended Release
How this form is used
What it may be used for
  • Minocycline Hydrochloride tablets are used for infections caused by susceptible bacteria.
  • Minolira is used for inflammatory lesions of non-nodular moderate to severe acne in patients 12 and older.
Important instructions
  • Minocycline Hydrochloride tablets may be taken with or without food and swallowed whole with plenty of fluid.
  • Minolira is taken once daily for about 12 weeks and may be taken with or without food. Taking it with food may help reduce esophageal irritation.
Available strengths 3 strengths
50 mg 75 mg 100 mg
22 FDA-listed product records ⓘ

Inhaler

On the skin
Brands Amzeeq Zilxi
How this form is used
What it may be used for
  • Amzeeq foam is used on the skin for inflammatory acne lesions in patients 9 and older.
  • Zilxi foam is used on the skin for inflammatory rosacea lesions in adults.
Important instructions
  • Amzeeq and Zilxi are for skin use only, applied once daily at least 1 hour before bedtime.
  • With Amzeeq and Zilxi, do not bathe, shower or swim for at least 1 hour after applying.
Available strengths 2 strengths
15 mg/g 40 mg/g
6 FDA-listed product records ⓘ

Injection

Into a vein
Brands Minocin
How this form is used
What it may be used for
  • Minocin Intravenous is used for infections caused by susceptible bacteria.
Important instructions
  • Minocin Intravenous is given slowly through a vein by a healthcare professional, and oral therapy is used as soon as possible.
Available strengths 1 strength
100 mg
3 FDA-listed product records ⓘ

Oral powder

By mouth
Brands Arestin
How this form is used
What it may be used for
  • Arestin is used with scaling and root planing to reduce pocket depth in adults with periodontitis.
Important instructions
  • Arestin is placed into gum pockets by a dental professional and does not require local anesthesia.
Available strengths 1 strength
1 mg
2 FDA-listed product records ⓘ

Minocycline on the U.S. market: products, makers and brands

How Minocycline appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

23 companies list 132 Minocycline product records with the FDA, mostly as extended-release tablet, capsule, tablet; the earliest marketing or approval year on record is 1971. Brand names on the directory include Dynacin, Minocin, Solodyn and 8 more; the rest are generics.

6
Dose forms ⓘ
23
Labelers (makers, repackagers, distributors)
6
Brand names
132
FDA-listed product records ⓘ
1971
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (11) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack23%
Aurobindo Pharma Limited11%
PD-Rx Pharmaceuticals, Inc.8%
Zydus Lifesciences Limited8%
Zydus Pharmaceuticals (USA) Inc.8%
Ascend Laboratories, LLC6%
Other makers36%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Minocycline is used (Medicaid data)

A general measure of how commonly Minocycline is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Minocycline is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

255,328
Medicaid prescriptions filled (Q1–Q4 2025)
$5.6M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Minocycline prescribed? Of the 1,601 medications we measure, Minocycline ranks #354 by Medicaid prescriptions — more than 78% of them.

Where Minocycline ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #354 of 1,601
#349 Dorzolamide and Timolo... 259,157 Rx #350 Brimonidine 258,429 Rx #351 Morphine Injection 257,677 Rx #352 Brimonidine Ophthalmic 257,228 Rx #353 Triprolidine 256,126 Rx #354 Minocycline 255,328 Rx #355 Epoetin Alfa, Injectio... 255,197 Rx #356 Memantine 254,572 Rx #357 Moxifloxacin 251,847 Rx #358 Lumateperone 251,587 Rx #359 Haloperidol Injection 250,807 Rx

Utilization by Minocycline product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 100 mg oral capsule is the most-dispensed Minocycline product — about 74% of these Medicaid prescriptions.

minocycline 100 MG Oral Capsule Most dispensed

188,040 Medicaid prescriptions (Q1–Q4 2025) 74% of Minocycline prescriptions shown $4.2M gross reimbursement (before rebates) ≈ $23 per prescription (gross)

Summed across the 6 of 128 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197984

minocycline 50 MG Oral Capsule

53,695 Medicaid prescriptions (Q1–Q4 2025) 21% of Minocycline prescriptions shown $847,307 gross reimbursement (before rebates) ≈ $16 per prescription (gross)

Summed across the 6 of 52 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197985

minocycline 100 MG Oral Tablet

7,587 Medicaid prescriptions (Q1–Q4 2025) 3% of Minocycline prescriptions shown $305,616 gross reimbursement (before rebates) ≈ $40 per prescription (gross)

Summed across the 2 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 207364

minocycline 75 MG Oral Capsule

2,905 Medicaid prescriptions (Q1–Q4 2025) 1% of Minocycline prescriptions shown $64,622 gross reimbursement (before rebates) ≈ $22 per prescription (gross)

Summed across the 3 of 17 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 314108

minocycline 50 MG Oral Tablet

2,855 Medicaid prescriptions (Q1–Q4 2025) 1% of Minocycline prescriptions shown $87,160 gross reimbursement (before rebates) ≈ $31 per prescription (gross)

Summed across the 2 of 10 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 207362

24 HR minocycline 55 MG Extended Release Oral Tablet

54 Medicaid prescriptions (Q1–Q4 2025) <1% of Minocycline prescriptions shown $8,204 gross reimbursement (before rebates) ≈ $152 per prescription (gross)

Summed across the 1 of 28 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1013662

minocycline 75 MG Oral Tablet

52 Medicaid prescriptions (Q1–Q4 2025) <1% of Minocycline prescriptions shown $1,671 gross reimbursement (before rebates) ≈ $32 per prescription (gross)

Summed across the 1 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 403840

minocycline 100 MG Injection

46 Medicaid prescriptions (Q1–Q4 2025) <1% of Minocycline prescriptions shown $61,356 gross reimbursement (before rebates) ≈ $1,334 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 317127

24 HR minocycline 65 MG Extended Release Oral Tablet

46 Medicaid prescriptions (Q1–Q4 2025) <1% of Minocycline prescriptions shown $8,404 gross reimbursement (before rebates) ≈ $183 per prescription (gross)

Summed across the 1 of 26 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 858372

24 HR minocycline 90 MG Extended Release Oral Tablet

37 Medicaid prescriptions (Q1–Q4 2025) <1% of Minocycline prescriptions shown $3,923 gross reimbursement (before rebates) ≈ $106 per prescription (gross)

Summed across the 1 of 38 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 629699

24 HR minocycline 45 MG Extended Release Oral Tablet

11 Medicaid prescriptions (Q1–Q4 2025) <1% of Minocycline prescriptions shown $2,033 gross reimbursement (before rebates) ≈ $185 per prescription (gross)

Summed across the 1 of 37 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 629697

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Minocycline, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 25 of 354 listed Minocycline NDCs with Medicaid activity.

Compare Minocycline products

A representative set of FDA-listed product records for Minocycline — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 104 of 132 products — FDA National Drug Code Directory. See every product, package size and price: browse all 132 Minocycline NDCs →

Minocycline recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list one Minocycline recall since July 2021. It is still ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Ongoing Class II Jun 1, 2026 · Ascend Laboratories, LLC
Failed Dissolution Specifications: An out-of-specification (OOS) result was observed during the 9th month of dissolution test analysis
  • Minocycline Hydrochloride Extended-Release Tablets, USP, 115 mg, 30-count bottle, Rx Only, Manufactured by: Alkem Laboratories Ltd., INDIA. Distributed by: Ascend Laboratories, LLC, Parsippany, NJ 07… Lots: Lot# 25141635, Exp 4/30/2028 FDA record D-0597-2026 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Minocycline RxCUI 6980 9 dose forms · 24 strengths
  1. Dose form (SCDF) Extended Release Oral Capsule RxCUI 384629 No current FDA listing
    Clinical drug / strength (SCD) 24 HR minocycline 135 MG RxCUI 1302674 24 HR minocycline 40 MG RxCUI 2706371 24 HR minocycline 45 MG RxCUI 1302650 24 HR minocycline 90 MG RxCUI 1302664
  3. Dose form (SCDF) Injection RxCUI 1740905 In current FDA listings
    Clinical drug / strength (SCD) 100 MG RxCUI 317127
  4. Dose form (SCDF) Oral Capsule RxCUI 372933 In current FDA listings
    Clinical drug / strength (SCD) 50 MG RxCUI 197985 75 MG RxCUI 314108 100 MG RxCUI 197984
  5. Dose form (SCDF) Oral Gel RxCUI 385778 No current FDA listing
    Clinical drug / strength (SCD) 0.02 MG/MG RxCUI 103823
  6. Dose form (SCDF) Oral Powder RxCUI 378771 In current FDA listings
    Clinical drug / strength (SCD) 1 MG RxCUI 351121
  7. Dose form (SCDF) Oral Suspension RxCUI 372935 No current FDA listing
    Clinical drug / strength (SCD) 10 MG/ML RxCUI 242807
  8. Dose form (SCDF) Oral Tablet RxCUI 372936 In current FDA listings
    Clinical drug / strength (SCD) 50 MG RxCUI 207362 75 MG RxCUI 403840 100 MG RxCUI 207364
  9. Dose form (SCDF) Topical Foam RxCUI 2257672 No current FDA listing
    Clinical drug / strength (SCD) 15 MG/ML RxCUI 2375333 40 MG/ML RxCUI 2257673

Look up RxCUI 6980 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Minocycline costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Capsule · Oral 100 mg $0.343 per capsule NDC details & price history
Capsule · Oral 50 mg $0.180 per capsule NDC details & price history
Capsule · Oral 75 mg $0.424 per capsule NDC details & price history
Tablet · Oral 50 mg $0.344 per tablet NDC details & price history
Tablet · Oral 100 mg $0.704 per tablet NDC details & price history
Tablet · Oral 75 mg $0.302 per tablet NDC details & price history
Capsule 75 mg $0.424 per capsule NDC details & price history
Capsule 100 mg $0.343 per capsule NDC details & price history
Capsule 50 mg $0.180 per capsule NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Minocycline brand names

Minocycline is sold under 11 brand names in the FDA directory — Dynacin, Minocin, Solodyn, Myrac and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Dynacin Minocin Solodyn Myrac Ximino Minolira Amzeeq Zilxi Emrosi Arestin Cleeravue-M

Who makes Minocycline: manufacturers and labelers

23 companies list Minocycline products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, Aurobindo Pharma Limited, PD-Rx Pharmaceuticals, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Bryant Ranch Prepack 30 Aurobindo Pharma Limited 14 PD-Rx Pharmaceuticals, Inc. 11 Zydus Lifesciences Limited 11 Zydus Pharmaceuticals (USA) Inc. 11 Ascend Laboratories, LLC 8 Proficient Rx LP 6 Torrent Pharmaceuticals Limited 6 A-S Medication Solutions 4 Lupin Pharmaceuticals, Inc. 4 Actavis Pharma, Inc. 3 Chartwell RX, LLC 3 Journey Medical Corporation 3 Northwind Health Company, LLC 3 NuCare Pharmaceuticals,Inc. 3 Strides Pharma Science Limited 3 Advanced Rx Pharmacy of Tennessee, LLC 2 Remedyrepack Inc. 2 American Health Packaging 1 Major Pharamceuticals 1 Melinta Therapeutics, LLC 1 OraPharma, Inc. 1 Preferred Pharmaceuticals Inc. 1

Minocycline drug class (RxNorm)

Minocycline belongs to the Tetracycline-class Drug class.

Pharmacologic class Tetracycline-class Drug
Drug family (ATC) Antiinfectives and antiseptics for local oral treatment, Antiinfectives for treatment of acne, Tetracyclines

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Minocycline page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Apr 11, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Minocycline.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Minocycline after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
80
Finished products in the current FDA directory
132
Companies listing them (makers, repackagers, distributors)
23
FDA labeler codes behind them ⓘ
30
Linked representative label ⓘ
Aurobindo Pharma Limited
Linked label effective
Apr 11, 2025
Composite sections available
25
Linked SPL Set ID
e7b88a48-12b3-461d-b356-0d7ae4e8fd44
Linked SPL Document ID
5569f0f6-b36f-4149-aee7-2699fa5ebe53
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 30
65862-0554-01 Minocycline Hydrochloride 45 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0554-19 Minocycline Hydrochloride 45 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0554-30 Minocycline Hydrochloride 45 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0554-99 Minocycline Hydrochloride 45 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0555-19 Minocycline Hydrochloride 65 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0555-30 Minocycline Hydrochloride 65 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0555-99 Minocycline Hydrochloride 65 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0556-01 Minocycline Hydrochloride 90 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0556-30 Minocycline Hydrochloride 90 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0556-61 Minocycline Hydrochloride 90 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0556-99 Minocycline Hydrochloride 90 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0557-30 Minocycline Hydrochloride 115 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0557-61 Minocycline Hydrochloride 115 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0557-99 Minocycline Hydrochloride 115 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0558-01 Minocycline Hydrochloride 135 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0558-30 Minocycline Hydrochloride 135 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0558-49 Minocycline Hydrochloride 135 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0558-99 Minocycline Hydrochloride 135 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0883-01 Minocycline Hydrochloride 55 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0883-05 Minocycline Hydrochloride 55 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Aurobindo Pharma Limited is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →