FDA-filed SPL labeling · retrieved through openFDA

Minocycline

Minocycline is a tetracycline-class antibiotic used across multiple formulations to treat a wide range of bacterial infections, acne vulgaris, and rosacea.

Brand names DynacinMinocinSolodynMyracXimino +7 more
Drug classes ⓘ Tetracycline-class Drug
Rx Forms 7 Routes Oral · Topical · Intravenous
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 80 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveApr 11, 2025
Clinical labels in scope ⓘ80
AvailabilityRx
Earliest approval/marketing year ⓘ1971
FDA-listed product records ⓘ384
Boxed warningNone found in compared labels
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 25, 2026 🚨Recall on record
Other forms & routes:
Topical
⭐ Minocycline at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Minocycline is a versatile tetracycline antibiotic available in several formulations for treating bacterial infections, acne vulgaris, and rosacea — but the right product matters, since not every form is approved for every use. It requires care around pregnancy, young children, sun exposure, and potential interactions with common medications. Always follow your prescriber's instructions closely and report any unusual symptoms, especially dizziness, vision changes, or severe skin reactions, right away.
How we write & review this content — our editorial policy →

📖 Minocycline: Patient Information Guide

A plain-language walkthrough of Minocycline — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Minocycline is available in multiple formulations, each approved for specific uses. Here is the full supported range:

  • Oral capsules and tablets (standard, for infections): Rocky Mountain spotted fever and other rickettsial fevers; respiratory tract infections (including Mycoplasma pneumoniae and Haemophilus influenzae); lymphogranuloma venereum; psittacosis (parrot fever); trachoma and inclusion conjunctivitis; nongonococcal urethritis and related genital infections; relapsing fever; chancroid; plague; tularemia; cholera; brucellosis; bartonellosis; granuloma inguinale; campylobacter infections; and certain infections caused by susceptible gram-negative bacteria including E. coli, Shigella, Acinetobacter, and Klebsiella species
  • MINOCIN Intravenous: The same range of susceptible bacterial infections as above, plus gram-positive coverage, used when oral therapy is not adequate or tolerated
  • Extended-release oral tablets (minocycline hydrochloride ER): Inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 12 years and older — not evaluated for treating infections
  • AMZEEQ (topical foam): Inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 9 years and older — not evaluated for treating infections
  • ZILXI (topical foam): Inflammatory lesions of rosacea in adults — not evaluated for treating infections
  • EMROSI (oral capsule): Inflammatory lesions (papules and pustules) of rosacea in adults — not evaluated for treating infections
  • ARESTIN (oral powder, dental use only): Adjunct to scaling and root planing to reduce pocket depth in adult periodontitis; may be used as part of a periodontal maintenance program
⚙️How it works▾

Minocycline belongs to the tetracycline class of antibiotics. It works by blocking bacterial protein synthesis — it enters bacterial cells and interferes with the machinery bacteria use to build the proteins they need to grow and survive. This halts bacterial growth (bacteriostatic action) so the body's immune system can eliminate the infection. It works against a broad spectrum of both gram-positive and gram-negative bacteria.

One important note: bacteria can develop resistance to tetracyclines, and cross-resistance among drugs in this class is common. When minocycline is used for acne or rosacea, the precise mechanism behind its benefit is not fully known — the anti-inflammatory properties of the drug are thought to play a role.

💊How it's taken▾

The right way to take minocycline depends entirely on which product you have been prescribed. Key points by formulation:

  • Oral capsules and standard tablets (infections): Taken by mouth with or without food, typically twice daily. Swallow whole with a full glass of water. Do not take at bedtime without adequate fluid, as this increases the risk of esophageal irritation.
  • MINOCIN Intravenous: Given by slow intravenous infusion (over 60 minutes) by a healthcare professional; oral therapy is started as soon as possible.
  • Extended-release tablets (acne): Taken once daily by mouth for 12 weeks; dose is weight-based.
  • EMROSI capsules (rosacea): One capsule taken orally once daily, with or without food. Swallow whole — do not crush or chew. Food may help reduce the chance of esophageal irritation.
  • AMZEEQ and ZILXI topical foams: Applied to the skin once daily, at approximately the same time each day, at least 1 hour before bedtime. Do not bathe, shower, or swim for at least 1 hour after applying. For external use only.
  • ARESTIN powder: Applied by a dental professional into gum pockets — not self-administered.

Always follow your prescriber's or dentist's instructions exactly. Do not exceed the recommended dose, as this increases the risk of side effects.

🤒Side effects — in detail▾

Minocycline can cause a range of side effects depending on the form used. Common ones include:

  • Nausea, vomiting, diarrhea, or stomach upset
  • Dizziness, lightheadedness, or a spinning sensation (vertigo)
  • Headache
  • Skin or mucous membrane discoloration (darkening)
  • Tooth discoloration with prolonged use
  • Increased sensitivity to sunlight (easier sunburn)
  • Itching or rash
  • Tinnitus (ringing in the ears) or decreased hearing

More serious reactions — including severe liver injury, dangerous pressure in the skull, DRESS syndrome (a severe drug hypersensitivity reaction), lupus-like syndrome, and severe C. difficile diarrhea — are less common but require prompt medical attention. Stop the medication and contact your doctor or seek emergency care if any of these occur.

⚠️Warnings & precautions▾
  • Tooth and bone development: Taking minocycline orally during the second or third trimester of pregnancy, infancy, or childhood through age 8 can permanently stain teeth yellow-gray-brown and may slow bone growth. Minocycline should not be used in this age group unless no alternatives exist.
  • Serious liver injury: Fatal liver failure has been reported with long-term oral minocycline use, particularly for acne. Watch for yellowing skin or eyes, dark urine, or severe fatigue and report these immediately.
  • Intracranial hypertension (pressure buildup in the skull): Can cause headache, blurred or double vision, and vision loss. Women who are overweight or have a prior history of this condition are most at risk. Do not take minocycline with isotretinoin. Seek prompt eye evaluation if vision changes occur.
  • DRESS syndrome and serious skin reactions: Rare but potentially fatal. Signs include spreading rash, fever, swollen lymph nodes, and organ involvement. Discontinue minocycline immediately if suspected.
  • Autoimmune syndromes: Long-term use has been linked to a lupus-like syndrome, autoimmune hepatitis, and vasculitis. Stop treatment if these symptoms appear.
  • C. difficile-associated diarrhea: Can occur during or up to two months after antibiotic use. Severe cases can be life-threatening. Contact your doctor for any significant diarrhea after taking minocycline.
  • Photosensitivity: Minimize sun exposure and avoid tanning beds while on minocycline. Stop use at the first sign of sunburn.
🔀What it interacts with▾

Minocycline can interact with several common medications and supplements. Talk to your doctor or pharmacist about everything you take:

  • Antacids (containing aluminum, calcium, or magnesium) and iron supplements: These bind to minocycline in the gut and significantly reduce how much is absorbed — take minocycline separately.
  • Blood thinners (anticoagulants such as warfarin): Minocycline can increase their blood-thinning effect, raising bleeding risk; your anticoagulant dose may need to be lowered.
  • Penicillin antibiotics: Minocycline can interfere with how penicillin kills bacteria; these two should generally not be used together.
  • Methoxyflurane (an inhaled anesthetic): Combining with tetracyclines has been associated with fatal kidney toxicity.
  • Isotretinoin (Accutane): Both drugs can raise pressure in the skull; using them together is dangerous and should be avoided.
  • Low-dose oral contraceptives: Minocycline may affect hormone levels; a backup contraceptive method is recommended during treatment.

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Allergy to tetracyclines: Do not take minocycline if you have had a hypersensitivity reaction to any tetracycline antibiotic.
  • Pregnancy: Minocycline can harm the fetus — it may cause permanent tooth discoloration and skeletal abnormalities. If you become pregnant while taking it, contact your prescriber right away.
  • Breastfeeding: Minocycline passes into breast milk. Breastfeeding is not recommended during minocycline therapy and for 4 days after the last dose.
  • Children under 8 years old: Not recommended due to risk of permanent tooth staining. Extended-release tablets are only approved from age 12 and up; AMZEEQ topical foam from age 9 and up.
  • Kidney impairment: Minocycline can accumulate to dangerous levels; doses may need to be reduced and kidney function monitored.
  • Liver disease: Minocycline can be toxic to the liver at higher exposures; use with extra caution and monitoring.
  • Overweight women or those with a history of intracranial hypertension: At greater risk of developing dangerous pressure inside the skull during minocycline treatment.
  • Older adults: Start at the lower end of the dosing range, as reduced kidney, liver, or heart function is more common with age.
🚑If you take too much▾

Taking too much minocycline most commonly causes dizziness, nausea, and vomiting. There is no specific antidote. If an overdose is suspected, stop the medication, seek medical care, and treatment will focus on managing symptoms with supportive care. Minocycline is not effectively removed by dialysis.

🔬Pharmacokinetics — how your body processes it▾

When taken orally, minocycline is well absorbed and reaches peak blood levels within roughly 1 to 4 hours (about 2 hours on average for capsules). Food may delay the time to peak levels slightly but does not meaningfully change the total amount absorbed for most oral formulations. The drug has a half-life of approximately 11 to 22 hours, meaning it stays in the body for a meaningful period after each dose.

Minocycline is lipid soluble, which means it distributes well into tissues including skin and sebum — relevant to its use for acne and rosacea. In patients with significant kidney impairment, the half-life can extend considerably (up to 69 hours in some cases), increasing the risk of drug accumulation. EMROSI is not bioequivalent to other minocycline products, and its pharmacokinetics should be considered separately.

📦How to store it▾

Store at 20°C - 25°C (68°F - 77°F); excursions are permitted to 15°C-30°C (59°-86°F) . Protect from light and moisture. Dispense in tight, light-resistant container as defined in USP with child-resistant closure.

📄 Written from Minocycline’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

331

Supplements & herbs that interact with Minocycline

331 supplements and herbal products have documented interactions with Minocycline in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 9
  • Moderate · 290
  • Minor · 32
ACTIVATED CHARCOAL Major ASARABACCA Major BEER Major DANSHEN Major OLEANDER Major PIRACETAM Major SIBERIAN COCKLEBUR Major ST. JOHN'S WORT Major +323 more
Every supplement checked against Minocycline — ranked by severity The full interaction hub: 9 major · 290 moderate · 32 minor · every one linked to its full report. Check Minocycline against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

11

Nutrient depletion considerations

Minocycline has been associated with lower levels of 11 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

Evidence & significance mix
  • Higher significance · 10
  • Moderate · 1
BIOTIN Insignificant Depletion CALCIUM Insignificant Depletion FOLIC ACID Insignificant Depletion IRON Insignificant Depletion MAGNESIUM Insignificant Depletion RIBOFLAVIN Insignificant Depletion THIAMINE Insignificant Depletion VITAMIN B12 Insignificant Depletion +3 more
See the full Minocycline nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Minocycline — the kind of thing our pharmacy team would talk through with you at the counter.

Can I take my minocycline capsule or tablet with food, or does it have to be on an empty stomach? ▾
Good news — standard minocycline oral capsules and tablets can be taken with or without food, so you have flexibility there. The most important thing is to take it with a full glass of water and avoid lying down right afterward, especially at bedtime. This helps prevent the tablet or capsule from sitting in your esophagus and causing irritation or ulceration. EMROSI capsules for rosacea can also be taken with or without food, though eating something with it may help reduce any stomach upset.
I've been prescribed the extended-release minocycline tablets for acne. How long does it take to work, and how long do I take it? ▾
The extended-release tablets for acne are typically taken once daily for 12 weeks. As with most acne treatments, you likely won't see dramatic results overnight — it takes time for the inflammation to settle down. Keep taking it as directed even if you don't notice changes right away. It's also worth knowing that this formulation targets the inflammatory pimples specifically and has not been shown to help non-inflammatory acne, like blackheads or whiteheads. Follow your prescriber's plan and check in with them if you have concerns about your progress.
What side effects are most likely, and which ones should make me call my doctor? ▾
The most common side effects you might notice are nausea, dizziness, or a spinning sensation — especially early in treatment. Some people also notice increased sensitivity to sun (burning more easily), headache, or mild stomach upset. These often improve on their own. However, you should call your doctor right away if you get severe or persistent diarrhea (which can signal a serious gut infection even weeks after finishing the antibiotic), yellowing of the skin or eyes, severe headache with vision changes, or a widespread rash with fever and swollen lymph nodes. These rare but serious reactions need prompt attention.
Is it safe to take minocycline if I'm pregnant or trying to get pregnant? ▾
Minocycline is not safe to take during pregnancy, especially in the second and third trimesters. It can cross the placenta, potentially cause permanent staining of the baby's developing teeth, and may affect bone development. If you become pregnant while taking minocycline, stop it and contact your prescriber right away. If you're trying to conceive, talk to your doctor before starting — they can weigh the benefits and risks and explore alternatives if appropriate.
Can minocycline interfere with my birth control pill? ▾
Possibly. Studies suggest minocycline may affect hormone levels related to low-dose oral contraceptives — meaning there's a chance your pill could be less effective. To stay protected, it's a good idea to use a backup method of contraception (like condoms) while you're taking minocycline. Talk to your prescriber or pharmacist about this, especially if you're on a low-dose hormonal contraceptive.
I take antacids regularly. Is that a problem with minocycline? ▾
Yes, this is an important one. Antacids that contain aluminum, calcium, or magnesium can bind to minocycline in your stomach and significantly reduce how much of the drug your body absorbs — making it less effective. The same applies to iron supplements. If you need to take an antacid or iron, try to space it well apart from your minocycline dose. Check with your pharmacist about the best timing for your specific products.
Is Minocycline available over the counter? ▾
Minocycline is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
When was Minocycline first available? ▾
Minocycline has been available in the United States since at least 1971, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Minocycline? ▾
Minocycline is supplied by 57 manufacturers listed in the FDA NDC Directory, including Bryant Ranch Prepack, Aurobindo Pharma Limited, PD-Rx Pharmaceuticals, Inc..

💬 Answers drafted from Minocycline’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

📊Minocycline supplement interactions331 checked — ranked by severity 🌿Drug & Supplement CheckerMinocycline vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Minocycline NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Minocycline comes

Minocycline is available in 7 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Capsule

By mouth
Brands Emrosi Minocin
Available strengths 4 strengths
40 mg 50 mg 75 mg 100 mg
152 FDA-listed product records ⓘ

Tablet

By mouth
Brands Minolira Extended Release
Available strengths 5 strengths
50 mg 75 mg 100 mg 105 mg 135 mg
37 FDA-listed product records ⓘ

Extended-release capsule

By mouth
Brands Ximino
Available strengths 3 strengths
45 mg 90 mg 135 mg
12 FDA-listed product records ⓘ

Inhaler

On the skin
Brands Amzeeq Zilxi
Available strengths 2 strengths
15 mg/g 40 mg/g
9 FDA-listed product records ⓘ

Injection

Into a vein
Brands Minocin
Available strengths 1 strength
100 mg
3 FDA-listed product records ⓘ

Oral powder

By mouth
Brands Arestin
Available strengths 1 strength
1 mg
2 FDA-listed product records ⓘ

📊 Minocycline across the U.S. market

How Minocycline appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

7
Dose forms ⓘ
57
Manufacturers
10
Brand names
384
FDA-listed product records ⓘ
1971
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (11) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack16%
Aurobindo Pharma Limited11%
PD-Rx Pharmaceuticals, Inc.7%
Zydus Lifesciences Limited5%
Zydus Pharmaceuticals (USA) Inc.5%
Journey Medical Corporation4%
Other makers52%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Minocycline is used

A general measure of how commonly Minocycline is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Minocycline is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

255,328
Medicaid prescriptions filled (Q1–Q4 2025)
$5.6M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Minocycline prescribed? Of the 1,597 medications we measure, Minocycline ranks #354 by Medicaid prescriptions — more than 78% of them.

Where Minocycline ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #354 of 1,597
#349 Dorzolamide and Timolo... 259,157 Rx #350 Brimonidine 258,429 Rx #351 Morphine Injection 257,677 Rx #352 Brimonidine Ophthalmic 257,228 Rx #353 Triprolidine 256,126 Rx #354 Minocycline 255,328 Rx #355 Epoetin Alfa, Injectio... 255,197 Rx #356 Memantine 254,572 Rx #357 Moxifloxacin 251,847 Rx #358 Lumateperone 251,587 Rx #359 Haloperidol Injection 250,807 Rx

Utilization by Minocycline product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 100 mg oral capsule is the most-dispensed Minocycline product — about 74% of these Medicaid prescriptions.

minocycline 100 MG Oral Capsule Most dispensed

188,040 Medicaid prescriptions (Q1–Q4 2025) 74% of Minocycline prescriptions shown $4.2M gross reimbursement (before rebates) ≈ $23 per prescription (gross)

Summed across the 6 of 128 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197984

minocycline 50 MG Oral Capsule

53,695 Medicaid prescriptions (Q1–Q4 2025) 21% of Minocycline prescriptions shown $847,307 gross reimbursement (before rebates) ≈ $16 per prescription (gross)

Summed across the 6 of 52 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197985

minocycline 100 MG Oral Tablet

7,587 Medicaid prescriptions (Q1–Q4 2025) 3% of Minocycline prescriptions shown $305,616 gross reimbursement (before rebates) ≈ $40 per prescription (gross)

Summed across the 2 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 207364

minocycline 75 MG Oral Capsule

2,905 Medicaid prescriptions (Q1–Q4 2025) 1% of Minocycline prescriptions shown $64,622 gross reimbursement (before rebates) ≈ $22 per prescription (gross)

Summed across the 3 of 17 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 314108

minocycline 50 MG Oral Tablet

2,855 Medicaid prescriptions (Q1–Q4 2025) 1% of Minocycline prescriptions shown $87,160 gross reimbursement (before rebates) ≈ $31 per prescription (gross)

Summed across the 2 of 10 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 207362

24 HR minocycline 55 MG Extended Release Oral Tablet

54 Medicaid prescriptions (Q1–Q4 2025) <1% of Minocycline prescriptions shown $8,204 gross reimbursement (before rebates) ≈ $152 per prescription (gross)

Summed across the 1 of 28 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1013662

minocycline 75 MG Oral Tablet

52 Medicaid prescriptions (Q1–Q4 2025) <1% of Minocycline prescriptions shown $1,671 gross reimbursement (before rebates) ≈ $32 per prescription (gross)

Summed across the 1 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 403840

minocycline 100 MG Injection

46 Medicaid prescriptions (Q1–Q4 2025) <1% of Minocycline prescriptions shown $61,356 gross reimbursement (before rebates) ≈ $1,334 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 317127

24 HR minocycline 65 MG Extended Release Oral Tablet

46 Medicaid prescriptions (Q1–Q4 2025) <1% of Minocycline prescriptions shown $8,404 gross reimbursement (before rebates) ≈ $183 per prescription (gross)

Summed across the 1 of 26 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 858372

24 HR minocycline 90 MG Extended Release Oral Tablet

37 Medicaid prescriptions (Q1–Q4 2025) <1% of Minocycline prescriptions shown $3,923 gross reimbursement (before rebates) ≈ $106 per prescription (gross)

Summed across the 1 of 38 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 629699

24 HR minocycline 45 MG Extended Release Oral Tablet

11 Medicaid prescriptions (Q1–Q4 2025) <1% of Minocycline prescriptions shown $2,033 gross reimbursement (before rebates) ≈ $185 per prescription (gross)

Summed across the 1 of 37 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 629697

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Minocycline, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 25 of 354 listed Minocycline NDCs with Medicaid activity.

🔍 Compare Minocycline products

A representative set of FDA-listed product records for Minocycline — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 384 products — FDA National Drug Code Directory. See every product, package size and price: browse all 384 Minocycline NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Minocycline RxCUI 6980 9 dose forms · 24 strengths
  1. Dose form (SCDF) Extended Release Oral Capsule RxCUI 384629 In current FDA listings
    Clinical drug / strength (SCD) 24 HR minocycline 135 MG RxCUI 1302674 24 HR minocycline 40 MG RxCUI 2706371 24 HR minocycline 45 MG RxCUI 1302650 24 HR minocycline 90 MG RxCUI 1302664
  3. Dose form (SCDF) Injection RxCUI 1740905 In current FDA listings
    Clinical drug / strength (SCD) 100 MG RxCUI 317127
  4. Dose form (SCDF) Oral Capsule RxCUI 372933 In current FDA listings
    Clinical drug / strength (SCD) 50 MG RxCUI 197985 75 MG RxCUI 314108 100 MG RxCUI 197984
  5. Dose form (SCDF) Oral Gel RxCUI 385778 No current FDA listing
    Clinical drug / strength (SCD) 0.02 MG/MG RxCUI 103823
  6. Dose form (SCDF) Oral Powder RxCUI 378771 In current FDA listings
    Clinical drug / strength (SCD) 1 MG RxCUI 351121
  7. Dose form (SCDF) Oral Suspension RxCUI 372935 No current FDA listing
    Clinical drug / strength (SCD) 10 MG/ML RxCUI 242807
  8. Dose form (SCDF) Oral Tablet RxCUI 372936 In current FDA listings
    Clinical drug / strength (SCD) 50 MG RxCUI 207362 75 MG RxCUI 403840 100 MG RxCUI 207364
  9. Dose form (SCDF) Topical Foam RxCUI 2257672 No current FDA listing
    Clinical drug / strength (SCD) 15 MG/ML RxCUI 2375333 40 MG/ML RxCUI 2257673

Look up RxCUI 6980 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Dynacin Minocin Solodyn Myrac Ximino Minolira Amzeeq Zilxi Emrosi Arestin Cleeravue-M Minolira Extended Release

🏭 Manufacturers & labelers

Bryant Ranch Prepack 57 Aurobindo Pharma Limited 39 PD-Rx Pharmaceuticals, Inc. 25 Zydus Lifesciences Limited 19 Zydus Pharmaceuticals (USA) Inc. 18 Journey Medical Corporation 16 Ascend Laboratories, LLC 16 Torrent Pharmaceuticals Limited 15 A-S Medication Solutions 12 Actavis Pharma, Inc. 10 Bausch Health US LLC 10 Sun Pharmaceutical Industries, Inc. 9 NuCare Pharmaceuticals,Inc. 9 Lupin Pharmaceuticals, Inc. 8 Proficient Rx LP 8 JG Pharma, Inc. 6 Zydus Pharmaceuticals USA Inc. 6 Preferred Pharmaceuticals Inc. 6 Remedyrepack Inc. 6 Cadila Healthcare Limited 5 Amneal Pharmaceuticals of New York, LLC 4 AvKARE 4 RPK Pharmaceuticals, Inc. 4 Denton Pharma, Inc. DBA Northwind Pharmaceuticals 3

…and 16 more on the FDA NDC directory.

RxNorm drug class

Minocycline belongs to the Tetracycline-class Drug class.

Pharmacologic class Tetracycline-class Drug
Drug family (ATC) Antiinfectives and antiseptics for local oral treatment, Antiinfectives for treatment of acne, Tetracyclines

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Apr 11, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Minocycline.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Minocycline after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
80
NDC products indexed
384
Distinct labelers/manufacturers represented
57
Linked representative label ⓘ
Aurobindo Pharma Limited
Linked label effective
Apr 11, 2025
Composite sections available
25
Linked SPL Set ID
e7b88a48-12b3-461d-b356-0d7ae4e8fd44
Linked SPL Document ID
5569f0f6-b36f-4149-aee7-2699fa5ebe53
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 30
65862-0554-01 Minocycline Hydrochloride 45 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0554-19 Minocycline Hydrochloride 45 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0554-30 Minocycline Hydrochloride 45 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0554-99 Minocycline Hydrochloride 45 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0555-19 Minocycline Hydrochloride 65 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0555-30 Minocycline Hydrochloride 65 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0555-99 Minocycline Hydrochloride 65 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0556-01 Minocycline Hydrochloride 90 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0556-30 Minocycline Hydrochloride 90 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0556-61 Minocycline Hydrochloride 90 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0556-99 Minocycline Hydrochloride 90 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0557-30 Minocycline Hydrochloride 115 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0557-61 Minocycline Hydrochloride 115 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0557-99 Minocycline Hydrochloride 115 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0558-01 Minocycline Hydrochloride 135 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0558-30 Minocycline Hydrochloride 135 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0558-49 Minocycline Hydrochloride 135 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0558-99 Minocycline Hydrochloride 135 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0883-01 Minocycline Hydrochloride 55 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo 65862-0883-05 Minocycline Hydrochloride 55 mg/1 TABLET, FILM COATED, EXTENDED RELEASE Aurobindo

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 80 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Aurobindo Pharma Limited is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.