Minocycline

112 interactions 271 cited references

Also sold as: Amzeeq Arestin Cleeravue-M Dynacin® Emrosi Minocin Minocin® Minolira Myrac® Solodyn Solodyn® Ximino Ximino® Zilxi

About Minocycline

Minocycline is a tetracycline antibiotic used to treat bacterial infections and acne. Read the full Minocycline drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acitretin Isotretinoin Estradiol Topical Penicillin V Potassium Bexarotene Topical Penicillin G Benzathine Injection

1 Contraindicated 88 Major 23 Moderate

All (112) Contraindicated (1) Major (88) Moderate (23)

Contraindicated

Minocycline Acitretin Soriatane® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details

Major

Minocycline Isotretinoin Absorica An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Minocycline Amoxicillin Amoxi Drop Decreased antibacterial effectiveness Details Minocycline Ampicillin Amcill® Decreased antibacterial effectiveness Details Minocycline Ampicillin Injection Omnipen-N® Decreased antibacterial effectiveness Details Minocycline Apixaban Eliquis An increased risk of bleeding Details Minocycline Azathioprine Azasan An increased risk of hepatotoxicity Details Minocycline Betrixaban Bevyxxa® An increased risk of bleeding Details Minocycline Bexarotene Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Minocycline Bexarotene Topical Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Minocycline Dabigatran Pradaxa® An increased risk of bleeding Details Minocycline Dabigatran Etexilate An increased risk of bleeding Details Minocycline Dalteparin Injection Fragmin An increased risk of bleeding Details Minocycline Digoxin Cardoxin® Increased digoxin levels and digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Minocycline Edoxaban Savaysa An increased risk of bleeding Details Minocycline Enoxaparin Lovenox An increased risk of bleeding Details Minocycline Enoxaparin Injection Lovenox An increased risk of bleeding Details Minocycline Estradiol Delestrogen Decreased contraceptive efficacy Details Minocycline Estradiol Topical Divigel Decreased contraceptive efficacy Details Minocycline Estradiol Transdermal Patch Alora® Decreased contraceptive efficacy Details Minocycline Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Minocycline Fondaparinux Arixtra An increased risk of bleeding Details Minocycline Fondaparinux Injection Arixtra An increased risk of bleeding Details Minocycline Heparin An increased risk of bleeding Details Minocycline Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Minocycline Levonorgestrel After banger Decreased contraceptive efficacy Details Minocycline Levonorgestrel Intrauterine System Kyleena Decreased contraceptive efficacy Details Minocycline Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Minocycline Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Minocycline Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Minocycline Acenocoumarol An increased risk of bleeding Details Minocycline Ardeparin An increased risk of bleeding Details Minocycline Argatroban An increased risk of bleeding Details Minocycline Atazanavir Reyataz Decreased atazanavir exposure and plasma concentrations Details Minocycline Bacampicillin Decreased antibacterial effectiveness Details Minocycline Bemiparin An increased risk of bleeding Details Minocycline Bivalirudin Angiomax An increased risk of bleeding Details Minocycline Certoparin An increased risk of bleeding Details Minocycline Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Minocycline Cloxacillin Decreased antibacterial effectiveness Details

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