Eszopiclone

Generic name: Pronounced as (es zoe' pi clone)
Brand names
  • Lunesta®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 12/15/2019

Eszopiclone may cause serious or possibly life-threatening sleep behaviors. Some people who took eszopiclone got out of bed and drove their cars, prepared and ate food, had sex, made phone calls, sleep-walked, or were involved in other activities while not fully awake. After they woke up, these people were unable to remember what they had done. Tell your doctor if you have ever had an unusual sleep behavior while taking eszopiclone. Be sure that your family or caregiver are aware that these symptoms are serious and to call your doctor if they occur. Stop taking eszopiclone and call your doctor right away if you find out that you have been driving or doing anything else unusual while you were sleeping.

Eszopiclone is used to treat insomnia (difficulty falling asleep or staying asleep). Eszopiclone is in a class of medications called hypnotics. It works by slowing activity in the brain to allow sleep.

Eszopiclone comes as a tablet to take by mouth. It is usually taken once a day at bedtime or after unsuccessfully trying to fall asleep. Do not take eszopiclone with or shortly after a heavy, high-fat meal. Eszopiclone may not work well if it is taken with high fat foods. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take eszopiclone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

You will probably become very sleepy soon after you take eszopiclone and will remain sleepy for some time after you take the medication. You should only take eszopiclone immediately before you go to bed or after you have gone to bed and have been unable to fall asleep. Only take eszopiclone if you will be able to stay in bed for at least 7 to 8 hours after taking the medication. If you do not go to bed right after you take eszopiclone or if you get up too soon after taking eszopiclone, you may experience dizziness, lightheadedness, hallucinations (seeing things or hearing voices that do not exist), and problems with coordination and memory.

Your doctor may change your dose of eszopiclone during your treatment. Your doctor may increase your dose to help you sleep better or decrease your dose if you are too drowsy during the daytime.

You should be sleeping well within 7 to 10 days after you start taking eszopiclone. Call your doctor if your sleep problems do not improve during this time, if they get worse at any time during your treatment, or if you notice any changes in your thoughts or behavior.

Do not stop taking eszopiclone without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking eszopiclone you may experience withdrawal symptoms such as anxiety, unusual dreams, stomach and muscle cramps,nausea, vomiting, sweating, shakiness, and rarely, seizures.

After you stop taking eszopiclone, you may have more difficulty falling asleep and staying asleep than you did before you took the medication. These sleep problems are normal and usually get better without treatment after one or two nights.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with eszopiclone and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking eszopiclone,

  • tell your doctor and pharmacist if you are allergic to eszopiclone, any other medications, or any of the ingredients in eszopiclone tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants; certain antifungals such as itraconazole (Onmel, Sporanox) and ketoconazole (Nizoral); antihistamines; clarithromycin (Biaxin); certain HIV protease inhibitors such as nelfinavir (Viracept) and ritonavir (Norvir); medications for anxiety, mental illness, or seizures; nefazodone; olanzapine (Zyprexa); rifampin (Rifadin, Rimactane); sedatives; other sleeping pills; tranquilizers; and troleandomycin (TAO) (not available in the US). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you drink or have ever drunk large amounts of alcohol and if you use or have ever used street drugs or have overused prescription medications. Also tell your doctor if you have ever thought about killing yourself or tried to do so and if you have or have ever had depression, mental illness, lung disease or breathing problems, or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking eszopiclone, call your doctor.

  • talk to your doctor about the risks and benefits of taking eszopiclone if you are 65 years of age or older. Older adults should not usually take eszopiclone because it is not as safe or effective as other medications that can be used to treat the same condition.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking eszopiclone.

  • you should know that eszopiclone may make you drowsy during the daytime, may decrease your mental alertness, and may increase the risk that you could fall. Take extra care to be sure you do not fall, especially if you get out of bed in the middle of the night. Do not drive a car or operate machinery until you know how this medication affects you.

  • do not drink alcohol while you are taking eszopiclone. Alcohol can make the side effects from eszopiclone worse.

  • you should know that your mental health may change in unexpected ways while you are taking this medication. These changes may be caused by eszopiclone or they may be caused by physical or mental illnesses that you already have or that you develop during your treatment. Tell your doctor right away if you experience any of the following symptoms: aggressiveness, strange or unusually outgoing behavior, hallucinations (seeing things or hearing voices that do not exist), feeling as if you are outside of your body, memory problems, new or worsening depression, thinking about killing yourself, confusion, and any other changes in your usual thoughts or behavior. Be sure that your family knows which symptoms may be serious so that they can call the doctor if you are unable to seek treatment on your own.

Talk to your doctor about drinking grapefruit juice while taking this medication.

Eszopiclone should only be taken at bedtime. If you did not take eszopiclone before you went to bed and you are unable to fall asleep, you may take eszopiclone if you will be able to stay in bed for at least 7 to 8 hours afterward.

  • Eszopiclone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • pain

    • daytime drowsiness

    • lightheadedness

    • dizziness

    • loss of coordination

    • nausea

    • vomiting

    • heartburn

    • unpleasant taste

    • dry mouth

    • unusual dreams

    • decreased sexual desire

    • painful menstrual periods

    • breast enlargement in males

  • Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNINGS or SPECIAL PRECAUTIONS sections, call your doctor immediately or get emergency medical treatment:

    • hives

    • rash

    • itching

    • swelling of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs

    • difficulty breathing or swallowing

    • feeling that the throat is closing

    • hoarseness

  • Eszopiclone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • drowsiness

  • coma (loss of consciousness for a period of time)

Keep all appointments with your doctor.

Do not let anyone else take your medication. Eszopiclone is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Repaglinide can be decreased when combined with Eszopiclone.
Montelukast Montelukast The metabolism of Eszopiclone can be decreased when combined with Montelukast.
Delavirdine Delavirdine The serum concentration of Eszopiclone can be increased when it is combined with Delavirdine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Eszopiclone.
Dolasetron Dolasetron The risk or severity of CNS depression can be increased when Dolasetron is combined with Eszopiclone.
Candesartan Candesartan The metabolism of Eszopiclone can be decreased when combined with Candesartan.
Cilostazol Cilostazol Eszopiclone may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Clopidogrel Clopidogrel The metabolism of Eszopiclone can be decreased when combined with Clopidogrel.
Diphenoxylate Diphenoxylate The risk or severity of CNS depression can be increased when Diphenoxylate is combined with Eszopiclone.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Eszopiclone can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Fenofibrate Fenofibrate Eszopiclone may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine Guanfacine The risk or severity of CNS depression can be increased when Guanfacine is combined with Eszopiclone.
Magnesium Hydroxide Magnesium Hydroxide Eszopiclone may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Methylergonovine Methylergonovine The metabolism of Eszopiclone can be decreased when combined with Methylergometrine.
Mycophenolate Mycophenolate Eszopiclone may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of CNS depression can be increased when Naratriptan is combined with Eszopiclone.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Paregoric Paregoric The risk or severity of CNS depression can be increased when Morphine is combined with Eszopiclone.
Pentazocine Pentazocine The risk or severity of CNS depression can be increased when Pentazocine is combined with Eszopiclone.
Potassium Potassium Potassium may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Eszopiclone may decrease the excretion rate of Prednisone which could result in a higher serum level.
Ranitidine Ranitidine Eszopiclone may decrease the excretion rate of Ranitidine which could result in a higher serum level.
Reserpine Reserpine The risk or severity of CNS depression can be increased when Reserpine is combined with Eszopiclone.
Rizatriptan Rizatriptan The risk or severity of CNS depression can be increased when Rizatriptan is combined with Eszopiclone.
Sumatriptan Sumatriptan The risk or severity of CNS depression can be increased when Sumatriptan is combined with Eszopiclone.
Tacrolimus Tacrolimus The metabolism of Eszopiclone can be decreased when combined with Tacrolimus.
Tizanidine Tizanidine The risk or severity of CNS depression can be increased when Tizanidine is combined with Eszopiclone.
Triamcinolone Triamcinolone The serum concentration of Eszopiclone can be decreased when it is combined with Triamcinolone.
Zolmitriptan Zolmitriptan The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Eszopiclone.
Ampicillin Injection Ampicillin Injection Eszopiclone may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection The metabolism of Eszopiclone can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The risk or severity of CNS depression can be increased when Hydromorphone is combined with Eszopiclone.
Levofloxacin Injection Levofloxacin Injection Eszopiclone may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection The risk or severity of CNS depression can be increased when Meperidine is combined with Eszopiclone.
Methylprednisolone Injection Methylprednisolone Injection The serum concentration of Eszopiclone can be decreased when it is combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Eszopiclone is combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The metabolism of Eszopiclone can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of CNS depression can be increased when Morphine is combined with Eszopiclone.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Eszopiclone may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Eszopiclone.
Altretamine Altretamine The risk or severity of CNS depression can be increased when Amphetamine is combined with Eszopiclone.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Cyclosporine Cyclosporine The metabolism of Eszopiclone can be decreased when combined with Cyclosporine.
Ondansetron Ondansetron The risk or severity of CNS depression can be increased when Ondansetron is combined with Eszopiclone.
Granisetron Granisetron The risk or severity of CNS depression can be increased when Granisetron is combined with Eszopiclone.
Torsemide Torsemide The metabolism of Eszopiclone can be decreased when combined with Torasemide.
Olanzapine Olanzapine The risk or severity of CNS depression can be increased when Olanzapine is combined with Eszopiclone.
Alosetron Alosetron The risk or severity of CNS depression can be increased when Alosetron is combined with Eszopiclone.
Entacapone Entacapone The risk or severity of CNS depression can be increased when Entacapone is combined with Eszopiclone.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Eszopiclone.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Orlistat Orlistat The serum concentration of Eszopiclone can be decreased when it is combined with Orlistat.
Oxcarbazepine Oxcarbazepine The risk or severity of CNS depression can be increased when Oxcarbazepine is combined with Eszopiclone.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Temozolomide Temozolomide Eszopiclone may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon The risk or severity of CNS depression can be increased when Zaleplon is combined with Eszopiclone.
Anakinra Anakinra The metabolism of Eszopiclone can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of CNS depression can be increased when Desloratadine is combined with Eszopiclone.
Linezolid Linezolid The risk or severity of CNS depression can be increased when Linezolid is combined with Eszopiclone.
Trimipramine Trimipramine The risk or severity of CNS depression can be increased when Trimipramine is combined with Eszopiclone.
Etanercept Injection Etanercept Injection The metabolism of Eszopiclone can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil Modafinil The serum concentration of Eszopiclone can be decreased when it is combined with Modafinil.
Perindopril Perindopril Eszopiclone may decrease the excretion rate of Perindopril which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Epinephrine Injection Epinephrine Injection The metabolism of Eszopiclone can be decreased when combined with Epinephrine.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of CNS depression can be increased when Escitalopram is combined with Eszopiclone.
Zonisamide Zonisamide The risk or severity of CNS depression can be increased when Zonisamide is combined with Eszopiclone.
Adalimumab Injection Adalimumab Injection The metabolism of Eszopiclone can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of CNS depression can be increased when Aripiprazole is combined with Eszopiclone.
Atomoxetine Atomoxetine The risk or severity of CNS depression can be increased when Atomoxetine is combined with Eszopiclone.
Dexmethylphenidate Dexmethylphenidate The risk or severity of CNS depression can be increased when Dexmethylphenidate is combined with Eszopiclone.
Atazanavir Atazanavir The serum concentration of Eszopiclone can be increased when it is combined with Atazanavir.
Almotriptan Almotriptan The risk or severity of CNS depression can be increased when Almotriptan is combined with Eszopiclone.
Eletriptan Eletriptan The risk or severity of CNS depression can be increased when Eletriptan is combined with Eszopiclone.
Mefloquine Mefloquine The metabolism of Eszopiclone can be decreased when combined with Mefloquine.
Aprepitant Aprepitant The metabolism of Eszopiclone can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Eszopiclone may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine Eszopiclone may decrease the excretion rate of Memantine which could result in a higher serum level.
Tegaserod Tegaserod The metabolism of Eszopiclone can be decreased when combined with Tegaserod.
Tadalafil Tadalafil Eszopiclone may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Frovatriptan Frovatriptan The risk or severity of CNS depression can be increased when Frovatriptan is combined with Eszopiclone.
Progesterone Progesterone The serum concentration of Eszopiclone can be decreased when it is combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of CNS depression can be increased when Apomorphine is combined with Eszopiclone.
Infliximab Injection Infliximab Injection The metabolism of Eszopiclone can be increased when combined with Infliximab.
Protriptyline Protriptyline The risk or severity of CNS depression can be increased when Protriptyline is combined with Eszopiclone.
Rifaximin Rifaximin The serum concentration of Eszopiclone can be decreased when it is combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of CNS depression can be increased when Duloxetine is combined with Eszopiclone.
Tinidazole Tinidazole Eszopiclone may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium Trospium Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan Bosentan The serum concentration of Eszopiclone can be decreased when it is combined with Bosentan.
Cefditoren Cefditoren Eszopiclone may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Eszopiclone can be decreased when combined with Erlotinib.
Ganciclovir Ganciclovir Eszopiclone may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin Ribavirin Eszopiclone may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin Solifenacin Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir Valganciclovir Eszopiclone may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The serum concentration of Eszopiclone can be increased when it is combined with Voriconazole.
Adefovir Adefovir Adefovir may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine The risk or severity of CNS depression can be increased when Amphetamine is combined with Eszopiclone.
Sodium Oxybate Sodium Oxybate Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Isocarboxazid Isocarboxazid The risk or severity of CNS depression can be increased when Isocarboxazid is combined with Eszopiclone.
Ramelteon Ramelteon The risk or severity of CNS depression can be increased when Ramelteon is combined with Eszopiclone.
Darifenacin Darifenacin Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Fentanyl Fentanyl The risk or severity of CNS depression can be increased when Fentanyl is combined with Eszopiclone.
Pregabalin Pregabalin The therapeutic efficacy of Eszopiclone can be increased when used in combination with Pregabalin.
Deferasirox Deferasirox The serum concentration of Eszopiclone can be decreased when it is combined with Deferasirox.
Tipranavir Tipranavir The serum concentration of Eszopiclone can be increased when it is combined with Tipranavir.
Felbamate Felbamate The risk or severity of CNS depression can be increased when Felbamate is combined with Eszopiclone.
Ranolazine Ranolazine The metabolism of Eszopiclone can be decreased when combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Eszopiclone can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of CNS depression can be increased when Rasagiline is combined with Eszopiclone.
Imatinib Imatinib The metabolism of Eszopiclone can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Eszopiclone.
Varenicline Varenicline Eszopiclone may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Eszopiclone can be decreased when combined with Gefitinib.
Albuterol Albuterol Eszopiclone may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone The risk or severity of CNS depression can be increased when Paliperidone is combined with Eszopiclone.
Clofarabine Injection Clofarabine Injection Eszopiclone may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Lubiprostone Lubiprostone Eszopiclone may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Posaconazole Posaconazole The serum concentration of Eszopiclone can be increased when it is combined with Posaconazole.
Primaquine Primaquine The metabolism of Eszopiclone can be decreased when combined with Primaquine.
Darunavir Darunavir The serum concentration of Eszopiclone can be increased when it is combined with Darunavir.
Pemetrexed Injection Pemetrexed Injection Eszopiclone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate The risk or severity of CNS depression can be increased when Dimenhydrinate is combined with Eszopiclone.
Nabilone Nabilone The risk or severity of CNS depression can be increased when Nabilone is combined with Eszopiclone.
Sorafenib Sorafenib The metabolism of Eszopiclone can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Eszopiclone can be decreased when combined with Sunitinib.
Dronabinol Dronabinol The risk or severity of CNS depression can be increased when Dronabinol is combined with Eszopiclone.
Lapatinib Lapatinib The metabolism of Eszopiclone can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine The risk or severity of CNS depression can be increased when Levocetirizine is combined with Eszopiclone.
Pegaptanib Injection Pegaptanib Injection Eszopiclone may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Eszopiclone can be decreased when combined with Dasatinib.
Armodafinil Armodafinil The serum concentration of Eszopiclone can be decreased when it is combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Eszopiclone may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Lenalidomide Lenalidomide Eszopiclone may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Nilotinib Nilotinib The serum concentration of Eszopiclone can be increased when it is combined with Nilotinib.
Bexarotene Bexarotene The serum concentration of Eszopiclone can be decreased when it is combined with Bexarotene.
Budesonide Budesonide The serum concentration of Eszopiclone can be decreased when it is combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Eszopiclone can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Eszopiclone.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of CNS depression can be increased when Botulinum Toxin Type B is combined with Eszopiclone.
Doripenem Injection Doripenem Injection Eszopiclone may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine Etravirine The serum concentration of Eszopiclone can be decreased when it is combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection Eszopiclone may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Eszopiclone can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The risk or severity of CNS depression can be increased when Desvenlafaxine is combined with Eszopiclone.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Eszopiclone.
Pilocarpine Pilocarpine The metabolism of Eszopiclone can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Eszopiclone can be increased when combined with Certolizumab pegol.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Mitotane Mitotane The serum concentration of Eszopiclone can be decreased when it is combined with Mitotane.
Methylnaltrexone Injection Methylnaltrexone Injection Eszopiclone may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Rufinamide Rufinamide The risk or severity of CNS depression can be increased when Rufinamide is combined with Eszopiclone.
Midazolam Midazolam The risk or severity of CNS depression can be increased when Midazolam is combined with Eszopiclone.
Naltrexone Injection Naltrexone Injection The risk or severity of respiratory depression can be increased when Naltrexone is combined with Eszopiclone.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Eszopiclone can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The risk or severity of CNS depression can be increased when Milnacipran is combined with Eszopiclone.
Plerixafor Injection Plerixafor Injection Eszopiclone may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Iloperidone Iloperidone The risk or severity of CNS depression can be increased when Iloperidone is combined with Eszopiclone.
Prasugrel Prasugrel Eszopiclone may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide Lacosamide The risk or severity of CNS depression can be increased when Lacosamide is combined with Eszopiclone.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Eszopiclone.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone Dronedarone The metabolism of Eszopiclone can be decreased when combined with Dronedarone.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Eszopiclone.
Pralatrexate Injection Pralatrexate Injection Eszopiclone may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection The risk or severity of CNS depression can be increased when Palonosetron is combined with Eszopiclone.
Saxagliptin Saxagliptin Eszopiclone may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Eszopiclone may decrease the excretion rate of Telavancin which could result in a higher serum level.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.
Topotecan Topotecan The serum concentration of Eszopiclone can be decreased when it is combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Eszopiclone can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Eszopiclone can be decreased when combined with Pazopanib.
Asenapine Asenapine The risk or severity of CNS depression can be increased when Asenapine is combined with Eszopiclone.
Vigabatrin Vigabatrin The risk or severity of CNS depression can be increased when Vigabatrin is combined with Eszopiclone.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Eszopiclone.
Oxymorphone Oxymorphone The risk or severity of CNS depression can be increased when Oxymorphone is combined with Eszopiclone.
Tocilizumab Injection Tocilizumab Injection The serum concentration of Eszopiclone can be decreased when it is combined with Tocilizumab.
Dalfampridine Dalfampridine Eszopiclone may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Eszopiclone.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Eszopiclone.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of CNS depression can be increased when Lurasidone is combined with Eszopiclone.
Acetaminophen Injection Acetaminophen Injection The serum concentration of Eszopiclone can be decreased when it is combined with Acetaminophen.
Vilazodone Vilazodone The risk or severity of CNS depression can be increased when Vilazodone is combined with Eszopiclone.
Ipilimumab Injection Ipilimumab Injection Eszopiclone may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Eszopiclone can be decreased when combined with Aldesleukin.
Terbutaline Injection Terbutaline Injection Eszopiclone may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Roflumilast Roflumilast Eszopiclone may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin Linagliptin The metabolism of Eszopiclone can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Eszopiclone can be decreased when combined with Rilpivirine.
Cyclophosphamide Injection Cyclophosphamide Injection The serum concentration of Eszopiclone can be decreased when it is combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Eszopiclone can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban Eszopiclone may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The metabolism of Eszopiclone can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Eszopiclone can be decreased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib Eszopiclone may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam The risk or severity of CNS depression can be increased when Clobazam is combined with Eszopiclone.
Vemurafenib Vemurafenib The serum concentration of Eszopiclone can be decreased when it is combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Eszopiclone can be decreased when combined with Vismodegib.
Ivacaftor Ivacaftor The metabolism of Eszopiclone can be decreased when combined with Ivacaftor.
Deferiprone Deferiprone Eszopiclone may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Crizotinib Crizotinib The metabolism of Eszopiclone can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The risk or severity of CNS depression can be increased when Cabergoline is combined with Eszopiclone.
Naloxone Injection Naloxone Injection The serum concentration of Eszopiclone can be increased when it is combined with Naloxone.
Fondaparinux Injection Fondaparinux Injection Eszopiclone may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Ezogabine Ezogabine The risk or severity of CNS depression can be increased when Tiagabine is combined with Eszopiclone.
Enzalutamide Enzalutamide The serum concentration of Eszopiclone can be decreased when it is combined with Enzalutamide.
Mirabegron Mirabegron Eszopiclone may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Regorafenib Regorafenib The metabolism of Eszopiclone can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Eszopiclone can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The serum concentration of Eszopiclone can be decreased when it is combined with Corticotropin.
Teriflunomide Teriflunomide The metabolism of Eszopiclone can be decreased when combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Eszopiclone can be decreased when combined with Cabozantinib.
Teduglutide Injection Teduglutide Injection Eszopiclone may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin Eszopiclone may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Eszopiclone can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide The risk or severity of CNS depression can be increased when Pomalidomide is combined with Eszopiclone.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Eszopiclone can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Eszopiclone.
Canagliflozin Canagliflozin Eszopiclone may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The serum concentration of Eszopiclone can be decreased when it is combined with Dabrafenib.
Trametinib Trametinib The serum concentration of Eszopiclone can be decreased when it is combined with Trametinib.
Levomilnacipran Levomilnacipran The risk or severity of CNS depression can be increased when Levomilnacipran is combined with Eszopiclone.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Vortioxetine Vortioxetine The risk or severity of CNS depression can be increased when Vortioxetine is combined with Eszopiclone.
Perampanel Perampanel The risk or severity of CNS depression can be increased when Perampanel is combined with Eszopiclone.
Lomitapide Lomitapide The metabolism of Eszopiclone can be decreased when combined with Lomitapide.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Simeprevir Simeprevir The metabolism of Eszopiclone can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Eszopiclone may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast The metabolism of Eszopiclone can be increased when combined with Apremilast.
Droxidopa Droxidopa Eszopiclone may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Eszopiclone can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The serum concentration of Eszopiclone can be decreased when it is combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The risk or severity of CNS depression can be increased when Eslicarbazepine is combined with Eszopiclone.
Idelalisib Idelalisib The metabolism of Eszopiclone can be decreased when combined with Idelalisib.
Testosterone Injection Testosterone Injection The serum concentration of Eszopiclone can be decreased when it is combined with Testosterone.
Oritavancin Injection Oritavancin Injection The serum concentration of Eszopiclone can be decreased when it is combined with Oritavancin.
Hydrocodone Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.
Suvorexant Suvorexant Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Edoxaban Edoxaban Eszopiclone may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Olaparib Olaparib The metabolism of Eszopiclone can be decreased when combined with Olaparib.
Methamphetamine Methamphetamine The risk or severity of CNS depression can be increased when Metamfetamine is combined with Eszopiclone.
Tasimelteon Tasimelteon The risk or severity of CNS depression can be increased when Tasimelteon is combined with Eszopiclone.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Eszopiclone.
Lanreotide Injection Lanreotide Injection The metabolism of Eszopiclone can be decreased when combined with Lanreotide.
Secukinumab Injection Secukinumab Injection The metabolism of Eszopiclone can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of CNS depression can be increased when Risperidone is combined with Eszopiclone.
Palbociclib Palbociclib The metabolism of Eszopiclone can be decreased when combined with Palbociclib.
Lenvatinib Lenvatinib The serum concentration of Eszopiclone can be decreased when it is combined with Lenvatinib.
Haloperidol Injection Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Eszopiclone.
Amiloride Amiloride Amiloride may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Eszopiclone can be decreased when it is combined with Isavuconazonium.
Macitentan Macitentan Eszopiclone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flibanserin Flibanserin The risk or severity of CNS depression can be increased when Flibanserin is combined with Eszopiclone.
Prednisolone Prednisolone The serum concentration of Eszopiclone can be decreased when it is combined with Prednisolone.
Brexpiprazole Brexpiprazole The risk or severity of CNS depression can be increased when Brexpiprazole is combined with Eszopiclone.
Ziprasidone Injection Ziprasidone Injection The risk or severity of CNS depression can be increased when Ziprasidone is combined with Eszopiclone.
Cariprazine Cariprazine The risk or severity of CNS depression can be increased when Cariprazine is combined with Eszopiclone.
Penicillin G Procaine Injection Penicillin G Procaine Injection Eszopiclone may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline Eluxadoline The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Eszopiclone.
Osimertinib Osimertinib The serum concentration of Eszopiclone can be decreased when it is combined with Osimertinib.
Ixazomib Ixazomib Eszopiclone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rifapentine Rifapentine The serum concentration of Eszopiclone can be decreased when it is combined with Rifapentine.
Lesinurad Lesinurad Eszopiclone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Eszopiclone can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The serum concentration of Eszopiclone can be decreased when it is combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The risk or severity of CNS depression can be increased when Brivaracetam is combined with Eszopiclone.
Venetoclax Venetoclax The metabolism of Eszopiclone can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Eszopiclone can be increased when it is combined with Cobicistat.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Eszopiclone.
Pimavanserin Pimavanserin The risk or severity of CNS depression can be increased when Pimavanserin is combined with Eszopiclone.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of CNS depression can be increased when Diphenhydramine is combined with Eszopiclone.
Furosemide Injection Furosemide Injection Eszopiclone may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The metabolism of Eszopiclone can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Eszopiclone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib Ribociclib The serum concentration of Eszopiclone can be increased when it is combined with Ribociclib.
Brigatinib Brigatinib The serum concentration of Eszopiclone can be decreased when it is combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The risk or severity of CNS depression can be increased when Doxepin is combined with Eszopiclone.
Deutetrabenazine Deutetrabenazine The risk or severity of sedation and somnolence can be increased when Eszopiclone is combined with Deutetrabenazine.
Valbenazine Valbenazine Eszopiclone may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Safinamide Safinamide The risk or severity of CNS depression can be increased when Safinamide is combined with Eszopiclone.
Naldemedine Naldemedine Eszopiclone may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Sarilumab Injection Sarilumab Injection The serum concentration of Eszopiclone can be decreased when it is combined with Sarilumab.
Midostaurin Midostaurin The serum concentration of Eszopiclone can be decreased when it is combined with Midostaurin.
Enasidenib Enasidenib The serum concentration of Eszopiclone can be decreased when it is combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The serum concentration of Eszopiclone can be decreased when it is combined with Fosaprepitant.
Benznidazole Benznidazole Eszopiclone may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin The serum concentration of Eszopiclone can be decreased when it is combined with Delafloxacin.
Acalabrutinib Acalabrutinib The metabolism of Eszopiclone can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Eszopiclone can be decreased when combined with Letermovir.
Tetrabenazine Tetrabenazine The risk or severity of sedation and somnolence can be increased when Eszopiclone is combined with Tetrabenazine.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide The serum concentration of Eszopiclone can be decreased when it is combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Eszopiclone can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The metabolism of Eszopiclone can be increased when combined with Avatrombopag.
Baricitinib Baricitinib Eszopiclone may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Eszopiclone can be increased when used in combination with Lofexidine.
Plazomicin Injection Plazomicin Injection Eszopiclone may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Ivosidenib Ivosidenib The serum concentration of Eszopiclone can be decreased when it is combined with Ivosidenib.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Eszopiclone.
Cannabidiol Cannabidiol The risk or severity of CNS depression can be increased when Cannabidiol is combined with Eszopiclone.
Stiripentol Stiripentol The risk or severity of CNS depression can be increased when Stiripentol is combined with Eszopiclone.
Glasdegib Glasdegib The metabolism of Glasdegib can be decreased when combined with Eszopiclone.
Lorlatinib Lorlatinib The serum concentration of Lorlatinib can be decreased when it is combined with Eszopiclone.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The serum concentration of Eszopiclone can be decreased when it is combined with Paclitaxel.
Rifamycin Rifamycin The serum concentration of Eszopiclone can be decreased when it is combined with Rifamycin.
Prucalopride Prucalopride Eszopiclone may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Eszopiclone can be increased when combined with Emapalumab.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Alpelisib Alpelisib The serum concentration of Eszopiclone can be decreased when it is combined with Alpelisib.
Brexanolone Injection Brexanolone Injection The risk or severity of CNS depression can be increased when Brexanolone is combined with Eszopiclone.
Solriamfetol Solriamfetol The risk or severity of CNS depression can be increased when Solriamfetol is combined with Eszopiclone.
Triclabendazole Triclabendazole The metabolism of Eszopiclone can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Eszopiclone.
Pitolisant Pitolisant The serum concentration of Eszopiclone can be decreased when it is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The risk or severity of CNS depression can be increased when Phenytoin is combined with Eszopiclone.
Fosphenytoin Injection Fosphenytoin Injection The risk or severity of CNS depression can be increased when Fosphenytoin is combined with Eszopiclone.
Lumateperone Lumateperone The risk or severity of CNS depression can be increased when Lumateperone is combined with Eszopiclone.
Lasmiditan Lasmiditan The risk or severity of CNS depression can be increased when Lasmiditan is combined with Eszopiclone.
Cenobamate Cenobamate The serum concentration of Eszopiclone can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Eszopiclone.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Eszopiclone.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Eszopiclone.
Remdesivir Injection Remdesivir Injection The metabolism of Eszopiclone can be decreased when combined with Remdesivir.
Selpercatinib Selpercatinib The serum concentration of Eszopiclone can be increased when it is combined with Selpercatinib.
Lemborexant Lemborexant The risk or severity of CNS depression can be increased when Lemborexant is combined with Eszopiclone.
Fenfluramine Fenfluramine The risk or severity of CNS depression can be increased when Fenfluramine is combined with Eszopiclone.
Octreotide Octreotide The metabolism of Eszopiclone can be decreased when combined with Octreotide.
Pralsetinib Pralsetinib The serum concentration of Eszopiclone can be decreased when it is combined with Pralsetinib.
Opicapone Opicapone The metabolism of Eszopiclone can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Eszopiclone can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine The risk or severity of CNS depression can be increased when Viloxazine is combined with Eszopiclone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The serum concentration of Eszopiclone can be decreased when it is combined with Vitamin E.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Theophylline Theophylline The metabolism of Eszopiclone can be decreased when combined with Theophylline.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid The metabolism of Eszopiclone can be decreased when combined with Mefenamic acid.
Naproxen Naproxen Naproxen may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Trazodone Trazodone The risk or severity of CNS depression can be increased when Trazodone is combined with Eszopiclone.
Isotretinoin Isotretinoin Eszopiclone may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Phenobarbital Phenobarbital The risk or severity of CNS depression can be increased when Phenobarbital is combined with Eszopiclone.
Metaxalone Metaxalone The risk or severity of CNS depression can be increased when Metaxalone is combined with Eszopiclone.
Methotrexate Injection Methotrexate Injection Methotrexate may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Levorphanol Levorphanol The risk or severity of CNS depression can be increased when Levorphanol is combined with Eszopiclone.
Primidone Primidone The risk or severity of CNS depression can be increased when Primidone is combined with Eszopiclone.
Methsuximide Methsuximide The risk or severity of CNS depression can be increased when Methsuximide is combined with Eszopiclone.
Diethylpropion Diethylpropion The risk or severity of CNS depression can be increased when Diethylpropion is combined with Eszopiclone.
Chlorpromazine Chlorpromazine The risk or severity of CNS depression can be increased when Chlorpromazine is combined with Eszopiclone.
Diazepam Diazepam The risk or severity of CNS depression can be increased when Diazepam is combined with Eszopiclone.
Oxazepam Oxazepam The risk or severity of CNS depression can be increased when Oxazepam is combined with Eszopiclone.
Flurazepam Flurazepam The risk or severity of CNS depression can be increased when Flurazepam is combined with Eszopiclone.
Clorazepate Clorazepate The risk or severity of CNS depression can be increased when Clorazepic acid is combined with Eszopiclone.
Lorazepam Lorazepam The risk or severity of CNS depression can be increased when Lorazepam is combined with Eszopiclone.
Carmustine Carmustine Carmustine may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Amantadine Amantadine Eszopiclone may decrease the excretion rate of Amantadine which could result in a higher serum level.
Codeine Codeine The risk or severity of CNS depression can be increased when Codeine is combined with Eszopiclone.
Meprobamate Meprobamate The risk or severity of CNS depression can be increased when Meprobamate is combined with Eszopiclone.
Chlordiazepoxide Chlordiazepoxide The risk or severity of CNS depression can be increased when Chlordiazepoxide is combined with Eszopiclone.
Bromocriptine Bromocriptine The risk or severity of CNS depression can be increased when Bromocriptine is combined with Eszopiclone.
Tranylcypromine Tranylcypromine The risk or severity of CNS depression can be increased when Tranylcypromine is combined with Eszopiclone.
Phenelzine Phenelzine The risk or severity of CNS depression can be increased when Phenelzine is combined with Eszopiclone.
Procarbazine Procarbazine The risk or severity of CNS depression can be increased when Procarbazine is combined with Eszopiclone.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of CNS depression can be increased when Ergoloid mesylate is combined with Eszopiclone.
Tetracycline Tetracycline The metabolism of Eszopiclone can be decreased when combined with Tetracycline.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.
Prochlorperazine Prochlorperazine The risk or severity of CNS depression can be increased when Prochlorperazine is combined with Eszopiclone.
Thioridazine Thioridazine The risk or severity of CNS depression can be increased when Thioridazine is combined with Eszopiclone.
Trifluoperazine Trifluoperazine The risk or severity of CNS depression can be increased when Trifluoperazine is combined with Eszopiclone.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Dapsone Dapsone The metabolism of Eszopiclone can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Eszopiclone can be decreased when combined with Sulfadiazine.
Oxycodone Oxycodone The risk or severity of CNS depression can be increased when Oxycodone is combined with Eszopiclone.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Eszopiclone.
Oxybutynin Oxybutynin The metabolism of Eszopiclone can be decreased when combined with Oxybutynin.
Benztropine Benztropine Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline Maprotiline The risk or severity of CNS depression can be increased when Maprotiline is combined with Eszopiclone.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Trihexyphenidyl Trihexyphenidyl Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine The risk or severity of CNS depression can be increased when Orphenadrine is combined with Eszopiclone.
Perphenazine Perphenazine The risk or severity of CNS depression can be increased when Perphenazine is combined with Eszopiclone.
Azathioprine Azathioprine Eszopiclone may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Fluphenazine Fluphenazine The risk or severity of CNS depression can be increased when Fluphenazine is combined with Eszopiclone.
Methylphenidate Methylphenidate Eszopiclone may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Amoxapine Amoxapine The risk or severity of CNS depression can be increased when Amoxapine is combined with Eszopiclone.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Hydrocortisone Hydrocortisone The serum concentration of Eszopiclone can be decreased when it is combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Eszopiclone can be decreased when combined with Doxorubicin.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Carbamazepine Carbamazepine The risk or severity of CNS depression can be increased when Carbamazepine is combined with Eszopiclone.
Molindone Molindone The risk or severity of CNS depression can be increased when Molindone is combined with Eszopiclone.
Methyldopa Methyldopa Eszopiclone may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Eszopiclone.
Hydralazine Hydralazine The metabolism of Eszopiclone can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Eszopiclone can be decreased when combined with Cimetidine.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Warfarin Warfarin The serum concentration of Warfarin can be decreased when it is combined with Eszopiclone.
Clonazepam Clonazepam The risk or severity of CNS depression can be increased when Clonazepam is combined with Eszopiclone.
Loperamide Loperamide The serum concentration of Eszopiclone can be increased when it is combined with Loperamide.
Promethazine Promethazine The risk or severity of CNS depression can be increased when Promethazine is combined with Eszopiclone.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Daunorubicin Daunorubicin The metabolism of Eszopiclone can be decreased when combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin Eszopiclone may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin Griseofulvin The serum concentration of Eszopiclone can be decreased when it is combined with Griseofulvin.
Digoxin Digoxin Eszopiclone may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine The risk or severity of CNS depression can be increased when Loxapine is combined with Eszopiclone.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Eszopiclone.
Quinine Quinine The risk or severity of CNS depression can be increased when Quinine is combined with Eszopiclone.
Ethosuximide Ethosuximide The risk or severity of CNS depression can be increased when Ethosuximide is combined with Eszopiclone.
Calcitriol Calcitriol The serum concentration of Eszopiclone can be decreased when it is combined with Calcitriol.
Triamterene Triamterene Triamterene may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Sulfinpyrazone Sulfinpyrazone The serum concentration of Eszopiclone can be decreased when it is combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide Chlorothiazide may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Eszopiclone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital The risk or severity of CNS depression can be increased when Secobarbital is combined with Eszopiclone.
Desipramine Desipramine The risk or severity of CNS depression can be increased when Desipramine is combined with Eszopiclone.
Amitriptyline Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Eszopiclone.
Imipramine Imipramine The risk or severity of CNS depression can be increased when Imipramine is combined with Eszopiclone.
Probenecid Probenecid The serum concentration of Eszopiclone can be decreased when it is combined with Probenecid.
Quinidine Quinidine The metabolism of Eszopiclone can be decreased when combined with Quinidine.
Procainamide Procainamide Eszopiclone may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid The metabolism of Eszopiclone can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Rifampin Rifampin The serum concentration of Eszopiclone can be decreased when it is combined with Rifampicin.
Disopyramide Disopyramide Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
Valproic Acid Valproic Acid The risk or severity of CNS depression can be increased when Valproic acid is combined with Eszopiclone.
Tamoxifen Tamoxifen The serum concentration of Eszopiclone can be decreased when it is combined with Tamoxifen.
Butabarbital Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Eszopiclone.
Levothyroxine Levothyroxine The metabolism of Eszopiclone can be decreased when combined with Levothyroxine.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Methimazole Methimazole The serum concentration of Eszopiclone can be increased when it is combined with Methimazole.
Chlorpropamide Chlorpropamide Eszopiclone may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Eszopiclone.
Tolazamide Tolazamide Eszopiclone may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Dextromethorphan Dextromethorphan The risk or severity of CNS depression can be increased when Dextromethorphan is combined with Eszopiclone.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Cyclobenzaprine is combined with Eszopiclone.
Baclofen Baclofen The risk or severity of CNS depression can be increased when Baclofen is combined with Eszopiclone.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.
Cyproheptadine Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Eszopiclone.
Clemastine Clemastine The risk or severity of CNS depression can be increased when Clemastine is combined with Eszopiclone.
Chlorpheniramine Chlorpheniramine The risk or severity of CNS depression can be increased when Chlorpheniramine is combined with Eszopiclone.
Brompheniramine Brompheniramine The risk or severity of CNS depression can be increased when Dexbrompheniramine is combined with Eszopiclone.
Meclizine Meclizine The risk or severity of CNS depression can be increased when Meclizine is combined with Eszopiclone.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Methyclothiazide Methyclothiazide Methyclothiazide may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Dantrolene Dantrolene The risk or severity of CNS depression can be increased when Dantrolene is combined with Eszopiclone.
Chlorzoxazone Chlorzoxazone The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Eszopiclone.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Eszopiclone.
Methocarbamol Methocarbamol The risk or severity of CNS depression can be increased when Methocarbamol is combined with Eszopiclone.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Danazol Danazol The metabolism of Eszopiclone can be decreased when combined with Danazol.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Eszopiclone may decrease the excretion rate of Propranolol which could result in a higher serum level.
Nortriptyline Nortriptyline The risk or severity of CNS depression can be increased when Nortriptyline is combined with Eszopiclone.
Spironolactone Spironolactone The metabolism of Eszopiclone can be decreased when combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection The metabolism of Eszopiclone can be decreased when combined with Amphotericin B.
Phytonadione Phytonadione Eszopiclone may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Nadolol Nadolol Eszopiclone may decrease the excretion rate of Nadolol which could result in a higher serum level.
Butorphanol Injection Butorphanol Injection The risk or severity of CNS depression can be increased when Butorphanol is combined with Eszopiclone.
Nalbuphine Injection Nalbuphine Injection The risk or severity of CNS depression can be increased when Nalbuphine is combined with Eszopiclone.
Allopurinol Allopurinol Eszopiclone may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Trimethobenzamide Trimethobenzamide The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Eszopiclone.
Flavoxate Flavoxate Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Eszopiclone.
Colchicine Colchicine The serum concentration of Eszopiclone can be decreased when it is combined with Colchicine.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Dacarbazine Dacarbazine Eszopiclone may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acetazolamide Acetazolamide The risk or severity of CNS depression can be increased when Acetazolamide is combined with Eszopiclone.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Ketoconazole Ketoconazole The serum concentration of Eszopiclone can be increased when it is combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of CNS depression can be increased when Pyrantel is combined with Eszopiclone.
Vinblastine Vinblastine The serum concentration of Eszopiclone can be decreased when it is combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Metoprolol Metoprolol Metoprolol may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.
Thiothixene Thiothixene The risk or severity of CNS depression can be increased when Thiothixene is combined with Eszopiclone.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Alprazolam Alprazolam The risk or severity of CNS depression can be increased when Alprazolam is combined with Eszopiclone.
Temazepam Temazepam The risk or severity of CNS depression can be increased when Temazepam is combined with Eszopiclone.
Triazolam Triazolam The risk or severity of CNS depression can be increased when Triazolam is combined with Eszopiclone.
Dicyclomine Dicyclomine Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline Propantheline Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim Trimethoprim The metabolism of Eszopiclone can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Eszopiclone can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The serum concentration of Eszopiclone can be decreased when it is combined with Nifedipine.
Timolol Timolol Timolol may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Verapamil Verapamil The metabolism of Eszopiclone can be decreased when combined with Verapamil.
Pindolol Pindolol The risk or severity of CNS depression can be increased when Pindolol is combined with Eszopiclone.
Cisplatin Injection Cisplatin Injection Eszopiclone may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Bumetanide Bumetanide Eszopiclone may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide Etoposide The serum concentration of Eszopiclone can be decreased when it is combined with Etoposide.
Glyburide Glyburide The metabolism of Eszopiclone can be decreased when combined with Glyburide.
Glipizide Glipizide Eszopiclone may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide Indapamide Eszopiclone may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Eszopiclone may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Dicloxacillin Dicloxacillin The serum concentration of Eszopiclone can be decreased when it is combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The serum concentration of Eszopiclone can be decreased when it is combined with Nafcillin.
Oxacillin Injection Oxacillin Injection Eszopiclone may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline Eszopiclone may decrease the excretion rate of Pentoxifylline which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Labetalol Labetalol Eszopiclone may decrease the excretion rate of Labetalol which could result in a higher serum level.
Auranofin Auranofin Eszopiclone may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Gemfibrozil Gemfibrozil The metabolism of Eszopiclone can be decreased when combined with Gemfibrozil.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Pimozide Pimozide The risk or severity of CNS depression can be increased when Pimozide is combined with Eszopiclone.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Amiodarone Amiodarone The metabolism of Eszopiclone can be decreased when combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Buspirone Buspirone Eszopiclone may decrease the excretion rate of Buspirone which could result in a higher serum level.
Lovastatin Lovastatin The metabolism of Eszopiclone can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Eszopiclone can be decreased when combined with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Fluoxetine Fluoxetine The risk or severity of CNS depression can be increased when Fluoxetine is combined with Eszopiclone.
Clozapine Clozapine The risk or severity of CNS depression can be increased when Clozapine is combined with Eszopiclone.
Estazolam Estazolam The risk or severity of CNS depression can be increased when Estazolam is combined with Eszopiclone.
Didanosine Didanosine Eszopiclone may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Eszopiclone may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Clarithromycin Clarithromycin The serum concentration of Eszopiclone can be increased when it is combined with Clarithromycin.
Etodolac Etodolac Etodolac may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Felodipine Felodipine The metabolism of Eszopiclone can be decreased when combined with Felodipine.
Fosinopril Fosinopril Eszopiclone may decrease the excretion rate of Fosinopril which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Eszopiclone can be decreased when combined with Simvastatin.
Teniposide Injection Teniposide Injection The metabolism of Eszopiclone can be decreased when combined with Teniposide.
Itraconazole Itraconazole The serum concentration of Eszopiclone can be increased when it is combined with Itraconazole.
Lisinopril Lisinopril Eszopiclone may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Rifabutin Rifabutin The serum concentration of Eszopiclone can be decreased when it is combined with Rifabutin.
Bisoprolol Bisoprolol Eszopiclone may decrease the excretion rate of Bisoprolol which could result in a higher serum level.
Zolpidem Zolpidem Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Isradipine Isradipine The metabolism of Eszopiclone can be decreased when combined with Isradipine.
Omeprazole Omeprazole The serum concentration of Eszopiclone can be decreased when it is combined with Omeprazole.
Cisapride Cisapride The risk or severity of CNS depression can be increased when Cisapride is combined with Eszopiclone.
Gabapentin Gabapentin The risk or severity of CNS depression can be increased when Gabapentin is combined with Eszopiclone.
Fluvastatin Fluvastatin The metabolism of Eszopiclone can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of CNS depression can be increased when Venlafaxine is combined with Eszopiclone.
Fluvoxamine Fluvoxamine The risk or severity of CNS depression can be increased when Fluvoxamine is combined with Eszopiclone.
Nefazodone Nefazodone The risk or severity of CNS depression can be increased when Nefazodone is combined with Eszopiclone.
Lamotrigine Lamotrigine The risk or severity of CNS depression can be increased when Lamotrigine is combined with Eszopiclone.
Losartan Losartan The metabolism of Eszopiclone can be decreased when combined with Losartan.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Tramadol Tramadol The risk or severity of CNS depression can be increased when Tramadol is combined with Eszopiclone.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Lansoprazole Lansoprazole The serum concentration of Eszopiclone can be decreased when it is combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The serum concentration of Eszopiclone can be decreased when it is combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Eszopiclone can be decreased when combined with Nicardipine.
Bupropion Bupropion The risk or severity of CNS depression can be increased when Bupropion is combined with Eszopiclone.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Saquinavir Saquinavir The serum concentration of Eszopiclone can be increased when it is combined with Saquinavir.
Metformin Metformin Metformin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Nisoldipine Nisoldipine Nisoldipine may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Lamivudine Lamivudine Eszopiclone may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole The risk or severity of CNS depression can be increased when Riluzole is combined with Eszopiclone.
Acarbose Acarbose Acarbose may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Anastrozole Anastrozole The metabolism of Anastrozole can be decreased when combined with Eszopiclone.
Gemcitabine Injection Gemcitabine Injection Eszopiclone may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Indinavir Indinavir The metabolism of Eszopiclone can be decreased when combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Eszopiclone can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Eszopiclone can be decreased when combined with Docetaxel.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Meropenem Injection Meropenem Injection Eszopiclone may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine The risk or severity of CNS depression can be increased when Clomipramine is combined with Eszopiclone.
Zafirlukast Zafirlukast The metabolism of Eszopiclone can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Eszopiclone may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine The risk or severity of CNS depression can be increased when Mirtazapine is combined with Eszopiclone.
Topiramate Topiramate The risk or severity of CNS depression can be increased when Topiramate is combined with Eszopiclone.
Pramipexole Pramipexole Eszopiclone may increase the sedative activities of Pramipexole.
Donepezil Donepezil The risk or severity of CNS depression can be increased when Donepezil is combined with Eszopiclone.
Nelfinavir Nelfinavir The metabolism of Eszopiclone can be decreased when combined with Nelfinavir.
Loratadine Loratadine The metabolism of Eszopiclone can be decreased when combined with Loratadine.
Nilutamide Nilutamide The metabolism of Eszopiclone can be decreased when combined with Nilutamide.
Flutamide Flutamide Eszopiclone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Selegiline Selegiline The risk or severity of CNS depression can be increased when Selegiline is combined with Eszopiclone.
Bicalutamide Bicalutamide The metabolism of Eszopiclone can be decreased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of CNS depression can be increased when Sertraline is combined with Eszopiclone.
Raloxifene Raloxifene The metabolism of Eszopiclone can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Eszopiclone can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin Eszopiclone may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Ropinirole Ropinirole The risk or severity of CNS depression can be increased when Ropinirole is combined with Eszopiclone.
Quetiapine Quetiapine The risk or severity of CNS depression can be increased when Quetiapine is combined with Eszopiclone.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Cetirizine Cetirizine The risk or severity of CNS depression can be increased when Cetirizine is combined with Eszopiclone.
Paroxetine Paroxetine The risk or severity of CNS depression can be increased when Paroxetine is combined with Eszopiclone.
Tolcapone Tolcapone The risk or severity of CNS depression can be increased when Tolcapone is combined with Eszopiclone.
Citalopram Citalopram The risk or severity of CNS depression can be increased when Citalopram is combined with Eszopiclone.
Capecitabine Capecitabine Eszopiclone may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Efavirenz Efavirenz The risk or severity of CNS depression can be increased when Efavirenz is combined with Eszopiclone.
Abacavir Abacavir Eszopiclone may decrease the excretion rate of Abacavir which could result in a higher serum level.
Pioglitazone Pioglitazone The metabolism of Eszopiclone can be decreased when combined with Pioglitazone.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Eszopiclone.
Rosiglitazone Rosiglitazone The metabolism of Eszopiclone can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide Thalidomide Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Nateglinide Nateglinide Eszopiclone may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Levetiracetam Levetiracetam The risk or severity of CNS depression can be increased when Levetiracetam is combined with Eszopiclone.
Rabeprazole Rabeprazole The metabolism of Eszopiclone can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The serum concentration of Eszopiclone can be decreased when it is combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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