Cefazolin
Cefazolin is a cephalosporin antibiotic given by injection to treat bacterial infections of the respiratory tract, urinary tract, skin, bile ducts, bones and joints, and genital area, as well as septicemia and endocarditis, and to help prevent infection around surgery.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 34 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Cefazolin is an injectable cephalosporin antibiotic that kills bacteria by blocking cell wall construction. It is used for skin, urinary, bone, joint, bloodstream and heart valve infections and is the go-to choice to prevent infection around surgery, on the market since about 1988 and available as a generic. Most people tolerate it well, and nausea, loose stools or soreness at the injection site are the usual complaints. Tell your care team about any penicillin or cephalosporin allergy and any kidney problems, and report rash, swelling, breathing trouble or severe watery diarrhea promptly. Its boxed warning concerns pharmacy bulk packages, which are never for direct infusion.
Clinical pearls
- Severe diarrhea from C. difficile, a gut infection, can start up to two months after the last dose.
- If you take a blood thinner, expect closer clotting checks, because cefazolin can lower prothrombin activity, a clotting measure.
- Older copper-based urine sugar tests (Benedict’s-type) can read falsely positive, so tell the lab you are on cefazolin.
- Cefazolin can cause a positive Coombs’ test, which may complicate blood matching if you need a transfusion.
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾
Pharmacy bulk packages of cefazolin are not for direct infusion. This warning applies to bulk-package products. They must be prepared by a pharmacy into proper solutions before being given into a vein. As a patient, you would not receive the bulk package itself.
Patient information guide A plain-language walkthrough of Cefazolin, written from its FDA label.
What Cefazolin is used for
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Cefazolin is a cephalosporin antibiotic with several supported uses, depending on the product.
- Respiratory tract infections
- Urinary tract infections
- Skin and skin structure infections
- Biliary tract infections
- Bone and joint infections
- Genital infections (such as prostatitis and epididymitis on some labels)
- Septicemia (bloodstream infection)
- Endocarditis (infection of the heart lining or valves)
- Perioperative prophylaxis (preventing infection around surgery). Cefazolin for Injection and Dextrose Injection and Cefazolin in Dextrose Injection list this for ages 10 to 17 (and adults). One Cefazolin for Injection label lists it for adults.
How Cefazolin works
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Cefazolin kills bacteria by blocking the building of their cell walls. Without a strong wall, the bacteria cannot survive.
Some bacteria resist it, including those that make extended-spectrum beta-lactamases. Methicillin-resistant staphylococci are uniformly resistant, as are many Pseudomonas, Serratia, and Enterobacter species.
Cefazolin dosage
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Cefazolin is given by injection or infusion into a vein, and some products can be given into a muscle. Timing depends on the infection, often every several hours. For surgery prevention, it is generally given shortly before the procedure and sometimes repeated during long operations.
- Some products are intravenous only.
- Pharmacy bulk packages are for preparing IV solutions and are not for direct infusion.
- Some premixed dextrose products are not recommended if the needed dose is not a set amount.
- Your care team gives each dose, so missed-dose steps are handled by them.
Dosing details from the FDA-approved label
From the Cefazolin prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Moderate to severe infections (adults, CLcr greater than or equal to 55 mL/min)
- 500 mg to 1 gram every 6 to 8 hours
- Intravenous over approximately 30 minutes; dosage adjustment required if CLcr less than 55 mL/min
- Mild infections caused by susceptible gram-positive cocci (adults)
- 250 mg to 500 mg every 8 hours
- Acute, uncomplicated urinary tract infections (adults)
- 1 gram every 12 hours
- Pneumococcal pneumonia (adults)
- 500 mg every 12 hours
- Severe, life-threatening infections (e.g., endocarditis, septicemia) (adults)
- 1 gram to 1.5 grams every 6 hours
- Maximum: In rare instances, doses of up to 12 grams of cefazolin per day have been used
- Perioperative prophylaxis in adults (CLcr greater than or equal to 55 mL/min)
- Less than 120 kg: 1 gram to 2 grams 1/2 hour to 1 hour prior to start of surgery
- Greater than or equal to 120 kg: 3 grams
- Additional 500 mg to 1 gram during lengthy operative procedures
- 500 mg to 1 gram every 6 to 8 hours for 24 hours postoperatively
- Weight-based: less than 120 kg vs greater than or equal to 120 kg
- Pediatric patients with CLcr greater than or equal to 70 mL/min: mild to moderate/moderate to severe infections
- 25 mg/kg to 50 mg/kg, divided into 3 or 4 equal doses
- Dosage adjustment required if CLcr less than 70 mL/min
- Pediatric patients with severe infections
- May increase to 100 mg/kg, divided into 3 or 4 equal doses
- Maximum: 100 mg/kg
- Perioperative prophylaxis in pediatric patients 10 to 17 years old (CLcr greater than or equal to 70 mL/min)
- Less than 50 kg: 1 gram
- Greater than or equal to 50 kg: 2 grams, 1/2 to 1 hour prior to start of surgery
- Additional 500 mg to 1 gram during lengthy procedures
- 500 mg to 1 gram every 6 to 8 hours for 24 hours postoperatively
- Weight-based: less than 50 kg vs greater than or equal to 50 kg
- Adults with reduced renal function (injection powder label)
- CLcr 55 mL/min or greater: full doses
- 35 to 54 mL/min: full doses at least 8 hour intervals
- 11 to 34 mL/min: 1/2 the usual dose every 12 hours
- 10 mL/min or less: 1/2 the usual dose every 18 to 24 hours
- Reduced dosages apply after an initial loading dose appropriate to the severity of the infection
Read the label’s full dosing text
2 DOSAGE AND ADMINISTRATION If a dose of Cefazolin for Injection and Dextrose Injection is required that does not equal 1 gram, 2 grams or 3 grams, this product is not recommended for use and an alternative formulation of cefazolin should be considered. ( 2.1 ) For intravenous use only administered over approximately 30 minutes. ( 2.1 ) Recommended Dosing Schedule in Adult Patients with CLcr Greater Than or Equal To 55 mL/min. ( 2.1 , 2.2 and 2.3 ) Site and Type of Infection Dose Frequency Moderate to severe infections 500 milligram (mg) to 1 gram every 6 to 8 hours Mild infections caused by susceptible gram-positive cocci 250 mg to 500 mg every 8 hours Acute, uncomplicated urinary tract infections 1 gram every 12 hours Pneumococcal pneumonia 500 mg every 12 hours Severe, life-threatening infections (e.g., endocarditis, septicemia) In rare instances, doses of up to 12 grams of cefazolin per day have been used. 1 gram to 1.5 grams every 6 hours Perioperative prophylaxis less than 120 kg: 1 gram to 2 grams 1/2 to 1 hour prior to start of surgery greater than or equal to 120 kg: 3 grams 500 mg to 1 gram additional dose during lengthy operative procedures 500 mg to 1 gram every 6 to 8 hours for 24 hours postoperatively Recommended Dosing Schedule in Pediatric Patients with CLcr Greater than or Equal to 70 mL/min. ( 2.1 , 2.2 , and 2.3 ) Site and Type of Infection Dose Frequency Moderate to severe infections For the treatment indications (1.1 to 1.8) 25 to 50 mg per kilogram (kg) divided into 3 or 4 equal doses Severe infections May increase to 100 mg per kg divided into 3 or 4 equal doses Perioperative prophylaxis (10 to 17 years old) less than 50 kg: 1 gram 1/2 to 1 hour prior to start of surgery greater than or equal to 50 kg: 2 grams 500 mg to 1 gram Additional dose during lengthy operative procedures 500 mg to 1 gram every 6 to 8 hours for 24 hours postoperatively Dosage adjustment is required for adult patients with CLcr that is less than 55 mL/min and pediatric patients with CLcr that is less than 70 mL/min. ( 2.4 and 8.6 ) See full prescribing information for preparation and administration instructions.
Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →
Cefazolin side effects
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Most side effects are mild and affect the stomach or skin.
Common side effects
- Nausea
- Vomiting
- Diarrhea
- Stomach cramps or heartburn
- Skin rash or itching
- Headache
- Pain or irritation at the injection site
- Oral thrush (yeast infection in the mouth)
When to get medical help
- Get help right away for signs of a severe allergic reaction, such as trouble breathing, swelling, hives, or a serious skin reaction.
- Call your doctor if you have diarrhea, especially if it is severe or watery. It can happen even two months after treatment.
- Seek help if you have a seizure. This is more likely with kidney problems if the dose is not lowered.
- Report unusual bleeding or bruising, since cefazolin may lower prothrombin activity (a blood clotting factor).
- Tell your doctor about signs of serious skin reactions such as blistering or peeling, or severe rash.
- Report new fever, sore mouth, or signs of a new infection that appear during treatment.
- Report reduced urination or signs of kidney or liver problems.
Cefazolin warnings and precautions
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- Serious allergic reactions: can be fatal. Cross-reactions occur in up to 10% of people with penicillin allergy.
- C. difficile diarrhea: can range from mild to fatal colitis and may appear weeks after treatment.
- Seizures: risk is higher with kidney problems if the dose is not reduced.
- Bleeding risk: prothrombin activity may fall, especially with kidney or liver problems, poor nutrition, long treatment, or anticoagulants.
- Drug resistance: use only for proven or strongly suspected bacterial infections.
- Dextrose-containing products can cause hypersensitivity reactions and need caution in diabetes.
Cefazolin interactions
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Few interactions are listed, but these matter.
- Probenecid: slows cefazolin clearance, so blood levels are higher and last longer.
- Anticoagulants (blood thinners): clotting may be affected.
- Urine glucose tests (Benedict’s type): can give false-positive results.
- Coombs’ test: can turn positive because of the drug.
Interactions listed in the FDA-approved label
From the Cefazolin prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.
- Probenecid: May decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels.
Read the label’s full interactions text
7 DRUG INTERACTIONS Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels. Probenecid: May decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood concentrations. ( 7 )
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Cefazolin
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- You must not receive it if you have had an immediate allergic reaction (like anaphylaxis) to cefazolin, cephalosporins, penicillins, or other beta-lactams.
- Tell your doctor about kidney problems. Lower doses are needed when kidney function is reduced.
- Tell your doctor about liver problems or poor nutrition.
- Pregnancy: studies have not established a risk, and it crosses the placenta.
- Breastfeeding: small amounts pass into milk.
- Children: not recommended for premature infants and neonates for some products.
- Older adults: kidney function may be lower, so monitoring may help.
- People with diabetes should be cautious with dextrose-containing products.
Cefazolin overdose
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Too much cefazolin can cause seizures, particularly in people with kidney problems. If this occurs, the drug is stopped and supportive treatment is given.
How your body processes Cefazolin
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After an IV dose, cefazolin levels peak quickly and the half-life is about 1.8 hours. Following IM dosing, the half-life is about 2 hours. It spreads into bile and joint fluid and crosses the placenta. It is cleared unchanged by the kidneys, with about 60% in urine within 6 hours and 70% to 80% within 24 hours.
How to store Cefazolin
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Store the unactivated unit at 20-25°C (68-77°F). Do not freeze. , within the stated recommendations.
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Cefazolin: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Cefazolin — the kind of thing our pharmacy team would talk through with you at the counter.
What is cefazolin used for?
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How will I receive it?
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What side effects should I expect?
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When should I call for help?
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I’m allergic to penicillin. Is it safe?
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Can I take it if I’m pregnant or breastfeeding?
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Is Cefazolin available over the counter?
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When was Cefazolin first available?
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Who makes Cefazolin?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Cefazolin on HelloPharmacist
Cefazolin forms and strengths (how it comes)
Cefazolin is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Injection
How this form is used
- Cefazolin for Injection, USP is indicated for respiratory, urinary tract, skin, biliary tract, bone and joint, and genital infections, septicemia, and endocarditis due to susceptible organisms.
- Cefazolin labels with a perioperative section also list prevention of infection around surgery.
- Cefazolin Sodium powder for injection is given into a vein or muscle.
- Cefazolin pharmacy bulk packages are for preparing IV infusion solutions only, not for direct injection.
- Cefazolin for Injection 3 grams/vial is for intravenous infusion only, not IM or IV bolus.
- Follow your prescriber and the product label.
Cefazolin on the U.S. market: products, makers and brands
How Cefazolin appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
17 companies list 48 Cefazolin product records with the FDA, mostly as injection; the earliest marketing or approval year on record is 1973.
Also listed with the FDA, not a patient dose form: Powder (3) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Cefazolin is used (Medicaid data)
A general measure of how commonly Cefazolin is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Cefazolin is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Cefazolin prescribed? Of the 1,601 medications we measure, Cefazolin ranks #372 by Medicaid prescriptions — more than 77% of them.
Utilization by Cefazolin product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
cefazolin 1000 MG Injection Most dispensed
Summed across the 12 of 37 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1665050
cefazolin 2000 MG Injection
Summed across the 5 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1665060
cefazolin 200 MG/ML Injectable Solution
Summed across the 8 of 25 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313920
cefazolin 3000 MG Injection
Summed across the 5 of 8 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2630753
cefazolin 500 MG Injection
Summed across the 2 of 12 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1665052
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Cefazolin, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 32 of 91 listed Cefazolin NDCs with Medicaid activity.
Compare Cefazolin products
A representative set of FDA-listed product records for Cefazolin — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Injection | ||||
| 330 mg/mL | Intramuscular, Intravenous | A-S Medication Solutions | ANDA | View NDC → |
| 1 g | Intramuscular, Intravenous | Apotex Corp. × 2 listings | ANDA | View NDC → |
| 2 g | Intramuscular, Intravenous | Apotex Corp. | ANDA | View NDC → |
| 3 g | Intramuscular, Intravenous | Apotex Corp. | ANDA | View NDC → |
| 10 g | Intravenous | Apotex Corp. × 2 listings | ANDA | View NDC → |
| 1 g/50 mL | Intravenous | B. Braun Medical Inc. | NDA | View NDC → |
| 2 g/50 mL | Intravenous | B. Braun Medical Inc. | NDA | View NDC → |
| 3 g/50 mL | Intravenous | B. Braun Medical Inc. | NDA | View NDC → |
| 1 g/50 mL | Intravenous | Baxter Healthcare Corporation | NDA | View NDC → |
| 2 g/100 mL | Intravenous | Baxter Healthcare Corporation | NDA | View NDC → |
| 3 g/150 mL | Intravenous | Baxter Healthcare Corporation | NDA | View NDC → |
| 1 g | Intramuscular, Intravenous | Civica, Inc. | ANDA | View NDC → |
| 2 g | Intravenous | Civica, Inc. | NDA | View NDC → |
| 10 g | Intravenous | Civica, Inc. | ANDA | View NDC → |
| 1 g | Intramuscular, Intravenous | Direct_rx | ANDA | View NDC → |
| 500 mg/2.2 mL | Intramuscular, Intravenous | Fresenius Kabi USA, LLC | ANDA | View NDC → |
| 1 g/3 mL | Intramuscular, Intravenous | Fresenius Kabi USA, LLC | ANDA | View NDC → |
| 10 g | Intravenous | Fresenius Kabi USA, LLC | ANDA | View NDC → |
| 330 mg/mL | Intramuscular, Intravenous | Henry Schein, Inc. | ANDA | View NDC → |
| 1 g | Intramuscular, Intravenous | Henry Schein, Inc. | ANDA | View NDC → |
| 225 mg/mL | Intramuscular, Intravenous | Henry Schein Inc. | ANDA | View NDC → |
| 225 mg/mL | Intramuscular, Intravenous | Hikma Pharmaceuticals USA Inc. | ANDA | View NDC → |
| 330 mg/mL | Intramuscular, Intravenous | Hikma Pharmaceuticals USA Inc. × 2 listings | ANDA | View NDC → |
| 2 g | Intravenous | Hikma Pharmaceuticals USA Inc. | NDA | View NDC → |
| 3 g | Intravenous | Hikma Pharmaceuticals USA Inc. | NDA | View NDC → |
| 10 g | Intravenous | Hikma Pharmaceuticals USA Inc. × 2 listings | ANDA | View NDC → |
| 20 g | Intravenous | Hikma Pharmaceuticals USA Inc. | ANDA | View NDC → |
| 1 g | Intravenous | Hospira, Inc | ANDA | View NDC → |
| 330 mg/mL | Intramuscular, Intravenous | Medical Purchasing Solutions, LLC | ANDA | View NDC → |
| 1 g | Intramuscular, Intravenous | Medical Purchasing Solutions, LLC | ANDA | View NDC → |
| 1 g | Intramuscular, Intravenous | Proficient Rx LP | ANDA | View NDC → |
| 1 g | Intramuscular, Intravenous | ProPharma Distribution | ANDA | View NDC → |
| 1 g | Intramuscular, Intravenous | Qilu Pharmaceutical Co., Ltd. | ANDA | View NDC → |
| 100 g | Intravenous | Samson Medical Technologies, L.L.C. | ANDA | View NDC → |
| 300 g | Intravenous | Samson Medical Technologies, L.L.C. | ANDA | View NDC → |
| 500 mg | Intramuscular, Intravenous, Parenteral | Sandoz Inc | ANDA | View NDC → |
| 1 g | Intramuscular, Intravenous, Parenteral | Sandoz Inc | ANDA | View NDC → |
| 10 g | Intravenous, Parenteral | Sandoz Inc | ANDA | View NDC → |
| 500 mg | Intramuscular, Intravenous | WG Critical Care, LLC | ANDA | View NDC → |
| 1 g | Intramuscular, Intravenous | WG Critical Care, LLC × 2 listings | ANDA | View NDC → |
| 2 g | Intravenous | WG Critical Care, LLC | NDA | View NDC → |
| 3 g | Intravenous | WG Critical Care, LLC | NDA | View NDC → |
| 10 g | Intravenous | WG Critical Care, LLC | ANDA | View NDC → |
Showing 48 of 48 products — FDA National Drug Code Directory. See every product, package size and price: browse all 48 Cefazolin NDCs →
Cefazolin side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Cefazolin — a signal of what to watch for, not proof the drug caused it.
The effects most often named in FDA reports that mention Cefazolin are hypotension, anaphylactic reaction, anaphylactic shock; about 93% of the reports were classed as serious. These are voluntary reports, so they show what people report, not how often it happens.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Cefazolin in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Cefazolin FDA approval history
How Cefazolin went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Cefazolin was first approved by the FDA in 1973 (Brand: ANCEF · Glaxosmithkline). It remains available in U.S. pharmacies today.
Source: Drugs@FDA.
Cefazolin recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list 2 Cefazolin recalls since July 2021, covering 3 product listings. One of them is still ongoing and is listed first. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.
- Cefazolin for Injection, USP, 1 gram per vial, Sterile, For Intramuscular or Intravenous Use, Rx Only, Manufactured by Sandoz GmbH for Sandoz Inc. Princeton, NJ 08540, NDC: 0781 3451-70 (vial), NDC:… Lots: Lot # PG4360, PG4362, Exp. 11/30/2027 FDA record D-0569-2025 →
- Cefazolin for injection USP, and Dextrose Injection, USP, 2 g, 50 mL duplex container, Rx only, MFG: B. Braun Medical Inc., NDC 0264-3105-11 Lots: McKesson Medical-Surgical (MMS) is not able to identify the particular lot number received by a particular consignee for the recalled prescription products. Each letter includes the date it was distributed to customers and the dates that i… FDA record D-1118-2022 →
- Cefazolin for injection USP, and Dextrose Injection, USP, 1G, 50 ML duplex container, Rx only, MFG: B. Braun Medical Inc., NDC 0264-3103-11 Lots: McKesson Medical-Surgical (MMS) is not able to identify the particular lot number received by a particular consignee for the recalled prescription products. Each letter includes the date it was distributed to customers and the dates that i… FDA record D-1117-2022 →
Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 2180 2 dose forms · 5 strengths
-
Dose form (SCDF) Injectable Solution RxCUI 371324In current FDA listingsClinical drug / strength (SCD) 200 MG/MLRxCUI 313920 -
Dose form (SCDF) Injection RxCUI 1665049In current FDA listings
Look up RxCUI 2180 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Cefazolin supply and shortage status
Whether Cefazolin is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
💵 What Cefazolin costs pharmacies (NADAC benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Injection, Powder, For Solution · Intramuscular, Intravenous | 330 mg/mL | $1.07 each | NDC details & price history |
| Injection, Powder, For Solution · Intramuscular; Intravenous | 330 mg/mL | $1.07 each | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Who makes Cefazolin: manufacturers and labelers
17 companies list Cefazolin products with the FDA. By number of product records, the largest are Hikma Pharmaceuticals USA Inc., Apotex Corp., WG Critical Care, LLC. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
Cefazolin drug class (RxNorm)
Cefazolin belongs to the Cephalosporin Antibacterial class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Cefazolin page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Hikma Pharmaceuticals USA Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →