Herb & supplement monograph

Lentinan Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Lentinan interacts with medications. The heart of this page is the interaction list — every drug Lentinan is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Lentinan is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Lentinan Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated August 2026

Based on the available evidence, the overall risk of a clinically significant Lentinan drug interaction appears low for most people, since every reported interaction comes from lab or animal research rather than human studies. None of the listed interactions are rated major, and none have actually been documented in people so far.

Interactions deserving the most attention

The main theme is that lentinan may speed up several enzymes the body uses to clear medications, which could lower drug levels and make some medicines less effective. Animal studies showed reduced blood levels of metoprolol, a blood pressure and heart medication, as well as midazolam and omeprazole. Because the concern is a weaker drug effect rather than toxicity, it matters most for medicines where steady levels are important, such as heart, blood pressure, and mood medications.

What the rest of the list means

The long list of medications reflects one shared mechanism, not hundreds of separate proven problems. Almost any drug cleared by these enzymes gets counted, even though the effect has only been seen in lab and animal research. Whether it causes meaningful changes in people has not been shown.

Check your medications against Lentinan

Based on HelloPharmacist’s Lentinan interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Lentinan

816 medications have a known interaction with Lentinan, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Lentinan using our pharmacist-reviewed interaction data.

AI summaries are generated from our Lentinan interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Lentinan combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Lentinan affects

Every type of medication (drug category) Lentinan is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 8 drug categories Lentinan interacts with

Cytochrome P450 1a2 (cyp1a2) SubstratesCytochrome P450 2c19 (cyp2c19) SubstratesCytochrome P450 2d6 (cyp2d6) SubstratesCytochrome P450 3a4 (cyp3a4) SubstratesMetoprolol (toprol)Midazolam (versed)Omeprazole (prilosec)Phenacetin

Cytochrome P450 1A2 (Cyp1A2) Substrates

Laboratory evidence suggests that lentinan might increase the activity of cytochrome P450 1A2 (CYP1A2). So far, this interaction has not been reported in humans. However, watch for a decrease in the levels of drugs metabolized by CYP1A2 in patients taking lentinan.
Some drugs metabolized by CYP1A2 include amitriptyline (Elavil), haloperidol (Haldol), ondansetron (Zofran), propranolol (Inderal), theophylline (Theo-Dur, others), verapamil (Calan, Isoptin, others), and others.