Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Glycan Renew Ingredients & Drug Interactions

by Nutri-West Functional Health Series

Glycan Renew label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Glycan Renew against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Glycan Renew is a dietary supplement by Nutri-West Functional Health Series with 8 active ingredients. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 1,197 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lentinan, Reishi Mushroom, Lions Mane mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Glycan Renew by Nutri-West Functional Health Series

Ask about any prescription or over-the-counter medication and we check it for interactions with Glycan Renew by Nutri-West Functional Health Series — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Glycan Renew by Nutri-West Functional Health Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (725 mg) without saying how much of each component you get.

Glycan Renew contains eight active ingredients, all mushroom extracts and a polysaccharide component. The proprietary blend includes lion's mane mushroom, reishi mushroom, cordyceps, maitake mushroom, coriolus versicolor (turkey tail), shiitake mushroom, 1,3 beta-glucans, and lentinan — each chosen for their polysaccharide and immune-supporting compounds.

The product also contains inactive ingredients (microcrystalline cellulose, vegetable stearine, stearic acid, and magnesium stearate) as binders and fillers in the tablet.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Coronary heart disease (CHD) — rated "Likely Effective" (Beta-glucans) (Natural Medicines).
  • On file: Dyslipidemia — rated "Likely Effective" (Beta-glucans) (Natural Medicines).
  • On file: Cancer — rated "Possibly Effective" (Turkey Tail Mushroom) (Natural Medicines).
  • On file: Malignant pleural effusions — rated "Possibly Effective" (Lentinan) (Natural Medicines).

The evidence for these mushroom ingredients is mixed and often limited. Beta-glucans stand out with likely effectiveness for high cholesterol (dyslipidemia) and heart disease risk reduction.

Turkey tail is possibly effective for cancer support. Most other uses — lion's mane for cognitive function and Alzheimer disease, reishi for sleep or immune support, cordyceps for athletic performance, maitake and shiitake for various conditions — lack reliable evidence; the data rates them as having insufficient evidence to draw a conclusion.

If you're considering this product for a specific health goal, check with your doctor or pharmacist about what the research actually supports.

The evidence, ingredient by ingredient Lion's Mane Mushroom Reishi Mushroom Cordyceps Maitake Mushroom Turkey Tail Mushroom Shiitake Mushroom Beta-glucans Lentinan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The mushroom ingredients in Glycan Renew are generally well tolerated as foods, but as concentrated supplements the long-term safety data is sparse. The most commonly reported side effects are mild gastrointestinal ones — nausea, diarrhea, stomach discomfort, and bloating.

Lion's mane, reishi, cordyceps, maitake, turkey tail, and shiitake all lack enough safety data in pregnancy and during breastfeeding; the facts advise avoiding them during these times. Beta-glucans from food are well tolerated, but concentrated supplements lack safety data too, and lentinan should be avoided in pregnancy and breastfeeding.

If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist before starting this product.

Side effects, ingredient by ingredient Lion's Mane Mushroom Reishi Mushroom Cordyceps Maitake Mushroom Turkey Tail Mushroom Shiitake Mushroom Beta-glucans Lentinan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 8 of the 8 matched ingredients can interact with medications — Maitake Mushroom, Cordyceps, Turkey Tail Mushroom, Shiitake Mushroom, Lentinan, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,198 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Glycan Renew, double-check the following medication types with your doctor or pharmacist: blood thinners and antiplatelet drugs (moderate risk of increased bleeding), blood pressure medications (moderate risk of drops in pressure), diabetes medications (moderate risk of low blood sugar), immunosuppressants (moderate risk of reduced effectiveness), chemotherapy drugs like cyclophosphamide and tamoxifen (moderate risk), liver-processed medications like certain antidepressants and sedatives (moderate risk of reduced effectiveness from enzyme induction), and if you take testosterone therapy or supplements (minor risk of additive effects). Altogether, these interactions span 1,198 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Glycan Renew is a multi-ingredient mushroom supplement that may interest people exploring immune support or those looking into beta-glucans for cholesterol and heart health — the one ingredient with solid research backing. However, if you take blood thinners, diabetes drugs, blood pressure medications, immunosuppressants, or chemotherapy, you need to check your specific medications against the interactions listed here before taking it.

Pregnant or breastfeeding people should avoid it. Have a conversation with your own doctor or pharmacist about whether this product makes sense for you and your current health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Glycan Renew, straight from the product label.

Brand Nutri-West Functional Health Series
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 214612
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Glycan Renew by Nutri-West Functional Health Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
IngredientAmount% DV
Proprietary Blend725 mg--
Lions Mane mushroom0 NP--
Reishi Mushroom0 NP--
Cordyceps0 NP--
Maitake Mushroom0 NP--
Coriolus versicolor0 NP--
Shiitake Mushroom0 NP--
1,3 Beta Glucans0 NP--
Lentinan0 NP--

Other ingredients: Microcrystalline Cellulose, Vegetable Stearine, Stearic Acid, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

For distribution by health care professionals only.

“When you want the best”

Formulation

Gluten/Dairy Free

Storage

Store in cool, dry place. Best if kept refrigerated.

Precautions

Keep out of reach of children.

Tamper resistant outer seal – do not use if broken.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Glycan Renew by Nutri-West Functional Health Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Glycan Renew label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Glycan Renew by Nutri-West Functional Health Series

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Stearine, Stearic Acid, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Glycan Renew by Nutri-West Functional Health Series Drug Interactions

Want to check YOUR meds against Glycan Renew?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,197Drugs
1,176 Moderate 21 Minor

Ingredients driving the most interactions

Lentinan 814
Reishi Mushroom 375
Lions Mane mushroom 327
Shiitake Mushroom 312
1,3 Beta Glucans 293

Individual Drug Interactions

The ingredients in Glycan Renew interact with 1,197 drugs. Click any drug to see the details.

8 of the 8 ingredients in Glycan Renew interact with drugs. Each result below shows which ingredient is responsible. Lentinan Reishi Mushroom Lions Mane mushroom Shiitake Mushroom 1,3 Beta Glucans Maitake Mushroom Cordyceps Coriolus versicolor

Each ingredient & the kinds of drugs it affects

For each ingredient in Glycan Renew with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lentinan8 drug types · 814 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Laboratory evidence suggests that lentinan might increase the activity of cytochrome P450 1A2 (CYP1A2). So far, this interaction has not been reported in humans. However, watch for a decrease in the levels of drugs metabolized by CYP1A2 in patients taking lentinan.
Some drugs metabolized by CYP1A2 include amitriptyline (Elavil), haloperidol (Haldol), ondansetron (Zofran), propranolol (Inderal), theophylline (Theo-Dur, others), verapamil (Calan, Isoptin, others), and others.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Laboratory research suggests that lentinan might increase the activity of cytochrome P450 2C19 (CYP2C19). So far, this interaction has not been reported in humans. However, watch for a decrease in the levels of drugs metabolized by CYP2C19 in patients taking lentinan.
Some drugs metabolized by CYP2C19 include proton pump inhibitors including omeprazole (Prilosec), lansoprazole (Prevacid), and pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); and others.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Laboratory research suggests that lentinan might increase the activity of cytochrome P450 2D6 (CYP2D6). So far, this interaction has not been reported in humans. However, watch for a decrease in the levels of drugs metabolized by CYP2D6 in patients taking lentinan.
Some drugs metabolized by CYP2D6 include tricyclic antidepressants such as imipramine (Tofranil) and amitriptyline (Elavil); antipsychotics such as haloperidol (Haldol), risperidone (Risperdal), and chlorpromazine (Thorazine); beta-blockers such as propranolol (Inderal), metoprolol (Lopressor, Toprol XL), and carvedilol (Coreg); tamoxifen (Nolvadex); and others.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Laboratory research suggests that lentinan might increase the activity of cytochrome P450 3A4 (CYP3A4). So far, this interaction has not been reported in humans. However, watch for a decrease in the levels of drugs metabolized by CYP3A4 in patients taking lentinan.
Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and numerous others.

Likelihood Possible Evidence D
Metoprolol (Toprol)

In animal research, lentinan decreases plasma levels of metoprolol. This may be due to induction of cytochrome P450 2D6 (CYP2D6) metabolism.

Likelihood Possible Evidence D
Midazolam (Versed)

In animal research, lentinan decreases plasma levels of midazolam. This may be due to induction of cytochrome P450 3A4 (CYP3A4) metabolism.

Likelihood Possible Evidence D
Omeprazole (Prilosec)

In animal research, lentinan decreases plasma levels of omeprazole. This may be due to induction of cytochrome P450 2C19 (CYP2C19) metabolism.

Likelihood Possible Evidence D
Phenacetin

In animal research, lentinan decreases plasma levels of phenacetin. This may be due to induction of cytochrome P450 1A2 (CYP1A2) metabolism.

Likelihood Possible Evidence D
Lentinan full monograph & interactions

Reishi Mushroom3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Mushroom full monograph & interactions

Lions Mane mushroom3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lions Mane mushroom full monograph & interactions

Shiitake Mushroom2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
Shiitake Mushroom full monograph & interactions

1,3 Beta Glucans2 drug types · 293 drugs

Antihypertensive Drugs

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.

Likelihood Possible Evidence D
1,3 Beta Glucans full monograph & interactions

Maitake Mushroom3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake Mushroom full monograph & interactions

Cordyceps3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps full monograph & interactions

Coriolus versicolor4 drug types · 187 drugs

Antidiabetes Drugs

Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that turkey tail mushroom and a polysaccharide component can have hypoglycemic effects.

Likelihood Possible Evidence D
Cyclophosphamide

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might increase exposure to cyclophosphamide.
Some animal research shows that the PSP component of turkey tail mushroom can increase the area under the concentration-time curve (AUC) of cyclophosphamide by 44% to 50% and the half-life by 34% to 43%. This interaction could potentially increase the effects and adverse effects of cyclophosphamide. However, it is not known whether PSP affects the levels of the active metabolites of cyclophosphamide that are responsible for its clinical activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might interfere with the absorption of tamoxifen.
Animal research suggests that PSP increases the time to reach maximum concentration of a single dose of tamoxifen by about 9.5 hours, or 228%. When repeated doses of tamoxifen were given, the time to reach maximum concentration was increased by about 5.6 hours, or 93%. However, PSP did not affect the maximum concentration or the area under the curve of tamoxifen.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might inhibit CYP2C9.
Laboratory research suggests that the PSP component of turkey tail mushroom dose-dependently inhibits CYP2C9. Theoretically, taking PSP with drugs metabolized by CYP2C9 might increase drug levels and the risk of adverse effects. However, this has not been reported in humans.

Likelihood Possible Evidence D
Coriolus versicolor full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Glycan Renew, from the product label.

Nutri-West Functional Health Series

See all Nutri-West Functional Health Series products
Name
Nutri-West
Street Address
P.O. Box 950
City
Douglas
State
WY
ZipCode
82633
Pharmacist Counseling Corner

Glycan Renew by Nutri-West Functional Health Series: Common Questions

Does Glycan Renew by Nutri-West Functional Health Series interact with any medications?
Yes. Based on its ingredients, Glycan Renew has a known interaction with 1,197 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Glycan Renew contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Glycan Renew safe to take during pregnancy or while breastfeeding?
No. The facts show that lion's mane, reishi, cordyceps, maitake, turkey tail, shiitake, and lentinan all lack enough safety data, and the guidance is to avoid them during pregnancy and breastfeeding. Beta-glucans in food amounts are likely fine, but the safety of concentrated supplements during these times is not well studied either. Talk with your doctor or pharmacist before taking this product if you're pregnant, nursing, or planning to become pregnant.
What are the most common side effects of Glycan Renew?
The mushroom ingredients in this product most often cause mild gastrointestinal effects — nausea, diarrhea, stomach discomfort, bloating, and constipation. These are generally uncommon and tend to improve if you take the product with food. Rare reports include rash, dizziness, and dry mouth. If side effects persist or worsen, stop taking it and talk with your pharmacist.
Does lion's mane mushroom in Glycan Renew actually work for brain health or memory?
The evidence isn't established yet. The data rates lion's mane for cognitive function, cognitive impairment, and Alzheimer disease as having insufficient reliable evidence — meaning there isn't enough quality research to say whether it works. It's a popular ingredient in wellness supplements, but solid proof is lacking.
Which ingredient in Glycan Renew has the most research behind it?
Beta-glucans are rated likely effective for high cholesterol and heart disease risk, making them the ingredient with the strongest evidence in this product. Turkey tail is possibly effective for cancer support. The other mushrooms mostly lack enough research to draw firm conclusions about their effectiveness.
Can I take Glycan Renew if I'm on a blood thinner like warfarin?
Not without checking with your doctor first. Several ingredients in Glycan Renew — lion's mane, reishi, cordyceps, maitake, and beta-glucans — may increase bleeding risk when combined with blood thinners. Maitake specifically has a case report of raising warfarin levels. You need to talk with your own doctor or pharmacist about your specific blood thinner and whether this product is safe for you.
Does Glycan Renew interact with diabetes medications?
Yes. Lion's mane, maitake, and turkey tail may lower blood sugar and could have additive effects with diabetes drugs, raising your risk of low blood sugar (hypoglycemia). If you take diabetes medication, check with your doctor or pharmacist before starting Glycan Renew and monitor your blood sugar closely.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Glycan Renew is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Glycan Renew label
Go deeper

The Full Monographs Behind Glycan Renew’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Turkey Tail Mushroom

Interacts with 187 drugs

Turkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system. Some of its purified extracts (PSK and PSP) have been studie...

Read the full Turkey Tail Mushroom monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph → Herb & supplement monograph

Beta-glucans

Interacts with 293 drugs

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...

Read the full Beta-glucans monograph → Herb & supplement monograph

Lentinan

Interacts with 814 drugs

Lentinan is a beta-glucan polysaccharide from shiitake mushrooms that is studied mainly as an immune-modulating add-on to cancer chemotherapy, where it is given by injection in a few countri...

Read the full Lentinan monograph →
Sources

Sources & How We Checked

Glycan Renew's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 157 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Reishi Mushroom 17 references
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Cordyceps 14 references
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Maitake Mushroom 8 references
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Turkey Tail Mushroom 15 references
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Shiitake Mushroom 67 references
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Beta-glucans 11 references
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  5. Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
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  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
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See these in context on the Beta-glucans monograph →

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See these in context on the Lentinan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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