Drug & supplement interaction

Maitake Mushroom + Acebutolol

Acebutolol brand names: Sectral, Rhotral.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Maitake Mushroom has a moderate interaction with Acebutolol. Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Maitake Mushroom and Acebutolol

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Acebutolol

Acebutolol falls under ANTIHYPERTENSIVE DRUGS — the group Maitake Mushroom interacts with.

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: acebutolol already works to bring your blood pressure down and slow your heart rate. Maitake mushroom may have a mild blood pressure lowering effect of its own, so stacking the two could, in theory, push your numbers a little lower than expected. If that happens, you might notice things like dizziness, lightheadedness when you stand up, unusual tiredness, or a slower-than-usual heartbeat.

I want to be honest about the strength of this: it's theoretical, mostly from animal studies, and eating maitake as food is unlikely to cause trouble. Concentrated supplements are the bigger question mark. If you'd like to try one, check in with your pharmacist or doctor first, and keep an eye on your blood pressure at home.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Maitake Mushroom Also Interacts With Other Medications

Maitake Mushroom has 259 moderate known drug interactions in our database — the Acebutolol one above is one of them. If you take anything else, check it against the full list below.

Moderate 259 No known interaction 2,571 (incl. Acebutolol)
Taking anything else?

Check Another of Your Medications Against Maitake Mushroom

Covers the 2,830 medications we’ve checked against Maitake Mushroom. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Acebutolol

This page covers Maitake Mushroom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acebutolol page lists 173 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Beer (major) and Indian Snakeroot (major).

By severity: 8 major · 143 moderate · 22 minor.

From our pharmacist’s overview on the Acebutolol page

“Acebutolol (Sectral) lowers blood pressure and slows the heart, so the eight major-rated interactions on this list of 173 supplements deserve real attention. Most of the entries, well over a hundred, either stack on its blood-pressure-lowering effect and drop you too low, or push the other way and let your pressure climb back up.”

Reviewed by 2 · Jul 18, 2026

Open the Acebutolol interaction page

One more smart check

Taking Maitake Mushroom as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,788 real supplement products containing Maitake Mushroom, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Maitake Mushroom. Your product may carry other ingredients that interact with Acebutolol too, on top of Maitake Mushroom — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Maitake Mushroom and Acebutolol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Maitake Mushroom
Top 25%

#165 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acebutolol
Steady interest

#1,687 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Maitake Mushroom

What is Maitake Mushroom?

Maitake Mushroom
  • Immune support
  • Blood sugar support in diabetes
  • High blood pressure
  • High cholesterol
  • General wellness and antioxidant support

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence is still limited and not strong enough to recommend it as a treatment. It is generally well tolerated as food, but talk to your pharmacist or doctor before using concentrated supplements.

Read the full Maitake Mushroom monograph & all interactions
Medication

About Acebutolol

What Is Acebutolol Used For?

Brand names: Sectral, Rhotral

Acebutolol Hydrochloride capsules are used to manage high blood pressure (hypertension) in adults. They can be used on their own or alongside other blood pressure medications, particularly thiazide-type diuretics.

They are also used to treat ventricular premature beats — extra, out-of-rhythm heartbeats that originate in the lower chambers of the heart. Acebutolol reduces how often these abnormal beats occur, including complex patterns that can be more concerning.

See full Acebutolol drug information
Keep checking

Other Drugs & Maitake Mushroom

Browse every other medication we’ve checked against Maitake Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
259Moderate
0Minor
2,570No known interaction
259 Moderate 2,570 No interaction
Moderate

259 interactions

Showing 60 of 259 moderate interactions — see all 259 on the Maitake Mushroom page.

No interaction 2,570 drugs checked — show the list

We also checked Maitake Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,570 medications checked with no known interaction — see the full Maitake Mushroom list.

See the full Maitake Mushroom interactions page
See every supplement checked against Acebutolol, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Maitake Mushroom monograph › Uses, safety, and every drug interaction in one place Acebutolol supplement interactions › Every supplement checked against Acebutolol, ranked by severity Acebutolol drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Maitake Mushroom and Acebutolol Together: Common Questions

Can you take Maitake Mushroom with Acebutolol?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Maitake Mushroom and Acebutolol interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Acebutolol and Maitake Mushroom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.