Drug & supplement interaction

Maitake Mushroom + Methyclothiazide

Methyclothiazide brand names: Enduron, Aquatensen.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Maitake Mushroom has a moderate interaction with Methyclothiazide. Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Maitake Mushroom and Methyclothiazide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Methyclothiazide

Methyclothiazide falls under ANTIHYPERTENSIVE DRUGS — the group Maitake Mushroom interacts with.

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: methyclothiazide is a water pill that lowers your blood pressure by flushing out extra salt and fluid. Maitake mushroom may have a mild blood pressure lowering effect of its own. So when you put the two together, the concern is that they could stack up and push your pressure a little too low.

If that happened, you might feel lightheaded, dizzy, weak, or faint, especially when standing up quickly. I'll be honest with you though, this warning is theoretical and mostly based on animal studies, not strong human data. Eating maitake as food is unlikely to cause trouble, but a concentrated supplement is worth a quick chat with your pharmacist or doctor first, especially if your pressure already runs low.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Maitake Mushroom Also Interacts With Other Medications

Maitake Mushroom has 259 moderate known drug interactions in our database — the Methyclothiazide one above is one of them. If you take anything else, check it against the full list below.

Moderate 259 No known interaction 2,571 (incl. Methyclothiazide)
Taking anything else?

Check Another of Your Medications Against Maitake Mushroom

Covers the 2,830 medications we’ve checked against Maitake Mushroom. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Methyclothiazide

This page covers Maitake Mushroom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methyclothiazide page lists 227 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 192 moderate · 25 minor.

Open the Methyclothiazide interaction page

One more smart check

Taking Maitake Mushroom as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,788 real supplement products containing Maitake Mushroom, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Maitake Mushroom. Your product may carry other ingredients that interact with Methyclothiazide too, on top of Maitake Mushroom — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Maitake Mushroom and Methyclothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Maitake Mushroom
Top 25%

#165 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methyclothiazide
Top half

#1,285 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Maitake Mushroom

What is Maitake Mushroom?

Maitake Mushroom
  • Immune support
  • Blood sugar support in diabetes
  • High blood pressure
  • High cholesterol
  • General wellness and antioxidant support

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence is still limited and not strong enough to recommend it as a treatment. It is generally well tolerated as food, but talk to your pharmacist or doctor before using concentrated supplements.

Read the full Maitake Mushroom monograph & all interactions
Medication

About Methyclothiazide

What Is Methyclothiazide Used For?

Brand names: Enduron, Aquatensen

  • Methyclothiazide is used to treat high blood pressure. Methyclothiazide is also used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Methyclothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine.

  • High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

See full Methyclothiazide drug information
Keep checking

Other Drugs & Maitake Mushroom

Browse every other medication we’ve checked against Maitake Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
259Moderate
0Minor
2,570No known interaction
259 Moderate 2,570 No interaction
Moderate

259 interactions

Showing 60 of 259 moderate interactions — see all 259 on the Maitake Mushroom page.

No interaction 2,570 drugs checked — show the list

We also checked Maitake Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,570 medications checked with no known interaction — see the full Maitake Mushroom list.

See the full Maitake Mushroom interactions page
See every supplement checked against Methyclothiazide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Maitake Mushroom monograph › Uses, safety, and every drug interaction in one place Methyclothiazide supplement interactions › Every supplement checked against Methyclothiazide, ranked by severity Methyclothiazide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Maitake Mushroom and Methyclothiazide Together: Common Questions

Can you take Maitake Mushroom with Methyclothiazide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Maitake Mushroom and Methyclothiazide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Methyclothiazide and Maitake Mushroom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.