Drug & supplement interaction

Maitake Mushroom + Amphetamine

Amphetamine brand names: Dyanavel XR, Adensys XR-ODT, Mydayis, Adzenys ER.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Maitake Mushroom and Amphetamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Maitake Mushroom and Amphetamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amphetamine and Maitake Mushroom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Maitake Mushroom safety at a glance

Maitake Mushroom overall Use caution Generally well tolerated as food, but supplement safety has not been fully studied.

Pregnancy Avoid Not enough safety data, so concentrated supplements should be avoided during pregnancy.

Breastfeeding Avoid Not enough safety data, so concentrated supplements should be avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amphetamine and Maitake Mushroom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Amphetamine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Amphetamine is filed under 6 classifications — including monoamine oxidase inhibitors (maois), amphetamines, stimulant drugs. Maitake Mushroom has documented interactions with 3 drug classes — the most serious being antidiabetes drugs (moderate), antihypertensive drugs (moderate) and warfarin (coumadin) (moderate) — and none of Amphetamine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Maitake Mushroom Does Interact With Other Medications

Maitake Mushroom has 260 moderate known drug interactions in our database — Amphetamine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 260 No known interaction 2,570 (incl. Amphetamine)

Taking anything else?

Check Another of Your Medications Against Maitake Mushroom

Covers the 2,830 medications we’ve checked against Maitake Mushroom. Pick one to open its full report.

What to actually watch for

What Maitake Mushroom Itself Has Been Linked To

This is not an interaction — nothing below involves Amphetamine. It is the side-effect record for Maitake Mushroom on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Maitake Mushroom, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

An allergic reaction Worth acting on Additional detail
“In a clinical trial, one patient experienced rash and pruritus after two doses of maitake mushroom polysaccharide extract. The allergic reaction cleared without intervention.”

Maitake Mushroom · Natural Medicines adverse-effect record, reported in pruritus.
1 source cited

61239. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
Itching / A skin rash Additional detail

Recorded for Maitake Mushroom in the same Natural Medicines adverse-effect record shown under An allergic reaction above.
Diarrhea Additional detail
“In clinical research of a polysaccharide extract from maitake mushroom, one patient reported nausea and 2 out of 26 reported epigastric pain. In a clinical trial of a liquid extract from maitake mushroom, 2 out of 21 patients experienced diarrhea, and one experienced nausea. One patient withdrew from the study due to diarrhea.”

Maitake Mushroom · Natural Medicines adverse-effect record, reported in diarrhea.
3 sources cited

61239. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i

17131. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl

92843. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed
Nausea Additional detail

Recorded for Maitake Mushroom in the same Natural Medicines adverse-effect record shown under Diarrhea above.

Everything above comes from the Natural Medicines adverse-effect record for Maitake Mushroom — expand a row for the licensed statement it rests on. We haven’t matched Amphetamine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Amphetamine.

Overlapping uses

What Amphetamine Is Prescribed For, and What Maitake Mushroom Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Amphetamine is a prescription medicine with approved uses on its FDA label. Maitake Mushroom is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Amphetamine is prescribed for: Amphetamine treats Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years and older. Adzenys XR-ODT, Dyanavel XR, and the amphetamine extended-release orally disintegrating tablet formulations are specifically approved for ADHD in this age group. Amphetamine Sulfate tablets and Evekeo (amphetamine sulfate tablets) are also approved for narcolepsy (a sleep disorder causing uncontrollable daytime sleepiness) and as a short-term aid in a calorie-restricted weight-loss program for exogenous obesity (weight gain from external factors like overeating) in patients who have not responded to other approaches.

Maitake Mushroom has been studied for:

Obesity studied, not established Maitake Mushroom has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Maitake Mushroom for obesity

Although there has been interest in using oral maitake mushroom for obesity, there is insufficient reliable information about the clinical effects of maitake mushroom for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Amphetamine on your own; if you are taking Maitake Mushroom for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Maitake Mushroom or Amphetamine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Maitake Mushroom or Amphetamine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Amphetamine

This page covers Maitake Mushroom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amphetamine page lists 130 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Bitter Orange (major), Brewer's Yeast (major) and Cowhage (major).

By severity: 16 major · 97 moderate · 17 minor.

From our pharmacist’s overview on the Amphetamine page

“Amphetamine (Dyanavel XR, Adzenys ER, Mydayis) is a prescription stimulant, usually taken for ADHD, and its interaction list is one to approach with genuine care. Of the 130 supplements and herbal ingredients on file, 16 carry a major rating, and many of those work the same way, either inhibiting monoamine oxidase, as yohimbe does, or…”

Reviewed by 2 · Jul 18, 2026

Open the Amphetamine interaction page

One more smart check

Taking Maitake Mushroom as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,788 real supplement products containing Maitake Mushroom, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Maitake Mushroom. Even though Maitake Mushroom itself has no known interaction with Amphetamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Maitake Mushroom and Amphetamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Maitake Mushroom

Top 25%

#165 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Amphetamine

Top 5%

#46 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Maitake Mushroom reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Maitake Mushroom and Amphetamine records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Maitake Mushroom

What is Maitake Mushroom?

Immune support
Blood sugar support in diabetes
High blood pressure
High cholesterol
General wellness and antioxidant support

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence is still limited and not strong enough to recommend it as a treatment. It is generally well tolerated as food, but talk to your pharmacist or doctor before using concentrated supplements.

Grifola frondosa · Meripilaceae · Fruiting body (mushroom) and mycelium; also purified extracts such as the 'D-fraction' · Capsules, tablets, powders, liquid extracts (D-fraction/SX-fraction), and whole mushroom used as food

An interaction check asks whether these two react with each other — it does not ask whether Maitake Mushroom is a good idea for someone in your situation. Here is what our Maitake Mushroom record says about it on its own.

Maitake Mushroom: dosing

There is no official, well-established dose for maitake supplements. Products vary widely in strength and in how they are prepared, including whole mushroom powders and standardized extracts like the D-fraction.The best approach is to follow the directions on the product label and to choose products from reputable brands.

From our Maitake Mushroom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Maitake Mushroom monograph & all interactions

Medication

About Amphetamine

What Is Amphetamine Used For?

Brand names: Dyanavel XR, Adensys XR-ODT, Mydayis, Adzenys ER

Amphetamine treats Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years and older. Adzenys XR-ODT, Dyanavel XR, and the amphetamine extended-release orally disintegrating tablet formulations are specifically approved for ADHD in this age group.

Amphetamine Sulfate tablets and Evekeo (amphetamine sulfate tablets) are also approved for narcolepsy (a sleep disorder causing uncontrollable daytime sleepiness) and as a short-term aid in a calorie-restricted weight-loss program for exogenous obesity (weight gain from external factors like overeating) in patients who have not responded to other approaches.

See full Amphetamine drug information

Keep checking

Other Drugs & Maitake Mushroom

Browse every other medication we’ve checked against Maitake Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

260Moderate

0Minor

2,569No known interaction

260 Moderate 2,569 No interaction

Moderate

260 interactions

Showing 60 of 260 moderate interactions — see all 260 on the Maitake Mushroom page.

No interaction 2,569 drugs checked — show the list

We also checked Maitake Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,569 medications checked with no known interaction — see the full Maitake Mushroom list.

See the full Maitake Mushroom interactions page

See every supplement checked against Amphetamine, ranked by severity

Evidence & sources

Maitake Mushroom References

The 8 references that drive our Maitake Mushroom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Maitake Mushroom and Amphetamine Together: Common Questions

Is it safe to take Maitake Mushroom with Amphetamine?

We do not list a known interaction between Maitake Mushroom and Amphetamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Are Maitake Mushroom and Amphetamine used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Maitake Mushroom in each. That is a conversation for your prescriber, especially if Amphetamine is being adjusted to a target.

How was the Maitake Mushroom and Amphetamine combination checked?

Interactions in our licensed database are recorded against drug classes. Amphetamine is filed under 6 classifications, and Maitake Mushroom has documented interactions with 3 drug classes — none of Amphetamine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Maitake Mushroom interact with any other medications?

Yes. Maitake Mushroom has 260 documented drug interactions in our database — Amphetamine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Amphetamine interact with any supplements?

Yes. Amphetamine has documented interactions with 130 supplements in our database — Maitake Mushroom is not one of them. The Amphetamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Maitake Mushroom monograph Uses, safety profile, and every drug interaction in one place Amphetamine drug information The full plain-English guide to this medication Amphetamine supplement interactions Every supplement checked against Amphetamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amphetamine and Maitake Mushroom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.