Medication interaction hub

What Supplements Interact with Acebutolol?

Acebutolol brand names: Sectral, Rhotral. Every interaction below applies to the brands too.

173 Interactions 8 Major 143 Moderate 22 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acebutolol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acebutolol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Acebutolol (Sectral) lowers blood pressure and slows the heart, so the eight major-rated interactions on this list of 173 supplements deserve real attention. Most of the entries, well over a hundred, either stack on its blood-pressure-lowering effect and drop you too low, or push the other way and let your pressure climb back up. Tyramine can raise blood pressure enough to blunt the drug, and American hellebore is potent enough to drag both pressure and heart rate dangerously low.

A second group of 38 ingredients adds strain on the liver, and heavy alcohol, beer and wine included, carries a major rating there. Activated charcoal can soak up an oral dose before it reaches your bloodstream, so keep the two well apart in time. With 143 moderate and 22 minor entries beyond the majors, most pairings are workable, but the eight serious ones are the reason to read this page closely.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 143 Minor 22 No known interaction 1,279

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acebutolol: Top Interactions at a Glance

The Acebutolol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 173 interacting ingredients — plus 1,279 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acebutolol Combinations Today

The Acebutolol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Niacin + Acebutololi

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Acebutololi

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Minor Likelihood Possible Beet + Acebutololi

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.

Read the full interaction Minor Likelihood Possible Coenzyme Q10 + Acebutololi

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Probable Fish Oil + Acebutololi

Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Probable Sodium + Acebutololi

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Acebutolol

All 1,452 ingredients in our database, ranked by severity — 173 with a Acebutolol interaction on file and 1,279 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acebutolol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Niacin with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.

Full Niacin + Acebutolol answer

Can you take Ashwagandha with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.

Full Ashwagandha + Acebutolol answer

Can you take Beet with Acebutolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.

Full Beet + Acebutolol answer

Can you take Coenzyme Q10 with Acebutolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Full Coenzyme Q10 + Acebutolol answer

Can you take Fish Oil with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Acebutolol answer

Can you take Horny Goat Weed with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the risk of hypotension.

Full Horny Goat Weed + Acebutolol answer

Can you take Isopropylnorsynephrine with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, isopropylnorsynephrine might decrease the effects of antihypertensive drugs.

Full Isopropylnorsynephrine + Acebutolol answer

Can you take Kava with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using kava with hepatotoxic drugs might increase the risk of liver damage.

Full Kava + Acebutolol answer

Can you take Khat with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Human research shows that khat and its constituent, cathinone, can increase blood pressure.

Full Khat + Acebutolol answer

Can you take Khella with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, khella might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Khella + Acebutolol answer

Can you take Kiwi with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Clinical research suggests that consuming kiwi reduces systolic and diastolic blood pressure in hypertensive individuals.

Full Kiwi + Acebutolol answer

Can you take Korean Pine with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that Korean pine nut oil reduces blood pressure in spontaneously hypertensive rats.

Full Korean Pine + Acebutolol answer

Can you take Kudzu with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Kudzu + Acebutolol answer

Can you take L-citrulline with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotensio...

Full L-citrulline + Acebutolol answer

Can you take Licorice with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might reduce the effects of antihypertensive drugs.

Full Licorice + Acebutolol answer

Can you take Ligandrol with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Ligandrol + Acebutolol answer

Can you take Maitake Mushroom with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Full Maitake Mushroom + Acebutolol answer

Can you take Malic Acid with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.

Full Malic Acid + Acebutolol answer

Can you take Manchurian Thorn with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that high doses of Manchurian thorn can induce liver damage.

Full Manchurian Thorn + Acebutolol answer

Can you take Melatonin with Acebutolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.

Full Melatonin + Acebutolol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acebutolol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acebutolol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acebutolol sits in 5 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Acebutolol through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acebutolol through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acebutolol through this category.

Beta-Blockers 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Acebutolol through this category.

Acebutolol (Sectral) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Acebutolol through this category.

About Acebutolol

Acebutolol is a beta-blocker used to treat high blood pressure and certain irregular heartbeats (ventricular arrhythmias).

Generic name: Acebutolol  ·  Brand names: Sectral, Rhotral.

See the full Acebutolol drug information

Related: does Acebutolol deplete any nutrients?

Acebutolol has 4 reported nutrient associations in the research literature — see the Acebutolol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acebutolol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acebutolol.

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Pharmacist Counseling Corner

Acebutolol & Supplements: Common Questions

What supplements interact with Acebutolol?
Our database currently documents 173 ingredients with a known Acebutolol interaction (8 major, 143 moderate, 22 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 173. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Acebutolol supplement interactions are the most serious?
Focus on the major group: American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Acebutolol?
Plenty of supplements coexist fine with Acebutolol; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Sectral have the same supplement interactions as Acebutolol?
Yes — Sectral, Rhotral all contain Acebutolol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acebutolol deplete any vitamins or nutrients?
It might — Acebutolol has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acebutolol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acebutolol and my other medications?
This page covers Acebutolol against supplements and herbal ingredients. Checking Acebutolol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Acebutolol drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.