Medication interaction hub

What Supplements Interact with Labetalol?

Labetalol brand names: Normodyne, Trandate. Every interaction below applies to the brands too.

176 Interactions 8 Major 148 Moderate 20 Minor
Curated & coded by · Clinical Pharmacist · Updated September 26, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Labetalol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Labetalol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Labetalol blocks both alpha and beta receptors to lower blood pressure, and it is often the first choice in pregnancy, so the 176 supplement and herbal interactions on file call for genuine care, starting with the eight rated major. Most of the list pushes on blood pressure itself: over a hundred ingredients either add to labetalol's effect or, like tyramine, fight it. A smaller cluster, alcohol from beer or wine included, adds strain on the liver.

Activated charcoal works differently, binding the drug in the gut so less is absorbed; space it and similar items well apart from your dose. A few, Indian snakeroot among them, can slow the heart too far on top of a beta blocker. The remaining 148 moderate and 20 minor entries mostly nudge blood pressure a little further down, and everyday fish oil is in that group.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 148 Minor 20 No known interaction 1,276

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Labetalol: Top Interactions at a Glance

The most significant Labetalol supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 176 interacting ingredients — plus 1,276 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Labetalol + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely American Hellebore + Labetaloli

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Labetaloli

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Likely Tyramine + Labetaloli

Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Read the full interaction Major Likelihood Probable Activated Charcoal + Labetaloli

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable American Mistletoe + Labetaloli

American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially increasing blood pre...

Read the full interaction Major Likelihood Probable Beer + Labetaloli

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Labetalol

All 1,452 ingredients in our database, ranked by severity — 176 with a Labetalol interaction on file and 1,276 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Labetalol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Flaxseed with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Full Flaxseed + Labetalol answer

Can you take Flaxseed Oil with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.

Full Flaxseed Oil + Labetalol answer

Can you take Fo-ti with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Fo-ti + Labetalol answer

Can you take Gamma-aminobutyric Acid (gaba) with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.

Full Gamma-aminobutyric Acid (gaba) + Labetalol answer

Can you take Garcinia with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.

Full Garcinia + Labetalol answer

Can you take Garden Cress with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking garden cress with antihypertensive drugs might increase the risk of hypotension.

Full Garden Cress + Labetalol answer

Can you take Garlic with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.

Full Garlic + Labetalol answer

Can you take Gentian with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.

Full Gentian + Labetalol answer

Can you take Ginkgo with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.

Full Ginkgo + Labetalol answer

Can you take Goji with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.

Full Goji + Labetalol answer

Can you take Goldenseal with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase the risk of hypotension when taken with antihypertensive drugs.

Full Goldenseal + Labetalol answer

Can you take Gotu Kola with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.

Full Gotu Kola + Labetalol answer

Can you take Greater Celandine with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that greater celandine can adversely affect the liver.

Full Greater Celandine + Labetalol answer

Can you take Guar Gum with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Labetalol answer

Can you take Guarumo with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that aqueous and ethanolic extracts of guarumo leaf can lower blood pressure when administered intrav...

Full Guarumo + Labetalol answer

Can you take Gum Arabic with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Labetalol answer

Can you take Hawthorn with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might cause additive effects on blood pressure and heart rate.

Full Hawthorn + Labetalol answer

Can you take Hemp Agrimony with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA).

Full Hemp Agrimony + Labetalol answer

Can you take Hesperidin with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.

Full Hesperidin + Labetalol answer

Can you take Hibiscus Sabdariffa with Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Hibiscus sabdariffa with antihypertensive drugs might increase the risk of hypotension.

Full Hibiscus Sabdariffa + Labetalol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Labetalol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Labetalol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Labetalol sits in 5 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Labetalol through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Labetalol through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Labetalol through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Labetalol through this category.

Beta-Blockers 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Labetalol through this category.

About Labetalol

Labetalol is a beta blocker used to treat high blood pressure.

Generic name: Labetalol  ·  Brand names: Normodyne, Trandate.

See the full Labetalol drug information

Related: does Labetalol deplete any nutrients?

Labetalol has 4 reported nutrient associations in the research literature — see the Labetalol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Labetalol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Labetalol.

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Pharmacist Counseling Corner

Labetalol & Supplements: Common Questions

What supplements interact with Labetalol?
Our database currently documents 176 ingredients with a known Labetalol interaction (8 major, 148 moderate, 20 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 176. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Labetalol supplement interactions are the most serious?
The 8 major-rated combinations — led by American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Labetalol?
Plenty of supplements coexist fine with Labetalol; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Normodyne have the same supplement interactions as Labetalol?
Yes — Normodyne, Trandate all contain Labetalol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Labetalol deplete any vitamins or nutrients?
It might — Labetalol has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Labetalol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Labetalol and my other medications?
This page covers Labetalol against supplements and herbal ingredients. Checking Labetalol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Labetalol drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 26, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.