Malic Acid Interactions Overview
Check For Interactions With Malic Acid
Malic Acid
Malic acid is a naturally occurring organic compound found in various fruits, particularly apples. It contributes to the sour or tart taste of these fruits and is commonly used as a food additive to enhance flavor. In addition to its role in the food industry, malic acid is utilized in the production of beverages, candies, and skincare products for its acidulant properties. Some studies suggest that malic acid may have potential health benefits, such as supporting muscle function and alleviating symptoms of conditions like fibromyalgia.
Additional Details
Is Malic Acid Safe? Are There Any Warnings?
Caution: Malic acid is an alpha hydroxy acid (AHA), distinct from other AHAs. Generally Recognized as Safe (GRAS) in the US, it's safe when consumed in typical food amounts. However, limited information exists about its safety during pregnancy, lactation, or topical skin use. Oral and short-term medicinal use seem safe, but caution is advised.
How Does Malic Acid Work? What is the Mechanism of Action?
Malic acid, an AHA found in fruits and wines, has diverse applications. In skincare, it acts as an exfoliant, disrupting skin adhesions and promoting desquamation. For dry mouth, its acidity stimulates saliva production, but excessive use may harm teeth. Animal studies suggest it may have hypotensive effects and influence weight gain through its involvement in the Krebs cycle.
Pharmacokinetics
Unfortunately, reliable information on the pharmacokinetics of malic acid is lacking. Further research is needed to understand how the body processes this compound.
Interaction Overview (See Bottom of Page For Full List)
Malic acid may interact with antihypertensive drugs, potentially increasing the risk of hypotension. Caution is advised when combining malic acid with herbs or supplements that have hypotensive effects.
Common Side Effects To Watch For
Generally well-tolerated, malic acid may cause eye and skin irritation when used topically. Specific adverse effects include dry mouth when used orally. Limited evidence suggests possible skin benefits, such as improved symptoms in patients with dry mouth, but more research is needed for other potential uses.
Are Supplements Standardized?
Information on standardized malic acid supplements is scarce. Formulations in clinical research include topical creams, oral tablets, and oral mouth sprays. Dosing recommendations vary, and further research is required to establish standardized guidelines.
What Is Malic Acid Typically Used For?
Malic acid is commonly used to acidify or flavor foods, prevent food discoloration, and adjust the acidity of cosmetics. Medicinally, it may be used for conditions like dry mouth, although research on its effectiveness for other purposes, such as acne, fatigue, and psoriasis, is inconclusive and requires more evidence.
Drugs that interact with Malic Acid
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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