Herb & supplement monograph

Rauwolscine Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Rauwolscine interacts with medications. The heart of this page is the interaction list — every drug Rauwolscine is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Rauwolscine is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Rauwolscine Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated August 2026

Based on the available evidence, the overall risk of a clinically significant Rauwolscine drug interaction appears low for most people, since every reported interaction is theoretical rather than proven in humans. None of the listed interactions are rated major, and all of them rest on lab or animal findings rather than human studies.

Interactions deserving the most attention

The combinations we watch most closely involve anticoagulant and antiplatelet drugs, because a related compound reduced platelet clumping in lab research, so a bleeding risk cannot be ruled out. Rauwolscine also blocked the effects of clonidine in animal studies, which could matter for blood pressure control. In animals it lowered the seizure threshold, so people taking seizure threshold lowering drugs or stimulants have a bit more reason for caution.

What the rest of the list means

Rauwolscine appears on a very long list of interacting medications, but that mostly reflects one theory: it may affect an enzyme the body uses to clear many common drugs, which automatically pulls hundreds of medications onto the list. None of these effects have been confirmed in people, so a listed interaction is a reason for awareness, not proof of harm.

Check your medications against Rauwolscine

Based on HelloPharmacist’s Rauwolscine interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Rauwolscine

677 medications have a known interaction with Rauwolscine, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Rauwolscine using our pharmacist-reviewed interaction data.

AI summaries are generated from our Rauwolscine interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Rauwolscine combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Rauwolscine affects

Every type of medication (drug category) Rauwolscine is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 6 drug categories Rauwolscine interacts with

Anticoagulant/antiplatelet DrugsCalcium Channel BlockersClonidine (catapres)Cytochrome P450 2d6 (cyp2d6) SubstratesSeizure Threshold Lowering DrugsStimulant Drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, rauwolscine may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Rauwolscine is structurally related to yohimbine. In vitro research shows that yohimbine inhibits platelet aggregation.