Rauwolscine + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide
Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide brand name: Ascriptin Codeine #2.
Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide falls into 3 drug categories that Rauwolscine can interact with; the most serious is rated moderate. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.
Read the full interaction reportRauwolscine and Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Rauwolscine interacts with whole categories of medication. Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide falls into 3 of those categories, so it can interact with Rauwolscine in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
SEIZURE THRESHOLD LOWERING DRUGS
1 of 3Why this applies to Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide
Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide falls under SEIZURE THRESHOLD LOWERING DRUGS — the group Rauwolscine interacts with.
In animal research, intraperitoneal rauwolscine lowered the seizure threshold level of the drug metrazol.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combination product (Ascriptin Codeine) pairs aspirin and codeine for pain with two antacids to protect your stomach. The piece that matters here is the codeine, an opioid. The concern with rauwolscine isn't really about how your body breaks these medicines down. Instead, rauwolscine is a stimulant that can make the brain a bit more excitable and, in animal studies, it nudged the seizure threshold lower.
So in theory, stacking a stimulant like rauwolscine with a medicine combo that can also affect seizure risk might slightly raise the odds of a seizure, especially at high opioid doses. Keep in mind this is weak, animal-only evidence, not proven in people. Still, if you have a history of seizures, or feel jittery or your heart races, check with your pharmacist or doctor before combining them.
- Aziz TA, Hussain SA, Mahwi TO, Ahmed ZA, Rahman HS, Rasedee A. The efficacy and safety of Ginkgo biloba extract as an adjuvant in type 2 diabetes mellitus patients ineffectively managed with metformin: a double-blind, randomized, placebo-controlled trial.
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
2 of 3Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide also falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES.
Rauwolscine is structurally related to yohimbine. In vitro research shows that yohimbine inhibits CYP2D6 enzyme activity.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
The piece of this combo product that matters here is the codeine. Codeine is what we call a prodrug, meaning it doesn't do much until your body converts it into morphine, and the enzyme that does that job is CYP2D6. Rauwolscine is a cousin of yohimbine, and lab studies suggest yohimbine can block CYP2D6. If that same blocking happens with rauwolscine, your body may make less morphine from the codeine, so you could get weaker pain relief than expected.
Keep in mind this is only a theoretical concern based on lab data, not real-world cases, so I wouldn't panic. The aspirin, aluminum hydroxide, and magnesium hydroxide aren't really involved. If your pain isn't controlled, or you're unsure, check with your pharmacist or doctor before making any changes.
- VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. PubMed
ANTICOAGULANT/ANTIPLATELET DRUGS
3 of 3Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide also falls under ANTICOAGULANT/ANTIPLATELET DRUGS.
Rauwolscine is structurally related to yohimbine. In vitro research shows that yohimbine inhibits platelet aggregation.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to know about this combo product: it already contains aspirin, which thins your blood and makes it harder for platelets to clump and form clots. Rauwolscine is the concern here because lab studies on its close cousin yohimbine suggest it may also lightly discourage platelets from sticking together. Stack the two and you could, in theory, nudge up your bleeding risk a bit more.
In real life that might look like easier bruising, nosebleeds, bleeding gums, or a cut that takes longer to stop. I'll be honest though, this is a theoretical interaction based on how these compounds behave, not proven in people, so don't panic. Just mention to your pharmacist or doctor that you're taking a rauwolscine supplement, especially before any surgery or dental work.
- Mustonen, P., Savola, J., and Lassila, R. Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine. Thromb.Res 8-1-2000;99(3):231-237.
- Berlin, I., Crespo-Laumonnier, B., Cournot, A., Landault, C., Aubin, F., Legrand, J. C., and Puech, A. J. The alpha 2-adrenergic receptor antagonist yohimbine inhibits epinephrine-induced platelet aggregation in healthy subjects. Clin Pharmacol.Ther. 199
- Braddock, L., Cowen, P. J., Elliott, J. M., Fraser, S., and Stump, K. Binding of yohimbine and imipramine to platelets in depressive illness. Psychol.Med 1986;16(4):765-773. PubMed
- Boon, N. A., Elliott, J. M., Grahame-Smith, D. G., John-Green, T., and Stump, K. A comparison of alpha 2-adrenoreceptor binding characteristics of intact human platelets identified by [3H]-yohimbine and [3H]- dihydroergocryptine. J Auton.Pharmacol 1983;3
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Rauwolscine Also Interacts With Other Medications
Rauwolscine has 676 moderate known drug interactions in our database — the Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Rauwolscine
We haven’t checked that one against Rauwolscine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Rauwolscine. Pick one to open its full report.
See Every Supplement That Interacts With Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide
This page covers Rauwolscine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide page lists 339 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).
By severity: 11 major · 286 moderate · 42 minor.
From our pharmacist’s overview on the Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide page
“A person taking Ascriptin Codeine #2 for pain is getting aspirin, codeine, and two antacids in a single tablet, and the 339 supplement interactions on file deserve real attention before adding anything alongside it. Most of the list splits two ways.”
Reviewed by 2 · Jul 18, 2026
Open the Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interaction page
Taking Rauwolscine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 196 real supplement products containing Rauwolscine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rauwolscine. Your product may carry other ingredients that interact with Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide too, on top of Rauwolscine — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Rauwolscine and Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#278 of 1,452 supplements looked up here in the last 7 days
#117 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Rauwolscine
What is Rauwolscine?
- Fat loss and weight management
- Bodybuilding and physique support
- Energy and stimulant effects
- Athletic performance
- Libido support
Rauwolscine (alpha-yohimbine) is a stimulant alkaloid closely related to yohimbine that is marketed mainly in fat-burning and pre-workout supplements. Human evidence for its benefits is very limited, and it can raise heart rate and blood pressure and cause anxiety, so it should be used with caution and is not recommended for people with heart conditions, anxiety, or during pregnancy or breastfeeding.
Other Drugs & Rauwolscine
Browse every other medication we’ve checked against Rauwolscine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
676 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Metronidazole ›
- Phentermine ›
- Diphenhydramine ›
- Aspirin ›
- Methylphenidate ›
- Naproxen ›
- Doxycycline ›
- Minocycline ›
- Propranolol ›
- Lidocaine ›
- Amoxicillin ›
- Verapamil ›
- Phenylpropanolamine ›
- Quinidine ›
- Cyclosporine ›
- Bupropion ›
- Chloroquine ›
- Ciprofloxacin ›
- Fentanyl ›
- Nicotine ›
- Oxycodone ›
- Penicillin V Potassium ›
- Phenytoin ›
- Tacrolimus ›
- Amphotericin B ›
- Ampicillin ›
- Carbamazepine ›
- Ceftazidime ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Formoterol ›
- Indomethacin ›
- Morphine Sulfate ›
- Penicillin G Potassium ›
- Phenylephrine ›
- Pseudoephedrine ›
- Acyclovir ›
- Amphetamine ›
- Baclofen ›
- Buprenorphine ›
- Cephalexin ›
- Dicloxacillin Sodium ›
- Diethylpropion ›
- Dimenhydrinate ›
- Famotidine ›
- Ketoprofen ›
- Lofepramine ›
- Methotrexate ›
- Nortriptyline ›
- Ofloxacin ›
- Oxymorphone ›
- Propoxyphene ›
- Sotalol ›
- Aripiprazole ›
Showing 60 of 676 moderate interactions — see all 676 on the Rauwolscine page.
No interaction 2,153 drugs checked — show the list
We also checked Rauwolscine against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Acetaminophen ›
- Losartan Potassium ›
- Rosuvastatin ›
- Escitalopram ›
- Atorvastatin ›
- Isotretinoin ›
- Tirzepatide ›
- Docusate ›
- Tadalafil ›
- Sumatriptan ›
- Hydroxyurea ›
- Prednisone ›
- Metformin ›
- Semaglutide ›
- Levothyroxine, Liothyronine ›
- Lisinopril ›
- Azithromycin ›
- Bendamustine ›
- Pregabalin ›
- Gabapentin ›
- Lamotrigine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Candesartan Cilexetil ›
- Insulin Degludec, Liraglutide ›
- Diazepam ›
- Ezetimibe ›
- Dapsone ›
- Cyclopentolate ›
- Thyroid Hormone ›
- Avatrombopag Maleate ›
- Belladonna, Ergotamine, Phenobarbital ›
- Levetiracetam ›
- Hydrochlorothiazide, Losartan Potassium ›
- Mannitol ›
- Roxithromycin ›
- Bendroflumethiazide, Rauwolfia Serpentina ›
- Sacubitril, Valsartan ›
- Atorvastatin Calcium ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Ado-trastuzumab Emtansine ›
- Canagliflozin, Metformin ›
- Valsartan ›
- Acarbose ›
- Spironolactone ›
- Sulfamethoxazole, Trimethoprim ›
- Enalapril Maleate ›
- Progestin, Oral Contraceptive ›
- Ceftolozane Sulfate, Tazobactam Sodium ›
- Alginic Acid, Aluminum Hydroxide ›
- Mitomycin ›
- Azelastine Hydrochloride, Fluticasone Propionate ›
- Finasteride ›
Showing the 60 most looked-up of 2,153 medications checked with no known interaction — see the full Rauwolscine list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide Is Linked to Lower Levels of 7 Nutrients
Natural Medicines records Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide as a medicine that can lower these. This is not an interaction with Rauwolscine — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Rauwolscine and Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide Together: Common Questions
Can you take Rauwolscine with Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide?
Why are there 3 interactions listed for Rauwolscine and Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide?
How serious is the Rauwolscine and Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide and Rauwolscine?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.