Rauwolscine + Aspirin, Butalbital, Caffeine, Codeine Phosphate
Aspirin, Butalbital, Caffeine, Codeine Phosphate brand name: Fiorinal w/ Codeine.
Aspirin, Butalbital, Caffeine, Codeine Phosphate falls into 4 drug categories that Rauwolscine can interact with; the most serious is rated moderate. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.
Read the full interaction reportRauwolscine and Aspirin, Butalbital, Caffeine, Codeine Phosphate
These two interact in 4 distinct ways. Each one is explained separately below.
Why Are There 4 Interactions?
Rauwolscine interacts with whole categories of medication. Aspirin, Butalbital, Caffeine, Codeine Phosphate falls into 4 of those categories, so it can interact with Rauwolscine in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
SEIZURE THRESHOLD LOWERING DRUGS
1 of 4Why this applies to Aspirin, Butalbital, Caffeine, Codeine Phosphate
Aspirin, Butalbital, Caffeine, Codeine Phosphate falls under SEIZURE THRESHOLD LOWERING DRUGS — the group Rauwolscine interacts with.
In animal research, intraperitoneal rauwolscine lowered the seizure threshold level of the drug metrazol.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist with Fiorinal with Codeine, which combines aspirin, butalbital, caffeine, and codeine. The concern isn't really about how these get broken down. It's that rauwolscine, a stimulant cousin of yohimbine, may lower the seizure threshold, meaning it could make seizures a little easier to trigger. Stacking it with the caffeine in this product (also a stimulant) leans the same direction.
To be honest, this is a theoretical worry based only on animal lab work, where rauwolscine lowered the seizure threshold for a test chemical. For most people taking this medication as directed, the practical risk is low. Still, if you have a seizure history, or notice racing heart, jitteriness, or anxiety, please loop in your pharmacist or doctor before combining them.
- Aziz TA, Hussain SA, Mahwi TO, Ahmed ZA, Rahman HS, Rasedee A. The efficacy and safety of Ginkgo biloba extract as an adjuvant in type 2 diabetes mellitus patients ineffectively managed with metformin: a double-blind, randomized, placebo-controlled trial.
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
2 of 4Aspirin, Butalbital, Caffeine, Codeine Phosphate also falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES.
Rauwolscine is structurally related to yohimbine. In vitro research shows that yohimbine inhibits CYP2D6 enzyme activity.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the wrinkle with this combo product: one of its ingredients, codeine, is a prodrug. It doesn't do much on its own. Your body uses an enzyme called CYP2D6 to turn codeine into morphine, which is what actually relieves pain. Rauwolscine is a cousin of yohimbine, and lab studies suggest yohimbine can slow down that same CYP2D6 enzyme.
So in theory, rauwolscine might block codeine from converting to morphine, meaning you could get less pain relief than expected. Keep in mind this is only a theoretical concern based on lab data, not real-world reports. There's also a separate issue worth mentioning: rauwolscine and the caffeine here are both stimulants, so together they may bump up heart rate, blood pressure, and jitteriness. If you take Fiorinal with Codeine regularly, run this by your pharmacist before adding the supplement.
- VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. PubMed
ANTICOAGULANT/ANTIPLATELET DRUGS
3 of 4Aspirin, Butalbital, Caffeine, Codeine Phosphate also falls under ANTICOAGULANT/ANTIPLATELET DRUGS.
Rauwolscine is structurally related to yohimbine. In vitro research shows that yohimbine inhibits platelet aggregation.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the piece worth knowing: your medication contains aspirin, which already thins the blood and makes platelets less sticky. Rauwolscine may, in theory, do a little of the same thing. Lab studies on its cousin yohimbine show it can block platelets from clumping together. Stack that on top of aspirin and you could, at least on paper, raise your bleeding risk a bit. That might look like easier bruising, nosebleeds that take a while to stop, or bleeding gums.
I want to be honest about the strength of this: it's theoretical, drawn from test-tube research, not from people. It's not a reason to panic. Still, since rauwolscine also pushes up heart rate and blood pressure, I'd run it by your pharmacist or doctor before combining the two.
- Mustonen, P., Savola, J., and Lassila, R. Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine. Thromb.Res 8-1-2000;99(3):231-237.
- Berlin, I., Crespo-Laumonnier, B., Cournot, A., Landault, C., Aubin, F., Legrand, J. C., and Puech, A. J. The alpha 2-adrenergic receptor antagonist yohimbine inhibits epinephrine-induced platelet aggregation in healthy subjects. Clin Pharmacol.Ther. 199
- Braddock, L., Cowen, P. J., Elliott, J. M., Fraser, S., and Stump, K. Binding of yohimbine and imipramine to platelets in depressive illness. Psychol.Med 1986;16(4):765-773. PubMed
- Boon, N. A., Elliott, J. M., Grahame-Smith, D. G., John-Green, T., and Stump, K. A comparison of alpha 2-adrenoreceptor binding characteristics of intact human platelets identified by [3H]-yohimbine and [3H]- dihydroergocryptine. J Auton.Pharmacol 1983;3
STIMULANT DRUGS
4 of 4Aspirin, Butalbital, Caffeine, Codeine Phosphate also falls under STIMULANT DRUGS.
Rauwolscine has demonstrated stimulant effects in animal research.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the piece that matters for Fiorinal with Codeine: this combination pill already contains caffeine, which is a stimulant. Rauwolscine is also a stimulant, and it works by ramping up norepinephrine, one of your body's own "go" chemicals. So the worry here isn't about how your liver breaks the medicine down. It's simply about stacking two stimulating substances on top of each other.
Together, the caffeine in Fiorinal plus rauwolscine could leave you feeling more jittery, anxious, or shaky, with a faster heartbeat and higher blood pressure. To be fair, this concern comes mostly from animal and lab research, so it's more theoretical than proven. Still, if you have heart issues or anxiety, please run this by your pharmacist or doctor before combining them.
- Aziz TA, Hussain SA, Mahwi TO, Ahmed ZA, Rahman HS, Rasedee A. The efficacy and safety of Ginkgo biloba extract as an adjuvant in type 2 diabetes mellitus patients ineffectively managed with metformin: a double-blind, randomized, placebo-controlled trial.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Rauwolscine Also Interacts With Other Medications
Rauwolscine has 676 moderate known drug interactions in our database — the Aspirin, Butalbital, Caffeine, Codeine Phosphate one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Rauwolscine
We haven’t checked that one against Rauwolscine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Rauwolscine. Pick one to open its full report.
See Every Supplement That Interacts With Aspirin, Butalbital, Caffeine, Codeine Phosphate
This page covers Rauwolscine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Butalbital, Caffeine, Codeine Phosphate page lists 398 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).
By severity: 17 major · 334 moderate · 47 minor.
From our pharmacist’s overview on the Aspirin, Butalbital, Caffeine, Codeine Phosphate page
“Fiorinal with Codeine packs four active drugs into one capsule, and I would treat its supplement list with genuine wariness rather than a quick skim. The aspirin component is why roughly half of the 398 ingredients on file raise bleeding risk, while the codeine and butalbital explain a second large cluster that deepens sedation, someti…”
Reviewed by 2 · Jul 18, 2026
Open the Aspirin, Butalbital, Caffeine, Codeine Phosphate interaction page
Taking Rauwolscine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 196 real supplement products containing Rauwolscine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rauwolscine. Your product may carry other ingredients that interact with Aspirin, Butalbital, Caffeine, Codeine Phosphate too, on top of Rauwolscine — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Rauwolscine and Aspirin, Butalbital, Caffeine, Codeine Phosphate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#266 of 1,452 supplements looked up here in the last 7 days
#286 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Rauwolscine
What is Rauwolscine?
- Fat loss and weight management
- Bodybuilding and physique support
- Energy and stimulant effects
- Athletic performance
- Libido support
Rauwolscine (alpha-yohimbine) is a stimulant alkaloid closely related to yohimbine that is marketed mainly in fat-burning and pre-workout supplements. Human evidence for its benefits is very limited, and it can raise heart rate and blood pressure and cause anxiety, so it should be used with caution and is not recommended for people with heart conditions, anxiety, or during pregnancy or breastfeeding.
Other Drugs & Rauwolscine
Browse every other medication we’ve checked against Rauwolscine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
676 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Metronidazole ›
- Phentermine ›
- Diphenhydramine ›
- Aspirin ›
- Methylphenidate ›
- Naproxen ›
- Doxycycline ›
- Minocycline ›
- Propranolol ›
- Lidocaine ›
- Amoxicillin ›
- Verapamil ›
- Phenylpropanolamine ›
- Quinidine ›
- Cyclosporine ›
- Bupropion ›
- Chloroquine ›
- Ciprofloxacin ›
- Fentanyl ›
- Nicotine ›
- Oxycodone ›
- Penicillin V Potassium ›
- Phenytoin ›
- Tacrolimus ›
- Amphotericin B ›
- Ampicillin ›
- Carbamazepine ›
- Ceftazidime ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Formoterol ›
- Indomethacin ›
- Morphine Sulfate ›
- Penicillin G Potassium ›
- Phenylephrine ›
- Pseudoephedrine ›
- Acyclovir ›
- Amphetamine ›
- Baclofen ›
- Buprenorphine ›
- Cephalexin ›
- Dicloxacillin Sodium ›
- Diethylpropion ›
- Dimenhydrinate ›
- Famotidine ›
- Ketoprofen ›
- Lofepramine ›
- Methotrexate ›
- Nortriptyline ›
- Ofloxacin ›
- Oxymorphone ›
- Propoxyphene ›
- Sotalol ›
- Aripiprazole ›
Showing 60 of 676 moderate interactions — see all 676 on the Rauwolscine page.
No interaction 2,153 drugs checked — show the list
We also checked Rauwolscine against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Losartan Potassium ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Atorvastatin ›
- Isotretinoin ›
- Tirzepatide ›
- Levothyroxine, Liothyronine ›
- Docusate ›
- Prednisone ›
- Metformin ›
- Tadalafil ›
- Semaglutide ›
- Hydroxyurea ›
- Sumatriptan ›
- Lisinopril ›
- Azithromycin ›
- Pregabalin ›
- Gabapentin ›
- Lamotrigine ›
- Bendamustine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Candesartan Cilexetil ›
- Insulin Degludec, Liraglutide ›
- Enalapril Maleate ›
- Diazepam ›
- Avatrombopag Maleate ›
- Bendroflumethiazide, Rauwolfia Serpentina ›
- Ado-trastuzumab Emtansine ›
- Bismuth Subcarbonate, Calcium Carbonate, Opium ›
- Ezetimibe ›
- Dapsone ›
- Rosiglitazone Maleate ›
- Sacubitril, Valsartan ›
- Levetiracetam ›
- Hydrochlorothiazide, Losartan Potassium ›
- Cyclopentolate ›
- Sulfamethoxazole, Trimethoprim ›
- Insulin Aspart, Insulin Degludec ›
- Belladonna, Ergotamine, Phenobarbital ›
- Canagliflozin, Metformin ›
- Azelastine Hydrochloride, Fluticasone Propionate ›
- Netupitant, Palonosetron (oral) ›
- Hydrocortisone, Clioquinol, Pramoxine ›
- Candesartan Cilexetil, Hydrochlorothiazide ›
- Sodium Bicarbonate (otc Drug) ›
- Saxagliptin, Metformin Xr ›
- Progestin, Oral Contraceptive ›
- Efgartigimod Alfa-fcab ›
- Alginic Acid, Aluminum Hydroxide ›
- Measles, Mumps, Rubella Virus Live ›
- Ceftolozane Sulfate, Tazobactam Sodium ›
Showing the 60 most looked-up of 2,153 medications checked with no known interaction — see the full Rauwolscine list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Aspirin, Butalbital, Caffeine, Codeine Phosphate Is Linked to Lower Levels of 4 Nutrients
Natural Medicines records Aspirin, Butalbital, Caffeine, Codeine Phosphate as a medicine that can lower these. This is not an interaction with Rauwolscine — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Aspirin, Butalbital, Caffeine, Codeine Phosphate nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Rauwolscine and Aspirin, Butalbital, Caffeine, Codeine Phosphate Together: Common Questions
Can you take Rauwolscine with Aspirin, Butalbital, Caffeine, Codeine Phosphate?
Why are there 4 interactions listed for Rauwolscine and Aspirin, Butalbital, Caffeine, Codeine Phosphate?
How serious is the Rauwolscine and Aspirin, Butalbital, Caffeine, Codeine Phosphate interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Aspirin, Butalbital, Caffeine, Codeine Phosphate and Rauwolscine?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.