Rauwolscine + Aspirin, Caffeine, Hydrocodone
Aspirin, Caffeine, Hydrocodone brand name: Damason-P.
Aspirin, Caffeine, Hydrocodone falls into 4 drug categories that Rauwolscine can interact with; the most serious is rated moderate. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.
Read the full interaction reportRauwolscine and Aspirin, Caffeine, Hydrocodone
These two interact in 4 distinct ways. Each one is explained separately below.
Why Are There 4 Interactions?
Rauwolscine interacts with whole categories of medication. Aspirin, Caffeine, Hydrocodone falls into 4 of those categories, so it can interact with Rauwolscine in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
SEIZURE THRESHOLD LOWERING DRUGS
1 of 4Why this applies to Aspirin, Caffeine, Hydrocodone
Aspirin, Caffeine, Hydrocodone falls under SEIZURE THRESHOLD LOWERING DRUGS — the group Rauwolscine interacts with.
In animal research, intraperitoneal rauwolscine lowered the seizure threshold level of the drug metrazol.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the simple version. This combination pill (Damason-P) contains caffeine, which is a mild stimulant, and rauwolscine is a stronger stimulant found in fat-burner and pre-workout products. On their own, certain stimulants can slightly lower the brain's seizure threshold, meaning they make a seizure a touch more likely in people who are prone to them. The concern here is that stacking two stimulant-type ingredients together could nudge that risk up a bit.
I want to be honest about the strength of this: it's theoretical, based on an animal study, not on people. For most folks it likely won't be a problem. But if you have a seizure history, or you feel jittery, anxious, or notice a racing heart, please check with your pharmacist or doctor before combining them.
- Aziz TA, Hussain SA, Mahwi TO, Ahmed ZA, Rahman HS, Rasedee A. The efficacy and safety of Ginkgo biloba extract as an adjuvant in type 2 diabetes mellitus patients ineffectively managed with metformin: a double-blind, randomized, placebo-controlled trial.
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
2 of 4Aspirin, Caffeine, Hydrocodone also falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES.
Rauwolscine is structurally related to yohimbine. In vitro research shows that yohimbine inhibits CYP2D6 enzyme activity.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
The piece of this combo pill that matters here is the hydrocodone. Your liver uses an enzyme called CYP2D6 to convert hydrocodone into a stronger pain-relieving form. Rauwolscine is a close cousin of yohimbine, and lab (test tube) studies suggest yohimbine can slow that same enzyme down. If CYP2D6 is partly blocked, you might get a bit less of that converted pain relief, though the parent hydrocodone still works to some degree.
I want to be honest that this is theoretical, based on pharmacology and not real-world cases, so don't be alarmed. There's a separate practical concern though: rauwolscine is a stimulant that raises heart rate and blood pressure, which doesn't pair well with an opioid plus caffeine. Please run this by your pharmacist or doctor before combining them.
- VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. PubMed
ANTICOAGULANT/ANTIPLATELET DRUGS
3 of 4Aspirin, Caffeine, Hydrocodone also falls under ANTICOAGULANT/ANTIPLATELET DRUGS.
Rauwolscine is structurally related to yohimbine. In vitro research shows that yohimbine inhibits platelet aggregation.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combination product contains aspirin, which already thins the blood a bit by keeping platelets from clumping together. Rauwolscine, a cousin of yohimbine, may have a mild blood-thinning effect of its own based on lab studies. Put the two together and, in theory, you could see a slightly higher chance of bruising, nosebleeds, or stomach upset and bleeding.
I want to be honest though: this concern is theoretical, drawn from test-tube research rather than real patients, so it is far from certain. Keep in mind rauwolscine can also raise your heart rate and blood pressure, separate from any bleeding worry. Before pairing them, have a quick chat with your pharmacist or doctor, especially if you bruise easily or have ulcer history.
- Mustonen, P., Savola, J., and Lassila, R. Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine. Thromb.Res 8-1-2000;99(3):231-237.
- Berlin, I., Crespo-Laumonnier, B., Cournot, A., Landault, C., Aubin, F., Legrand, J. C., and Puech, A. J. The alpha 2-adrenergic receptor antagonist yohimbine inhibits epinephrine-induced platelet aggregation in healthy subjects. Clin Pharmacol.Ther. 199
- Braddock, L., Cowen, P. J., Elliott, J. M., Fraser, S., and Stump, K. Binding of yohimbine and imipramine to platelets in depressive illness. Psychol.Med 1986;16(4):765-773. PubMed
- Boon, N. A., Elliott, J. M., Grahame-Smith, D. G., John-Green, T., and Stump, K. A comparison of alpha 2-adrenoreceptor binding characteristics of intact human platelets identified by [3H]-yohimbine and [3H]- dihydroergocryptine. J Auton.Pharmacol 1983;3
STIMULANT DRUGS
4 of 4Aspirin, Caffeine, Hydrocodone also falls under STIMULANT DRUGS.
Rauwolscine has demonstrated stimulant effects in animal research.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the piece that matters most with Damason-P: it contains caffeine, which is itself a stimulant. Rauwolscine also acts like a stimulant by ramping up your body's own norepinephrine. So the concern isn't about how this medicine gets broken down. It's that you'd be stacking two stimulants on top of each other.
Together they could add up to a faster heart rate, higher blood pressure, jitteriness, trouble sleeping, or feeling anxious or wired. Keep in mind this warning is theoretical and comes mainly from animal studies, so it's a caution, not a sure thing. Still, if you have heart issues or anxiety, it's worth a quick chat with your pharmacist or doctor before combining them.
- Aziz TA, Hussain SA, Mahwi TO, Ahmed ZA, Rahman HS, Rasedee A. The efficacy and safety of Ginkgo biloba extract as an adjuvant in type 2 diabetes mellitus patients ineffectively managed with metformin: a double-blind, randomized, placebo-controlled trial.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Rauwolscine Also Interacts With Other Medications
Rauwolscine has 676 moderate known drug interactions in our database — the Aspirin, Caffeine, Hydrocodone one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Rauwolscine
We haven’t checked that one against Rauwolscine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Rauwolscine. Pick one to open its full report.
See Every Supplement That Interacts With Aspirin, Caffeine, Hydrocodone
This page covers Rauwolscine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Caffeine, Hydrocodone page lists 398 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).
By severity: 17 major · 334 moderate · 47 minor.
From our pharmacist’s overview on the Aspirin, Caffeine, Hydrocodone page
“Damason-P packs three drugs into one tablet, the opioid hydrocodone, aspirin, and caffeine, so a supplement can collide with any one of them, and its list of 398 interacting ingredients earns real respect. More than 200 of those can add to aspirin's bleeding risk, while 78 can deepen the opioid's sedation.”
Reviewed by 2 · Jul 18, 2026
Taking Rauwolscine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 196 real supplement products containing Rauwolscine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rauwolscine. Your product may carry other ingredients that interact with Aspirin, Caffeine, Hydrocodone too, on top of Rauwolscine — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Rauwolscine and Aspirin, Caffeine, Hydrocodone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#361 of 1,452 supplements looked up here in the last 7 days
#2,049 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Rauwolscine
What is Rauwolscine?
- Fat loss and weight management
- Bodybuilding and physique support
- Energy and stimulant effects
- Athletic performance
- Libido support
Rauwolscine (alpha-yohimbine) is a stimulant alkaloid closely related to yohimbine that is marketed mainly in fat-burning and pre-workout supplements. Human evidence for its benefits is very limited, and it can raise heart rate and blood pressure and cause anxiety, so it should be used with caution and is not recommended for people with heart conditions, anxiety, or during pregnancy or breastfeeding.
Other Drugs & Rauwolscine
Browse every other medication we’ve checked against Rauwolscine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
676 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Metronidazole ›
- Phentermine ›
- Diphenhydramine ›
- Aspirin ›
- Methylphenidate ›
- Naproxen ›
- Doxycycline ›
- Minocycline ›
- Propranolol ›
- Lidocaine ›
- Amoxicillin ›
- Verapamil ›
- Phenylpropanolamine ›
- Quinidine ›
- Cyclosporine ›
- Bupropion ›
- Chloroquine ›
- Ciprofloxacin ›
- Fentanyl ›
- Nicotine ›
- Oxycodone ›
- Penicillin V Potassium ›
- Phenytoin ›
- Tacrolimus ›
- Amphotericin B ›
- Ampicillin ›
- Carbamazepine ›
- Ceftazidime ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Formoterol ›
- Indomethacin ›
- Morphine Sulfate ›
- Penicillin G Potassium ›
- Phenylephrine ›
- Pseudoephedrine ›
- Acyclovir ›
- Amphetamine ›
- Baclofen ›
- Buprenorphine ›
- Cephalexin ›
- Dicloxacillin Sodium ›
- Diethylpropion ›
- Dimenhydrinate ›
- Famotidine ›
- Ketoprofen ›
- Lofepramine ›
- Methotrexate ›
- Nortriptyline ›
- Ofloxacin ›
- Oxymorphone ›
- Propoxyphene ›
- Sotalol ›
- Aripiprazole ›
Showing 60 of 676 moderate interactions — see all 676 on the Rauwolscine page.
No interaction 2,153 drugs checked — show the list
We also checked Rauwolscine against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Acetaminophen ›
- Losartan Potassium ›
- Rosuvastatin ›
- Escitalopram ›
- Atorvastatin ›
- Tirzepatide ›
- Docusate ›
- Tadalafil ›
- Sumatriptan ›
- Hydroxyurea ›
- Isotretinoin ›
- Prednisone ›
- Semaglutide ›
- Metformin ›
- Lisinopril ›
- Bendamustine ›
- Pregabalin ›
- Lamotrigine ›
- Azithromycin ›
- Gabapentin ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Omeprazole ›
- Buspirone ›
- Letrozole ›
- Methylene Blue ›
- Candesartan Cilexetil ›
- Diazepam ›
- Dapsone ›
- Ezetimibe ›
- Cyclopentolate ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Roxithromycin ›
- Levetiracetam ›
- Mannitol ›
- Thyroid Hormone ›
- Atorvastatin Calcium ›
- Spironolactone ›
- Insulin Degludec, Liraglutide ›
- Valsartan ›
- Finasteride ›
- Mitomycin ›
- Estrogen ›
- Canagliflozin, Metformin ›
- Hydrochlorothiazide, Losartan Potassium ›
- Levothyroxine Sodium ›
- Alginic Acid, Aluminum Hydroxide ›
- Phentermine, Topiramate ›
- Minoxidil ›
- Magnesium Hydroxide (otc Drug) ›
- Dexamethasone ›
- Alprazolam ›
- Progestin, Oral Contraceptive ›
- Daptomycin ›
- Acarbose ›
- Bromocriptine ›
Showing the 60 most looked-up of 2,153 medications checked with no known interaction — see the full Rauwolscine list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Aspirin, Caffeine, Hydrocodone Is Linked to Lower Levels of 4 Nutrients
Natural Medicines records Aspirin, Caffeine, Hydrocodone as a medicine that can lower these. This is not an interaction with Rauwolscine — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Aspirin, Caffeine, Hydrocodone nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Rauwolscine and Aspirin, Caffeine, Hydrocodone Together: Common Questions
Can you take Rauwolscine with Aspirin, Caffeine, Hydrocodone?
Why are there 4 interactions listed for Rauwolscine and Aspirin, Caffeine, Hydrocodone?
How serious is the Rauwolscine and Aspirin, Caffeine, Hydrocodone interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Aspirin, Caffeine, Hydrocodone and Rauwolscine?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.