Rauwolscine + Voriconazole
Voriconazole brand name: Vfend.
We found no known interaction between Rauwolscine and Voriconazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Rauwolscine and Voriconazole
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Voriconazole and Rauwolscine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Rauwolscine safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Voriconazole
Interactions in our licensed database are recorded against drug classes, not just single drug names. Voriconazole is filed under 11 classifications — including antifungals, cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 2c9 (cyp2c9) inhibitors. Rauwolscine has documented interactions with 6 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), calcium channel blockers (moderate) and clonidine (catapres) (moderate) — and none of Voriconazole’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Rauwolscine Does Interact With Other Medications
Rauwolscine has 677 moderate known drug interactions in our database — Voriconazole isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Rauwolscine
We haven’t checked that one against Rauwolscine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Rauwolscine. Pick one to open its full report.
See Every Supplement That Interacts With Voriconazole
This page covers Rauwolscine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Voriconazole page lists 205 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).
By severity: 6 major · 159 moderate · 40 minor.
From our pharmacist’s overview on the Voriconazole page
“Voriconazole (Vfend) is a heavy-hitter antifungal, usually prescribed for dangerous infections like invasive aspergillosis, and its list of 205 interacting supplements includes six rated major, enough that anyone on this drug should read those entries before touching a supplement bottle. Most interactions run through the liver enzymes…”
Reviewed by 2 · Jul 18, 2026
Taking Rauwolscine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 196 real supplement products containing Rauwolscine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rauwolscine. Even though Rauwolscine itself has no known interaction with Voriconazole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Rauwolscine and Voriconazole Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#358 of 1,452 supplements looked up here in the last 7 days
#1,914 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rauwolscine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Rauwolscine and Voriconazole records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Rauwolscine
What is Rauwolscine?
- Fat loss and weight management
- Bodybuilding and physique support
- Energy and stimulant effects
- Athletic performance
- Libido support
Rauwolscine (alpha-yohimbine) is a stimulant alkaloid closely related to yohimbine that is marketed mainly in fat-burning and pre-workout supplements. Human evidence for its benefits is very limited, and it can raise heart rate and blood pressure and cause anxiety, so it should be used with caution and is not recommended for people with heart conditions, anxiety, or during pregnancy or breastfeeding.
Bark and roots (alkaloid extracted from plants such as Rauvolfia and Pausinystalia) · Capsules, tablets, powders (often in fat-burner and pre-workout blends)
An interaction check asks whether these two react with each other — it does not ask whether Rauwolscine is a good idea for someone in your situation. Here is what our Rauwolscine record says about it on its own.
Rauwolscine: dosing
There is no well-established or standardized dose for rauwolscine, and it has not been studied the way medicines are. Supplement products vary widely in how much they contain, and it is often combined with other stimulants.If you choose to use a product that contains it, follow the directions on the label, do not exceed the recommended amount, and consider starting with the lowest amount to see how you react.
From our Rauwolscine monograph — the full record covers uses, side effects and every documented interaction.
About Voriconazole
What Is Voriconazole Used For?
Brand name: Vfend
Voriconazole treats several serious fungal infections. Across all available forms — tablets, oral suspension, and intravenous (IV) injection — it is used for invasive aspergillosis (a dangerous mold infection), candidemia (Candida fungus in the bloodstream) in patients who are not neutropenic (not severely low on white blood cells), other deep-tissue Candida infections, and serious infections caused by Scedosporium apiospermum or Fusarium species in patients who cannot tolerate or have not responded to other antifungal treatments.
Esophageal candidiasis (a Candida infection of the esophagus, the swallowing tube) is also an approved use for most formulations. Note on the oral tablet form (generic voriconazole tablets): that specific tablet formulation is approved for patients aged 12 to 14 years weighing at least 50 kg, and all patients 15 years and older — not for younger or smaller children. The oral suspension and the IV injection are approved for patients 2 years and older for most of these conditions.
Most-Reported Side Effects for Voriconazole
From FAERS, the FDA’s public side-effect reporting system (30,194 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Rauwolscine
Browse every other medication we’ve checked against Rauwolscine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
677 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Metronidazole ›
- Phentermine ›
- Diphenhydramine ›
- Aspirin ›
- Methylphenidate ›
- Naproxen ›
- Doxycycline ›
- Minocycline ›
- Propranolol ›
- Lidocaine ›
- Amoxicillin ›
- Verapamil ›
- Phenylpropanolamine ›
- Quinidine ›
- Cyclosporine ›
- Bupropion ›
- Chloroquine ›
- Ciprofloxacin ›
- Fentanyl ›
- Nicotine ›
- Oxycodone ›
- Penicillin V Potassium ›
- Phenytoin ›
- Tacrolimus ›
- Amphotericin B ›
- Ampicillin ›
- Carbamazepine ›
- Ceftazidime ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Formoterol ›
- Indomethacin ›
- Morphine Sulfate ›
- Penicillin G Potassium ›
- Phenylephrine ›
- Pseudoephedrine ›
- Acyclovir ›
- Amphetamine ›
- Baclofen ›
- Buprenorphine ›
- Cephalexin ›
- Dicloxacillin Sodium ›
- Diethylpropion ›
- Dimenhydrinate ›
- Famotidine ›
- Ketoprofen ›
- Lofepramine ›
- Methotrexate ›
- Nortriptyline ›
- Ofloxacin ›
- Oxymorphone ›
- Propoxyphene ›
- Sotalol ›
- Aripiprazole ›
Showing 60 of 677 moderate interactions — see all 677 on the Rauwolscine page.
No interaction 2,152 drugs checked — show the list
We also checked Rauwolscine against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Abemaciclib ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Metformin ›
- Lisinopril ›
- Isotretinoin ›
- Bendamustine ›
- Azithromycin ›
- Pregabalin ›
- Lamotrigine ›
- Gabapentin ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Buspirone ›
- Candesartan Cilexetil ›
- Diazepam ›
- Dapsone ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Cyclopentolate ›
- Atorvastatin Calcium ›
- Ezetimibe ›
- Mannitol ›
- Roxithromycin ›
- Levetiracetam ›
- Spironolactone ›
- Phentermine, Topiramate ›
- Thyroid Hormone ›
- Levothyroxine Sodium ›
- Estrogen ›
- Valsartan ›
- Finasteride ›
- Pizotifen ›
- Alprazolam ›
- Daptomycin ›
- Lenvatinib ›
- Canagliflozin, Metformin ›
- Hexobarbitone ›
- Ethinyl Estradiol, Drospirenone ›
- Bromocriptine ›
- Pegunigalsidase Alfa-iwxj ›
- Mitomycin ›
- Flutemetamol F-18 ›
- Magnesium Hydroxide (otc Drug) ›
- Insulin Degludec, Liraglutide ›
Showing the 60 most looked-up of 2,152 medications checked with no known interaction — see the full Rauwolscine list.
Rauwolscine References
The 28 references that drive our Rauwolscine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
- Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.
- Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
- Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed
- Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
- VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. PubMed
- Mustonen, P., Savola, J., and Lassila, R. Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine. Thromb.Res 8-1-2000;99(3):231-237.
- Bagheri, H., Schmitt, L., Berlan, M., and Montastruc, J. L. Effect of 3 weeks treatment with yohimbine on salivary secretion in healthy volunteers and in depressed patients treated with tricyclic antidepressants. Br J Clin Pharmacol 1992;34(6):555-558. PubMed
- Swann, A. C., Birnbaum, D., Jagar, A. A., Dougherty, D. M., and Moeller, F. G. Acute yohimbine increases laboratory-measured impulsivity in normal subjects. Biol.Psychiatry 5-15-2005;57(10):1209-1211. PubMed
- Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407. PubMed
- Giampreti, A., Lonati, D., Locatelli, C., Rocchi, L., and Campailla, M. T. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol.(Phila) 2009;47(8):827-829. PubMed
- Myers, A. and Barrueto, F., Jr. Refractory priapism associated with ingestion of yohimbe extract. J Med Toxicol. 2009;5(4):223-225.
- Berlin, I., Crespo-Laumonnier, B., Cournot, A., Landault, C., Aubin, F., Legrand, J. C., and Puech, A. J. The alpha 2-adrenergic receptor antagonist yohimbine inhibits epinephrine-induced platelet aggregation in healthy subjects. Clin Pharmacol.Ther. 199
- Swann, A. C. Mechanisms of impulsivity in bipolar disorder and related illness. Epidemiol.Psichiatr.Soc. 2010;19(2):120-130.
- Landis, E. and Shore, E. Yohimbine-induced bronchospasm. Chest 1989;96(6):1424. PubMed
- Susset, J. G., Tessier, C. D., Wincze, J., Bansal, S., Malhotra, C., and Schwacha, M. G. Effect of yohimbine hydrochloride on erectile impotence: a double-blind study. J Urol. 1989;141(6):1360-1363. PubMed
- Braddock, L., Cowen, P. J., Elliott, J. M., Fraser, S., and Stump, K. Binding of yohimbine and imipramine to platelets in depressive illness. Psychol.Med 1986;16(4):765-773. PubMed
- Charney, D. S., Heninger, G. R., and Sternberg, D. E. Assessment of alpha 2 adrenergic autoreceptor function in humans: effects of oral yohimbine. Life Sci 6-7-1982;30(23):2033-2041.
- Boon, N. A., Elliott, J. M., Grahame-Smith, D. G., John-Green, T., and Stump, K. A comparison of alpha 2-adrenoreceptor binding characteristics of intact human platelets identified by [3H]-yohimbine and [3H]- dihydroergocryptine. J Auton.Pharmacol 1983;3
- Riley AJ, Goodman R, Kellett JM, and et al. Double blind trial of yohimbine hydrochloride in the treatment of erection inadequacy. Sexual Marital Ther 1989;4(1):17-26. DOI
- Wylie KR. Yohimbine and sinusitis. Br J Psychiatry. 1996;169(3):384-5. PubMed
- Aziz TA, Hussain SA, Mahwi TO, Ahmed ZA, Rahman HS, Rasedee A. The efficacy and safety of Ginkgo biloba extract as an adjuvant in type 2 diabetes mellitus patients ineffectively managed with metformin: a double-blind, randomized, placebo-controlled trial.
- Godfraind T, Miller RC, Socrates Lima J. Effects of yohimbine, rauwolscine and corynanthine on contractions and calcium fluxes induced by depolarization and prostaglandin F2 alpha in rat aorta. Br J Pharmacol. 1983;80(1):115-21.
- Shepperson NB, Duval N, Massingham R, Langer SZ. Pre- and postsynaptic alpha adrenoceptor selectivity studies with yohimbine and its two diastereoisomers rauwolscine and corynanthine in the anesthetized dog. J Pharmacol Exp Ther. 1981;219(2):540-6. DOI
- Szabo B, Hedler L, Starke K. Peripheral presynaptic and central effects of clonidine, yohimbine and rauwolscine on the sympathetic nervous system in rabbits. Naunyn Schmiedebergs Arch Pharmacol. 1989;340(6):648-57. PubMed
- Doxey JC, Lane AC, Roach AG, Virdee NK. Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine. Naunyn Schmiedebergs Arch Pharmacol. 1984;325(2):136-44.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Rauwolscine and Voriconazole Together: Common Questions
Is it safe to take Rauwolscine with Voriconazole?
Do Rauwolscine and Voriconazole have any of the same side effects?
How was the Rauwolscine and Voriconazole combination checked?
Does Rauwolscine interact with any other medications?
Does Voriconazole interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.