Nattokinase Interactions Overview

Check For Interactions With Nattokinase


Also known as
  • BSP
  • Extrait de Natto
  • Fermented Soybeans
  • Haricots de Soja Fermentés
  • Natto de Soja
  • Natto Extract
  • Nattokinasa
  • NK
  • Soy Natto
  • Subtilisin NAT.
Nattokinase Nattokinase is an enzyme extracted from a traditional Japanese food called nattō, which is made by fermenting soybeans with the bacteria Bacillus subtilis. Nattokinase is purported to have a number of health benefits, including the ability to reduce the risk of blood clots and improve cardiovascular health. It is thought to work by breaking down proteins called fibrins, which can help to dissolve blood clot and restore normal blood flow. Some studies have suggested that nattokinase may be effective at reducing the risk of blood clots and improving cardiovascular health, although more research is needed.
There are 285 drugs known to interact with Nattokinase

Additional Details

Is Nattokinase Safe? Are There Any Warnings?

Nattokinase, extracted from the traditional Japanese food natto, has a long history of safe oral use in typical food amounts. However, caution is advised for medicinal purposes, especially during pregnancy and lactation. Adverse effects are generally rare but can include serious issues like anaphylaxis and hemorrhage.

How Is Nattokinase Thought To Work? What is the Mechanism of Action?

Nattokinase, a serine proteinase enzyme, is derived from fermented soybeans. It is produced through the fermentation process with Bacillus subtilis, unique to natto. With potential antithrombotic effects, nattokinase works by inactivating plasminogen activator inhibitor 1 (PAI-1). Its strong fibrinolytic activity helps prevent atherosclerosis by reducing vessel wall thickening and causing thrombi lysis. Additionally, there is interest in its use for gastrointestinal conditions, with evidence suggesting anti-inflammatory effects in colitis.


Oral nattokinase appears to be bioavailable in humans, and animal studies indicate systemic effects. It is absorbed in the intestinal tract after consumption.

Interaction Overview

With Drugs: Moderate caution is advised when using nattokinase with anticoagulant/antiplatelet and antihypertensive drugs. It may increase the risk of bleeding and hypotension, respectively.

With Supplements: Potential interactions with anticoagulant/antiplatelet herbs and supplements, as well as those with hypotensive effects.

With Conditions: Individuals with bleeding disorders and those in the perioperative period should exercise caution.

Common Side Effects To Watch For

Nattokinase is generally well-tolerated, with adverse effects similar to a placebo. Serious adverse effects, though rare, include anaphylaxis and hemorrhage.

Are Supplements Standardized?

There is insufficient information available about the standardization of nattokinase supplements.

What Is Nattokinase Typically Used For?

While there is ongoing interest in various conditions like angina, atherosclerosis, and cancer, there's insufficient reliable information to determine the clinical effects of nattokinase for these conditions. Research is needed for a conclusive understanding of its potential uses.

Dosing & Administration

Typical oral doses range from 2000 to 10,800 fibrinolytic units daily for various conditions. Condition-specific information can be found in the effectiveness section.

Drugs that interact with Nattokinase

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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