Herb & supplement monograph

Breadfruit Drug Interactions, Uses, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Breadfruit interacts with medications. The heart of this page is the interaction list — every drug Breadfruit is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Breadfruit is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Breadfruit Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Breadfruit drug interaction appears low for most people. None of the listed interactions are rated major, and every one rests on lab or animal research rather than documented effects in people.

Interactions deserving the most attention

The combinations most worth watching involve anticoagulant and antiplatelet drugs such as warfarin, aspirin, and clopidogrel, since lab studies suggest breadfruit compounds could reduce platelet clumping and, in theory, add to bleeding risk. Antihypertensive drugs also deserve a mention, because animal research found breadfruit leaf extract may slow the heart and lower blood pressure. Neither effect has been confirmed in humans, but bleeding risk and blood pressure are areas where even a small added effect can matter.

What the rest of the list means

Breadfruit appears alongside hundreds of medications largely because its compounds may affect enzymes the body uses to clear many drugs. These predictions come from test-tube and animal work, and none has been shown to cause meaningful changes in people so far. A long list here reflects theoretical possibilities, not proven harm from every combination.

Check your medications against Breadfruit

Based on HelloPharmacist’s Breadfruit interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Breadfruit

944 medications have a known interaction with Breadfruit, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Breadfruit using our pharmacist-reviewed interaction data.

AI summaries are generated from our Breadfruit interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Breadfruit combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Breadfruit affects

Every type of medication (drug category) Breadfruit is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 5 drug categories Breadfruit interacts with

Anticoagulant/antiplatelet DrugsAntihypertensive DrugsCytochrome P450 2c8 (cyp2c8) SubstratesGlucuronidated DrugsCytochrome P450 3a4 (cyp3a4) Substrates

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use with anticoagulant/antiplatelet drugs might increase the risk of bleeding. In vitro research shows that certain flavonoid constituents from breadfruit root extract can inhibit thromboxane formation and reduce platelet aggregation.
Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.