Drug & supplement interaction

Breadfruit + Ceftriaxone

Ceftriaxone brand name: Rocephin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Breadfruit and Ceftriaxone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Breadfruit and Ceftriaxone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ceftriaxone and Breadfruit in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Breadfruit safety at a glance

Breadfruit overall Use caution Breadfruit is safe as a food, but medicinal extracts and leaf teas are not well studied.
Pregnancy Use caution Eating the fruit as food is generally fine, but avoid concentrated medicinal extracts due to a lack of safety data.
Breastfeeding Use caution The fruit as food is likely fine, but medicinal preparations have not been studied, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ceftriaxone and Breadfruit? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ceftriaxone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ceftriaxone is filed under 6 classifications — including organic anion transporter 3 (oat3) substrates, organic anion transporter 1 (oat1) substrates, antibiotic drugs. Breadfruit has documented interactions with 5 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antihypertensive drugs (moderate) and cytochrome p450 2c8 (cyp2c8) substrates (moderate) — and none of Ceftriaxone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Breadfruit Does Interact With Other Medications

Breadfruit has 438 moderate, 504 minor known drug interactions in our database — Ceftriaxone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 438 Minor 504 No known interaction 1,888 (incl. Ceftriaxone)
Taking anything else?

Check Another of Your Medications Against Breadfruit

Covers the 2,830 medications we’ve checked against Breadfruit. Pick one to open its full report.

What to actually watch for

What Breadfruit Itself Has Been Linked To

This is not an interaction — nothing below involves Ceftriaxone. It is the side-effect record for Breadfruit on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Breadfruit, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Hives / An allergic reaction Worth acting on Additional detail

    “Topically, exposure to breadfruit latex can cause allergic reactions such as hives and rhinitis.”

    Breadfruit · Natural Medicines adverse-effect record, reported in urticaria.

    1 source cited
    1. 26380. De Greef JM, Lieutier-Colas F, Bessot JC, et al. Urticaria and rhinitis to shrubs of Ficus benjamina and breadfruit in a banana-allergic road worker: evidence for a cross-sensitization between Moracea, banana and latex. Int Arch Allergy Immunol 2001;125(2

    “Topically, breadfruit latex can cause allergic reactions such as hives and rhinitis. In a case report, a male who was allergic to bananas developed hives and rhinitis while cutting shrubs of breadfruit.”

    Breadfruit · Natural Medicines adverse-effect record, reported in urticaria.

    1 source cited
    1. 26380. De Greef JM, Lieutier-Colas F, Bessot JC, et al. Urticaria and rhinitis to shrubs of Ficus benjamina and breadfruit in a banana-allergic road worker: evidence for a cross-sensitization between Moracea, banana and latex. Int Arch Allergy Immunol 2001;125(2
  • A stuffy or runny nose Additional detail

    Recorded for Breadfruit in the same Natural Medicines adverse-effect record shown under Hives / An allergic reaction above.

Everything above comes from the Natural Medicines adverse-effect record for Breadfruit — expand a row for the licensed statement it rests on. We haven’t matched Ceftriaxone to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Ceftriaxone.

Everything else you take

See Every Supplement That Interacts With Ceftriaxone

This page covers Breadfruit only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ceftriaxone page lists 44 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Asarabacca (major), Calcium (major), Siberian Cocklebur (major), African Wild Potato (moderate) and Aristolochia (moderate).

By severity: 3 major · 39 moderate · 2 minor.

From our pharmacist’s overview on the Ceftriaxone page

“Kidney strain is the risk to understand first on this page. Ceftriaxone (Rocephin) is an injectable antibiotic used for serious infections, and three of the 44 supplements on file carry major ratings, two of them because they can harm the kidneys on their own: Siberian cocklebur and asarabacca, which is often contaminated with kidney-d…”

Reviewed by 2 · Jul 18, 2026

Open the Ceftriaxone interaction page

How much people look this up

Where Breadfruit and Ceftriaxone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Breadfruit
Top half

#468 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ceftriaxone
Top half

#1,136 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Breadfruit reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Breadfruit and Ceftriaxone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Breadfruit

What is Breadfruit?

  • Source of nutrition and energy
  • High blood pressure
  • Diabetes and blood sugar support
  • Inflammation and joint discomfort
  • Skin conditions

Breadfruit is a starchy tropical fruit eaten as a staple food, and its leaves are used in traditional medicine for conditions like high blood pressure and diabetes. As a food it is nutritious and generally safe, but the medicinal use of leaf teas or extracts has very little human research to back it up. Talk with your pharmacist or doctor before using breadfruit products for a health condition.

Artocarpus altilis · Moraceae · Fruit, seeds, leaves, and sometimes the bark or latex · Whole fruit (food), flour, leaf tea, capsules, and powders

An interaction check asks whether these two react with each other — it does not ask whether Breadfruit is a good idea for someone in your situation. Here is what our Breadfruit record says about it on its own.

Breadfruit: dosing

There is no established standardized dose for breadfruit as a medicine. When eaten as a food, normal serving sizes are used the same way you would eat potatoes or other starchy vegetables.For supplements, leaf teas, or extracts, follow the directions on the product label, since the strength of products can vary widely.

From our Breadfruit monograph — the full record covers uses, side effects and every documented interaction.

Read the full Breadfruit monograph & all interactions
Medication

About Ceftriaxone Injection

What Is Ceftriaxone Injection Used For?

Brand name: Rocephin

Ceftriaxone Injection is used to treat bacterial infections in many parts of the body, including the lungs (lower respiratory tract infections), urinary tract, skin, bones and joints, abdomen, and bloodstream (septicemia). It also treats bacterial meningitis (infection of the lining around the brain and spinal cord), pelvic inflammatory disease, acute bacterial ear infections (otitis media), and gonorrhea.

In addition, a single dose of ceftriaxone may be given before certain surgeries — such as hysterectomy, gallbladder surgery, or coronary artery bypass surgery — to help prevent postoperative infection. It works only against bacterial infections; it will not treat viral illnesses like the flu or a cold.

Most-Reported Side Effects for Ceftriaxone

From FAERS, the FDA’s public side-effect reporting system (38,242 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 2,054 reports
Acute kidney injury 1,826 reports
Dyspnea 1,592 reports
Pneumonia 1,338 reports
Vomiting 1,265 reports
See full Ceftriaxone Injection drug information
Keep checking

Other Drugs & Breadfruit

Browse every other medication we’ve checked against Breadfruit — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
438Moderate
504Minor
1,887No known interaction
438 Moderate 504 Minor 1,887 No interaction
Moderate

438 interactions

Showing 60 of 438 moderate interactions — see all 438 on the Breadfruit page.

Minor

504 interactions

Showing 60 of 504 minor interactions — see all 504 on the Breadfruit page.

No interaction 1,887 drugs checked — show the list

We also checked Breadfruit against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,887 medications checked with no known interaction — see the full Breadfruit list.

See the full Breadfruit interactions page
See every supplement checked against Ceftriaxone, ranked by severity
Evidence & sources

Breadfruit References

The 5 references that drive our Breadfruit monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Weng JR, Chan SC, Lu YH, et al. Antiplatelet prenylflavonoids from Artocarpus communis. Phytochemistry 2006;67(8):824-829. PubMed
  2. Young RE, Williams LAD, Gardner MT, Fletcher CK. An extract of the leaves of the breadfruit Artocarpus altilis (parkinson) fosberg exerts a negative inotropic effect on rat myocardium. Phytother Res 2006;7(2):190-193.
  3. De Greef JM, Lieutier-Colas F, Bessot JC, et al. Urticaria and rhinitis to shrubs of Ficus benjamina and breadfruit in a banana-allergic road worker: evidence for a cross-sensitization between Moracea, banana and latex. Int Arch Allergy Immunol 2001;125(2
  4. Nwokocha CR, Owu DU, McLaren M, et al. Possible mechanisms of action of the aqueous extract of Artocarpus altilis (breadfruit) leaves in producing hypotension in normotensive Sprague-Dawley rats. Pharm Biol. 2012;50(9):1096-102.
  5. Qu W, Liu X. Identification of cytochrome P450 isoforms involved in the metabolism of artocarpin and assessment of its drug-drug interaction. Biomed Chromatogr. 2018;32(4). PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Breadfruit and Ceftriaxone Together: Common Questions

Is it safe to take Breadfruit with Ceftriaxone?
We do not list a known interaction between Breadfruit and Ceftriaxone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Breadfruit and Ceftriaxone combination checked?
Interactions in our licensed database are recorded against drug classes. Ceftriaxone is filed under 6 classifications, and Breadfruit has documented interactions with 5 drug classes — none of Ceftriaxone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Breadfruit interact with any other medications?
Yes. Breadfruit has 942 documented drug interactions in our database — Ceftriaxone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ceftriaxone interact with any supplements?
Yes. Ceftriaxone has documented interactions with 44 supplements in our database — Breadfruit is not one of them. The Ceftriaxone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Breadfruit monograph Uses, safety profile, and every drug interaction in one place Ceftriaxone Injection drug information The full plain-English guide to this medication Ceftriaxone supplement interactions Every supplement checked against Ceftriaxone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ceftriaxone and Breadfruit?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.