Drug & supplement interaction

Breadfruit + Fesoterodine Fumarate

Fesoterodine Fumarate brand name: Toviaz.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Breadfruit has a minor interaction with Fesoterodine Fumarate. Theoretically, breadfruit might inhibit cytochrome P450 3A4 (CYP3A4) and increase levels of drugs metabolized by these enzymes; until more is known, use with caution.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Breadfruit and Fesoterodine Fumarate

Here is the interaction we found between these two, with the evidence behind it.

Minor

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

Why this applies to Fesoterodine Fumarate

Fesoterodine Fumarate falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group Breadfruit interacts with.

Theoretically, breadfruit might inhibit cytochrome P450 3A4 (CYP3A4) and increase levels of drugs metabolized by these enzymes; until more is known, use with caution. In vitro, the breadfruit constituent artocarpin can inhibit CYP3A4 enzymes. Also, animal research shows that breadfruit leaf extract can weakly inhibit CYP3A4 enzymes. However, it is unclear if this inhibitory activity causes a clinically meaningful effect on the metabolism of CYP3A4 substrates.
Some drugs metabolized by CYP3A4 include amitriptyline (Elavil), amiodarone (Cordarone), citalopram (Celexa), felodipine (Plendil), lansoprazole (Prevacid), ondansetron (Zofran), prednisone (Deltasone), sertraline (Zoloft), and many others.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for your Toviaz. Your body relies on an enzyme called CYP3A4 to help break down fesoterodine. Lab and animal studies hint that compounds in breadfruit leaf may gently slow that enzyme down. In theory, that could let a little more fesoterodine linger in your system, which might nudge up its usual side effects like dry mouth, constipation, blurry vision, or feeling drowsy.

Keep this in perspective, though. This is very weak, early evidence, mostly from test tubes and animals, not people. Eating breadfruit as a regular food almost certainly won't matter. Concentrated leaf teas or extracts are the bigger unknown. If you're thinking about using breadfruit for blood pressure or blood sugar, just run it by your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Nwokocha CR, Owu DU, McLaren M, et al. Possible mechanisms of action of the aqueous extract of Artocarpus altilis (breadfruit) leaves in producing hypotension in normotensive Sprague-Dawley rats. Pharm Biol. 2012;50(9):1096-102.
  2. Qu W, Liu X. Identification of cytochrome P450 isoforms involved in the metabolism of artocarpin and assessment of its drug-drug interaction. Biomed Chromatogr. 2018;32(4). PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Breadfruit Also Interacts With Other Medications

Breadfruit has 438 moderate, 503 minor known drug interactions in our database — the Fesoterodine Fumarate one above is one of them. If you take anything else, check it against the full list below.

Moderate 438 Minor 503 No known interaction 1,889 (incl. Fesoterodine Fumarate)
Taking anything else?

Check Another of Your Medications Against Breadfruit

Covers the 2,830 medications we’ve checked against Breadfruit. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Fesoterodine Fumarate

This page covers Breadfruit only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fesoterodine Fumarate page lists 195 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 147 moderate · 39 minor.

From our pharmacist’s overview on the Fesoterodine Fumarate page

“Fesoterodine (Toviaz) calms an overactive bladder, and this list deserves genuine care, because nine of its 195 entries are rated major. Most of the supplements here change how your body clears the drug.”

Reviewed by 2 · Jul 18, 2026

Open the Fesoterodine Fumarate interaction page

How much people look this up

Where Breadfruit and Fesoterodine Fumarate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Breadfruit
Top half

#540 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fesoterodine Fumarate
Steady interest

#2,661 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Breadfruit

What is Breadfruit?

  • Source of nutrition and energy
  • High blood pressure
  • Diabetes and blood sugar support
  • Inflammation and joint discomfort
  • Skin conditions

Breadfruit is a starchy tropical fruit eaten as a staple food, and its leaves are used in traditional medicine for conditions like high blood pressure and diabetes. As a food it is nutritious and generally safe, but the medicinal use of leaf teas or extracts has very little human research to back it up. Talk with your pharmacist or doctor before using breadfruit products for a health condition.

Read the full Breadfruit monograph & all interactions
Medication

About Fesoterodine

What Is Fesoterodine Used For?

Brand name: Toviaz

Fesoterodine extended-release tablets treat overactive bladder (OAB) in adults — specifically the symptoms of urgent, frequent urination and urge urinary incontinence (leaking urine when you feel a sudden, strong urge to go).

Toviaz (fesoterodine fumarate extended-release tablets) is also approved to treat neurogenic detrusor overactivity (NDO) — bladder muscle overactivity caused by a nerve or spinal condition — in children 6 years and older who weigh more than 25 kg (about 55 lbs).

See full Fesoterodine drug information
Keep checking

Other Drugs & Breadfruit

Browse every other medication we’ve checked against Breadfruit — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
438Moderate
503Minor
1,888No known interaction
438 Moderate 503 Minor 1,888 No interaction
Moderate

438 interactions

Showing 60 of 438 moderate interactions — see all 438 on the Breadfruit page.

Minor

503 interactions

Showing 60 of 503 minor interactions — see all 503 on the Breadfruit page.

No interaction 1,888 drugs checked — show the list

We also checked Breadfruit against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,888 medications checked with no known interaction — see the full Breadfruit list.

See the full Breadfruit interactions page
See every supplement checked against Fesoterodine Fumarate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Breadfruit monograph › Uses, safety, and every drug interaction in one place Fesoterodine Fumarate supplement interactions › Every supplement checked against Fesoterodine Fumarate, ranked by severity Fesoterodine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Breadfruit and Fesoterodine Fumarate Together: Common Questions

Can you take Breadfruit with Fesoterodine Fumarate?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Breadfruit and Fesoterodine Fumarate interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Fesoterodine Fumarate and Breadfruit?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.