Herb & supplement monograph

Corydalis Yanhusuo Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Corydalis Yanhusuo interacts with medications. The heart of this page is the interaction list — every drug Corydalis Yanhusuo is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Corydalis Yanhusuo is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Corydalis Yanhusuo Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Corydalis Yanhusuo drug interaction appears low for most people, because almost every reported concern is theoretical rather than confirmed in humans. None of the interactions are rated major, and all of them carry only a possible likelihood, resting mainly on lab or animal findings or limited human reports.

Interactions deserving the most attention

The concerns with the most human backing involve the transplant medicines tacrolimus and cyclosporine, whose blood levels rose when people took berberine, a compound found in this plant, and these narrow-margin drugs can become toxic at higher levels. Diabetes medications also deserve care, since human research shows berberine can lower blood sugar and could add to their effect. Weaker, theoretical concerns include extra bleeding risk with blood thinners and added drowsiness with sedating medicines.

What the rest of the list means

The long list of interactions largely reflects one idea: berberine may slow enzymes the body uses to clear many medications, so every drug handled by those enzymes gets flagged. Corydalis yanhusuo itself has not been directly shown to cause these changes in people, so most combinations are predictions rather than proven problems.

Check your medications against Corydalis Yanhusuo

Based on HelloPharmacist’s Corydalis Yanhusuo interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Corydalis Yanhusuo

1162 medications have a known interaction with Corydalis Yanhusuo, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Corydalis Yanhusuo using our pharmacist-reviewed interaction data.

AI summaries are generated from our Corydalis Yanhusuo interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Corydalis Yanhusuo combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Corydalis Yanhusuo affects

Every type of medication (drug category) Corydalis Yanhusuo is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 14 drug categories Corydalis Yanhusuo interacts with

Anticoagulant/antiplatelet DrugsAntidiabetes DrugsAntihypertensive DrugsCns DepressantsCyclosporine (neoral, Sandimmune)Cytochrome P450 2c9 (cyp2c9) SubstratesCytochrome P450 2d6 (cyp2d6) SubstratesCytochrome P450 3a4 (cyp3a4) SubstratesDextromethorphan (robitussin Dm, Others)Losartan (cozaar)Metformin (glucophage)Midazolam (versed)Pentobarbital (nembutal)Tacrolimus (prograf)

Anticoagulant/Antiplatelet Drugs

Theoretically, Corydalis yanhusuo might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Corydalis yanhusuo contains berberine. In vitro and in vivo research suggest that berberine can inhibit platelet aggregation. Theoretically, Corydalis yanhusuo might also inhibit platelet aggregation.