Drug & supplement interaction

Corydalis Yanhusuo + Naloxone

Naloxone brand names: Narcan, Zimhi, Rivive.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Corydalis Yanhusuo and Naloxone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Corydalis Yanhusuo and Naloxone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Naloxone and Corydalis Yanhusuo in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Corydalis Yanhusuo safety at a glance

Corydalis Yanhusuo overall Use caution It has a long history of traditional use, but human safety data are limited and quality of products varies.
Pregnancy Likely Unsafe When used orally. Corydalis yanhusuo might promote menstrual flow and stimulate uterine contractions. The berberine constituent of Corydalis yanhusuo is thought... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. The berberine constituent of Corydalis yanhusuo and other harmful constituents can be transferred to the infant through breast milk. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Naloxone and Corydalis Yanhusuo? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Naloxone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Naloxone is filed under a single classification. Corydalis Yanhusuo has documented interactions with 14 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and antihypertensive drugs (moderate) — and none of Naloxone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Corydalis Yanhusuo Does Interact With Other Medications

Corydalis Yanhusuo has 1,160 moderate known drug interactions in our database — Naloxone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1,160 No known interaction 1,670 (incl. Naloxone)
Taking anything else?

Check Another of Your Medications Against Corydalis Yanhusuo

Covers the 2,830 medications we’ve checked against Corydalis Yanhusuo. Pick one to open its full report.

What to actually watch for

What Naloxone’s Own FDA Label Lists

This is not an interaction — none of it involves Corydalis Yanhusuo. These are the most notable effects listed in the ADVERSE REACTIONS section of Naloxone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 7 of them are worth acting on rather than waiting out — marked below.

  • Dependence or withdrawal symptoms Worth acting on
  • Hallucinations Worth acting on
  • An irregular heartbeat Worth acting on
  • Seizures Worth acting on
  • Low mood Worth acting on
  • Raised blood pressure Worth acting on
  • Shortness of breath Worth acting on
  • Mood changes or irritability
  • Chills
  • Tremor or shakiness

Showing the 10 most notable of 23 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Naloxone. Read the label on DailyMed › Corydalis Yanhusuo’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Corydalis Yanhusuo side to compare — that is a limit of the record, not a statement that Corydalis Yanhusuo has no side effects.

Special populations

Corydalis Yanhusuo in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Corydalis yanhusuo might promote menstrual flow and stimulate uterine contractions. The berberine constituent of Corydalis yanhusuo is thought to cross the placenta and may cause harm to the fetus. Kernicterus has developed in newborn infants exposed to berberine.

Lactation Likely Unsafe

When used orally. The berberine constituent of Corydalis yanhusuo and other harmful constituents can be transferred to the infant through breast milk.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Naloxone Is Prescribed For, and What Corydalis Yanhusuo Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Naloxone is a prescription medicine with approved uses on its FDA label. Corydalis Yanhusuo is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Naloxone is prescribed for: Naloxone Hydrochloride injection is used for the emergency treatment of known or suspected opioid overdose — reversing dangerous slowing of breathing and loss of consciousness caused by opioids. It is also approved for use in pediatric patients of all ages. Naloxone Hydrochloride injection is additionally indicated specifically for military personnel and chemical incident responders: for emergency treatment of patients 12 and older where high-potency opioids such as fentanyl analogues have been used as a chemical weapon, and for temporary protection against breathing and nervous system depression when entering an area contaminated with such opioids. Zimhi (naloxone HCl) is a pre-filled, single-dose injectable product approved for intramuscular or subcutaneous use in known or suspected opioid overdose.

Corydalis Yanhusuo has been studied for:

  • Depression studied, not established Corydalis Yanhusuo has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Corydalis Yanhusuo for depression

    Although there has been interest in using oral Corydalis yanhusuo for depression, there is insufficient reliable information about the clinical effects of Corydalis yanhusuo for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Naloxone on your own; if you are taking Corydalis Yanhusuo for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Naloxone

This page covers Corydalis Yanhusuo only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Naloxone page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (moderate), Gamma Butyrolactone (gbl) (moderate) and Gamma-hydroxybutyrate (ghb) (moderate).

By severity: 3 moderate.

From our pharmacist’s overview on the Naloxone page

“The list of supplements that interact with naloxone, the emergency spray or injection (Narcan, Zimhi, Rivive) that reverses opioid overdoses, is short and unusual. All three entries are forms of the same substance: gamma-hydroxybutyrate (GHB) and two chemicals the body converts into it, GBL and 1,4-butanediol.”

Reviewed by 2 · Jul 18, 2026

Open the Naloxone interaction page

How much people look this up

Where Corydalis Yanhusuo and Naloxone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Corydalis Yanhusuo
Steady interest

#887 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Naloxone
Top 25%

#494 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Corydalis Yanhusuo reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Corydalis Yanhusuo and Naloxone records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Corydalis Yanhusuo

What is Corydalis Yanhusuo?

  • Pain relief
  • Menstrual cramps
  • Headache
  • Stress and sleep support
  • Stomach and abdominal discomfort

Corydalis yanhusuo is a traditional Chinese herb used mainly for pain. Some early laboratory and animal research suggests its compounds may affect pain and the nervous system, but high-quality human studies are limited, so its true benefits and long-term safety are not well established. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Corydalis yanhusuo · Papaveraceae · Dried tuber (rhizome) · Capsules, tablets, powders, tinctures, and as part of traditional herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Corydalis Yanhusuo is a good idea for someone in your situation. Here is what our Corydalis Yanhusuo record says about it on its own.

Corydalis Yanhusuo: dosing

There is no well-established standard dose for corydalis. Doses used in traditional practice and in studies vary, and products differ in how concentrated they are.The safest approach is to follow the directions on the product label and to use the lowest amount that seems reasonable. Because product quality varies, choose brands that use third-party testing when possible.

From our Corydalis Yanhusuo monograph — the full record covers uses, side effects and every documented interaction.

Read the full Corydalis Yanhusuo monograph & all interactions
Medication

About Naloxone Injection

What Is Naloxone Injection Used For?

Brand names: Narcan, Zimhi, Rivive

Naloxone Hydrochloride injection is used for the emergency treatment of known or suspected opioid overdose — reversing dangerous slowing of breathing and loss of consciousness caused by opioids. It is also approved for use in pediatric patients of all ages.

Naloxone Hydrochloride injection is additionally indicated specifically for military personnel and chemical incident responders: for emergency treatment of patients 12 and older where high-potency opioids such as fentanyl analogues have been used as a chemical weapon, and for temporary protection against breathing and nervous system depression when entering an area contaminated with such opioids. Zimhi (naloxone HCl) is a pre-filled, single-dose injectable product approved for intramuscular or subcutaneous use in known or suspected opioid overdose.

See full Naloxone Injection drug information
Keep checking

Other Drugs & Corydalis Yanhusuo

Browse every other medication we’ve checked against Corydalis Yanhusuo — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1,160Moderate
0Minor
1,669No known interaction
1,160 Moderate 1,669 No interaction
Moderate

1,160 interactions

Showing 60 of 1,160 moderate interactions — see all 1,160 on the Corydalis Yanhusuo page.

No interaction 1,669 drugs checked — show the list

We also checked Corydalis Yanhusuo against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,669 medications checked with no known interaction — see the full Corydalis Yanhusuo list.

See the full Corydalis Yanhusuo interactions page
See every supplement checked against Naloxone, ranked by severity
Evidence & sources

Corydalis Yanhusuo References

The 21 references that drive our Corydalis Yanhusuo monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
  3. Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
  4. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
  5. Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
  6. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  7. Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
  8. Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
  9. Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
  10. Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
  11. Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
  12. Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
  13. Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. PubMed
  14. Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin re
  15. Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Corydalis Yanhusuo and Naloxone Together: Common Questions

Is it safe to take Corydalis Yanhusuo with Naloxone?
We do not list a known interaction between Corydalis Yanhusuo and Naloxone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Corydalis Yanhusuo and Naloxone used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Corydalis Yanhusuo in each. That is a conversation for your prescriber, especially if Naloxone is being adjusted to a target.
How was the Corydalis Yanhusuo and Naloxone combination checked?
Interactions in our licensed database are recorded against drug classes. Naloxone is filed under 1 classification, and Corydalis Yanhusuo has documented interactions with 14 drug classes — none of Naloxone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Corydalis Yanhusuo interact with any other medications?
Yes. Corydalis Yanhusuo has 1,160 documented drug interactions in our database — Naloxone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Naloxone interact with any supplements?
Yes. Naloxone has documented interactions with 3 supplements in our database — Corydalis Yanhusuo is not one of them. The Naloxone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Corydalis Yanhusuo monograph Uses, safety profile, and every drug interaction in one place Naloxone Injection drug information The full plain-English guide to this medication Naloxone supplement interactions Every supplement checked against Naloxone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 21 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Naloxone and Corydalis Yanhusuo?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.