Naloxone Injection

Generic name: Pronounced as (nal ox' one)
Brand names
  • Evzio®
  • Narcan®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 02/15/2016

Naloxone injection and naloxone prefilled auto-injection device (Evzio) are used along with emergency medical treatment to reverse the life-threatening effects of a known or suspected opiate (narcotic) overdose. Naloxone injection is also used after surgery to reverse the effects of opiates given during surgery. Naloxone injection is given to newborns to decrease the effects of opiates received by the pregnant mother prior to delivery. Naloxone injection is in a class of medications called opiate antagonists. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood.

Naloxone injection comes as a solution (liquid) to be injected intravenously (into a vein), intramuscularly (into a muscle), or subcutaneously (just under the skin). It also comes as a prefilled auto-injection device containing a solution to be injected intramuscularly or subcutaneously. It is usually given as needed to treat opiate overdoses.

You will probably be unable to treat yourself if you experience an opiate overdose. You should make sure that your family members, caregivers, or the people who spend time with you know how to tell if you are experiencing an overdose, how to use naloxone injection, and what to do until emergency medical help arrives. Your doctor or pharmacist will show you and your family members how to use the medication. You and anyone who may need to give the medication should read the instructions that come with the nasal injection. Ask your pharmacist for the instructions or visit the manufacturer's website to get the instructions.

Naloxone injection may not reverse the effects of certain opiates such as buprenorphine (Belbuca, Buprenex, Butrans) and pentazocine (Talwin) and may require additional naloxone doses.

You will probably be unable to treat yourself if you experience an opiate overdose. You should make sure that your family members, caregivers, or the people who spend time with you know how to tell if you are experiencing an overdose, how to inject naloxone, and what to do until emergency medical help arrives. Your doctor or pharmacist will show you and your family members how to administer the medication. You and anyone who may need to administer the medication should read the instructions that come with the device and practice with the training device provided with the medication. Ask your pharmacist for the instructions or visit the manufacturer's website. In case of emergency, even a person who has not been trained to inject naloxone should still try to inject the medication.

If you have been given an automatic injection device, you should keep the device available at all times in case you experience an opioid overdose. Be aware of the expiration date on your device and replace the device when this date passes. Look at the solution in the device from time to time. If the solution is discolored or contains particles, call your doctor to get a new injection device.

The automatic injection device has an electronic voice system that provides step by step directions for use in an emergency. The person who is injecting naloxone for you can follow these directions, but he or she should know that it is not necessary to wait for the voice system to finish one direction before beginning the next step. Also, at times the voice system may not work and the person may not hear the directions. However, the device will still work and will inject the medication even if the voice system is not working.

Symptoms of an opioid overdose include excessive sleepiness; not awakening when spoken to in a loud voice or when the middle of your chest is rubbed firmly; shallow or stopped breathing; or small pupils (black circles in the center of the eyes). If someone sees that you are experiencing these symptoms, he or she should give you your first dose of naloxone into the muscle or under the skin of your thigh. The medication may be injected through your clothing if necessary in an emergency. After injecting naloxone, the person should call 911 immediately and then stay with you and watch you closely until emergency medical help arrives. Your symptoms may return within a few minutes after you receive a naloxone injection. If your symptoms return, the person should use a new automatic injection device to give you another dose of naloxone. Additional injections may be given every 2-3 minutes if symptoms return before medical help arrives.

Each prefilled automatic injection device should be used only once and then should be discarded. Do not try to replace the red safety guard on the auto-injection device after you remove it, even if you did not inject the medication. Instead, replace the used device in the outer case before discarding. Ask your doctor or pharmacist how to safely dispose of used injection devices.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before using naloxone injection,

  • tell your doctor and pharmacist if you are allergic to naloxone injection, any other medications, or any of the ingredients in naloxone injection. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Many medications that affect your heart or blood pressure may increase the risk that you will develop serious side effects of naloxone injection. Be sure to tell your doctor about all the medications you are taking.

  • tell your doctor if you have or have ever had heart, kidney, or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you receive naloxone injection during pregnancy, your doctor may need to monitor your unborn baby carefully after you receive the medication.

  • Naloxone injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • pain, burning, or redness at the injection site

    • sweating

    • hot flashes or flushing

  • Some side effects can be serious. If you experience any of these symptoms, get emergency medical treatment:

    • rapid, pounding, or irregular heartbeat

    • seeing things or hearing voices that do not exist (hallucinations)

    • loss of consciousness

    • seizures

    • signs of opiate withdrawal such as body aches, diarrhea, fast heart beat, fever, runny nose, sneezing, sweating, yawning, nausea, vomiting, nervousness, restlessness, irritability, shivering or trembling, stomach cramps, weakness, and the appearance of hair on the skin standing on end

    • crying more than usual (in babies treated with naloxone injection)

    • stronger than normal reflexes (in babies treated with naloxone injection)

  • Naloxone injection may cause other side effects. Tell your doctor if you have any unusual problems while receiving this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the automatic injection device at room temperature and away from light. If the red safety guard has been removed, safely dispose of the automatic injection device.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • N-Allylnoroxymorphone Hydrochloride

Drug Interaction
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Naloxone.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Naloxone.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Naloxone.
Diphenoxylate Diphenoxylate The therapeutic efficacy of Diphenoxylate can be decreased when used in combination with Naloxone.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Naloxone which could result in a higher serum level.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Naloxone.
Guanfacine Guanfacine The metabolism of Guanfacine can be decreased when combined with Naloxone.
Magnesium Hydroxide Magnesium Hydroxide Naloxone may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Mycophenolate Mycophenolate Mycophenolic acid may decrease the excretion rate of Naloxone which could result in a higher serum level.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Paregoric Paregoric The therapeutic efficacy of Morphine can be decreased when used in combination with Naloxone.
Potassium Potassium Naloxone may increase the excretion rate of Potassium which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone The metabolism of Prednisone can be decreased when combined with Naloxone.
Ranitidine Ranitidine Ranitidine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Reserpine Reserpine Reserpine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Rizatriptan Rizatriptan Rizatriptan may decrease the excretion rate of Naloxone which could result in a higher serum level.
Sumatriptan Sumatriptan Sumatriptan may decrease the excretion rate of Naloxone which could result in a higher serum level.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Naloxone.
Triamcinolone Triamcinolone The metabolism of Triamcinolone can be decreased when combined with Naloxone.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Naloxone which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection Fluconazole may decrease the excretion rate of Naloxone which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Naloxone which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The therapeutic efficacy of Naloxone can be decreased when used in combination with Hydromorphone.
Levofloxacin Injection Levofloxacin Injection Levofloxacin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be decreased when combined with Naloxone.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Methylprednisolone can be decreased when combined with Naloxone.
Metoclopramide Injection Metoclopramide Injection Naloxone may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Morphine Injection Morphine Injection The therapeutic efficacy of Morphine can be decreased when used in combination with Naloxone.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Naloxone which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Naloxone may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The metabolism of Naloxone can be increased when combined with Zidovudine.
Altretamine Altretamine Amphetamine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Naloxone which could result in a higher serum level.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Naloxone.
Torsemide Torsemide Torasemide may increase the excretion rate of Naloxone which could result in a lower serum level and potentially a reduction in efficacy.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Naloxone.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Naloxone which could result in a higher serum level.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Naloxone which could result in a higher serum level.
Temozolomide Temozolomide Temozolomide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Zaleplon Zaleplon Zaleplon may decrease the excretion rate of Naloxone which could result in a higher serum level.
Perindopril Perindopril Perindopril may decrease the excretion rate of Naloxone which could result in a higher serum level.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Naloxone.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Naloxone which could result in a higher serum level.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Naloxone.
Eplerenone Eplerenone The metabolism of Eplerenone can be decreased when combined with Naloxone.
Zonisamide Zonisamide Zonisamide may increase the excretion rate of Naloxone which could result in a lower serum level and potentially a reduction in efficacy.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Naloxone.
Atomoxetine Atomoxetine Atomoxetine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Atazanavir Atazanavir The metabolism of Atazanavir can be decreased when combined with Naloxone.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Naloxone.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Naloxone.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Naloxone.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Naloxone.
Emtricitabine Emtricitabine Emtricitabine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Memantine Memantine Memantine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Tadalafil Tadalafil The serum concentration of Tadalafil can be increased when it is combined with Naloxone.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Naloxone.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Naloxone.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Naloxone which could result in a higher serum level.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Naloxone which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Naloxone can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be increased when it is combined with Naloxone.
Ganciclovir Ganciclovir Ganciclovir may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Valganciclovir Valganciclovir Naloxone may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Adefovir Adefovir Adefovir may decrease the excretion rate of Naloxone which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ramelteon Ramelteon Ramelteon may decrease the excretion rate of Naloxone which could result in a higher serum level.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Naloxone.
Pregabalin Pregabalin Pregabalin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Deferasirox Deferasirox The metabolism of Naloxone can be decreased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Naloxone can be increased when combined with Tipranavir.
Ranolazine Ranolazine The metabolism of Naloxone can be decreased when combined with Ranolazine.
Rasagiline Rasagiline Naloxone may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Sitagliptin Sitagliptin Naloxone may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Naloxone may decrease the excretion rate of Varenicline which could result in a higher serum level.
Albuterol Albuterol Salbutamol may decrease the excretion rate of Naloxone which could result in a higher serum level.
Paliperidone Paliperidone Naloxone may decrease the excretion rate of Paliperidone which could result in a higher serum level.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Naloxone.
Clofarabine Injection Clofarabine Injection Clofarabine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Lubiprostone Lubiprostone Lubiprostone may decrease the excretion rate of Naloxone which could result in a higher serum level.
Pemetrexed Injection Pemetrexed Injection Naloxone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Naloxone.
Sorafenib Sorafenib The metabolism of Naloxone can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Naloxone.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Naloxone.
Levocetirizine Levocetirizine Naloxone may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Naloxone may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Naloxone.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Naloxone.
Maraviroc Maraviroc The metabolism of Maraviroc can be decreased when combined with Naloxone.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Nilotinib can be decreased when combined with Naloxone.
Budesonide Budesonide The metabolism of Budesonide can be decreased when combined with Naloxone.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Doripenem Injection Doripenem Injection Naloxone may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection Arsenic trioxide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine Naloxone may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Naloxone which could result in a higher serum level.
Certolizumab Injection Certolizumab Injection Naloxone may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Naloxone.
Irinotecan Injection Irinotecan Injection The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Naloxone.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Naloxone may increase the opioid antagonism activities of Methylnaltrexone.
Rufinamide Rufinamide The metabolism of Rufinamide can be decreased when combined with Naloxone.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Naloxone.
Naltrexone Injection Naltrexone Injection The therapeutic efficacy of Naltrexone can be decreased when used in combination with Naloxone.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Naloxone which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Naloxone can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The metabolism of Milnacipran can be decreased when combined with Naloxone.
Plerixafor Injection Plerixafor Injection Naloxone may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Naloxone.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Naloxone.
Prasugrel Prasugrel Naloxone may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Naloxone.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Naloxone.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Naloxone can be decreased when combined with Tolvaptan.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Naloxone.
Pralatrexate Injection Pralatrexate Injection Naloxone may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Palonosetron may decrease the excretion rate of Naloxone which could result in a higher serum level.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Naloxone.
Telavancin Injection Telavancin Injection Naloxone may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Naloxone.
Tapentadol Tapentadol The therapeutic efficacy of Tapentadol can be decreased when used in combination with Naloxone.
Topotecan Topotecan Topotecan may decrease the excretion rate of Naloxone which could result in a higher serum level.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Naloxone.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Naloxone.
Oxymorphone Oxymorphone The therapeutic efficacy of Oxymorphone can be decreased when used in combination with Naloxone.
Dalfampridine Dalfampridine Naloxone may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Naloxone.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Naloxone which could result in a higher serum level.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may decrease the excretion rate of Naloxone which could result in a higher serum level.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Naloxone.
Ipilimumab Injection Ipilimumab Injection Naloxone may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Naloxone which could result in a higher serum level.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Naloxone.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Naloxone.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Naloxone.
Telaprevir Telaprevir The metabolism of Naloxone can be decreased when combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Naloxone.
Rivaroxaban Rivaroxaban Naloxone may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Naloxone.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Naloxone.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Naloxone.
Clobazam Clobazam Clobazam may decrease the excretion rate of Naloxone which could result in a higher serum level.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be decreased when combined with Naloxone.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Naloxone.
Deferiprone Deferiprone Naloxone may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Naloxone.
Crizotinib Crizotinib The metabolism of Crizotinib can be decreased when combined with Naloxone.
Cabergoline Cabergoline The metabolism of Cabergoline can be decreased when combined with Naloxone.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Naloxone which could result in a higher serum level.
Enzalutamide Enzalutamide Naloxone may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Naloxone may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Regorafenib Regorafenib The metabolism of Naloxone can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Bosutinib can be decreased when combined with Naloxone.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Corticotropin can be decreased when combined with Naloxone.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Naloxone.
Teduglutide Injection Teduglutide Injection Naloxone may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Bedaquiline Bedaquiline The metabolism of Bedaquiline can be decreased when combined with Naloxone.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Naloxone.
Alogliptin Alogliptin Naloxone may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Naloxone.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Naloxone.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Naloxone.
Canagliflozin Canagliflozin Naloxone may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide Naloxone may increase the excretion rate of Methazolamide which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be decreased when combined with Naloxone.
Trametinib Trametinib Naloxone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Naloxone.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Naloxone which could result in a higher serum level.
Vortioxetine Vortioxetine Naloxone may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Naloxone.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Naloxone.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Naloxone which could result in a higher serum level.
Sofosbuvir Sofosbuvir Naloxone may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the excretion rate of Naloxone which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast Naloxone may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa Droxidopa Naloxone may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Ceritinib can be decreased when combined with Naloxone.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Naloxone.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Naloxone which could result in a higher serum level.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Naloxone.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Naloxone.
Suvorexant Suvorexant The metabolism of Suvorexant can be decreased when combined with Naloxone.
Edoxaban Edoxaban Naloxone may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Naloxone.
Methamphetamine Methamphetamine Naloxone may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Naloxone.
Riociguat Riociguat The serum concentration of Riociguat can be increased when it is combined with Naloxone.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Naloxone.
Palbociclib Palbociclib The metabolism of Palbociclib can be decreased when combined with Naloxone.
Naloxegol Naloxegol Naloxone may increase the opioid antagonism activities of Naloxegol.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Naloxone.
Haloperidol Injection Haloperidol Injection The serum concentration of Naloxone can be increased when it is combined with Haloperidol.
Amiloride Amiloride Naloxone may increase the excretion rate of Amiloride which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Isavuconazonium can be increased when it is combined with Naloxone.
Macitentan Macitentan Naloxone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Naloxone.
Flibanserin Flibanserin The metabolism of Flibanserin can be decreased when combined with Naloxone.
Prednisolone Prednisolone The metabolism of Prednisolone can be decreased when combined with Naloxone.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Naloxone.
Brexpiprazole Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Naloxone.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be decreased when combined with Naloxone.
Penicillin G Procaine Injection Penicillin G Procaine Injection Naloxone may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline Eluxadoline The therapeutic efficacy of Eluxadoline can be decreased when used in combination with Naloxone.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Naloxone.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Naloxone.
Osimertinib Osimertinib The metabolism of Osimertinib can be decreased when combined with Naloxone.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Naloxone.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Naloxone.
Lesinurad Lesinurad Naloxone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Naloxone which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The metabolism of Dexamethasone can be decreased when combined with Naloxone.
Brivaracetam Injection Brivaracetam Injection Naloxone may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Venetoclax Venetoclax The metabolism of Venetoclax can be decreased when combined with Naloxone.
Furosemide Injection Furosemide Injection Furosemide may increase the excretion rate of Naloxone which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The metabolism of Naloxone can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Naloxone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib Ribociclib The metabolism of Ribociclib can be decreased when combined with Naloxone.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Naloxone.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Naloxone may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Naloxone may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The serum concentration of Deflazacort can be increased when it is combined with Naloxone.
Naldemedine Naldemedine Naloxone may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Midostaurin can be decreased when combined with Naloxone.
Neratinib Neratinib The serum concentration of Neratinib can be increased when it is combined with Naloxone.
Enasidenib Enasidenib The metabolism of Naloxone can be decreased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be decreased when combined with Naloxone.
Benznidazole Benznidazole Naloxone may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Naloxone.
Delafloxacin Delafloxacin Naloxone may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Naloxone.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be decreased when combined with Naloxone.
Ertugliflozin Ertugliflozin The metabolism of Naloxone can be decreased when combined with Ertugliflozin.
Apalutamide Apalutamide The metabolism of Apalutamide can be decreased when combined with Naloxone.
Fostamatinib Fostamatinib The metabolism of Naloxone can be decreased when combined with Fostamatinib.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Naloxone.
Lofexidine Lofexidine Naloxone may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Plazomicin Injection Plazomicin Injection Naloxone may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Naloxone.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Naloxone.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Naloxone.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Naloxone.
Stiripentol Stiripentol Naloxone may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Naloxone.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Naloxone.
Prucalopride Prucalopride The metabolism of Prucalopride can be decreased when combined with Naloxone.
Siponimod Siponimod The risk or severity of adverse effects can be increased when Naloxone is combined with Siponimod.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Naloxone which could result in a higher serum level.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Naloxone.
Alpelisib Alpelisib The metabolism of Alpelisib can be decreased when combined with Naloxone.
Polatuzumab vedotin-piiq Injection Polatuzumab vedotin-piiq Injection The risk or severity of adverse effects can be increased when Naloxone is combined with Polatuzumab vedotin.
Solriamfetol Solriamfetol Naloxone may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Naloxone.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Naloxone.
Pexidartinib Pexidartinib The metabolism of Naloxone can be decreased when combined with Pexidartinib.
Upadacitinib Upadacitinib The metabolism of Upadacitinib can be decreased when combined with Naloxone.
Pitolisant Pitolisant Naloxone may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Pretomanid Pretomanid The serum concentration of Pretomanid can be increased when it is combined with Naloxone.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Naloxone.
Phenytoin Injection Phenytoin Injection The metabolism of Naloxone can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Naloxone.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Naloxone.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Naloxone.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Naloxone.
Lumateperone Lumateperone The serum concentration of Lumateperone can be increased when it is combined with Naloxone.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Naloxone.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Naloxone.
Pemigatinib Pemigatinib The metabolism of Pemigatinib can be decreased when combined with Naloxone.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Naloxone.
Rimegepant Rimegepant The metabolism of Rimegepant can be decreased when combined with Naloxone.
Ripretinib Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Naloxone.
Lurbinectedin Injection Lurbinectedin Injection The serum concentration of Lurbinectedin can be increased when it is combined with Naloxone.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Naloxone.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Naloxone.
Viloxazine Viloxazine Naloxone may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Naloxone.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Naloxone which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Naloxone which could result in a higher serum level.
Naproxen Naproxen Naproxen may decrease the excretion rate of Naloxone which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Naloxone which could result in a higher serum level.
Trazodone Trazodone The serum concentration of Trazodone can be increased when it is combined with Naloxone.
Isotretinoin Isotretinoin Isotretinoin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Naloxone which could result in a higher serum level.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Phenobarbital Phenobarbital The metabolism of Naloxone can be increased when combined with Phenobarbital.
Metaxalone Metaxalone Metaxalone may decrease the excretion rate of Naloxone which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The metabolism of Naloxone can be decreased when combined with Methotrexate.
Levorphanol Levorphanol The therapeutic efficacy of Levorphanol can be decreased when used in combination with Naloxone.
Primidone Primidone The metabolism of Naloxone can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Naloxone.
Diazepam Diazepam Diazepam may decrease the excretion rate of Naloxone which could result in a higher serum level.
Oxazepam Oxazepam Oxazepam may decrease the excretion rate of Naloxone which could result in a higher serum level.
Flurazepam Flurazepam Flurazepam may decrease the excretion rate of Naloxone which could result in a higher serum level.
Clorazepate Clorazepate Clorazepic acid may decrease the excretion rate of Naloxone which could result in a higher serum level.
Lorazepam Lorazepam The metabolism of Lorazepam can be decreased when combined with Naloxone.
Carmustine Carmustine Carmustine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Amantadine Amantadine Amantadine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Codeine Codeine The therapeutic efficacy of Naloxone can be decreased when used in combination with Codeine.
Phenelzine Phenelzine Phenelzine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Naloxone which could result in a higher serum level.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Naloxone.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Sulfadiazine Sulfadiazine Sulfadiazine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Methadone Methadone The therapeutic efficacy of Naloxone can be decreased when used in combination with Methadone.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Maprotiline Maprotiline Maprotiline may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Naloxone which could result in a higher serum level.
Azathioprine Azathioprine Azathioprine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Phentermine Phentermine The metabolism of Phentermine can be decreased when combined with Naloxone.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Naloxone which could result in a higher serum level.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Hydrocortisone can be decreased when combined with Naloxone.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be decreased when combined with Naloxone.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Naloxone.
Methyldopa Methyldopa Methyldopa may decrease the excretion rate of Naloxone which could result in a higher serum level.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Naloxone.
Hydralazine Hydralazine Naloxone may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine Cimetidine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Naloxone.
Clonazepam Clonazepam Clonazepam may decrease the excretion rate of Naloxone which could result in a higher serum level.
Promethazine Promethazine Promethazine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Naloxone which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Digoxin Digoxin Naloxone may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine Chloroquine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Triamterene Triamterene Naloxone may decrease the excretion rate of Triamterene which could result in a higher serum level.
Chlorothiazide Chlorothiazide Naloxone may increase the excretion rate of Chlorothiazide which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Naloxone may increase the excretion rate of Chlorthalidone which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Metolazone may increase the excretion rate of Naloxone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide Naloxone may increase the excretion rate of Isosorbide which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital Secobarbital may decrease the excretion rate of Naloxone which could result in a higher serum level.
Desipramine Desipramine Desipramine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Amitriptyline Amitriptyline The metabolism of Naloxone can be decreased when combined with Amitriptyline.
Imipramine Imipramine Imipramine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Probenecid Probenecid The metabolism of Naloxone can be decreased when combined with Probenecid.
Quinidine Quinidine The metabolism of Quinidine can be decreased when combined with Naloxone.
Procainamide Procainamide Naloxone may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Isoniazid may decrease the excretion rate of Naloxone which could result in a higher serum level.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Rifampin Rifampin The metabolism of Naloxone can be increased when combined with Rifampicin.
Disopyramide Disopyramide Disopyramide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Valproic Acid Valproic Acid The metabolism of Naloxone can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Naloxone.
Butabarbital Butabarbital Butabarbital may decrease the excretion rate of Naloxone which could result in a higher serum level.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Methimazole Methimazole Methimazole may decrease the excretion rate of Naloxone which could result in a higher serum level.
Chlorpropamide Chlorpropamide Chlorpropamide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Tolbutamide Tolbutamide Tolbutamide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Tolazamide Tolazamide Tolazamide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Baclofen Baclofen Baclofen may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Naloxone which could result in a higher serum level.
Methyclothiazide Methyclothiazide Naloxone may increase the excretion rate of Methyclothiazide which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Naloxone may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Naloxone which could result in a higher serum level.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Naloxone which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Propranolol may decrease the excretion rate of Naloxone which could result in a higher serum level.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Naloxone.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Naloxone which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Naloxone which could result in a higher serum level.
Phytonadione Phytonadione Phylloquinone may decrease the excretion rate of Naloxone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Nadolol Nadolol Naloxone may decrease the excretion rate of Nadolol which could result in a higher serum level.
Butorphanol Injection Butorphanol Injection The therapeutic efficacy of Butorphanol can be decreased when used in combination with Naloxone.
Nalbuphine Injection Nalbuphine Injection The therapeutic efficacy of Nalbuphine can be decreased when used in combination with Naloxone.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Naloxone which could result in a higher serum level.
Flavoxate Flavoxate Flavoxate may decrease the excretion rate of Naloxone which could result in a higher serum level.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Naloxone.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Naloxone which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Naloxone which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Naloxone.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Dacarbazine Dacarbazine Dacarbazine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Acetazolamide Acetazolamide Naloxone may increase the excretion rate of Acetazolamide which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Naloxone which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ketoconazole Ketoconazole The metabolism of Naloxone can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel Naloxone may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Naloxone.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Naloxone.
Vinblastine Vinblastine The metabolism of Vinblastine can be decreased when combined with Naloxone.
Ethacrynic Acid Ethacrynic Acid Naloxone may decrease the excretion rate of Etacrynic acid which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Naloxone which could result in a higher serum level.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Naloxone.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Naloxone which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Naloxone which could result in a higher serum level.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Naloxone.
Temazepam Temazepam Temazepam may decrease the excretion rate of Naloxone which could result in a higher serum level.
Triazolam Triazolam Triazolam may decrease the excretion rate of Naloxone which could result in a higher serum level.
Dicyclomine Dicyclomine Dicyclomine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Propantheline Propantheline Propantheline may decrease the excretion rate of Naloxone which could result in a higher serum level.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Naloxone which could result in a higher serum level.
Nifedipine Nifedipine Nifedipine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Timolol Timolol Timolol may decrease the excretion rate of Naloxone which could result in a higher serum level.
Verapamil Verapamil Verapamil may decrease the excretion rate of Naloxone which could result in a higher serum level.
Pindolol Pindolol Pindolol may decrease the excretion rate of Naloxone which could result in a higher serum level.
Cisplatin Injection Cisplatin Injection Naloxone may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Naloxone which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Naloxone which could result in a higher serum level.
Bumetanide Bumetanide Bumetanide may increase the excretion rate of Naloxone which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide Etoposide The metabolism of Etoposide can be decreased when combined with Naloxone.
Glipizide Glipizide Glipizide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Indapamide Indapamide Indapamide may increase the excretion rate of Naloxone which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Amoxicillin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Pentoxifylline Pentoxifylline Pentoxifylline may decrease the excretion rate of Naloxone which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Naloxone which could result in a higher serum level.
Labetalol Labetalol Labetalol may decrease the excretion rate of Naloxone which could result in a higher serum level.
Auranofin Auranofin Auranofin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Gemfibrozil Gemfibrozil The metabolism of Gemfibrozil can be decreased when combined with Naloxone.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Naloxone which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Naloxone which could result in a higher serum level.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Naloxone.
Flurbiprofen Flurbiprofen The metabolism of Naloxone can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Naloxone.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Naloxone which could result in a higher serum level.
Buspirone Buspirone Buspirone may decrease the excretion rate of Naloxone which could result in a higher serum level.
Lovastatin Lovastatin The serum concentration of Lovastatin can be increased when it is combined with Naloxone.
Ciprofloxacin Ciprofloxacin Ciprofloxacin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Naloxone which could result in a higher serum level.
Clozapine Clozapine Clozapine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Estazolam Estazolam Naloxone may decrease the excretion rate of Estazolam which could result in a higher serum level.
Didanosine Didanosine Didanosine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Etodolac Etodolac Etodolac may decrease the excretion rate of Naloxone which could result in a higher serum level.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Naloxone which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Naloxone which could result in a higher serum level.
Amlodipine Amlodipine The metabolism of Amlodipine can be decreased when combined with Naloxone.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Naloxone.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Naloxone which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Bisoprolol Bisoprolol Bisoprolol may decrease the excretion rate of Naloxone which could result in a higher serum level.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Naloxone.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Naloxone.
Isradipine Isradipine Isradipine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Naloxone.
Venlafaxine Venlafaxine Venlafaxine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Famciclovir Famciclovir The metabolism of Famciclovir can be decreased when combined with Naloxone.
Fluvoxamine Fluvoxamine Fluvoxamine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Nefazodone Nefazodone Nefazodone may decrease the excretion rate of Naloxone which could result in a higher serum level.
Lamotrigine Lamotrigine The metabolism of Naloxone can be increased when combined with Lamotrigine.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Naloxone which could result in a higher serum level.
Tramadol Tramadol The metabolism of Naloxone can be decreased when combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Naloxone.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ifosfamide Injection Ifosfamide Injection The metabolism of Naloxone can be decreased when combined with Ifosfamide.
Bupropion Bupropion Bupropion may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Naloxone.
Metformin Metformin Metformin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Nisoldipine Nisoldipine Nisoldipine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Acarbose Acarbose Acarbose may decrease the excretion rate of Naloxone which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Indinavir Indinavir The metabolism of Naloxone can be decreased when combined with Indinavir.
Ritonavir Ritonavir The metabolism of Naloxone can be increased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Naloxone.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Naloxone which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Naloxone which could result in a higher serum level.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Naloxone.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Naloxone.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Topiramate Topiramate Topiramate may decrease the excretion rate of Naloxone which could result in a higher serum level.
Pramipexole Pramipexole Pramipexole may decrease the excretion rate of Naloxone which could result in a higher serum level.
Nelfinavir Nelfinavir The metabolism of Naloxone can be increased when combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Naloxone.
Nilutamide Nilutamide Nilutamide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Flutamide Flutamide Flutamide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be decreased when combined with Naloxone.
Tamsulosin Tamsulosin Tamsulosin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Quetiapine Quetiapine The serum concentration of Quetiapine can be increased when it is combined with Naloxone.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Naloxone which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Naloxone which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Naloxone which could result in a higher serum level.
Cetirizine Cetirizine Cetirizine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Tolcapone Tolcapone Tolcapone may decrease the excretion rate of Naloxone which could result in a higher serum level.
Capecitabine Capecitabine Capecitabine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Efavirenz Efavirenz The metabolism of Naloxone can be increased when combined with Efavirenz.
Abacavir Abacavir Abacavir may decrease the excretion rate of Naloxone which could result in a higher serum level.
Sildenafil Sildenafil The metabolism of Sildenafil can be decreased when combined with Naloxone.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Naloxone which could result in a higher serum level.
Rosiglitazone Rosiglitazone Rosiglitazone may decrease the excretion rate of Naloxone which could result in a higher serum level.
Tolterodine Tolterodine The serum concentration of Tolterodine can be increased when it is combined with Naloxone.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Naloxone which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Nateglinide Nateglinide Nateglinide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Naloxone which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists