Drug & supplement interaction

Corydalis Yanhusuo + Edoxaban

Edoxaban brand name: Savaysa.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Corydalis Yanhusuo has a moderate interaction with Edoxaban. Theoretically, Corydalis yanhusuo might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Corydalis Yanhusuo and Edoxaban

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Edoxaban

Edoxaban falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Corydalis Yanhusuo interacts with.

Theoretically, Corydalis yanhusuo might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Corydalis yanhusuo contains berberine. In vitro and in vivo research suggest that berberine can inhibit platelet aggregation. Theoretically, Corydalis yanhusuo might also inhibit platelet aggregation.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the situation with Edoxaban (Savaysa) and Corydalis yanhusuo. Edoxaban is already a blood thinner, working by blocking a clotting factor called factor Xa. Corydalis contains berberine, and in lab and animal studies berberine seems to make platelets (the cells that help blood clump) a little less sticky. Stack that on top of edoxaban, and in theory you could tip toward easier bleeding.

What might that look like in real life? Easy bruising, nosebleeds, bleeding gums, or cuts that take longer to stop. I want to be honest though: this concern is theoretical and based only on lab and animal data, not solid human studies. So please don't start or stop anything on your own. Just loop in your pharmacist or doctor first so they can weigh in.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
  2. Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Corydalis Yanhusuo Also Interacts With Other Medications

Corydalis Yanhusuo has 1,159 moderate known drug interactions in our database — the Edoxaban one above is one of them. If you take anything else, check it against the full list below.

Moderate 1,159 No known interaction 1,671 (incl. Edoxaban)
Taking anything else?

Check Another of Your Medications Against Corydalis Yanhusuo

Covers the 2,830 medications we’ve checked against Corydalis Yanhusuo. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Edoxaban

This page covers Corydalis Yanhusuo only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Edoxaban page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Piracetam (major), Aconite (moderate) and Allspice (moderate).

By severity: 3 major · 190 moderate · 25 minor.

From our pharmacist’s overview on the Edoxaban page

“The interaction I would flag first for edoxaban (Savaysa) is activated charcoal, which can soak up the drug in the gut and lower its levels, and an underdosed blood thinner leaves you exposed to the clots and strokes it exists to prevent. It is one of three major-rated entries here, alongside danshen and piracetam, which push the oppos…”

Reviewed by 2 · Jul 18, 2026

Open the Edoxaban interaction page

How much people look this up

Where Corydalis Yanhusuo and Edoxaban Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Corydalis Yanhusuo
Top half

#651 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Edoxaban
Top 10%

#149 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Corydalis Yanhusuo

What is Corydalis Yanhusuo?

  • Pain relief
  • Menstrual cramps
  • Headache
  • Stress and sleep support
  • Stomach and abdominal discomfort

Corydalis yanhusuo is a traditional Chinese herb used mainly for pain. Some early laboratory and animal research suggests its compounds may affect pain and the nervous system, but high-quality human studies are limited, so its true benefits and long-term safety are not well established. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Read the full Corydalis Yanhusuo monograph & all interactions
Medication

About Edoxaban

What Is Edoxaban Used For?

Brand name: Savaysa

Savaysa (edoxaban) is used to reduce the risk of stroke and systemic embolism (when a clot travels to other parts of the body) in adults with nonvalvular atrial fibrillation — a type of irregular heartbeat not caused by a heart valve problem. Important: Savaysa is not appropriate for everyone with this condition; people with very high kidney function (creatinine clearance above 95 mL/min) should use a different anticoagulant instead.

Savaysa is also used to treat deep vein thrombosis (DVT — a blood clot in a deep vein, usually the leg) and pulmonary embolism (PE — a blood clot in the lungs). For DVT and PE, Savaysa is started after 5 to 10 days of initial treatment with an injectable blood thinner.

See full Edoxaban drug information
Keep checking

Other Drugs & Corydalis Yanhusuo

Browse every other medication we’ve checked against Corydalis Yanhusuo — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1,159Moderate
0Minor
1,670No known interaction
1,159 Moderate 1,670 No interaction
Moderate

1,159 interactions

Showing 60 of 1,159 moderate interactions — see all 1,159 on the Corydalis Yanhusuo page.

No interaction 1,670 drugs checked — show the list

We also checked Corydalis Yanhusuo against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,670 medications checked with no known interaction — see the full Corydalis Yanhusuo list.

See the full Corydalis Yanhusuo interactions page
See every supplement checked against Edoxaban, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Corydalis Yanhusuo monograph › Uses, safety, and every drug interaction in one place Edoxaban supplement interactions › Every supplement checked against Edoxaban, ranked by severity Edoxaban drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Corydalis Yanhusuo and Edoxaban Together: Common Questions

Can you take Corydalis Yanhusuo with Edoxaban?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Corydalis Yanhusuo and Edoxaban interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Edoxaban and Corydalis Yanhusuo?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.