Medication interaction hub

What Supplements Interact with Edoxaban?

Edoxaban brand name: Savaysa. Every interaction below applies to the brands too.

218 Interactions 3 Major 190 Moderate 25 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Edoxaban? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Edoxaban against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

The interaction I would flag first for edoxaban (Savaysa) is activated charcoal, which can soak up the drug in the gut and lower its levels, and an underdosed blood thinner leaves you exposed to the clots and strokes it exists to prevent. It is one of three major-rated entries here, alongside danshen and piracetam, which push the opposite way by adding bleeding risk. Edoxaban thins the blood on a fine balance, so I read these 218 pairings as ones to check carefully, not skim.

Nearly all the rest, 190 rated moderate and 25 minor, follow the bleeding theme, herbs and extracts with antiplatelet activity that can stack with edoxaban's own effect. A smaller cluster of fibers and charcoals changes how oral doses absorb, so space those well apart from your dose. Unexplained bruising, nosebleeds, or blood in stool or urine deserves a same-day call to your prescriber.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 190 Minor 25 No known interaction 1,234

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Edoxaban: Top Interactions at a Glance

The Edoxaban supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 218 interacting ingredients — plus 1,234 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Edoxaban Combinations Today

The Edoxaban + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Flaxseed + Edoxabani

Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.

Read the full interaction Moderate Likelihood Possible Mangosteen + Edoxabani

Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.

Read the full interaction Moderate Likelihood Possible Dandelion + Edoxabani

Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.

Read the full interaction Moderate Likelihood Possible Black Currant + Edoxabani

Theoretically, black currant seed oil might increase the risk of bleeding if used in combination with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Unlikely Green Tea + Edoxabani

Theoretically, green tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Dimethylsulfoxide (dmso) + Edoxabani

Theoretically, DMSO might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Edoxaban

All 1,452 ingredients in our database, ranked by severity — 218 with a Edoxaban interaction on file and 1,234 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Edoxaban?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Flaxseed with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of b...

Full Flaxseed + Edoxaban answer

Can you take Mangosteen with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.

Full Mangosteen + Edoxaban answer

Can you take Dandelion with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.

Full Dandelion + Edoxaban answer

Can you take Black Currant with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black currant seed oil might increase the risk of bleeding if used in combination with anticoagulant or antiplatelet drugs.

Full Black Currant + Edoxaban answer

Can you take Green Tea with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, green tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Green Tea + Edoxaban answer

Can you take Onion with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of anticoagulant or antiplatelet drugs with onion might increase the risk of bleeding.

Full Onion + Edoxaban answer

Can you take Oolong Tea with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oolong tea might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Oolong Tea + Edoxaban answer

Can you take Oregano with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Oregano + Edoxaban answer

Can you take Oregon Grape with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Oregon Grape + Edoxaban answer

Can you take Palm Oil with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.

Full Palm Oil + Edoxaban answer

Can you take Pantethine with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.

Full Pantethine + Edoxaban answer

Can you take Parsley with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Parsley + Edoxaban answer

Can you take Pau D'arco with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Pau D'arco + Edoxaban answer

Can you take Peony with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining peony with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Full Peony + Edoxaban answer

Can you take Phellodendron with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.

Full Phellodendron + Edoxaban answer

Can you take Plum with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, plum juice might have antiplatelet effects.

Full Plum + Edoxaban answer

Can you take Policosanol with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.

Full Policosanol + Edoxaban answer

Can you take Propolis with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.

Full Propolis + Edoxaban answer

Can you take Pu-erh Tea with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, pu-erh tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Pu-erh Tea + Edoxaban answer

Can you take Puravive with Edoxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Puravive, a dietary supplement, contains several ingredients that may interact with anticoagulant drugs due to their potential mild anticoag...

Full Puravive + Edoxaban answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Edoxaban is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Edoxaban, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Edoxaban sits in 2 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Edoxaban through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Edoxaban through this category.

About Edoxaban

Edoxaban is a blood thinner that prevents strokes and blood clots in people with irregular heartbeat or those recovering from blood clots.

Generic name: Edoxaban  ·  Brand name: Savaysa.

See the full Edoxaban drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Edoxaban

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Edoxaban.

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Pharmacist Counseling Corner

Edoxaban & Supplements: Common Questions

What supplements interact with Edoxaban?
In our interaction database, 218 supplement and herbal ingredients have an interaction with Edoxaban on file — 3 rated major, 190 moderate, and 25 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Danshen, Piracetam.
Which Edoxaban supplement interactions are the most serious?
The 3 major-rated combinations — led by Activated Charcoal, Danshen and Piracetam — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Edoxaban?
That depends entirely on which supplement. The honest answer for Edoxaban is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Savaysa have the same supplement interactions as Edoxaban?
Yes — Savaysa all contain Edoxaban, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Edoxaban and my other medications?
This page covers Edoxaban against supplements and herbal ingredients. Checking Edoxaban against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Edoxaban drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.