Drug & supplement interaction

Flaxseed Oil + Edoxaban

Edoxaban brand name: Savaysa.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Flaxseed Oil has a moderate interaction with Edoxaban. Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Flaxseed Oil and Edoxaban

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Edoxaban

Edoxaban falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Flaxseed Oil interacts with.

Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Small clinical studies show that consuming flaxseed oil might decrease platelet aggregation and increase bleeding time.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Edoxaban (Savaysa) already thins your blood by blocking a clotting factor called factor Xa. Flaxseed oil isn't a blood thinner in the same way, but the omega-3s in it (ALA) may slightly reduce how well your platelets stick together. Put the two together and, in theory, you could bleed a little more easily.

To be clear, this concern is mostly theoretical, based on how these two work and a few small studies, not strong proof. Still, it's worth watching for things like easy bruising, nosebleeds, bleeding gums, or cuts that take longer to stop. The small amounts of flax in food are very unlikely to matter; concentrated supplement doses are the bigger question. Before adding flaxseed oil, just check with your pharmacist or doctor so they can keep an eye on you.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
  2. Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur.J Clin.Nutr. 1995;49(3):169-178.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Flaxseed Oil Also Interacts With Other Medications

Flaxseed Oil has 292 moderate known drug interactions in our database — the Edoxaban one above is one of them. If you take anything else, check it against the full list below.

Moderate 292 No known interaction 2,538 (incl. Edoxaban)
Taking anything else?

Check Another of Your Medications Against Flaxseed Oil

Covers the 2,830 medications we’ve checked against Flaxseed Oil. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Edoxaban

This page covers Flaxseed Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Edoxaban page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Piracetam (major), Aconite (moderate) and Allspice (moderate).

By severity: 3 major · 190 moderate · 25 minor.

From our pharmacist’s overview on the Edoxaban page

“The interaction I would flag first for edoxaban (Savaysa) is activated charcoal, which can soak up the drug in the gut and lower its levels, and an underdosed blood thinner leaves you exposed to the clots and strokes it exists to prevent. It is one of three major-rated entries here, alongside danshen and piracetam, which push the oppos…”

Reviewed by 2 · Jul 18, 2026

Open the Edoxaban interaction page

One more smart check

Taking Flaxseed Oil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,329 real supplement products containing Flaxseed Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Flaxseed Oil. Your product may carry other ingredients that interact with Edoxaban too, on top of Flaxseed Oil — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Flaxseed Oil and Edoxaban Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Flaxseed Oil
Top 25%

#191 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Edoxaban
Top 25%

#338 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Flaxseed Oil

What is Flaxseed Oil?

  • Source of omega-3 (ALA) fatty acids
  • Heart and cholesterol health
  • Dry skin and inflammation
  • Constipation
  • General wellness

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help support heart health and provide healthy fats, but evidence for most specific health claims is limited or mixed. It is generally well tolerated, but talk to your pharmacist or doctor before starting, especially if you are pregnant or have a bleeding risk.

Read the full Flaxseed Oil monograph & all interactions
Medication

About Edoxaban

What Is Edoxaban Used For?

Brand name: Savaysa

Savaysa (edoxaban) is used to reduce the risk of stroke and systemic embolism (when a clot travels to other parts of the body) in adults with nonvalvular atrial fibrillation — a type of irregular heartbeat not caused by a heart valve problem. Important: Savaysa is not appropriate for everyone with this condition; people with very high kidney function (creatinine clearance above 95 mL/min) should use a different anticoagulant instead.

Savaysa is also used to treat deep vein thrombosis (DVT — a blood clot in a deep vein, usually the leg) and pulmonary embolism (PE — a blood clot in the lungs). For DVT and PE, Savaysa is started after 5 to 10 days of initial treatment with an injectable blood thinner.

See full Edoxaban drug information
Keep checking

Other Drugs & Flaxseed Oil

Browse every other medication we’ve checked against Flaxseed Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
292Moderate
0Minor
2,537No known interaction
292 Moderate 2,537 No interaction
Moderate

292 interactions

Showing 60 of 292 moderate interactions — see all 292 on the Flaxseed Oil page.

No interaction 2,537 drugs checked — show the list

We also checked Flaxseed Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,537 medications checked with no known interaction — see the full Flaxseed Oil list.

See the full Flaxseed Oil interactions page
See every supplement checked against Edoxaban, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
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Pharmacist Counseling Corner

Taking Flaxseed Oil and Edoxaban Together: Common Questions

Can you take Flaxseed Oil with Edoxaban?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Flaxseed Oil and Edoxaban interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Edoxaban and Flaxseed Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.