Sweet Woodruff - Savaysa (Edoxaban) Interaction
Herbal: Sweet Woodruff
Also Known As: Galium odoratum, Aspérula, Aspérule, Aspérule Odorante, Galii Odorati Herba, Master of the Wood, Petit Muguet, Reine des Bois, Thé Suisse, Waldmeister, Woodruff, Wordward
Drug: Edoxaban
Brand names:
Savaysa
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 15, 2025
Interaction Details
Edoxaban is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
Theoretically, concomitant use might increase the effects of some anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Sweet woodruff contains coumarin and coumarin derivatives. However, the levels of coumarin found in sweet woodruff are so low that clinically relevant effects are doubtful. Until more is known, use with caution.
Interaction Rating
Likelihood of Occurrence
UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
References
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Sulma, T. and Wierzchowska, K. [Studies on the content of coumarin in the herbs of the woodruff (Herba Asperulae odoratae) throughout the vegetative period of the plant.]. Acta Pol.Pharm 1963;20:77-82.
- Kovac-Besovic, E. E. and Duric, K. Thin layer chromatography-application in qualitative analysis on presence of coumarins and flavonoids in plant material. Bosn.J Basic Med.Sci. 2003;3(3):19-26.
- Kahkeshani N, Farahanikia B, Mahdaviani P, et al. Antioxidant and burn healing potential of Galium odoratum extracts. Res Pharm Sci 2013;8(3):197-203.
Sweet Woodruff Overview
Sweet woodruff (Galium odoratum) is a perennial herb belonging to the bedstraw family (Rubiaceae). It is native to Europe and is widely cultivated as an ornamental plant.
Sweet woodruff has a long history of use in traditional medicine, and is purported to have astringent, diuretic, and tonic properties. It has been used for a variety of conditions, such as respiratory tract, gastrointestinal tract, liver, gallbladder, and urinary tract disorders.
Edoxaban Overview
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Edoxaban is used help prevent strokes or blood clots in people who have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body and possibly causing strokes) that is not caused by heart valve disease. Edoxaban is also used to prevent deep vein thrombosis (DVT; a blood clot, usually in the leg) and pulmonary embolism (PE; a blood clot in the lung) in people who have been treated with an injectable blood thinner medicine for 5 to 10 days. Edoxaban is in a class of medications called factor Xa inhibitors. It works by blocking the action of a certain natural substance that helps blood clots to form.
Sweet Woodruff - More Interactions
Sweet Woodruff interacts with 121 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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