Corydalis Yanhusuo + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine
Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine brand name: Conar-A.
Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine falls into 3 drug categories that Corydalis Yanhusuo can interact with; the most serious is rated moderate. Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP2D6.
Read the full interaction reportCorydalis Yanhusuo and Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Corydalis Yanhusuo interacts with whole categories of medication. Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine falls into 3 of those categories, so it can interact with Corydalis Yanhusuo in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
1 of 3Why this applies to Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine
Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES — the group Corydalis Yanhusuo interacts with.
Corydalis yanhusuo contains berberine. In vitro research and preliminary clinical evidence show that berberine can inhibit CYP2D6. Theoretically, Corydalis yanhusuo might also inhibit CYP2D6.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Out of the four ingredients in Conar-A, the one to watch here is the dextromethorphan, the cough suppressant. Your body relies on a liver enzyme called CYP2D6 to break it down. Corydalis yanhusuo may slow that enzyme down, so the dextromethorphan could clear more slowly and build up a bit higher than usual.
If that happens, you might notice more of dextromethorphan's typical effects, like drowsiness, dizziness, or a foggy, lightheaded feeling. I want to be honest though: this is a theoretical concern based on lab work, not strong human studies, so it may never amount to much in real life. The acetaminophen, guaifenesin, and phenylephrine aren't really affected this way. Still, it's worth a quick word with your pharmacist before combining them.
- Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
- Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
2 of 3Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
Corydalis yanhusuo contains berberine. In vitro research and preliminary clinical research show that berberine moderately inhibits CYP3A4. Theoretically, Corydalis yanhusuo might also inhibit CYP3A4.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combination cold-and-cough product has a few moving parts, but the one most likely to be affected here is dextromethorphan, the cough suppressant. Some of its breakdown depends on the CYP3A4 pathway. Corydalis may mildly slow that enzyme, so in theory dextromethorphan could build up a bit and lead to more drowsiness, dizziness, or feeling foggy. The acetaminophen, guaifenesin, and phenylephrine pieces aren't strongly tied to this particular interaction.
I want to be honest that this is theoretical, based on lab findings rather than real patient reports, so for most people it's probably a small concern. Still, if you take Corydalis regularly, mention it to your pharmacist or doctor before pairing it with this product, especially if you notice extra grogginess.
- Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
- Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
DEXTROMETHORPHAN (Robitussin DM, others)
3 of 3Corydalis yanhusuo contains berberine. Preliminary clinical research shows that berberine can inhibit cytochrome P450 2D6 (CYP2D6) activity and reduce the metabolism of dextromethorphan. Theoretically, Corydalis yanhusuo may also inhibit the metabolism of dextromethorphan.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
The piece of this combo cold medicine that matters here is the dextromethorphan, the cough suppressant. Your body clears it using a liver enzyme called CYP2D6. Corydalis yanhusuo may contain berberine, which can slow that same enzyme down. In theory, that means dextromethorphan could build up a bit more than usual, so you might feel more of its effects like drowsiness, dizziness, or feeling foggy or lightheaded.
I want to be honest that this is a theoretical concern based on how these compounds behave, not strong human studies, so it may not amount to much for most people. The acetaminophen, guaifenesin, and phenylephrine parts aren't really involved. Still, if you plan to use them together, it's worth a quick chat with your pharmacist or doctor first.
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Corydalis Yanhusuo Also Interacts With Other Medications
Corydalis Yanhusuo has 1,159 moderate known drug interactions in our database — the Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Corydalis Yanhusuo
We haven’t checked that one against Corydalis Yanhusuo yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Corydalis Yanhusuo. Pick one to open its full report.
See Every Supplement That Interacts With Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine
This page covers Corydalis Yanhusuo only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine page lists 261 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Ephedra (major) and Grapefruit (major).
By severity: 12 major · 206 moderate · 43 minor.
From our pharmacist’s overview on the Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine page
“Picture the week someone takes Conar-A (acetaminophen, dextromethorphan, guaifenesin, phenylephrine): a miserable cold, coffee to push through, maybe wine at night or an herbal remedy on top. Those habits are exactly where this list turns serious.”
Reviewed by 2 · Jul 18, 2026
Open the Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interaction page
Where Corydalis Yanhusuo and Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#687 of 1,452 supplements looked up here in the last 7 days
#574 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Corydalis Yanhusuo
What is Corydalis Yanhusuo?
- Pain relief
- Menstrual cramps
- Headache
- Stress and sleep support
- Stomach and abdominal discomfort
Corydalis yanhusuo is a traditional Chinese herb used mainly for pain. Some early laboratory and animal research suggests its compounds may affect pain and the nervous system, but high-quality human studies are limited, so its true benefits and long-term safety are not well established. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
Other Drugs & Corydalis Yanhusuo
Browse every other medication we’ve checked against Corydalis Yanhusuo — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,159 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Diphenhydramine ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Lidocaine ›
- Guaifenesin ›
- Hydrochlorothiazide ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Flurazepam ›
- Glyburide ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Hydralazine ›
- Indomethacin ›
- Insulin (human) ›
- Miconazole ›
- Morphine Sulfate ›
- Nitrazepam ›
- Trimipramine ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
Showing 60 of 1,159 moderate interactions — see all 1,159 on the Corydalis Yanhusuo page.
No interaction 1,670 drugs checked — show the list
We also checked Corydalis Yanhusuo against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Amoxicillin ›
- Bupropion ›
- Bendamustine ›
- Acyclovir ›
- Methotrexate ›
- Doxycycline ›
- Azithromycin ›
- Isotretinoin ›
- Methylene Blue ›
- Ciprofloxacin ›
- Levothyroxine, Liothyronine ›
- Cephalexin ›
- Cyclopentolate ›
- Roxithromycin ›
- Pegunigalsidase Alfa-iwxj ›
- Ezetimibe ›
- Daptomycin ›
- Levothyroxine Sodium ›
- Dexmethylphenidate ›
- Mitomycin ›
- Amoxicillin, Clavulanate Potassium ›
- Hexobarbitone ›
- Thyroid Hormone ›
- Carbidopa, Levodopa ›
- Factor 7a ›
- Levodopa ›
- Hethylphenidate Hcl ›
- Cefaclor ›
- Lenvatinib ›
- Azelaic Acid ›
- Phenylephrine ›
- Hydroxychloroquine ›
- Dirithromycin ›
- Vancomycin ›
- Triptorelin ›
- Pizotifen ›
- Bentoquatam ›
- Digoxin ›
- Ribavirin Aerosol ›
- Procainamide ›
- Dextrothyroxine ›
- Tocainide ›
- Ropinirole ›
- Rocuronium ›
- Paracetamol ›
- Mitomycin C ›
- Lomustine ›
- Digitoxin ›
- Salbutamol Sulfate ›
- Chenodiol ›
Showing the 60 most looked-up of 1,670 medications checked with no known interaction — see the full Corydalis Yanhusuo list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine Is Linked to Lower Levels of One Nutrient
Natural Medicines records Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine as a medicine that can lower these. This is not an interaction with Corydalis Yanhusuo — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Corydalis Yanhusuo and Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine Together: Common Questions
Can you take Corydalis Yanhusuo with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine?
Why are there 3 interactions listed for Corydalis Yanhusuo and Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine?
How serious is the Corydalis Yanhusuo and Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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