Drug & supplement interaction

Lentinan + Aspirin, Omeprazole

Aspirin, Omeprazole brand name: Yosprala.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Aspirin, Omeprazole falls into 3 drug categories that Lentinan can interact with; the most serious is rated moderate. Laboratory research suggests that lentinan might increase the activity of cytochrome P450 2C19 (CYP2C19).

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions3
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Lentinan and Aspirin, Omeprazole

These two interact in 3 distinct ways. Each one is explained separately below.

Why Are There 3 Interactions?

Lentinan interacts with whole categories of medication. Aspirin, Omeprazole falls into 3 of those categories, so it can interact with Lentinan in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES

1 of 3

Why this applies to Aspirin, Omeprazole

Aspirin, Omeprazole falls under CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES — the group Lentinan interacts with.

Laboratory research suggests that lentinan might increase the activity of cytochrome P450 2C19 (CYP2C19). So far, this interaction has not been reported in humans. However, watch for a decrease in the levels of drugs metabolized by CYP2C19 in patients taking lentinan.
Some drugs metabolized by CYP2C19 include proton pump inhibitors including omeprazole (Prilosec), lansoprazole (Prevacid), and pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing with Yosprala, which pairs aspirin with omeprazole. The omeprazole half is the part that matters here. It's a proton pump inhibitor that your liver processes using an enzyme called CYP2C19. Some early lab and animal research hints that lentinan (a shiitake mushroom beta-glucan) may speed that enzyme up. If that happened in people, your body could clear omeprazole a little faster, meaning less stomach-acid protection. That's worth knowing, because the whole point of including omeprazole is to shield your stomach from aspirin's ulcer risk.

I want to be honest, though: this has only been seen in the lab, never confirmed in humans, so it's more theoretical than proven. Still, if you notice heartburn or stomach upset, mention it to your pharmacist or doctor before changing anything.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Lin Y, Wei Y, Hu X, et al. Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method. Iran J Basic Med Sci. 2019;22(3):296-301.
Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

2 of 3

Aspirin, Omeprazole also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.

Laboratory research suggests that lentinan might increase the activity of cytochrome P450 3A4 (CYP3A4). So far, this interaction has not been reported in humans. However, watch for a decrease in the levels of drugs metabolized by CYP3A4 in patients taking lentinan.
Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and numerous others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for your Yosprala (aspirin plus omeprazole). Lab studies hint that lentinan may speed up an enzyme called CYP3A4, which is one of the liver's drug-clearing systems. If that happened in people, drugs handled by that enzyme could clear a little faster and work a bit less. With Yosprala, the omeprazole piece partly relies on this pathway, so in theory it could become slightly less effective at lowering stomach acid, which is the part meant to protect you from an aspirin-related ulcer.

The honest part: this is only test-tube and animal data, and it has never been reported in actual patients. So I wouldn't be alarmed. Still, since this combo is protecting your heart and stomach, check with your pharmacist or doctor before adding lentinan, and watch for any return of heartburn or stomach upset.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Lin Y, Wei Y, Hu X, et al. Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method. Iran J Basic Med Sci. 2019;22(3):296-301.
Moderate

OMEPRAZOLE (Prilosec)

3 of 3
In animal research, lentinan decreases plasma levels of omeprazole. This may be due to induction of cytochrome P450 2C19 (CYP2C19) metabolism.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for Yosprala, which pairs aspirin with the acid-reducer omeprazole. The interaction on file involves the omeprazole half. In animal studies, lentinan seemed to speed up an enzyme called CYP2C19 that breaks down omeprazole. If that holds true in people, your body could clear the omeprazole a bit faster, leaving less of it around to calm stomach acid.

Why does that matter? In this combo, omeprazole is there to protect your stomach from aspirin. If it works less well, you might notice more heartburn or stomach upset, and over time a higher chance of irritation or ulcer. This is only based on lab and animal research, so it's far from certain. Don't change anything on your own. Just give your pharmacist or doctor a heads-up if you want to try lentinan.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Lin Y, Wei Y, Hu X, et al. Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method. Iran J Basic Med Sci. 2019;22(3):296-301.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Lentinan Also Interacts With Other Medications

Lentinan has 813 moderate known drug interactions in our database — the Aspirin, Omeprazole one above is among them. If you take anything else, check it against the full list below.

Moderate 813 No known interaction 2,017 (incl. Aspirin, Omeprazole)
Taking anything else?

Check Another of Your Medications Against Lentinan

Covers the 2,830 medications we’ve checked against Lentinan. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aspirin, Omeprazole

This page covers Lentinan only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Omeprazole page lists 318 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Grapefruit (major).

By severity: 9 major · 256 moderate · 53 minor.

From our pharmacist’s overview on the Aspirin, Omeprazole page

“Yosprala pairs aspirin, a blood thinner, with omeprazole, an acid reducer whose job is to shield the stomach from that aspirin, so this list carries real weight and warrants genuine care. Of the 318 supplements and herbs on file, nine are rated major, and understanding those first matters more than reading the rest.”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Omeprazole interaction page

One more smart check

Taking Lentinan as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Lentinan, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lentinan. Your product may carry other ingredients that interact with Aspirin, Omeprazole too, on top of Lentinan — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lentinan and Aspirin, Omeprazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lentinan
Steady interest

#795 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Omeprazole
Top 25%

#300 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Lentinan

What is Lentinan?

Lentinan
  • Immune support
  • Used alongside cancer treatment
  • Anti-inflammatory
  • General wellness/tonic
  • Antimicrobial support

Lentinan is a beta-glucan polysaccharide from shiitake mushrooms that is studied mainly as an immune-modulating add-on to cancer chemotherapy, where it is given by injection in a few countries. Evidence for oral supplements is limited, and quality varies widely between products. Talk with your pharmacist or doctor before using it, especially if you have a health condition or are pregnant or breastfeeding.

Read the full Lentinan monograph & all interactions
Keep checking

Other Drugs & Lentinan

Browse every other medication we’ve checked against Lentinan — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
813Moderate
0Minor
2,016No known interaction
813 Moderate 2,016 No interaction
Moderate

813 interactions

Showing 60 of 813 moderate interactions — see all 813 on the Lentinan page.

No interaction 2,016 drugs checked — show the list

We also checked Lentinan against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,016 medications checked with no known interaction — see the full Lentinan list.

See the full Lentinan interactions page
See every supplement checked against Aspirin, Omeprazole, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Lentinan monograph › Uses, safety, and every drug interaction in one place Aspirin, Omeprazole supplement interactions › Every supplement checked against Aspirin, Omeprazole, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Lentinan and Aspirin, Omeprazole Together: Common Questions

Can you take Lentinan with Aspirin, Omeprazole?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 3 interactions listed for Lentinan and Aspirin, Omeprazole?
Aspirin, Omeprazole belongs to more than one drug category, and Lentinan interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Lentinan and Aspirin, Omeprazole interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Aspirin, Omeprazole and Lentinan?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.