Stone Root Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Stone Root interacts with medications. The heart of this page is the interaction list — every drug Stone Root is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Stone Root is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Stone Root against your medication
Add one medicationDrugs that interact with Stone Root
0 medications have a known interaction with Stone Root, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Stone Root. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Stone Root combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Stone Root: Uses, Safety & Side Effects
Stone root is a North American herb traditionally used for hemorrhoids, urinary complaints, and digestive issues. There is very little modern scientific evidence to confirm it works for any of these uses, so it should be viewed as a traditional remedy rather than a proven treatment. Talk with your pharmacist or doctor before trying it, especially if you are pregnant, breastfeeding, or take other medicines.

- Scientific name
- Collinsonia canadensis
- Family
- Lamiaceae
- Part used
- Root and rhizome
- Common forms
- Tincture, capsules, dried root for tea, liquid extract
- Hemorrhoids
- Urinary and bladder discomfort
- Digestive upset
- Sore throat and hoarseness
- Kidney stones (traditional)
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Little safety data exists, so use with care and under professional guidance.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Stone root comes from Collinsonia canadensis, a flowering plant in the mint family that grows in woodlands across eastern North America. The part used in herbal medicine is mainly the root and underground stem (rhizome), which is dried and made into teas, tinctures, and capsules.
The plant gets its name from its very hard, stone-like root. Native American and early American herbalists used it for a range of problems, including hemorrhoids, sore throats, and urinary or digestive complaints. Today it is still sold as a dietary supplement, often combined with other herbs.
Uses & effectiveness
People have traditionally used stone root for hemorrhoids, varicose veins, urinary tract and bladder discomfort, kidney stones, indigestion, and sore throat or hoarseness. Singers and public speakers historically used it for vocal strain.
It is important to be honest here: there is very little modern scientific research on stone root. Most of what is known comes from traditional use and old herbal texts, not from well-designed human studies. There is not enough reliable evidence to say it is effective for any specific health condition.
Because the evidence is so limited, stone root should be thought of as an unproven traditional remedy. If you have hemorrhoids, urinary symptoms, or possible kidney stones, see a healthcare professional, since these can have causes that need real medical treatment.
How it works
Stone root contains plant compounds such as tannins, saponins, and aromatic oils. Tannins are astringent, meaning they can tighten and dry tissues, which is the proposed reason it was used for hemorrhoids, irritated throats, and loose tissues.
Herbalists also describe it as having mild diuretic (urine-increasing) and antispasmodic effects. These ideas are based largely on traditional use and basic laboratory observations rather than solid human research, so the way it actually works in the body is not well understood.
Safety & precautions
There is not much published safety information on stone root. Because of this, it should be used cautiously and ideally under the guidance of a pharmacist or doctor.
People with kidney disease, heart problems, or those who are prone to kidney stones should be especially careful and check with a professional first. Pregnant and breastfeeding people should avoid stone root because its safety has not been established. Do not give it to children unless directed by a healthcare provider.
Choose products from reputable companies, since herbal supplements are not tested by the FDA the way medicines are and quality can vary.
Side effects
Because stone root has not been well studied, its full side effect profile is unknown. Possible effects, based on its astringent and aromatic nature, include stomach upset, nausea, or dizziness, especially at higher doses.
Allergic reactions are always possible with herbal products. Stop using it and seek medical care if you develop a rash, swelling, trouble breathing, or other signs of a serious reaction.
Stone Root: Reported Adverse Effects
Documented safety reports on Stone Root from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Reports by conditionNausea and vomiting Gastrointestinal
Orally, large amounts of stone root can cause intestinal tract irritation and colic-like pain dizziness, and nausea.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no established standard dose for stone root. Traditional preparations include teas made from the dried root and alcohol-based tinctures, but reliable dosing guidelines from clinical studies do not exist.
The safest approach is to follow the directions on the product label and not exceed them. Because individual products differ in strength, talk with a pharmacist or doctor before starting, and let them know if you take other medicines or have health conditions.
Stone Root & Pregnancy
Stone Root & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 1 references that drive our Stone Root monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Stone Root
11 brands in our database make a supplement containing Stone Root.
Supplement products with Stone Root
18 products in our database contain Stone Root. Open any to see its full ingredient list and every drug interaction we check.
Stone Root: Common Questions
Does Stone Root interact with prescription medications?
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What is Stone Root used for?
Does Stone Root actually work?
Is Stone Root safe to take?
Can I take Stone Root while pregnant or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Stone Root
A rotating sample of real supplements in our database that list Stone Root — open any to see its full ingredients and every drug interaction we check.
- TG&P-W by Pure Herbs
- Peak #2 by Peak Pure & Natural
- Vein Health by Herb Pharm
- Vein Health by Herb Pharm Professional
- Core Black Radish Blend by Energetix
- TG&P-W by Pure Herbs
- Stone Root Complex by MBi Nutraceuticals
- Gallbladder Formula Extra Strength by Dr. Berg Nutritionals
- Bladder Comfort by Crystal Star
- Vein Health by Herb Pharm
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