Herb & supplement monograph

Stone Root Drug Interactions, Uses, Safety & More

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Interaction report

Drugs that interact with Stone Root

0 medications have a known interaction with Stone Root, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Stone Root. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Stone Root combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Stone Root: Uses, Safety & Side Effects

The bottom line

Stone root is a North American herb traditionally used for hemorrhoids, urinary complaints, and digestive issues. There is very little modern scientific evidence to confirm it works for any of these uses, so it should be viewed as a traditional remedy rather than a proven treatment. Talk with your pharmacist or doctor before trying it, especially if you are pregnant, breastfeeding, or take other medicines.

Stone Root
Scientific name
Collinsonia canadensis
Family
Lamiaceae
Part used
Root and rhizome
Common forms
Tincture, capsules, dried root for tea, liquid extract
People commonly use it for
  • Hemorrhoids
  • Urinary and bladder discomfort
  • Digestive upset
  • Sore throat and hoarseness
  • Kidney stones (traditional)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Little safety data exists, so use with care and under professional guidance.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Stone root comes from Collinsonia canadensis, a flowering plant in the mint family that grows in woodlands across eastern North America. The part used in herbal medicine is mainly the root and underground stem (rhizome), which is dried and made into teas, tinctures, and capsules.

The plant gets its name from its very hard, stone-like root. Native American and early American herbalists used it for a range of problems, including hemorrhoids, sore throats, and urinary or digestive complaints. Today it is still sold as a dietary supplement, often combined with other herbs.

Uses & effectiveness

People have traditionally used stone root for hemorrhoids, varicose veins, urinary tract and bladder discomfort, kidney stones, indigestion, and sore throat or hoarseness. Singers and public speakers historically used it for vocal strain.

It is important to be honest here: there is very little modern scientific research on stone root. Most of what is known comes from traditional use and old herbal texts, not from well-designed human studies. There is not enough reliable evidence to say it is effective for any specific health condition.

Because the evidence is so limited, stone root should be thought of as an unproven traditional remedy. If you have hemorrhoids, urinary symptoms, or possible kidney stones, see a healthcare professional, since these can have causes that need real medical treatment.

How it works

Stone root contains plant compounds such as tannins, saponins, and aromatic oils. Tannins are astringent, meaning they can tighten and dry tissues, which is the proposed reason it was used for hemorrhoids, irritated throats, and loose tissues.

Herbalists also describe it as having mild diuretic (urine-increasing) and antispasmodic effects. These ideas are based largely on traditional use and basic laboratory observations rather than solid human research, so the way it actually works in the body is not well understood.

Safety & precautions

There is not much published safety information on stone root. Because of this, it should be used cautiously and ideally under the guidance of a pharmacist or doctor.

People with kidney disease, heart problems, or those who are prone to kidney stones should be especially careful and check with a professional first. Pregnant and breastfeeding people should avoid stone root because its safety has not been established. Do not give it to children unless directed by a healthcare provider.

Choose products from reputable companies, since herbal supplements are not tested by the FDA the way medicines are and quality can vary.

Side effects

Because stone root has not been well studied, its full side effect profile is unknown. Possible effects, based on its astringent and aromatic nature, include stomach upset, nausea, or dizziness, especially at higher doses.

Allergic reactions are always possible with herbal products. Stop using it and seek medical care if you develop a rash, swelling, trouble breathing, or other signs of a serious reaction.

Stone Root: Reported Adverse Effects

Documented safety reports on Stone Root from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Nausea and vomiting Gastrointestinal

Orally, large amounts of stone root can cause intestinal tract irritation and colic-like pain dizziness, and nausea.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established standard dose for stone root. Traditional preparations include teas made from the dried root and alcohol-based tinctures, but reliable dosing guidelines from clinical studies do not exist.

The safest approach is to follow the directions on the product label and not exceed them. Because individual products differ in strength, talk with a pharmacist or doctor before starting, and let them know if you take other medicines or have health conditions.

Pregnancy & Breastfeeding

Stone Root & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Stone Root & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 references that drive our Stone Root monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Stone Root

18 products in our database contain Stone Root. Open any to see its full ingredient list and every drug interaction we check.

Bladder Comfort by Crystal Star Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Core Black Radish Blend by Energetix Liquid 2 Fluid Ounce(s) · 59.1 mL View ingredients & interactions Gallbladder Formula Extra Strength by Dr. Berg Nutritionals Capsule 90 Capsule(s) View ingredients & interactions Kidney Cleanz by Signature Supplements Capsule 100 Capsule(s) View ingredients & interactions Peak #2 by Peak Pure & Natural Capsule 90 Capsule(s) View ingredients & interactions Stone Root Complex by MBi Nutraceuticals Capsule 90 Capsule(s) View ingredients & interactions TG&P-W by Pure Herbs Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions TG&P-W by Pure Herbs Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions V-Vein Formula by Christopher's Original Formulas Capsule 100 Vegetarian Cap(s) View ingredients & interactions Vein Health by Herb Pharm Professional Liquid 2 fl. Oz. · 60 mL View ingredients & interactions Vein Health by Herb Pharm Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Vein Health by Herb Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Core Black Radish Blend by Energetix Liquid 2 fl. Oz. · 59.1 mL Off market View ingredients & interactions Hem-Care by Enzymatic Therapy Capsule 90 Capsule(s) Off market View ingredients & interactions Stoneroot Blend by Herb Pharm Liquid 1 Fluid Ounce(s) · 29.6 mL Off market View ingredients & interactions Stoneroot Blend by Herb Pharm Liquid 1 fl. Oz. · 30 mL Off market View ingredients & interactions Vein Health by Herb Pharm Liquid 1 fl. Oz. · 30 mL Off market View ingredients & interactions Vein Health by Herb Pharm Liquid 4 fl. Oz. · 120 mL Off market View ingredients & interactions
Pharmacist Counseling Corner

Stone Root: Common Questions

Does Stone Root interact with prescription medications?
We do not currently list any known drug interactions for Stone Root. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Stone Root interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Stone Root with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Stone Root interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Stone Root used for?
It has traditionally been used for hemorrhoids, varicose veins, urinary and bladder discomfort, indigestion, and sore throat or hoarseness. These are traditional uses and are not proven by strong scientific evidence.
Does Stone Root actually work?
There is very little modern research on Stone Root, so there is not enough evidence to say it is effective for any condition. It is best viewed as a traditional remedy rather than a proven treatment.
Is Stone Root safe to take?
Safety data is limited, so it should be used cautiously and ideally with advice from a pharmacist or doctor. People with kidney, heart, or other health conditions should be especially careful.
Can I take Stone Root while pregnant or breastfeeding?
No. Because its safety has not been studied in these situations, it is best to avoid Stone Root during pregnancy and breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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