Interactions on record — worth a quick check against your medications. Based on 5 of 7 ingredients. Check your meds →
Dietary supplement

Gallbladder Formula Extra Strength Ingredients & Drug Interactions

by Dr. Berg Nutritionals

Gallbladder Formula Extra Strength label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gallbladder Formula Extra Strength against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gallbladder Formula Extra Strength is a dietary supplement by Dr. Berg Nutritionals with 7 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 2,050 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Slippery Elm, Black Radish, Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gallbladder Formula Extra Strength by Dr. Berg Nutritionals

Ask about any prescription or over-the-counter medication and we check it for interactions with Gallbladder Formula Extra Strength by Dr. Berg Nutritionals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gallbladder Formula Extra Strength by Dr. Berg Nutritionals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Gallbladder Formula Extra Strength contains 7 active ingredients designed to support digestive function. Betaine hydrochloride increases stomach acid to aid digestion; slippery elm is a mucilage-rich plant traditionally used to soothe the digestive tract; pepsin is a digestive enzyme that breaks down protein; pancreatin 4X provides pancreatic enzymes to help break down fats, proteins, and carbohydrates; oxbile extract supplies bile compounds to assist fat digestion; black radish is a plant used to support bile and gallbladder function; and stone root is included for its traditional digestive support role.

The capsules also contain inactive ingredients: gelatin, silicon dioxide, rice flour, and magnesium stearate.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: gallbladder and liver health support.
  • We looked for evidence on: Biliary disorders, Gallbladder disease, Cholecystitis, Biliary colic, Hepatic function.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Gallbladder disease (Natural Medicines).
  • Also on file: Radish is rated "Insufficient Reliable Evidence To Rate" for Biliary disorders.

The evidence we hold doesn't establish how well this formula works for any condition. Betaine hydrochloride, slippery elm, and black radish all show insufficient reliable evidence for their listed uses — including digestive complaints, constipation, diarrhea, and gallbladder or biliary health.

Pepsin and stone root have no effectiveness ratings in our data. If you're considering this product for a specific digestive concern, talk with your doctor or pharmacist about what evidence supports its use for your situation.

The evidence, ingredient by ingredient Betaine Hydrochloride Slippery Elm Proteolytic Enzymes (proteases) Radish Stone Root

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine hydrochloride is not safe for anyone with ulcers, gastritis, or true acid reflux (GERD), as it irritates the stomach lining and may worsen heartburn. Slippery elm is generally well tolerated for short-term use, though long-term safety data are limited; it can rarely cause contact dermatitis or allergic reactions (including urticaria).

Pepsin is generally well tolerated but may trigger digestive upset or allergic reactions in some people. Black radish at normal food amounts is safe, but concentrated supplements carry less-studied risks; large amounts may irritate the digestive tract.

Stone root has very limited safety data and should be used cautiously. A case of radish allergy with throat tightness and full-body hives has been reported.

During pregnancy, betaine hydrochloride and stone root should be avoided due to insufficient safety data; slippery elm and black radish have cautions but not outright "avoid" ratings, so discuss with your doctor. During breastfeeding, betaine hydrochloride, pepsin, slippery elm, and stone root all lack solid safety data — avoid use without medical guidance.

Side effects, ingredient by ingredient Betaine Hydrochloride Slippery Elm Proteolytic Enzymes (proteases) Radish Stone Root

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — Betaine Hydrochloride, Radish, Slippery Elm.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 2,051 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any of these: antidiabetes drugs (black radish raises the risk of low blood sugar — Moderate), any oral medications in general (slippery elm may slow their absorption — Moderate), H2-blockers or antacids (betaine hydrochloride may reduce their effects — Minor), and proton pump inhibitors or PPIs (betaine hydrochloride may reduce their effects — Minor). If you're on diabetes medication or any regular oral drug, this product needs clearance from your own healthcare provider first.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This formula is designed to support digestive and gallbladder health through digestive enzymes and plant compounds, but the evidence for how well it works isn't established in our data. The biggest concern is that slippery elm can slow how your body absorbs other oral medications, and betaine hydrochloride may reduce the effects of acid-reducing drugs — if you take any medications (especially diabetes or acid-reflux drugs), check them against the tool below before starting.

Anyone with stomach ulcers, gastritis, or reflux should skip this product. Talk with your doctor or pharmacist about whether this formula is right for your needs and whether it's safe to combine with your current medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gallbladder Formula Extra Strength, straight from the product label.

Brand Dr. Berg Nutritionals
Barcode (UPC) X000O8GP5N
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 238795
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gallbladder Formula Extra Strength by Dr. Berg Nutritionals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
X000O8GP5N
IngredientAmount% DV
Betaine Hydrochloride200 mg--
Slippery Elm20 mg--
Pepsin30 mg--
Pancreatin 4X100 mg--
Oxbile extract100 mg--
Black Radish50 mg--
Stone Root50 mg--

Other ingredients: Gelatin, Silicon Dioxide, Rice Flour, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one (1) capsule with meals.

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Keep out of reach of children and do not use if safety seal is damaged or missing.

Keep out of reach of children and do not use if safety seal is damaged or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

To reorder: www.DrBerg.com (800-816-8184) Dr. Berg Approved

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place.

Formulation

Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gallbladder Formula Extra Strength by Dr. Berg Nutritionals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gallbladder Formula Extra Strength label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gallbladder Formula Extra Strength by Dr. Berg Nutritionals

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Betaine Hydrochloride

Interacts with
36 drugs
200 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Slippery Elm

Interacts with
2,022 drugs
20 mg per serving

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated di...

Slippery Elm monograph & interactions

Pepsin

No known
interactions
30 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Pancreatin 4X

100 mg per serving

Oxbile extract

100 mg per serving Form: Cholic Acid

Black Radish

Interacts with
86 drugs
50 mg per serving

Radish is a common edible root vegetable that is nutritious and generally safe to eat as food. Some people use radish (especially black radish) and it...

Black Radish monograph & interactions

Stone Root

No known
interactions
50 mg per serving

Stone root is a North American herb traditionally used for hemorrhoids, urinary complaints, and digestive issues. There is very little modern scientif...

Stone Root monograph & interactions

Other (inactive) ingredients: Gelatin, Silicon Dioxide, Rice Flour, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gallbladder Formula Extra Strength by Dr. Berg Nutritionals Drug Interactions

Want to check YOUR meds against Gallbladder Formula Extra Strength?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,050Drugs
2,050 Moderate

Ingredients driving the most interactions

Slippery Elm 2,022
Black Radish 86
Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in Gallbladder Formula Extra Strength interact with 2,050 drugs. Click any drug to see the details.

3 of the 7 ingredients in Gallbladder Formula Extra Strength interact with drugs. Each result below shows which ingredient is responsible. Slippery Elm Black Radish Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Gallbladder Formula Extra Strength with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Slippery Elm1 drug type · 2,022 drugs

Oral Drugs

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.

Likelihood Possible Evidence D
Slippery Elm full monograph & interactions

Black Radish1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, radish might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that radish extract, juice, and sprouts can reduce glucose levels. Animal research also shows that radish root juice 300 mg/kg reduces fasting and postprandial blood glucose in a rat model of diabetes, with effects similar to glibenclamide.

Likelihood Possible Evidence D
Black Radish full monograph & interactions

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gallbladder Formula Extra Strength, from the product label.

Dr. Berg Nutritionals

See all Dr. Berg Nutritionals products
Name
Dr. Berg Nutritionals
Street Address
4501 Ford Avenue
City
Alexandria
State
VA
ZipCode
22302
Phone Number
800-816-8184
Web Address
www.DrBerg.com
Pharmacist Counseling Corner

Gallbladder Formula Extra Strength by Dr. Berg Nutritionals: Common Questions

Does Gallbladder Formula Extra Strength by Dr. Berg Nutritionals interact with any medications?
Yes. Based on its ingredients, Gallbladder Formula Extra Strength has a known interaction with 2,050 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gallbladder Formula Extra Strength contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have acid reflux?
No — betaine hydrochloride in this formula increases stomach acid and is not safe if you have true acid reflux (GERD), gastritis, or ulcers. Talk with your doctor about whether a different digestive support might work better for you.
Does this product actually work for gallbladder or digestive issues?
The ingredients in this formula — betaine hydrochloride, slippery elm, and black radish — all have insufficient reliable evidence backing them for gallbladder health or digestive complaints. We don't have data showing how well it works. Your doctor or pharmacist can discuss what evidence supports it for your specific concern.
Is this safe during pregnancy or breastfeeding?
Not without medical advice. Betaine hydrochloride and stone root should be avoided during pregnancy; slippery elm and black radish have cautions but lack enough data. During breastfeeding, betaine hydrochloride, pepsin, slippery elm, and stone root are not recommended without your doctor's guidance. Talk with your healthcare provider before using this formula if you're pregnant or nursing.
What exactly is slippery elm doing in here?
Slippery elm is the inner bark of an elm tree — it's rich in a slimy substance called mucilage that's traditionally used to soothe and coat the digestive tract. The evidence for it isn't well established, though, and it may slow how your body absorbs other oral medications.
Why does this have pepsin and pancreatin if it's called a Gallbladder Formula?
Pepsin and pancreatin are digestive enzymes — pepsin breaks down protein in the stomach, and pancreatin provides enzymes from the pancreas to break down fats, proteins, and carbohydrates. They're included to support overall digestive function alongside the bile and gallbladder-focused ingredients.
Can I take this with my diabetes medication?
Not without checking with your doctor first. Black radish in this formula theoretically increases the risk of low blood sugar when taken with antidiabetes drugs — a Moderate interaction. Your doctor or pharmacist needs to clear it with your specific medication and dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gallbladder Formula Extra Strength label
Go deeper

The Full Monographs Behind Gallbladder Formula Extra Strength’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Slippery Elm

Interacts with 2,022 drugs

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...

Read the full Slippery Elm monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Radish

Interacts with 86 drugs

Radish is a common edible root vegetable that is nutritious and generally safe to eat as food. Some people use radish (especially black radish) and its extracts for digestion and liver suppo...

Read the full Radish monograph → Herb & supplement monograph

Stone Root

Stone root is a North American herb traditionally used for hemorrhoids, urinary complaints, and digestive issues. There is very little modern scientific evidence to confirm it works for any...

Read the full Stone Root monograph →
Sources

Sources & How We Checked

Gallbladder Formula Extra Strength's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Slippery Elm 3 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Czarnecki D, Nixon R, Bekhor P, and et al. Delayed prolonged contact urticaria from the elm tree. Contact Dermatitis 1993;28:196-197. PubMed

See these in context on the Slippery Elm monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Radish 5 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Damiani E, Aloia AM, Priore MG, Nardulli S, Ferrannini A. Generalized urticaria after ingestion of Raphanus sativus. Ann Allergy Asthma Immunol. 2011 Feb;106(2):168. PubMed
  3. Evans M, Paterson E, Barnes DM. An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects. BMC Complement Altern Med. 2014 Dec 9;14:475. PubMed
  4. Banihani SA. Radish (Raphanus sativus) and diabetes. Nutrients. 2017;9(9). pii: E1014. PubMed
  5. Shukla S, Chatterji S, Mehta S, Rai PK, Singh RK, Yadav DK, Watal G. Antidiabetic effect of Raphanus sativus root juice. Pharm Biol. 2011 Jan;49(1):32-7.

See these in context on the Radish monograph →

Stone Root 1 reference
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

See these in context on the Stone Root monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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