Animal-assisted Therapy Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Animal-assisted Therapy interacts with medications. The heart of this page is the interaction list — every drug Animal-assisted Therapy is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Animal-assisted Therapy is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Animal-assisted Therapy against your medication
Add one medicationDrugs that interact with Animal-assisted Therapy
0 medications have a known interaction with Animal-assisted Therapy, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Animal-assisted Therapy. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Animal-assisted Therapy combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Animal-assisted Therapy: Uses, Safety & Side Effects
Animal-assisted therapy uses trained animals, guided by professionals, to support emotional and physical well-being. Many people find it comforting and it appears generally low-risk, but high-quality evidence for treating specific medical conditions is still limited. It is best used alongside, not instead of, standard medical care.
- Part used
- Not applicable (this is a therapy, not an herb or supplement)
- Common forms
- Sessions with trained therapy animals such as dogs, horses, cats, or other animals, guided by a handler or health professional
- Anxiety and stress
- Depression and low mood
- Loneliness and social isolation
- Pain and comfort during hospital stays
- Support for children with autism or developmental needs
- Rehabilitation and physical therapy motivation
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally low-risk when supervised, but allergies, infection risk, and animal safety must be considered.
Insufficient reliable information available; however, there is no reason to expect significant safety issues when used appropriately.
Read the full pregnancy detailInsufficient reliable information available; however, there is no reason to expect significant safety issues when used appropriately.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Animal-assisted therapy (AAT) is a structured, goal-directed practice where trained animals help people improve their emotional, social, or physical health. Unlike simply owning a pet, AAT is usually guided by a healthcare provider or trained handler and is built into a treatment plan with specific goals.
The animals most often used are dogs and horses, but cats, rabbits, and other animals are also used. Sessions take place in hospitals, nursing homes, schools, rehabilitation centers, mental health clinics, and sometimes at home.
This is not a supplement, herb, or medicine you take by mouth. Instead, it is a hands-on, relationship-based approach meant to support standard care, not replace it.
How it works
The proposed benefits are thought to come from the calming and rewarding effect of interacting with a friendly animal. Petting or being near an animal may lower feelings of stress and encourage relaxation. Some research suggests these interactions may be linked to lower stress hormone levels and the release of feel-good brain chemicals, though these findings are still being studied.
Animals can also encourage social connection and movement. For example, a person may talk more, smile more, or be more willing to walk or do exercises when a friendly dog is involved. The animal can act as a gentle motivator and a source of comfort.
Because much of this is based on small studies and theory, the exact way AAT works is not fully understood.
Does Animal-assisted Therapy work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Animal-assisted Therapy, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 25 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Attention deficit-hyperactivity disorder (ADHD)
Small clinical studies suggest that animal-assisted therapy (AAT) may modestly improve symptoms in children with ADHD.
Insufficient Reliable Evidence To Rate Autism spectrum disorder
It is unclear if equine-assisted therapy or canine-assisted therapy are beneficial in children with autism spectrum disorder.
Insufficient Reliable Evidence To Rate Back pain
It is unclear if animal-assisted therapy (AAT) is beneficial in low back pain.
Insufficient Reliable Evidence To Rate Cancer-related pain
It is unclear if animal-assisted therapy (AAT) is beneficial for reducing pain associated with cancer in children and adolescents.
Insufficient Reliable Evidence To Rate Cerebral palsy
It is unclear if equine-assisted therapy is beneficial in children with cerebral palsy; some meta-analyses and small clinical studies suggest that it may improve gross motor function, particularly in those with milder forms of the illness.
Insufficient Reliable Evidence To Rate Dementia
It is unclear if animal-assisted therapy (AAT) is beneficial in dementia.
Insufficient Reliable Evidence To Rate Depression
It is unclear if animal-assisted therapy (AAT) is beneficial for reducing symptoms of depression; the available research is inconsistent.
Insufficient Reliable Evidence To Rate Down syndrome
It is unclear if animal-assisted therapy (AAT) is beneficial in children with Down syndrome.
Insufficient Reliable Evidence To Rate Fall prevention
It is unclear if equine-assisted therapy is beneficial in preventing falls.
Insufficient Reliable Evidence To Rate Fetal alcohol spectrum disorders (FASD)
It is unclear if animal-assisted therapy (AAT) is beneficial in children and adolescents with FASD.
Insufficient Reliable Evidence To Rate Fibromyalgia
It is unclear if animal-assisted therapy (AAT) is beneficial in fibromyalgia.
Insufficient Reliable Evidence To Rate Heart failure
It is unclear if animal-assisted therapy (AAT) is beneficial in heart failure.
Insufficient Reliable Evidence To Rate Intellectual disability
It is unclear if animal-assisted therapy (AAT) is beneficial in children with mild intellectual disability.
Insufficient Reliable Evidence To Rate Multiple sclerosis (MS)
It is unclear if animal-assisted therapy (AAT) is beneficial in MS.
Insufficient Reliable Evidence To Rate Post-traumatic stress disorder (PTSD)
It is unclear if animal-assisted therapy (AAT) is beneficial for PTSD.
Insufficient Reliable Evidence To Rate Postoperative pain
Small clinical studies suggest that canine-assisted therapy might be modestly beneficial for reducing postoperative pain in children or adults.
Insufficient Reliable Evidence To Rate Psychological well-being
It is unclear if animal-assisted therapy (AAT) is beneficial for improving psychological well-being in elderly individuals in long-term care; the available research is conflicting.
Insufficient Reliable Evidence To Rate Schizophrenia
It is unclear if animal-assisted therapy (AAT) is beneficial in schizophrenia.
Insufficient Reliable Evidence To Rate Scleroderma
It is unclear if animal-assisted therapy (AAT) is beneficial in scleroderma.
Insufficient Reliable Evidence To Rate Scoliosis
It is unclear if animal-assisted therapy (AAT) is beneficial for scoliosis.
Insufficient Reliable Evidence To Rate Social anxiety disorder
It is unclear if animal-assisted therapy (AAT) improves social anxiety disorder.
Insufficient Reliable Evidence To Rate Spinal cord injury
It is unclear if animal-assisted therapy (AAT) is beneficial in spinal cord injury.
Insufficient Reliable Evidence To Rate Stress
It is unclear if animal-assisted therapy (AAT) is beneficial in reducing stress.
Insufficient Reliable Evidence To Rate Stroke
Some clinical studies suggest that animal-assisted therapy may improve recovery post-stroke.
Insufficient Reliable Evidence To Rate Traumatic brain injury (TBI)
It is unclear if animal-assisted therapy (AAT) improves recovery after TBI.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Animal-assisted therapy is generally considered low-risk when it is done with trained animals and supervised handlers. Still, there are some safety points to keep in mind.
People with animal allergies, asthma, weakened immune systems, or open wounds should use caution, since animals can trigger allergies or carry germs. Good hand-washing and proper screening of the animals help reduce infection risk. There is also a small chance of bites, scratches, or falls, especially with larger animals.
During pregnancy and breastfeeding, AAT is usually fine, but extra care should be taken around certain animals that may carry infections. Always follow good hygiene and talk with your doctor first. Children, older adults, and people who are fearful of animals should be supervised closely.
Side effects
Most people tolerate animal-assisted therapy well. The most common problems are allergic reactions (sneezing, itchy eyes, skin rash) and minor issues such as scratches or being knocked over by an excited animal.
Less commonly, there is a risk of infection from animal contact, particularly in people with weakened immune systems. Some people may also feel anxious or uncomfortable if they are afraid of animals.
Serious harm is rare when sessions are properly supervised and the animals are health-screened and well-trained.
Animal-assisted Therapy: Reported Adverse Effects
Documented safety reports on Animal-assisted Therapy from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Animal-assisted therapy (AAT) is generally well tolerated, with few adverse effects reported. However, a thorough evaluation of safety outcomes has not been conducted.
Serious Adverse Effects (Rare):
Transmission of zoonotic diseases to patients, particularly those prone to infection. With equine therapy, falling and low back pain.
Back pain Musculoskeletal
AAT involving horseback riding has rarely resulted in falling and low back pain aggravation.
- Kwon JY, Chang HJ, Yi SH, Lee JY, Shin HY, Kim YH. Effect of hippotherapy on gross motor function in children with cerebral palsy: a randomized controlled trial. J Altern Complement Med. 2015;21(1):15-21.
- Jang B, Song J, Kim J, et al. Equine-assisted activities and therapy for treating children with attention-deficit/hyperactivity disorder. J Altern Complement Med. 2015;21(9):546-53.
- Vermöhlen V, Schiller P, Schickendantz S, et al. Hippotherapy for patients with multiple sclerosis: A multicenter randomized controlled trial (MS-HIPPO). Mult Scler. 2018;24(10):1375-1382.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no standard dose for animal-assisted therapy. The number, length, and frequency of sessions are usually tailored to the person and their goals by the therapist or program running it.
If you are interested in AAT, ask about programs run through reputable hospitals, clinics, or certified therapy-animal organizations. A pharmacist or doctor can help you decide if it is a reasonable addition to your care, especially if you have allergies or a weakened immune system.
Animal-assisted Therapy & Pregnancy
Animal-assisted Therapy & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 3 references that drive our Animal-assisted Therapy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Kwon JY, Chang HJ, Yi SH, Lee JY, Shin HY, Kim YH. Effect of hippotherapy on gross motor function in children with cerebral palsy: a randomized controlled trial. J Altern Complement Med. 2015;21(1):15-21. PubMed
- Jang B, Song J, Kim J, et al. Equine-assisted activities and therapy for treating children with attention-deficit/hyperactivity disorder. J Altern Complement Med. 2015;21(9):546-53. PubMed
- Vermöhlen V, Schiller P, Schickendantz S, et al. Hippotherapy for patients with multiple sclerosis: A multicenter randomized controlled trial (MS-HIPPO). Mult Scler. 2018;24(10):1375-1382. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Animal-assisted Therapy: Common Questions
What is Animal-assisted Therapy used for, and does it work?
Does Animal-assisted Therapy interact with prescription medications?
How are Animal-assisted Therapy interactions rated?
Is it safe to take Animal-assisted Therapy with my medications?
Where does this Animal-assisted Therapy interaction information come from?
What is Animal-assisted Therapy used for?
Is Animal-assisted Therapy safe?
Is it different from having a pet?
Can it cure anxiety or depression?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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