Herb & supplement monograph

Animal-assisted Therapy Drug Interactions, Uses, Effectiveness, Safety & More

Check Animal-assisted Therapy against your medication

Add one medication
Animal-assisted Therapy
+
Start typing any prescription or over-the-counter drug name.
Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Animal-assisted Therapy

0 medications have a known interaction with Animal-assisted Therapy, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Animal-assisted Therapy. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Animal-assisted Therapy combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Animal-assisted Therapy: Uses, Safety & Side Effects

The bottom line

Animal-assisted therapy uses trained animals, guided by professionals, to support emotional and physical well-being. Many people find it comforting and it appears generally low-risk, but high-quality evidence for treating specific medical conditions is still limited. It is best used alongside, not instead of, standard medical care.

Part used
Not applicable (this is a therapy, not an herb or supplement)
Common forms
Sessions with trained therapy animals such as dogs, horses, cats, or other animals, guided by a handler or health professional
People commonly use it for
  • Anxiety and stress
  • Depression and low mood
  • Loneliness and social isolation
  • Pain and comfort during hospital stays
  • Support for children with autism or developmental needs
  • Rehabilitation and physical therapy motivation

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally low-risk when supervised, but allergies, infection risk, and animal safety must be considered.

PregnancyInsufficient reliable information

Insufficient reliable information available; however, there is no reason to expect significant safety issues when used appropriately.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; however, there is no reason to expect significant safety issues when used appropriately.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Animal-assisted therapy (AAT) is a structured, goal-directed practice where trained animals help people improve their emotional, social, or physical health. Unlike simply owning a pet, AAT is usually guided by a healthcare provider or trained handler and is built into a treatment plan with specific goals.

The animals most often used are dogs and horses, but cats, rabbits, and other animals are also used. Sessions take place in hospitals, nursing homes, schools, rehabilitation centers, mental health clinics, and sometimes at home.

This is not a supplement, herb, or medicine you take by mouth. Instead, it is a hands-on, relationship-based approach meant to support standard care, not replace it.

How it works

The proposed benefits are thought to come from the calming and rewarding effect of interacting with a friendly animal. Petting or being near an animal may lower feelings of stress and encourage relaxation. Some research suggests these interactions may be linked to lower stress hormone levels and the release of feel-good brain chemicals, though these findings are still being studied.

Animals can also encourage social connection and movement. For example, a person may talk more, smile more, or be more willing to walk or do exercises when a friendly dog is involved. The animal can act as a gentle motivator and a source of comfort.

Because much of this is based on small studies and theory, the exact way AAT works is not fully understood.

Effectiveness

Does Animal-assisted Therapy work?

Evidence overview · 25 uses evaluated
25 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Animal-assisted Therapy, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 25 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Attention deficit-hyperactivity disorder (ADHD)
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that animal-assisted therapy (AAT) may modestly improve symptoms in children with ADHD.

Insufficient Reliable Evidence To Rate Autism spectrum disorder
Rating & evidence shown verbatim from Natural Medicines

It is unclear if equine-assisted therapy or canine-assisted therapy are beneficial in children with autism spectrum disorder.

Insufficient Reliable Evidence To Rate Back pain
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial in low back pain.

Insufficient Reliable Evidence To Rate Cancer-related pain
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial for reducing pain associated with cancer in children and adolescents.

Insufficient Reliable Evidence To Rate Cerebral palsy
Rating & evidence shown verbatim from Natural Medicines

It is unclear if equine-assisted therapy is beneficial in children with cerebral palsy; some meta-analyses and small clinical studies suggest that it may improve gross motor function, particularly in those with milder forms of the illness.

Insufficient Reliable Evidence To Rate Dementia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial in dementia.

Insufficient Reliable Evidence To Rate Depression
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial for reducing symptoms of depression; the available research is inconsistent.

Insufficient Reliable Evidence To Rate Down syndrome
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial in children with Down syndrome.

Insufficient Reliable Evidence To Rate Fall prevention
Rating & evidence shown verbatim from Natural Medicines

It is unclear if equine-assisted therapy is beneficial in preventing falls.

Insufficient Reliable Evidence To Rate Fetal alcohol spectrum disorders (FASD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial in children and adolescents with FASD.

Insufficient Reliable Evidence To Rate Fibromyalgia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial in fibromyalgia.

Insufficient Reliable Evidence To Rate Heart failure
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial in heart failure.

Insufficient Reliable Evidence To Rate Intellectual disability
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial in children with mild intellectual disability.

Insufficient Reliable Evidence To Rate Multiple sclerosis (MS)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial in MS.

Insufficient Reliable Evidence To Rate Post-traumatic stress disorder (PTSD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial for PTSD.

Insufficient Reliable Evidence To Rate Postoperative pain
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that canine-assisted therapy might be modestly beneficial for reducing postoperative pain in children or adults.

Insufficient Reliable Evidence To Rate Psychological well-being
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial for improving psychological well-being in elderly individuals in long-term care; the available research is conflicting.

Insufficient Reliable Evidence To Rate Schizophrenia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial in schizophrenia.

Insufficient Reliable Evidence To Rate Scleroderma
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial in scleroderma.

Insufficient Reliable Evidence To Rate Scoliosis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial for scoliosis.

Insufficient Reliable Evidence To Rate Social anxiety disorder
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) improves social anxiety disorder.

Insufficient Reliable Evidence To Rate Spinal cord injury
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial in spinal cord injury.

Insufficient Reliable Evidence To Rate Stress
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) is beneficial in reducing stress.

Insufficient Reliable Evidence To Rate Stroke
Rating & evidence shown verbatim from Natural Medicines

Some clinical studies suggest that animal-assisted therapy may improve recovery post-stroke.

Insufficient Reliable Evidence To Rate Traumatic brain injury (TBI)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if animal-assisted therapy (AAT) improves recovery after TBI.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Animal-assisted therapy is generally considered low-risk when it is done with trained animals and supervised handlers. Still, there are some safety points to keep in mind.

People with animal allergies, asthma, weakened immune systems, or open wounds should use caution, since animals can trigger allergies or carry germs. Good hand-washing and proper screening of the animals help reduce infection risk. There is also a small chance of bites, scratches, or falls, especially with larger animals.

During pregnancy and breastfeeding, AAT is usually fine, but extra care should be taken around certain animals that may carry infections. Always follow good hygiene and talk with your doctor first. Children, older adults, and people who are fearful of animals should be supervised closely.

Side effects

Most people tolerate animal-assisted therapy well. The most common problems are allergic reactions (sneezing, itchy eyes, skin rash) and minor issues such as scratches or being knocked over by an excited animal.

Less commonly, there is a risk of infection from animal contact, particularly in people with weakened immune systems. Some people may also feel anxious or uncomfortable if they are afraid of animals.

Serious harm is rare when sessions are properly supervised and the animals are health-screened and well-trained.

Animal-assisted Therapy: Reported Adverse Effects

Documented safety reports on Animal-assisted Therapy from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Animal-assisted therapy (AAT) is generally well tolerated, with few adverse effects reported. However, a thorough evaluation of safety outcomes has not been conducted.

Serious Adverse Effects (Rare):

Transmission of zoonotic diseases to patients, particularly those prone to infection. With equine therapy, falling and low back pain.

Reports by condition
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no standard dose for animal-assisted therapy. The number, length, and frequency of sessions are usually tailored to the person and their goals by the therapist or program running it.

If you are interested in AAT, ask about programs run through reputable hospitals, clinics, or certified therapy-animal organizations. A pharmacist or doctor can help you decide if it is a reasonable addition to your care, especially if you have allergies or a weakened immune system.

Pregnancy & Breastfeeding

Animal-assisted Therapy & Pregnancy

Insufficient reliable information

Insufficient reliable information available; however, there is no reason to expect significant safety issues when used appropriately.

Animal-assisted Therapy & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; however, there is no reason to expect significant safety issues when used appropriately.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 3 references that drive our Animal-assisted Therapy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kwon JY, Chang HJ, Yi SH, Lee JY, Shin HY, Kim YH. Effect of hippotherapy on gross motor function in children with cerebral palsy: a randomized controlled trial. J Altern Complement Med. 2015;21(1):15-21. PubMed
  2. Jang B, Song J, Kim J, et al. Equine-assisted activities and therapy for treating children with attention-deficit/hyperactivity disorder. J Altern Complement Med. 2015;21(9):546-53. PubMed
  3. Vermöhlen V, Schiller P, Schickendantz S, et al. Hippotherapy for patients with multiple sclerosis: A multicenter randomized controlled trial (MS-HIPPO). Mult Scler. 2018;24(10):1375-1382. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Animal-assisted Therapy: Common Questions

What is Animal-assisted Therapy used for, and does it work?
People use Animal-assisted Therapy for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Animal-assisted Therapy interact with prescription medications?
We do not currently list any known drug interactions for Animal-assisted Therapy. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Animal-assisted Therapy interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Animal-assisted Therapy with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Animal-assisted Therapy interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Animal-assisted Therapy used for?
It is commonly used to help reduce stress, anxiety, and loneliness, lift mood, provide comfort during hospital stays, and support people during rehabilitation. It is meant to support standard care, not replace it.
Is Animal-assisted Therapy safe?
For most people it is low-risk when supervised by trained handlers with health-screened animals. People with animal allergies, asthma, weakened immune systems, or a fear of animals should use extra caution.
Is it different from having a pet?
Yes. Animal-assisted Therapy is a structured, goal-directed program guided by a professional, while having a pet is simply personal companionship. Both can be comforting, but AAT is part of a planned approach to care.
Can it cure anxiety or depression?
No. While many people feel calmer and happier after sessions, the evidence does not show it cures any condition. It is best used alongside treatments recommended by your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Have a question about Animal-assisted Therapy?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist