Herb & supplement monograph

Angelica Archangelica Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Angelica Archangelica interacts with medications. The heart of this page is the interaction list — every drug Angelica Archangelica is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Angelica Archangelica is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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On this page

Angelica Archangelica Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Angelica Archangelica drug interaction appears low for most people, with sun sensitivity being the one concern worth knowing about. None of the listed interactions are rated major, and every one traces back to a single moderate concern that is only possibly documented in humans.

Interactions deserving the most attention

The interactions that deserve attention all involve photosensitizing drugs, medications that make skin more reactive to sunlight, such as the antibiotic doxycycline. Angelica archangelica itself, whether swallowed or applied to the skin, may increase sensitivity to the sun, so pairing it with these medications could raise the chance of a sunburn-like skin reaction. People taking these medicines who also use this supplement should be careful about prolonged time in the sun.

What the rest of the list means

Although the list of interacting medications looks long, it reflects one shared concern repeated across many drugs rather than hundreds of separate problems. The evidence behind it is limited, coming mainly from lab research or scattered reports, so the added sun-sensitivity effect is a sensible precaution rather than a proven harm for every combination.

Check your medications against Angelica Archangelica

Based on HelloPharmacist’s Angelica Archangelica interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Angelica Archangelica

335 medications have a known interaction with Angelica Archangelica, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcepromazineAtravet
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acepromazine interaction
Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Brompheniramine, Phenylpropanolamine interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Chlorpheniramine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interaction
Acetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Chlorpheniramine, Pseudoephedrine interaction
Acetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interaction
Acetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Diphenhydramine interaction
Acetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Diphenhydramine, Pseudoephedrine interaction
Acetaminophen, IbuprofenCombogesic
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Ibuprofen interaction
Acetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetaminophen, Phenylephrine, Chlorpheniramine interaction
AcetazolamideAk-Zol, Diamox
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetazolamide interaction Acetazolamide drug page: uses, dosage & side effects
AcetohexamideDymelor
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acetohexamide interaction
AcitretinSoriatane
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Acitretin interaction Acitretin drug page: uses, dosage & side effects
Alectinib HydrochlorideAlecensa
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Alectinib Hydrochloride interaction Alectinib Hydrochloride drug page: uses, dosage & side effects
AlitretinoinPanretin
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Alitretinoin interaction Alitretinoin drug page: uses, dosage & side effects
Amiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Amiloride, Hydrochlorothiazide interaction Amiloride, Hydrochlorothiazide drug page: uses, dosage & side effects
Aminolevulinic Acid HydrochlorideAmeluz, Gleolan
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Aminolevulinic Acid Hydrochloride interaction
AmiodaroneCordarone, Pacerone
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Amiodarone interaction Amiodarone drug page: uses, dosage & side effects
AmitriptylineElavil
Moderate Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full Angelica Archangelica + Amitriptyline interaction Amitriptyline drug page: uses, dosage & side effects
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Angelica Archangelica combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Angelica Archangelica affects

Every type of medication (drug category) Angelica Archangelica is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Angelica Archangelica interacts with
Photosensitizing Drugs
Photosensitizing Drugs

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions. It is advised that patients using Angelica archangelica in any form should avoid prolonged exposure to sunlight. When combined with photosensitizing drugs like doxycycline, there is an elevated risk of photosensitivity reactions. Patients should be cautioned to take appropriate sun protection measures and monitor for any signs of skin irritation or photosensitivity when using these substances concomitantly. (Source: https://pubmed.ncbi.nlm.nih.gov/10630112/)

Likelihood Possible Evidence C
Monograph

Angelica Archangelica: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Angelica archangelica is a tall aromatic herb used traditionally for digestive complaints, poor appetite, and to flavor foods and liqueurs. Solid human evidence for its health benefits is limited, and its skin-sensitizing furanocoumarins mean caution is warranted. Pregnant and breastfeeding people should avoid it, and anyone considering it should check with a pharmacist or doctor first.

Angelica Archangelica
Scientific name
Angelica archangelica
Family
Apiaceae (Umbelliferae)
Part used
Root, seeds (fruit), leaves, and essential oil
Common forms
Tea, dried root, tincture, capsules, essential oil, and as a flavoring in liqueurs
People commonly use it for
  • Digestive upset and gas
  • Loss of appetite
  • Anxiety and restlessness
  • Mild respiratory complaints
  • Flavoring in foods and drinks

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Often used in food amounts, but medicinal doses are not well studied and can cause skin sensitivity to sunlight.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Angelica archangelica is a tall, aromatic plant in the carrot and parsley family (Apiaceae). It can grow several feet high and has large leaves and clusters of small greenish-white flowers. It is native to cool, damp regions of northern and eastern Europe, including areas around the North and Baltic Seas, and is also grown in gardens elsewhere.

People have used many parts of the plant — the root, seeds, leaves, and the essential oil pressed from it. It has a long history in European folk medicine and in cooking. The candied stems are used in baking, and the plant is a classic flavoring in herbal liqueurs and bitters such as gin and certain digestive drinks.

Note that several different plants share the name "Angelica." The Chinese herb Dang Gui (Angelica sinensis) and Du Huo (Angelica pubescens) are different species with different traditional uses, even though they are sometimes listed under the same common names.

How it works

The plant contains a mix of natural compounds, including essential oils, plant sterols, flavonoids, caffeic acid derivatives, and a group of compounds called furanocoumarins (such as imperatorin and angelicin). These furanocoumarins are partly responsible for both its aroma and some of its effects on the body.

In laboratory studies, extracts have shown antioxidant and antimicrobial activity, and some compounds appear to relax smooth muscle, which could explain the traditional use for digestive cramping. Other research has explored possible effects on the nervous system and mood.

It is important to remember that these mechanisms are mostly based on test-tube and animal studies. They suggest how the herb might work but do not confirm meaningful benefits in humans.

Effectiveness

Does Angelica Archangelica work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 12 uses evaluated
12 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Angelica Archangelica, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 12 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Amenorrhea
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Angelica archangelica for amenorrhea, there is insufficient reliable information about the clinical effects of Angelica archangelica for this condition.

Insufficient Reliable Evidence To Rate Anxiety
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Angelica archangelica for anxiety, there is insufficient reliable information about the clinical effects of Angelica archangelica for this condition.

Insufficient Reliable Evidence To Rate Cognitive impairment
Rating & evidence shown verbatim from Natural Medicines

Oral Angelica archangelica has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Cough
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Angelica archangelica for cough, there is insufficient reliable information about the clinical effects of Angelica archangelica for this condition.

Insufficient Reliable Evidence To Rate Dementia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Angelica archangelica for dementia, there is insufficient reliable information about the clinical effects of Angelica archangelica for this condition.

Insufficient Reliable Evidence To Rate Dyspepsia
Rating & evidence shown verbatim from Natural Medicines

Oral Angelica archangelica has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Flatulence
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Angelica archangelica for flatulence, there is insufficient reliable information about the clinical effects of Angelica archangelica for this purpose.

Insufficient Reliable Evidence To Rate Insomnia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Angelica archangelica for insomnia, there is insufficient reliable information about the clinical effects of Angelica archangelica for this condition.

Insufficient Reliable Evidence To Rate Nocturia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Angelica archangelica is beneficial in patients with nocturia.

Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Angelica archangelica for RA, there is insufficient reliable information about the clinical effects of Angelica archangelica for this condition.

Insufficient Reliable Evidence To Rate Smoking cessation
Rating & evidence shown verbatim from Natural Medicines

It is unclear if inhaling the aroma of Angelica archangelica root essential oil is beneficial for people wanting to stop use of tobacco.

Insufficient Reliable Evidence To Rate Stroke
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral Angelica archangelica for stroke, there is insufficient reliable information about the clinical effects of Angelica archangelica for this condition.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Used in small amounts as a food or flavoring, Angelica archangelica is generally considered safe and has GRAS (Generally Recognized as Safe) status in the United States. Larger medicinal doses are far less studied.

The furanocoumarins in the plant can make your skin more sensitive to sunlight (a reaction called photosensitivity), which may lead to rashes or sunburn-like reactions. People with sensitive skin should be especially careful, and direct skin contact with the fresh plant or oil can cause irritation.

People who are pregnant should avoid medicinal use, since the herb has traditionally been thought to stimulate the uterus and its safety is not established. Those who are breastfeeding should also avoid it because of a lack of safety data. Use caution if you have a bleeding disorder, are scheduled for surgery, or are allergic to plants in the carrot/celery family (Apiaceae). When in doubt, check with a pharmacist or doctor before using.

Side effects

When used in usual food amounts, side effects are uncommon. With larger or concentrated forms, the most notable concern is increased sensitivity to sunlight, which can cause skin redness, rash, or sunburn-like reactions on exposed skin.

Other possible effects include skin irritation from direct contact, mild stomach upset, and allergic reactions, especially in people allergic to related plants like celery, carrot, or parsley. If you develop a rash, swelling, trouble breathing, or other signs of an allergic reaction, stop using it and seek medical care.

Angelica Archangelica: Reported Adverse Effects

Documented safety reports on Angelica Archangelica from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, Angelica archangelica is generally well tolerated in food amounts. There is limited information available about the adverse effects of Angelica archangelica when used as medicine.

Most Common Adverse Effects:

Orally: Constipation, photosensitivity.

Reports by condition
Constipation Gastrointestinal

Orally, Angelica archangelica has been reported to cause constipation in one out of 21 patients taking a specific Angelica archangelica leaf extract (SagaPro, SagaMedica).

  1. Sigurdsson S, Geirsson G, Gudmundsdottir H, Egilsdottir PB, Gudbjarnason S. A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men. Scand J Urol. 2013;47(1):26-32.
Dermatitis Dermatologic

Orally or topically, Angelica archangelica might cause photosensitivity reactions. Patients who take Angelica archangelica orally or apply it topically should be advised to avoid prolonged exposure to the sun. Some constituents of the leaves have a strong irritant effect on the skin and mucous membranes, referred to as "angelica dermatitis".

  1. Ojala T, Vuorela P, Kiviranta J, et al. A bioassay using Artemia salina for detecting phototoxicity of plant coumarins. Planta Med 1999;65:715-8.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established standardized dose for Angelica archangelica. Traditional preparations include teas made from the dried root or seeds, tinctures, and capsules, but the amount of active compounds can vary widely between products.

Because reliable dosing guidelines are lacking, the safest approach is to follow the directions on the product label and not exceed them. Talk with a pharmacist or doctor before starting, especially if you take other medicines or have a health condition. Avoid combining it with strong sun exposure or tanning.

Pregnancy & Breastfeeding

Angelica Archangelica & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Angelica Archangelica & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 3 references that drive our Angelica Archangelica monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Ojala T, Vuorela P, Kiviranta J, et al. A bioassay using Artemia salina for detecting phototoxicity of plant coumarins. Planta Med 1999;65:715-8. PubMed
  3. Sigurdsson S, Geirsson G, Gudmundsdottir H, Egilsdottir PB, Gudbjarnason S. A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men. Scand J Urol. 2013;47(1):26-32. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Angelica Archangelica: Common Questions

What is Angelica Archangelica used for, and does it work?
People use Angelica Archangelica for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Angelica Archangelica interact with prescription medications?
Yes. We list 335 medications with a known interaction with Angelica Archangelica. Use the checker above to see how Angelica Archangelica interacts with a specific drug.
How are Angelica Archangelica interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Angelica Archangelica with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Angelica Archangelica interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Angelica Archangelica used for?
It is traditionally used for digestive complaints like gas, bloating, and poor appetite, and as a flavoring in foods and liqueurs. Strong human evidence for treating any specific condition is limited.
Is Angelica Archangelica safe to take?
In small food amounts it is generally considered safe, but medicinal doses are not well studied and can make your skin more sensitive to sunlight. Check with a pharmacist or doctor before using it as a supplement.
Can I use it during pregnancy or while breastfeeding?
No — it is best to avoid medicinal amounts during pregnancy and breastfeeding because it may affect the uterus and there is not enough safety data.
Is Angelica Archangelica the same as Dong Quai (Dang Gui)?
No. Dong Quai is Angelica sinensis, a different species used mainly in Traditional Chinese Medicine. They share the Angelica name but are distinct plants with different uses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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