Drug & supplement interaction

Angelica Archangelica + Azithromycin

Azithromycin brand names: Zithromax, Zmax, Azasite.

Moderate Interaction
Medically reviewed by · Updated February 2024
The bottom line Moderate

Angelica Archangelica has a moderate interaction with Azithromycin. Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

Angelica Archangelica and Azithromycin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

Photosensitizing Drugs

Why this applies to Azithromycin

Azithromycin falls under Photosensitizing Drugs — the group Angelica Archangelica interacts with.

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions. It is advised that patients using Angelica archangelica in any form should avoid prolonged exposure to sunlight. When combined with photosensitizing drugs like doxycycline, there is an elevated risk of photosensitivity reactions. Patients should be cautioned to take appropriate sun protection measures and monitor for any signs of skin irritation or photosensitivity when using these substances concomitantly. (Source: https://pubmed.ncbi.nlm.nih.gov/10630112/)
Severity Moderate Likelihood Possible Evidence C

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know about combining Angelica archangelica with azithromycin. This isn't about your liver breaking the drug down faster or slower, and azithromycin is not a prodrug, so the antibiotic will still do its job fighting the infection. Instead, the concern is your skin. Angelica contains natural compounds called furanocoumarins that can make your skin more sensitive to sunlight, and azithromycin can do the same thing on its own.

Stacked together, you may sunburn more easily or notice redness, irritation, or a rash on sun-exposed skin. This is a possible reaction, not a guaranteed one, but it's easy to prevent: wear sunscreen, cover up, and limit long stretches in strong sun. If your skin reacts or you have questions, check with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Angelica Archangelica Also Interacts With Other Medications

Angelica Archangelica has 334 moderate known drug interactions in our database — the Azithromycin one above is one of them. If you take anything else, check it against the full list below.

Moderate 334 No known interaction 2,496 (incl. Azithromycin)
Taking anything else?

Check Another of Your Medications Against Angelica Archangelica

Covers the 2,830 medications we’ve checked against Angelica Archangelica. Pick one to open its full report.

From our Q&A

Questions About Angelica Archangelica or Azithromycin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Angelica Archangelica or Azithromycin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Azithromycin

This page covers Angelica Archangelica only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Azithromycin page lists 92 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 71 moderate · 13 minor.

From our pharmacist’s overview on the Azithromycin page

“A five-day Z-Pak for a sinus or chest infection seems too brief to fuss over, but azithromycin (Zithromax, Zmax) deserves genuine caution around supplements, and the eight major-rated entries on this list are the ones to understand first. Most of those involve the heart.”

Reviewed by 2 · Jul 18, 2026

Open the Azithromycin interaction page

How much people look this up

Where Angelica Archangelica and Azithromycin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Angelica Archangelica
Steady interest

#1,313 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Azithromycin
Top 5%

#38 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Angelica Archangelica

What is Angelica Archangelica?

Angelica Archangelica
  • Digestive upset and gas
  • Loss of appetite
  • Anxiety and restlessness
  • Mild respiratory complaints
  • Flavoring in foods and drinks

Angelica archangelica is a tall aromatic herb used traditionally for digestive complaints, poor appetite, and to flavor foods and liqueurs. Solid human evidence for its health benefits is limited, and its skin-sensitizing furanocoumarins mean caution is warranted. Pregnant and breastfeeding people should avoid it, and anyone considering it should check with a pharmacist or doctor first.

Read the full Angelica Archangelica monograph & all interactions
Medication

About Azithromycin

What Is Azithromycin Used For?

Brand names: Zithromax, Zmax, Azasite

Azithromycin treats mild to moderate infections caused by susceptible bacteria. Oral tablets and oral suspension are used for several infection types in adults and, for some, children.

Oral uses include acute bacterial flare-ups of chronic bronchitis, acute bacterial sinusitis, uncomplicated skin infections, urethritis and cervicitis, genital ulcer disease in men, ear infections (acute otitis media) in children, community-acquired pneumonia, and pharyngitis/tonsillitis. The injection (Zithromax and azithromycin for injection) is used for community-acquired pneumonia in adults and pelvic inflammatory disease. AzaSite eye drops are used only for bacterial conjunctivitis (pink eye).

See full Azithromycin drug information
Keep checking

Other Drugs & Angelica Archangelica

Browse every other medication we’ve checked against Angelica Archangelica — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
334Moderate
0Minor
2,495No known interaction
334 Moderate 2,495 No interaction
Moderate

334 interactions

Showing 60 of 334 moderate interactions — see all 334 on the Angelica Archangelica page.

No interaction 2,495 drugs checked — show the list

We also checked Angelica Archangelica against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,495 medications checked with no known interaction — see the full Angelica Archangelica list.

See the full Angelica Archangelica interactions page
See every supplement checked against Azithromycin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Angelica Archangelica monograph › Uses, safety, and every drug interaction in one place Azithromycin supplement interactions › Every supplement checked against Azithromycin, ranked by severity Azithromycin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Angelica Archangelica and Azithromycin Together: Common Questions

Can you take Angelica Archangelica with Azithromycin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Angelica Archangelica and Azithromycin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Azithromycin and Angelica Archangelica?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.