Drug & supplement interaction

Angelica Archangelica + Methylphenidate

Methylphenidate brand names: Ritalin, Ritalin-SR, Concerta, Methylin, Metadate, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Angelica Archangelica and Methylphenidate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Angelica Archangelica and Methylphenidate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methylphenidate and Angelica Archangelica in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Angelica Archangelica safety at a glance

Angelica Archangel... overall Use caution Often used in food amounts, but medicinal doses are not well studied and can cause skin sensitivity to sunlight.
Pregnancy Avoid Traditionally thought to affect the uterus and not well studied; best avoided in medicinal amounts.
Breastfeeding Avoid Not enough safety data, so avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methylphenidate and Angelica Archangelica? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Methylphenidate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Methylphenidate is filed under 6 classifications — including stimulant drugs, serotonergic drugs, serotonergic drugs. Angelica Archangelica has documented interactions with 1 drug class — the most serious being photosensitizing drugs (moderate) — and none of Methylphenidate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Angelica Archangelica Does Interact With Other Medications

Angelica Archangelica has 335 moderate known drug interactions in our database — Methylphenidate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 335 No known interaction 2,495 (incl. Methylphenidate)
Taking anything else?

Check Another of Your Medications Against Angelica Archangelica

Covers the 2,830 medications we’ve checked against Angelica Archangelica. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Angelica Archangelica and Methylphenidate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Constipation Additional detail

    Angelica Archangelica

    “Orally, Angelica archangelica has been reported to cause constipation in one out of 21 patients taking a specific Angelica archangelica leaf extract (SagaPro, SagaMedica).”

    Angelica Archangelica · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 92461. Sigurdsson S, Geirsson G, Gudmundsdottir H, Egilsdottir PB, Gudbjarnason S. A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men. Scand J Urol. 2013;47(1):26-32. PubMed

    Methylphenidate

    Listed in the ADVERSE REACTIONS section of the FDA label for Methylphenidate. Read the label on DailyMed ›

  • A skin rash Additional detail

    Angelica Archangelica

    “Orally or topically, Angelica archangelica might cause photosensitivity reactions. Patients who take Angelica archangelica orally or apply it topically should be advised to avoid prolonged exposure to the sun. Some constituents of the leaves have a strong irritant effect on the skin and mucous membranes, referred to as "angelica dermatitis" (18).”

    Angelica Archangelica · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 13406. Ojala T, Vuorela P, Kiviranta J, et al. A bioassay using Artemia salina for detecting phototoxicity of plant coumarins. Planta Med 1999;65:715-8. PubMed
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Methylphenidate

    Listed in the ADVERSE REACTIONS section of the FDA label for Methylphenidate. Read the label on DailyMed ›

Reported for Angelica Archangelica but not commonly for Methylphenidate: sun sensitivity.

Effects for Methylphenidate come from the ADVERSE REACTIONS section of its FDA label; effects for Angelica Archangelica come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 73,541 voluntary FDA FAERS reports for Methylphenidate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Angelica Archangelica or Methylphenidate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Angelica Archangelica or Methylphenidate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Methylphenidate

This page covers Angelica Archangelica only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methylphenidate page lists 85 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Lithium (major), Peyote (major) and Rauvolfia Vomitoria (major).

By severity: 6 major · 64 moderate · 15 minor.

From our pharmacist’s overview on the Methylphenidate page

“Methylphenidate (Ritalin, Concerta, Metadate) is itself a stimulant, and that one fact shapes most of this list. The largest cluster of interacting supplements adds a second stimulant on top of it, from ephedra and its relatives to everyday caffeine sources like coffee and green tea, which can push heart rate and blood pressure higher…”

Reviewed by 2 · Jul 18, 2026

Open the Methylphenidate interaction page

How much people look this up

Where Angelica Archangelica and Methylphenidate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Angelica Archangelica
Steady interest

#1,445 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methylphenidate
Top 10

#5 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Angelica Archangelica reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Angelica Archangelica and Methylphenidate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Angelica Archangelica

What is Angelica Archangelica?

Angelica Archangelica
  • Digestive upset and gas
  • Loss of appetite
  • Anxiety and restlessness
  • Mild respiratory complaints
  • Flavoring in foods and drinks

Angelica archangelica is a tall aromatic herb used traditionally for digestive complaints, poor appetite, and to flavor foods and liqueurs. Solid human evidence for its health benefits is limited, and its skin-sensitizing furanocoumarins mean caution is warranted. Pregnant and breastfeeding people should avoid it, and anyone considering it should check with a pharmacist or doctor first.

Angelica archangelica · Apiaceae (Umbelliferae) · Root, seeds (fruit), leaves, and essential oil · Tea, dried root, tincture, capsules, essential oil, and as a flavoring in liqueurs

An interaction check asks whether these two react with each other — it does not ask whether Angelica Archangelica is a good idea for someone in your situation. Here is what our Angelica Archangelica record says about it on its own.

Angelica Archangelica: dosing

There is no well-established standardized dose for Angelica archangelica. Traditional preparations include teas made from the dried root or seeds, tinctures, and capsules, but the amount of active compounds can vary widely between products.Because reliable dosing guidelines are lacking, the safest approach is to follow the directions on the product label and not exceed them. Avoid combining it with strong sun exposure or tanning.

From our Angelica Archangelica monograph — the full record covers uses, side effects and every documented interaction.

Read the full Angelica Archangelica monograph & all interactions
Medication

About Methylphenidate

What Is Methylphenidate Used For?

Brand names: Ritalin, Ritalin-SR, Concerta, Methylin, Metadate, Metadate CD, Methylin ER, Ritalin LA, Aptensio XR, Quillivant Xr, Cotempla XR-ODT, Jornay PM, Relexxii

Methylphenidate is used to treat Attention Deficit Hyperactivity Disorder (ADHD) — a condition marked by inattention, hyperactivity, and impulsivity that interferes with daily life at home, school, or work. It is available in many forms (oral tablets, capsules, liquid, chewable tablets, orally disintegrating tablets, and a skin patch), and each formulation has its own specific approved age range.

Some oral extended-release tablet formulations are also approved to treat narcolepsy (a sleep disorder causing excessive daytime sleepiness). The oral solution and chewable tablets are indicated for children with ADHD as part of a broader treatment program that may include counseling and educational support. Not every formulation is approved for every age group or condition — check with your prescriber or pharmacist for the specifics of your product.

Most-Reported Side Effects for Methylphenidate

From FAERS, the FDA’s public side-effect reporting system (73,541 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Product quality issue 5,596 reports
Fatigue 3,323 reports
Headache 3,182 reports
Nausea 3,111 reports
Anxiety 2,975 reports
See full Methylphenidate drug information
Keep checking

Other Drugs & Angelica Archangelica

Browse every other medication we’ve checked against Angelica Archangelica — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
335Moderate
0Minor
2,494No known interaction
335 Moderate 2,494 No interaction
Moderate

335 interactions

Showing 60 of 335 moderate interactions — see all 335 on the Angelica Archangelica page.

No interaction 2,494 drugs checked — show the list

We also checked Angelica Archangelica against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,494 medications checked with no known interaction — see the full Angelica Archangelica list.

See the full Angelica Archangelica interactions page
See every supplement checked against Methylphenidate, ranked by severity
Evidence & sources

Angelica Archangelica References

The 3 references that drive our Angelica Archangelica monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Ojala T, Vuorela P, Kiviranta J, et al. A bioassay using Artemia salina for detecting phototoxicity of plant coumarins. Planta Med 1999;65:715-8. PubMed
  3. Sigurdsson S, Geirsson G, Gudmundsdottir H, Egilsdottir PB, Gudbjarnason S. A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men. Scand J Urol. 2013;47(1):26-32. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Angelica Archangelica and Methylphenidate Together: Common Questions

Is it safe to take Angelica Archangelica with Methylphenidate?
We do not list a known interaction between Angelica Archangelica and Methylphenidate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Angelica Archangelica and Methylphenidate have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Angelica Archangelica and Methylphenidate combination checked?
Interactions in our licensed database are recorded against drug classes. Methylphenidate is filed under 6 classifications, and Angelica Archangelica has documented interactions with 1 drug class — none of Methylphenidate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Angelica Archangelica interact with any other medications?
Yes. Angelica Archangelica has 335 documented drug interactions in our database — Methylphenidate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Methylphenidate interact with any supplements?
Yes. Methylphenidate has documented interactions with 85 supplements in our database — Angelica Archangelica is not one of them. The Methylphenidate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Angelica Archangelica monograph Uses, safety profile, and every drug interaction in one place Methylphenidate drug information The full plain-English guide to this medication Methylphenidate supplement interactions Every supplement checked against Methylphenidate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Methylphenidate and Angelica Archangelica?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.