Capmatinib

Generic name: Pronounced as (kap ma' ti nib)
Brand names
  • Tabrecta®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 06/15/2020

Capmatinib is used to treat a certain type of non-small cell lung cancer (NSCLC) that has spread to other parts of the body. Capmatinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.

Capmatinib comes as a tablet to take by mouth. It is usually taken twice daily with or without food. Take capmatinib at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take capmatinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.

If you vomit after taking capmatinib, do not take another dose. Continue your regular dosing schedule.

Your doctor may need to temporarily or permanently stop your treatment or decrease your dose of capmatinib during your treatment. This depends on how well the medication works for you and the side effects you experience. Be sure to tell your doctor how you are feeling during your treatment with capmatinib.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking capmatinib,

  • tell your doctor and pharmacist if you are allergic to capmatinib, any other medications, or any of the ingredients in capmatinib tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amitriptyline, carbamazepine (Carbatrol, Epitol, Tegretol, others); clarithromycin (in Biaxin); clozapine (Versacloz); corticosteroids; certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as efavirenz (Sustiva, in Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); itraconazole (Onmel, Sporanox, Tolsura); ketoconazole; nefazodone; oxcarbazepine (Trileptal); phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos, in Duetact, Oseni); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifater); rosuvastatin (Crestor, Ezallor); verapamil (Verelan, in Tarka); or warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with capmatinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have or have ever had lung disease or breathing problems other than from lung cancer, or liver disease.

  • tell your doctor if you are pregnant, or plan to become pregnant. You should not become pregnant while you are taking capmatinib. You will need to have a pregnancy test before you start treatment, and you should use birth control to prevent pregnancy during your treatment and for at least 1 week after your final dose. If you are a male with a female partner who may become pregnant, you should use birth control to prevent pregnancy during you treatment and for at least 1 week after your final dose. Capmatinib may harm your unborn baby. If you or your partner become pregnant during your treatment with capmatinib, call your doctor immediately.

  • tell your doctor if you are breastfeeding. You should not breastfeed while you are taking capmatinib and for at least 1 week after your final dose.

  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear a hat, other protective clothing, sunglasses, and sunscreen.

Unless your doctor tells you otherwise, continue your normal diet.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Capmatinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • vomiting

    • nausea

    • fatigue

    • constipation

    • weight loss

    • back pain

    • loss of appetite

    • tiredness

    • swelling in hands, feet, ankles, or lower legs

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • shortness of breath, cough, fever, or other signs of infection

    • chest pain

    • pain in right upper part of the stomach; unusual bruising or bleeding; dark urine; yellowing of the skin and eyes; or loss of appetite

  • Capmatinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not remove the desiccant (small cartridge included with the tablets to absorb moisture) from your bottle. Discard any unused tablets 6 weeks after first opening the bottle.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to capmatinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Leflunomide Leflunomide The serum concentration of Leflunomide can be increased when it is combined with Capmatinib.
Atorvastatin Atorvastatin The serum concentration of Capmatinib can be decreased when it is combined with Atorvastatin.
Aminophylline Aminophylline The serum concentration of Aminophylline can be increased when it is combined with Capmatinib.
Anagrelide Anagrelide The serum concentration of Anagrelide can be increased when it is combined with Capmatinib.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Capmatinib.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Capmatinib.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The serum concentration of Conjugated estrogens can be increased when it is combined with Capmatinib.
Ranitidine Ranitidine The metabolism of Ranitidine can be decreased when combined with Capmatinib.
Reserpine Reserpine The serum concentration of Capmatinib can be decreased when it is combined with Reserpine.
Sumatriptan Sumatriptan The serum concentration of Sumatriptan can be increased when it is combined with Capmatinib.
Tizanidine Tizanidine The serum concentration of Tizanidine can be increased when it is combined with Capmatinib.
Zolmitriptan Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Capmatinib.
Levofloxacin Injection Levofloxacin Injection The excretion of Levofloxacin can be decreased when combined with Capmatinib.
Meperidine Injection Meperidine Injection The serum concentration of Capmatinib can be decreased when it is combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The serum concentration of Capmatinib can be decreased when it is combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection The metabolism of Metoclopramide can be decreased when combined with Capmatinib.
Zidovudine Injection Zidovudine Injection The serum concentration of Zidovudine can be increased when it is combined with Capmatinib.
Cyclosporine Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Capmatinib.
Olanzapine Olanzapine The metabolism of Olanzapine can be decreased when combined with Capmatinib.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Capmatinib.
Orlistat Orlistat The serum concentration of Capmatinib can be decreased when it is combined with Orlistat.
Oxcarbazepine Oxcarbazepine The serum concentration of Capmatinib can be decreased when it is combined with Oxcarbazepine.
Temozolomide Temozolomide The serum concentration of Capmatinib can be decreased when it is combined with Temozolomide.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Capmatinib.
Modafinil Modafinil The serum concentration of Capmatinib can be decreased when it is combined with Modafinil.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Capmatinib.
Ezetimibe Ezetimibe The serum concentration of Ezetimibe can be increased when it is combined with Capmatinib.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Capmatinib.
Atazanavir Atazanavir The serum concentration of Capmatinib can be increased when it is combined with Atazanavir.
Eletriptan Eletriptan The serum concentration of Capmatinib can be decreased when it is combined with Eletriptan.
Rosuvastatin Rosuvastatin The serum concentration of Rosuvastatin can be increased when it is combined with Capmatinib.
Emtricitabine Emtricitabine The excretion of Emtricitabine can be decreased when combined with Capmatinib.
Tegaserod Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Capmatinib.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be decreased when combined with Capmatinib.
Progesterone Progesterone The serum concentration of Capmatinib can be decreased when it is combined with Progesterone.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Capmatinib.
Rifaximin Rifaximin The serum concentration of Capmatinib can be decreased when it is combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Capmatinib.
Bosentan Bosentan The serum concentration of Capmatinib can be decreased when it is combined with Bosentan.
Cinacalcet Cinacalcet The metabolism of Cinacalcet can be decreased when combined with Capmatinib.
Erlotinib Erlotinib The serum concentration of Erlotinib can be increased when it is combined with Capmatinib.
Ganciclovir Ganciclovir The excretion of Ganciclovir can be decreased when combined with Capmatinib.
Entecavir Entecavir The metabolism of Entecavir can be decreased when combined with Capmatinib.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Capmatinib.
Deferasirox Deferasirox The serum concentration of Capmatinib can be decreased when it is combined with Deferasirox.
Felbamate Felbamate The serum concentration of Capmatinib can be decreased when it is combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Capmatinib can be increased when it is combined with Ranolazine.
Rasagiline Rasagiline The metabolism of Rasagiline can be decreased when combined with Capmatinib.
Imatinib Imatinib The serum concentration of Imatinib can be increased when it is combined with Capmatinib.
Gefitinib Gefitinib The serum concentration of Gefitinib can be increased when it is combined with Capmatinib.
Bortezomib Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Capmatinib.
Clofarabine Injection Clofarabine Injection The serum concentration of Clofarabine can be increased when it is combined with Capmatinib.
Oxaliplatin Injection Oxaliplatin Injection The serum concentration of Oxaliplatin can be increased when it is combined with Capmatinib.
Primaquine Primaquine The metabolism of Primaquine can be decreased when combined with Capmatinib.
Pemetrexed Injection Pemetrexed Injection The metabolism of Pemetrexed can be decreased when combined with Capmatinib.
Sorafenib Sorafenib The serum concentration of Sorafenib can be increased when it is combined with Capmatinib.
Dasatinib Dasatinib The serum concentration of Dasatinib can be increased when it is combined with Capmatinib.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Capmatinib.
Armodafinil Armodafinil The serum concentration of Capmatinib can be decreased when it is combined with Armodafinil.
Ivermectin Ivermectin The serum concentration of Ivermectin can be increased when it is combined with Capmatinib.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Capmatinib.
Nilotinib Nilotinib The serum concentration of Nilotinib can be increased when it is combined with Capmatinib.
Bexarotene Bexarotene The serum concentration of Capmatinib can be decreased when it is combined with Bexarotene.
Budesonide Budesonide The serum concentration of Capmatinib can be decreased when it is combined with Budesonide.
Etravirine Etravirine The serum concentration of Capmatinib can be decreased when it is combined with Etravirine.
Mitoxantrone Injection Mitoxantrone Injection The serum concentration of Mitoxantrone can be increased when it is combined with Capmatinib.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Capmatinib.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Capmatinib.
Irinotecan Injection Irinotecan Injection The serum concentration of Irinotecan can be increased when it is combined with Capmatinib.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Capmatinib.
Mitotane Mitotane The serum concentration of Capmatinib can be decreased when it is combined with Mitotane.
Rufinamide Rufinamide The serum concentration of Capmatinib can be decreased when it is combined with Rufinamide.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Capmatinib.
Betaxolol Betaxolol The metabolism of Betaxolol can be decreased when combined with Capmatinib.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Capmatinib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Capmatinib.
Pralatrexate Injection Pralatrexate Injection The serum concentration of Pralatrexate can be increased when it is combined with Capmatinib.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Capmatinib.
Topotecan Topotecan The serum concentration of Capmatinib can be decreased when it is combined with Topotecan.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Capmatinib.
Asenapine Asenapine The metabolism of Asenapine can be decreased when combined with Capmatinib.
Pitavastatin Pitavastatin The serum concentration of Pitavastatin can be increased when it is combined with Capmatinib.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Capmatinib.
Tocilizumab Injection Tocilizumab Injection The serum concentration of Capmatinib can be decreased when it is combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Cabazitaxel can be increased when it is combined with Capmatinib.
Acetaminophen Injection Acetaminophen Injection The serum concentration of Capmatinib can be decreased when it is combined with Acetaminophen.
Telaprevir Telaprevir The serum concentration of Capmatinib can be increased when it is combined with Glecaprevir.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Capmatinib.
Cyclophosphamide Injection Cyclophosphamide Injection The serum concentration of Capmatinib can be decreased when it is combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Capmatinib.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Capmatinib.
Clobazam Clobazam The serum concentration of Capmatinib can be decreased when it is combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Capmatinib can be decreased when it is combined with Vemurafenib.
Axitinib Axitinib The serum concentration of Axitinib can be increased when it is combined with Capmatinib.
Crizotinib Crizotinib The serum concentration of Crizotinib can be increased when it is combined with Capmatinib.
Cabergoline Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Capmatinib.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Capmatinib.
Enzalutamide Enzalutamide The serum concentration of Capmatinib can be decreased when it is combined with Enzalutamide.
Regorafenib Regorafenib The serum concentration of Regorafenib can be increased when it is combined with Capmatinib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Capmatinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The serum concentration of Capmatinib can be decreased when it is combined with Corticotropin.
Teriflunomide Teriflunomide The serum concentration of Teriflunomide can be increased when it is combined with Capmatinib.
Ponatinib Ponatinib The serum concentration of Ponatinib can be increased when it is combined with Capmatinib.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Capmatinib.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Capmatinib.
Apixaban Apixaban The serum concentration of Apixaban can be increased when it is combined with Capmatinib.
Dabrafenib Dabrafenib The serum concentration of Capmatinib can be decreased when it is combined with Dabrafenib.
Trametinib Trametinib The serum concentration of Capmatinib can be decreased when it is combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Capmatinib.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Capmatinib.
Perampanel Perampanel The serum concentration of Capmatinib can be decreased when it is combined with Perampanel.
Simeprevir Simeprevir The serum concentration of Simeprevir can be increased when it is combined with Capmatinib.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Capmatinib.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Capmatinib.
Apremilast Apremilast The metabolism of Apremilast can be decreased when combined with Capmatinib.
Ceritinib Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Capmatinib.
Siltuximab Injection Siltuximab Injection The serum concentration of Capmatinib can be decreased when it is combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The serum concentration of Capmatinib can be decreased when it is combined with Eslicarbazepine.
Idelalisib Idelalisib The serum concentration of Idelalisib can be increased when it is combined with Capmatinib.
Testosterone Injection Testosterone Injection The serum concentration of Capmatinib can be decreased when it is combined with Testosterone.
Oritavancin Injection Oritavancin Injection The serum concentration of Capmatinib can be decreased when it is combined with Oritavancin.
Suvorexant Suvorexant The serum concentration of Capmatinib can be increased when it is combined with Suvorexant.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Capmatinib.
Riociguat Riociguat The serum concentration of Riociguat can be increased when it is combined with Capmatinib.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Capmatinib.
Palbociclib Palbociclib The serum concentration of Palbociclib can be increased when it is combined with Capmatinib.
Lenvatinib Lenvatinib The serum concentration of Capmatinib can be decreased when it is combined with Lenvatinib.
Panobinostat Panobinostat The serum concentration of Panobinostat can be increased when it is combined with Capmatinib.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Capmatinib.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Capmatinib can be decreased when it is combined with Isavuconazonium.
Prednisolone Prednisolone The serum concentration of Capmatinib can be decreased when it is combined with Prednisolone.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Capmatinib.
Osimertinib Osimertinib The serum concentration of Capmatinib can be decreased when it is combined with Osimertinib.
Rifapentine Rifapentine The serum concentration of Capmatinib can be decreased when it is combined with Rifapentine.
Lesinurad Lesinurad The serum concentration of Capmatinib can be decreased when it is combined with Lesinurad.
Dexamethasone Injection Dexamethasone Injection The serum concentration of Capmatinib can be decreased when it is combined with Dexamethasone.
Venetoclax Venetoclax The serum concentration of Venetoclax can be increased when it is combined with Capmatinib.
Cobicistat Cobicistat The serum concentration of Capmatinib can be increased when it is combined with Cobicistat.
Rucaparib Rucaparib The serum concentration of Rucaparib can be increased when it is combined with Capmatinib.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Capmatinib.
Brigatinib Brigatinib The serum concentration of Capmatinib can be decreased when it is combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Capmatinib.
Sarilumab Injection Sarilumab Injection The serum concentration of Capmatinib can be decreased when it is combined with Sarilumab.
Midostaurin Midostaurin The serum concentration of Capmatinib can be decreased when it is combined with Midostaurin.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Capmatinib.
Enasidenib Enasidenib The serum concentration of Capmatinib can be decreased when it is combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Capmatinib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The serum concentration of Capmatinib can be decreased when it is combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Capmatinib.
Delafloxacin Delafloxacin The serum concentration of Capmatinib can be decreased when it is combined with Delafloxacin.
Abemaciclib Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Capmatinib.
Acalabrutinib Acalabrutinib The serum concentration of Capmatinib can be increased when it is combined with Acalabrutinib.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Capmatinib.
Apalutamide Apalutamide The serum concentration of Capmatinib can be decreased when it is combined with Apalutamide.
Baricitinib Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Capmatinib.
Lofexidine Lofexidine The metabolism of Lofexidine can be decreased when combined with Capmatinib.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Capmatinib.
Ivosidenib Ivosidenib The serum concentration of Capmatinib can be decreased when it is combined with Ivosidenib.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Capmatinib.
Dacomitinib Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Capmatinib.
Duvelisib Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Capmatinib.
Stiripentol Stiripentol The metabolism of Stiripentol can be decreased when combined with Capmatinib.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Capmatinib.
Glasdegib Glasdegib The serum concentration of Glasdegib can be increased when it is combined with Capmatinib.
Lorlatinib Lorlatinib The serum concentration of Capmatinib can be decreased when it is combined with Lorlatinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Capmatinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The serum concentration of Capmatinib can be decreased when it is combined with Paclitaxel.
Rifamycin Rifamycin The serum concentration of Capmatinib can be decreased when it is combined with Rifamycin.
Acyclovir Ophthalmic Acyclovir Ophthalmic The metabolism of Acyclovir can be decreased when combined with Capmatinib.
Alpelisib Alpelisib The serum concentration of Capmatinib can be decreased when it is combined with Alpelisib.
Cladribine Cladribine The serum concentration of Cladribine can be increased when it is combined with Capmatinib.
Solriamfetol Solriamfetol The excretion of Solriamfetol can be decreased when combined with Capmatinib.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Capmatinib.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Capmatinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Capmatinib.
Pitolisant Pitolisant The serum concentration of Capmatinib can be decreased when it is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The serum concentration of Capmatinib can be decreased when it is combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Capmatinib can be decreased when it is combined with Fosphenytoin.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Capmatinib.
Tazemetostat Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Capmatinib.
Cenobamate Cenobamate The serum concentration of Capmatinib can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod Capmatinib may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Capmatinib.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Capmatinib.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Capmatinib.
Remdesivir Injection Remdesivir Injection The serum concentration of Capmatinib can be increased when it is combined with Remdesivir.
Ripretinib Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Capmatinib.
Fostemsavir Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Capmatinib.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be decreased when it is combined with Capmatinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Capmatinib can be decreased when it is combined with Satralizumab.
Theophylline Theophylline The serum concentration of Theophylline can be increased when it is combined with Capmatinib.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Capmatinib.
Phenobarbital Phenobarbital The serum concentration of Capmatinib can be decreased when it is combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The serum concentration of Methotrexate can be increased when it is combined with Capmatinib.
Primidone Primidone The serum concentration of Capmatinib can be decreased when it is combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Capmatinib.
Carmustine Carmustine The metabolism of Carmustine can be decreased when combined with Capmatinib.
Trifluoperazine Trifluoperazine The metabolism of Trifluoperazine can be decreased when combined with Capmatinib.
Maprotiline Maprotiline The metabolism of Maprotiline can be decreased when combined with Capmatinib.
Perphenazine Perphenazine The metabolism of Perphenazine can be decreased when combined with Capmatinib.
Azathioprine Azathioprine The metabolism of Azathioprine can be decreased when combined with Capmatinib.
Sulfasalazine Sulfasalazine The serum concentration of Sulfasalazine can be increased when it is combined with Capmatinib.
Hydrocortisone Hydrocortisone The serum concentration of Capmatinib can be decreased when it is combined with Hydrocortisone.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Capmatinib.
Dactinomycin Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Capmatinib.
Pyridostigmine Pyridostigmine The serum concentration of Capmatinib can be decreased when it is combined with Pyridostigmine.
Carbamazepine Carbamazepine The serum concentration of Capmatinib can be decreased when it is combined with Carbamazepine.
Clonidine Clonidine The serum concentration of Clonidine can be increased when it is combined with Capmatinib.
Prazosin Prazosin The serum concentration of Prazosin can be increased when it is combined with Capmatinib.
Cimetidine Cimetidine The serum concentration of Capmatinib can be increased when it is combined with Cimetidine.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Capmatinib.
Daunorubicin Daunorubicin The serum concentration of Capmatinib can be decreased when it is combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin The serum concentration of Nitrofurantoin can be increased when it is combined with Capmatinib.
Griseofulvin Griseofulvin The serum concentration of Capmatinib can be decreased when it is combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Capmatinib.
Quinine Quinine The serum concentration of Capmatinib can be decreased when it is combined with Quinine.
Calcitriol Calcitriol The serum concentration of Capmatinib can be decreased when it is combined with Calcitriol.
Triamterene Triamterene The metabolism of Triamterene can be decreased when combined with Capmatinib.
Sulfinpyrazone Sulfinpyrazone The serum concentration of Capmatinib can be decreased when it is combined with Sulfinpyrazone.
Secobarbital Secobarbital The serum concentration of Capmatinib can be decreased when it is combined with Secobarbital.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Capmatinib.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Capmatinib.
Probenecid Probenecid The serum concentration of Capmatinib can be decreased when it is combined with Probenecid.
Quinidine Quinidine The serum concentration of Quinidine can be increased when it is combined with Capmatinib.
Procainamide Procainamide The serum concentration of Procainamide can be increased when it is combined with Capmatinib.
Rifampin Rifampin The serum concentration of Capmatinib can be decreased when it is combined with Rifampicin.
Disopyramide Disopyramide The metabolism of Disopyramide can be decreased when combined with Capmatinib.
Tamoxifen Tamoxifen The serum concentration of Capmatinib can be decreased when it is combined with Tamoxifen.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Capmatinib.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Capmatinib.
Methimazole Methimazole The therapeutic efficacy of Methimazole can be decreased when used in combination with Capmatinib.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Capmatinib.
Cyclobenzaprine Cyclobenzaprine The metabolism of Cyclobenzaprine can be decreased when combined with Capmatinib.
Chlorzoxazone Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Capmatinib.
Folic Acid Folic Acid The serum concentration of Folic acid can be increased when it is combined with Capmatinib.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Capmatinib.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Capmatinib.
Nadolol Nadolol The excretion of Nadolol can be decreased when combined with Capmatinib.
Allopurinol Allopurinol The serum concentration of Allopurinol can be increased when it is combined with Capmatinib.
Fluorouracil Injection Fluorouracil Injection The serum concentration of Fluorouracil can be increased when it is combined with Capmatinib.
Colchicine Colchicine The serum concentration of Capmatinib can be decreased when it is combined with Colchicine.
Cephalexin Cephalexin The excretion of Cephalexin can be decreased when combined with Capmatinib.
Dacarbazine Dacarbazine The serum concentration of Dacarbazine can be increased when it is combined with Capmatinib.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Capmatinib.
Ketoconazole Ketoconazole The serum concentration of Capmatinib can be increased when it is combined with Ketoconazole.
Vincristine Injection Vincristine Injection The serum concentration of Vincristine can be increased when it is combined with Capmatinib.
Vinblastine Vinblastine The serum concentration of Capmatinib can be decreased when it is combined with Vinblastine.
Thiothixene Thiothixene The metabolism of Thiothixene can be decreased when combined with Capmatinib.
Diltiazem Diltiazem The serum concentration of Capmatinib can be increased when it is combined with Diltiazem.
Nifedipine Nifedipine The serum concentration of Capmatinib can be decreased when it is combined with Nifedipine.
Verapamil Verapamil The serum concentration of Capmatinib can be increased when it is combined with Verapamil.
Etoposide Etoposide The serum concentration of Capmatinib can be decreased when it is combined with Etoposide.
Glyburide Glyburide The serum concentration of Glyburide can be increased when it is combined with Capmatinib.
Dicloxacillin Dicloxacillin The serum concentration of Capmatinib can be decreased when it is combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The serum concentration of Capmatinib can be decreased when it is combined with Nafcillin.
Pentoxifylline Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Capmatinib.
Guanabenz Guanabenz The metabolism of Guanabenz can be decreased when combined with Capmatinib.
Pimozide Pimozide The serum concentration of Pimozide can be increased when it is combined with Capmatinib.
Amiodarone Amiodarone The serum concentration of Capmatinib can be increased when it is combined with Amiodarone.
Ciprofloxacin Ciprofloxacin The serum concentration of Capmatinib can be increased when it is combined with Ciprofloxacin.
Diclofenac Diclofenac The metabolism of Diclofenac can be decreased when combined with Capmatinib.
Oxiconazole Oxiconazole The serum concentration of Capmatinib can be decreased when it is combined with Oxiconazole.
Fluoxetine Fluoxetine The metabolism of Fluoxetine can be decreased when combined with Capmatinib.
Clozapine Clozapine The serum concentration of Capmatinib can be decreased when it is combined with Clozapine.
Clarithromycin Clarithromycin The serum concentration of Capmatinib can be decreased when it is combined with Clarithromycin.
Nabumetone Nabumetone The metabolism of Nabumetone can be decreased when combined with Capmatinib.
Pravastatin Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Capmatinib.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Capmatinib.
Teniposide Injection Teniposide Injection The serum concentration of Teniposide can be increased when it is combined with Capmatinib.
Itraconazole Itraconazole The serum concentration of Capmatinib can be increased when it is combined with Itraconazole.
Rifabutin Rifabutin The serum concentration of Capmatinib can be decreased when it is combined with Rifabutin.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Capmatinib.
Omeprazole Omeprazole The serum concentration of Capmatinib can be decreased when it is combined with Omeprazole.
Fluvoxamine Fluvoxamine The serum concentration of Capmatinib can be increased when it is combined with Fluvoxamine.
Nefazodone Nefazodone The serum concentration of Capmatinib can be increased when it is combined with Nefazodone.
Lansoprazole Lansoprazole The serum concentration of Capmatinib can be decreased when it is combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The serum concentration of Capmatinib can be decreased when it is combined with Ifosfamide.
Nicardipine Nicardipine The serum concentration of Capmatinib can be increased when it is combined with Nicardipine.
Metformin Metformin The excretion of Metformin can be decreased when combined with Capmatinib.
Lamivudine Lamivudine The serum concentration of Lamivudine can be increased when it is combined with Capmatinib.
Riluzole Riluzole The serum concentration of Riluzole can be increased when it is combined with Capmatinib.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Capmatinib.
Indinavir Indinavir The serum concentration of Capmatinib can be increased when it is combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Capmatinib can be increased when it is combined with Ritonavir.
Clomipramine Clomipramine The serum concentration of Clomipramine can be increased when it is combined with Capmatinib.
Mirtazapine Mirtazapine The metabolism of Mirtazapine can be decreased when combined with Capmatinib.
Topiramate Topiramate The serum concentration of Capmatinib can be decreased when it is combined with Topiramate.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Capmatinib.
Donepezil Donepezil The serum concentration of Donepezil can be increased when it is combined with Capmatinib.
Nelfinavir Nelfinavir The serum concentration of Capmatinib can be increased when it is combined with Nelfinavir.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Capmatinib.
Flutamide Flutamide The metabolism of Flutamide can be decreased when combined with Capmatinib.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Capmatinib.
Propafenone Propafenone The metabolism of Propafenone can be decreased when combined with Capmatinib.
Raloxifene Raloxifene The serum concentration of Raloxifene can be increased when it is combined with Capmatinib.
Ropinirole Ropinirole The risk or severity of adverse effects can be increased when Capmatinib is combined with Ropinirole.
Paroxetine Paroxetine The serum concentration of Capmatinib can be increased when it is combined with Paroxetine.
Efavirenz Efavirenz The serum concentration of Capmatinib can be decreased when it is combined with Efavirenz.
Celecoxib Celecoxib The serum concentration of Celecoxib can be increased when it is combined with Capmatinib.
Thalidomide Thalidomide The serum concentration of Capmatinib can be decreased when it is combined with Thalidomide.
Terbinafine Terbinafine The serum concentration of Capmatinib can be decreased when it is combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists