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Enalapril and Hydrochlorothiazide

Enalapril and hydrochlorothiazide is a combination medicine used to treat high blood pressure (hypertension) in adults who need more than one medication to reach their blood pressure goal.

Brand name Vaseretic
Drug class Thiazide Diuretic
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 3 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 5, 2026
Enalapril and Hydrochlorothiazide at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Enalapril and hydrochlorothiazide (Vaseretic) pairs an ACE inhibitor that relaxes blood vessels with a water pill that clears extra fluid. It is a familiar add-on for high blood pressure when one medicine is not enough, on the market since about 1986 and available generically. Most people tolerate it well, and what they notice is lightheadedness on standing, mostly early on, and sometimes a dry, nagging cough from the enalapril. Its boxed warning covers pregnancy, because it can seriously harm or kill a developing baby, so anyone who could become pregnant should use reliable contraception and stop it as soon as pregnancy is confirmed.

Clinical pearls

  • Your prescriber usually settles the right dose of each drug separately first, then moves you onto this combination tablet.
  • Swelling of the lips, tongue or throat, or sudden severe belly pain, needs emergency care right away.
  • Avoid potassium supplements and potassium-sparing water pills unless prescribed together, because potassium can climb dangerously high.
  • Lithium can build to dangerous levels on this combination, and NSAIDs like ibuprofen or naproxen can weaken its effect.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Do not take this medicine during pregnancy. If you become pregnant while taking enalapril and hydrochlorothiazide, stop it as soon as possible and call your doctor right away. When taken during the second or third trimester of pregnancy, ACE inhibitor medicines like enalapril can cause serious injury — including kidney failure, skull defects, dangerously low blood pressure, and even death — to the unborn baby. First-trimester use may also carry risk. This is a critical safety warning.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asTablet
Earliest FDA record1986
Companies listing it with the FDA3
FDA label last updatedAug 31, 2020
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide A plain-language walkthrough of Enalapril and Hydrochlorothiazide, written from its FDA label.

What Enalapril and Hydrochlorothiazide is used for

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Enalapril and hydrochlorothiazide tablets are approved to treat high blood pressure (hypertension). This is an ingredient-level combination available in multiple products.

  • Enalapril maleate and hydrochlorothiazide tablets: treats high blood pressure in adults whose blood pressure is not adequately controlled by enalapril or hydrochlorothiazide alone
  • Vaseretic: treats high blood pressure in adults whose blood pressure is not adequately controlled by enalapril or hydrochlorothiazide alone
  • Neither product is intended as the first blood pressure medicine tried — both are used after dose adjustment with the individual components

How Enalapril and Hydrochlorothiazide works

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Enalapril works by blocking an enzyme called ACE (angiotensin-converting enzyme). Normally, ACE produces a hormone that tightens blood vessels. By blocking it, enalapril lets blood vessels relax, reducing blood pressure. It also slightly reduces a hormone called aldosterone, which has a small potassium-sparing effect. Hydrochlorothiazide is a diuretic (water pill) that makes the kidneys remove more salt and water, lowering the volume of fluid in the bloodstream and reducing blood pressure. Together, the two effects are roughly additive — and because enalapril counteracts the potassium loss that a diuretic can cause, the combination tends to keep potassium levels more stable than a diuretic alone.

It's worth knowing that enalapril alone tends to work somewhat less well in Black patients with high blood pressure, while hydrochlorothiazide tends to work better in that group. The combination of both medicines has been shown to be equally effective in Black and non-Black patients.

Enalapril and Hydrochlorothiazide dosage

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These tablets are taken by mouth. Enalapril can be taken with or without food — meals don't affect how it's absorbed. Your doctor will generally start you on each medicine separately to find the right doses before switching you to the combination tablet. The hydrochlorothiazide dose is typically not increased until at least 2–3 weeks have passed, since it takes time to see the full effect.

  • Taken once or twice daily depending on your doctor's instructions
  • Full blood pressure benefit may take several weeks to appear
  • Not recommended when kidney function is severely reduced
  • Never stop or change your dose without talking to your prescriber first

Dosing details from the FDA-approved label

From the Enalapril and Hydrochlorothiazide prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Hypertension (enalapril and hydrochlorothiazide, general usual ranges)
    • Usual dosage range of enalapril is 10 to 40 mg per day administered in a single or two divided doses
    • Hydrochlorothiazide is effective in doses of 12.5 to 50 mg daily
    • Maximum: In general, patients do not require doses in excess of 20 mg of enalapril or 50 mg of hydrochlorothiazide
    • Combination therapy is usually begun only after a patient has failed to achieve the desired effect with monotherapy
  • Hypertension not adequately controlled with enalapril or hydrochlorothiazide monotherapy (dose titration guided by clinical effect)
    • May be given enalapril maleate and hydrochlorothiazide tablets 5 mg/12.5 mg or 10 mg/25 mg (Vaseretic: 10-25 mg)
    • Further increases of enalapril, hydrochlorothiazide or both depend on clinical response
    • Maximum: Daily dosage should not exceed four tablets of 5 mg/12.5 mg or two tablets of 10 mg/25 mg (Vaseretic: two tablets of 10-25 mg)
    • The hydrochlorothiazide dose should generally not be increased until 2-3 weeks have elapsed
  • Replacement therapy
    • The combination may be substituted for the titrated components
  • Renal impairment: creatinine clearance >30 mL/min/1.73 m2 (serum creatinine approximately ≤3 mg/dL or 265 µmol/L)
    • The usual regimens of therapy need not be adjusted
  • Renal impairment: more severe (creatinine clearance not >30 mL/min/1.73 m2)
    • Enalapril maleate-hydrochlorothiazide is not recommended
    • Loop diuretics are preferred to thiazides in more severe renal impairment
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION Enalapril and hydrochlorothiazide are effective treatments for hypertension. The usual dosage range of enalapril is 10 to 40 mg per day administered in a single or two divided doses; hydrochlorothiazide is effective in doses of 12.5 to 50 mg daily. The side effects (see WARNINGS ) of enalapril are generally rare and apparently independent of dose; those of hydrochlorothiazide are a mixture of dose-dependent phenomena (primarily hypokalemia) and dose-independent phenomena (e.g., pancreatitis), the former much more common than the latter. Therapy with any combination of enalapril and hydrochlorothiazide will be associated with both sets of dose-independent side effects but the addition of enalapril in clinical trials blunted the hypokalemia normally seen with diuretics. To minimize dose-independent side effects, it is usually appropriate to begin combination therapy only after a patient has failed to achieve the desired effect with monotherapy. Dose Titration Guided by Clinical Effect A patient whose blood pressure is not adequately controlled with either enalapril or hydrochlorothiazide monotherapy may be given enalapril maleate and hydrochlorothiazide tablets 5 mg/12.5 mg or enalapril maleate and hydrochlorothiazide tablets 10 mg/25 mg. Further increases of enalapril, hydrochlorothiazide or both depend on clinical response. The hydrochlorothiazide dose should generally not be increased until 2-3 weeks have elapsed. In general, patients do not require doses in excess of 20 mg of enalapril or 50 mg of hydrochlorothiazide. The daily dosage should not exceed four tablets of enalapril maleate and hydrochlorothiazide tablets 5 mg/12.5 mg or two tablets of enalapril maleate and hydrochlorothiazide tablets 10 mg/25 mg. Replacement Therapy The combination may be substituted for the titrated components. Use in Renal Impairment The usual regimens of therapy with enalapril maleate and hydrochlorothiazide tablets need not be adjusted as long as the patient's creatinine clearance is >30 mL/min/1.73m 2 (serum creatinine approximately ≤3 mg/dL or 265 µmol/L). In patients with more severe renal impairment, loop diuretics are preferred to thiazides, so enalapril maleate– hydrochlorothiazide is not recommended (see WARNINGS, Anaphylactoid reactions during membrane exposure ).

Read the full Dosage and Administration section on DailyMed →

Enalapril and Hydrochlorothiazide side effects

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The most common side effects reported in clinical studies include:

Common side effects

  • Dizziness
  • Headache
  • Fatigue or weakness
  • Dry cough
  • Muscle cramps
  • Nausea
  • Lightheadedness when standing up quickly

When to get medical help

  • Get emergency help right away if you develop swelling of the face, lips, tongue, throat, or have trouble breathing — this could be a dangerous allergic reaction called angioedema
  • Call your doctor if you feel faint or pass out, especially early in treatment
  • Tell your doctor immediately if you develop yellowing of the skin or eyes (jaundice) — a rare but serious liver reaction
  • Contact your doctor if you notice signs of low white blood cell count such as fever, chills, or frequent infections, especially if you have kidney disease or a connective tissue condition
  • Seek care right away if you have severe abdominal pain — intestinal swelling (a type of angioedema) has been reported with ACE inhibitors
  • If you are pregnant, stop taking this medicine and call your doctor immediately

Most side effects are mild and temporary. However, seek emergency care right away for swelling of the face, lips, tongue, or throat, difficulty breathing, or fainting — these can be signs of a serious reaction.

Enalapril and Hydrochlorothiazide warnings and precautions

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  • Pregnancy: This medicine can cause severe injury or death to an unborn baby when taken during the second or third trimester. Stop immediately if you become pregnant and call your doctor.
  • Angioedema (dangerous swelling): Swelling of the face, lips, tongue, throat, or intestines can occur at any time, even without a prior history. Throat swelling can be fatal. Black patients have a higher reported risk. Get emergency help immediately if this happens.
  • Low blood pressure (hypotension): Especially in patients who are dehydrated or on other diuretics. Fainting was reported in about 1 in 75 patients in clinical trials.
  • Kidney function: Not recommended in severe kidney disease. Monitor closely in all kidney-impaired patients.
  • Liver failure: Rarely, ACE inhibitors have been linked to a serious liver condition. Tell your doctor right away if you develop yellowing of the skin or eyes.
  • Low white blood cell counts: A rare but serious risk, particularly in patients with kidney disease or connective tissue diseases like lupus.
  • Allergic reactions during dialysis or desensitization: Life-threatening reactions have been reported in patients on high-flux dialysis membranes or undergoing venom desensitization while taking ACE inhibitors.

Enalapril and Hydrochlorothiazide interactions

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This medicine can interact with several other drugs and substances — tell your doctor and pharmacist about everything you take:

  • Sacubitril/valsartan (Entresto): Do not take within 36 hours of switching to or from this drug — the combination greatly raises the risk of dangerous angioedema (swelling)
  • Aliskiren: Do not combine if you have diabetes; avoid in kidney disease — raises risk of low blood pressure, high potassium, and kidney damage
  • Other ACE inhibitors or ARBs: Using two medicines that block the same hormone system increases the risk of low blood pressure, high potassium, and kidney problems
  • Lithium: Hydrochlorothiazide can raise lithium levels to toxic ranges; generally should not be combined
  • Potassium supplements or potassium-sparing diuretics: ACE inhibitors already raise potassium slightly — adding more can push potassium to dangerous levels
  • NSAIDs (ibuprofen, naproxen, etc.): May reduce the blood pressure benefit and can stress the kidneys
  • Diabetes medicines: Hydrochlorothiazide can affect blood sugar control and may require medication adjustments

Interactions listed in the FDA-approved label

From the Enalapril and Hydrochlorothiazide prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Neprilysin inhibitors: Patients taking concomitant neprilysin inhibitors may be at increased risk for angioedema. See WARNINGS
  • Dual blockade of the renin-angiotensin system (angiotensin receptor blockers, ACE inhibitors, or aliskiren): Dual blockade is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy, with most patients obtaining no additional benefit. In general, avoid combined use of RAS inhibitors; closely monitor blood pressure, renal function and electrolytes.
  • Aliskiren: Dual RAS blockade with aliskiren increases risks of hypotension, hyperkalemia, and renal function changes. Do not coadminister with enalapril maleate and hydrochlorothiazide in patients with diabetes; avoid use in patients with renal impairment.
Read the label’s full interactions text

Drug Interactions Neprilysin Inhibitors Patients taking concomitant neprilysin inhibitors may be at increased risk for angioedema (see WARNINGS ). Enalapril Maleate Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Most patients receiving the combination of two RAS inhibitors do not obtain any additional benefit compared to monotherapy. In general, avoid combined use of RAS inhibitors. Closely monitor blood pressure, renal function and electrolytes in patients on enalapril maleate and hydrochlorothiazide and other agents that affect the RAS. Do not coadminister aliskiren with enalapril maleate and hydrochlorothiazide in patients with diabetes. Avoid use of aliskiren with enalapril maleate and hydrochlorothiazide in patients with renal impairment (GFR <60 mL/min). Hypotension – Patients on Diuretic Therapy Patients on diuretics and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with enalapril. The possibility of hypotensive effects with enalapril can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with enalapril. If it is necessary to continue the diuretic, provide medical supervision for at least two hours and until blood pressure has stabilized for at least an additional hour (see WARNINGS and DOSAGE AND ADMINISTRATION ). Agents Causing Renin Release The antihypertensive effect of enalapril is augmented by antihypertensive agents that cause renin release (e.g., diuretics).

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿238 supplements and herbs with documented Enalapril and Hydrochlorothiazide interactions, ranked by severity Check Enalapril and Hydrochlorothiazide against a supplement or herb →

Before taking Enalapril and Hydrochlorothiazide

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  • Pregnancy: Do not take this medicine if you are pregnant or planning to become pregnant — it can severely harm or kill a developing baby
  • Breastfeeding: Discuss with your doctor before taking — both components can pass into breast milk
  • History of angioedema: If you've ever had swelling of the face or throat from an ACE inhibitor, or have hereditary or unexplained angioedema, do not take this medicine
  • Kidney disease: Not recommended in severe kidney impairment; dose adjustments and close monitoring are needed in milder cases
  • Liver disease: Hydrochlorothiazide requires caution in liver disease; fluid and salt imbalances can trigger serious complications
  • Diabetes: Cannot be combined with aliskiren; blood sugar levels should be monitored more closely
  • Sulfa allergy: Hydrochlorothiazide is related to sulfonamide drugs — tell your doctor if you've had a reaction to sulfa medicines
  • Connective tissue disease (e.g., lupus): Higher risk of blood count problems; periodic monitoring may be recommended
  • Dialysis patients: Serious allergic-type reactions have been reported with certain dialysis membrane types — discuss with your care team

Enalapril and Hydrochlorothiazide overdose

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If too much of this medicine is taken, the most likely problem is a dangerous drop in blood pressure (which can cause fainting or shock) along with signs of dehydration and electrolyte imbalances such as low potassium, low sodium, or low chloride. If you suspect an overdose, seek emergency medical care immediately. Treatment focuses on supportive care, correcting fluid and electrolyte levels, and monitoring blood pressure — enalaprilat can be removed by hemodialysis if needed.

What Enalapril and Hydrochlorothiazide does in the body

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Enalapril and hydrochlorothiazide lowers both sitting and standing blood pressure in patients with mild to severe high blood pressure, generally without causing a sudden drop upon standing. Blood pressure reduction typically begins within one hour of a dose of enalapril, with peak effect at four to six hours; the antihypertensive effect of the combination is usually maintained for at least 24 hours. Some patients experience a slight lessening of effect toward the end of the dosing period when on enalapril alone, but this is less common with the combination. Enalapril also increases blood flow to the kidneys without significantly changing the rate at which the kidneys filter blood.

How your body processes Enalapril and Hydrochlorothiazide

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After you swallow enalapril, it is absorbed from the gut (about 60% is taken up) and then converted by the body into its active form, enalaprilat, which is a more potent ACE inhibitor. Food does not affect absorption. Peak levels of enalaprilat are reached about 3–4 hours after a dose, and the effective half-life — the time it takes for the drug's activity to reduce by half — is about 11 hours with regular dosing. The drug and its active form are cleared mainly by the kidneys; in people with severely reduced kidney function, the drug builds up more and takes longer to clear, which is why dosing must be adjusted. Enalaprilat can be removed by hemodialysis if necessary.

How to store Enalapril and Hydrochlorothiazide

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Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) . Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

238

Supplements & herbs that interact with Enalapril and Hydrochlorothiazide

238 supplements and herbal products have documented interactions with Enalapril and Hydrochlorothiazide in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 11
  • Moderate · 200
  • Minor · 27
ACTIVATED CHARCOAL Major AMERICAN HELLEBORE Major AMERICAN MISTLETOE Major ASARABACCA Major DOLOMITE Major LITHIUM Major OLEANDER Major PARA-AMINOBENZOIC ACID (PABA) Major +230 more
Every supplement checked against Enalapril and Hydrochlorothiazide — ranked by severity The full interaction hub: 11 major · 200 moderate · 27 minor · every one linked to its full report. Check Enalapril and Hydrochlorothiazide against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

7

Nutrient depletion considerations

Enalapril and Hydrochlorothiazide has been associated with lower levels of 7 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

Evidence & significance mix
  • Higher significance · 2
  • Moderate · 2
  • Unrated · 3
POTASSIUM Major Depletion VITAMIN C Insignificant Depletion MAGNESIUM Moderate Depletion THIAMINE Moderate Depletion COENZYME Q10 Insufficient Evidence FOLIC ACID Insufficient Evidence SODIUM Insufficient Evidence
See the full Enalapril and Hydrochlorothiazide nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Enalapril and Hydrochlorothiazide: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Enalapril and Hydrochlorothiazide — the kind of thing our pharmacy team would talk through with you at the counter.

Why am I on a combination pill instead of just one blood pressure medicine?

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This tablet combines two different types of blood pressure medicine — enalapril, which relaxes your blood vessels, and hydrochlorothiazide, a mild water pill that helps your kidneys remove extra fluid. Together they lower blood pressure better than either one alone. Your doctor has likely already tried adjusting each one separately and found that the combination gets your blood pressure to a safer level. It's also convenient to take one tablet instead of two separate ones.

I've heard about a serious cough with this type of medicine — is that true?

▾
Yes, a dry, persistent cough is one of the more common side effects of enalapril, reported in about 1 in 28 patients in clinical studies. It's not dangerous, but it can be bothersome. If the cough is really affecting your quality of life, don't just stop the medicine — talk to your doctor first. There may be alternatives, but that decision should be made together with your prescriber.

Is it safe to take this if I'm pregnant or might become pregnant?

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No — this is actually one of the most important things to know. This medicine can cause serious harm, including kidney failure and even death, to an unborn baby, especially in the second and third trimester. If you find out you're pregnant while taking it, stop the medicine right away and call your doctor immediately. If there's any chance you could become pregnant, talk to your doctor about birth control and about whether this is the right blood pressure medicine for you.

What should I watch for that would mean I need to call 911 or go to the ER?

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Call 911 immediately if you notice swelling of your face, lips, tongue, or throat, or if you're having trouble breathing — this can be a life-threatening allergic reaction called angioedema that can close off your airway. Also get emergency help if you faint or feel like you're going to faint, especially early in treatment. And if you develop severe stomach pain — even without face swelling — let your doctor know right away, as a type of internal swelling can also occur with this type of medicine.

Are there medicines or supplements I should avoid while taking this?

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A few important ones: don't take sacubitril/valsartan (Entresto) within 36 hours of this medicine — that combination can cause dangerous swelling. Avoid ibuprofen and naproxen (common pain relievers) as much as possible, since they can blunt the blood pressure effect and strain your kidneys. Don't take extra potassium supplements without asking your doctor first — this medicine can already raise potassium levels. And if you're on lithium or aliskiren, tell your prescriber, because those combinations need special attention or may not be safe.

How long will it take to see my blood pressure improve?

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You may start to see some effect within the first day, but getting your blood pressure to the target range often takes several weeks of consistent treatment. Don't be discouraged if your readings aren't perfect right away — your doctor may also adjust your dose over time based on your response. The most important thing is to keep taking it as prescribed and attend your follow-up appointments so your blood pressure can be monitored properly.

Is Enalapril and Hydrochlorothiazide available over the counter?

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No. Enalapril and Hydrochlorothiazide is a prescription medicine: every Enalapril and Hydrochlorothiazide product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Enalapril and Hydrochlorothiazide first available?

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The earliest FDA record we hold for Enalapril and Hydrochlorothiazide is from 1986: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Enalapril and Hydrochlorothiazide was first used.

Who makes Enalapril and Hydrochlorothiazide?

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3 companies currently list Enalapril and Hydrochlorothiazide products in the FDA's NDC Directory, including Dr. Reddy's Laboratories Limited, Taro Pharmaceuticals U.S.A., Inc., Bausch Health US, LLC. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Enalapril and Hydrochlorothiazide on HelloPharmacist

📊Enalapril and Hydrochlorothiazide supplement interactions238 checked — ranked by severity 🌿Drug & Supplement CheckerEnalapril and Hydrochlorothiazide vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Enalapril and Hydrochlorothiazide NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Enalapril and Hydrochlorothiazide Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Enalapril and Hydrochlorothiazide forms and strengths (how it comes)

Enalapril and Hydrochlorothiazide is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Tablet

By mouth
Brands Vaseretic
How this form is used
What it may be used for
  • Enalapril maleate and hydrochlorothiazide tablets are used to treat high blood pressure (hypertension) in patients not adequately controlled by a single blood pressure medicine
  • Vaseretic is used to treat high blood pressure (hypertension) in patients not adequately controlled by a single blood pressure medicine
  • Both products are fixed-dose combinations intended for use after doses of the individual medicines have already been established
Important instructions
  • Tablets are taken by mouth, with or without food
  • Enalapril maleate and hydrochlorothiazide tablets: the daily dosage should not exceed four tablets of the 5 mg/12.5 mg strength or two tablets of the 10 mg/25 mg strength — follow your doctor's instructions
  • Vaseretic: the daily dosage should not exceed two tablets — follow your doctor's instructions
  • Both products are not recommended for patients with severely reduced kidney function (creatinine clearance at or below 30 mL/min/1.73 m²)
Available strengths 2 strengths
5 mg / 12.5 mg 10 mg / 25 mg
12 FDA-listed product records ⓘ

Enalapril and Hydrochlorothiazide on the U.S. market: products, makers and brands

How Enalapril and Hydrochlorothiazide appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

3 companies list 5 Enalapril and Hydrochlorothiazide product records with the FDA, mostly as tablet; the earliest marketing or approval year on record is 1986. Brand names on the directory include Vaseretic; the rest are generics.

1
Dose forms ⓘ
3
Labelers (makers, repackagers, distributors)
2
Brand names
5
FDA-listed product records ⓘ
1986
Earliest FDA record ⓘ
Dr. Reddy's Laboratories Limited40%
Taro Pharmaceuticals U.S.A., Inc.40%
Bausch Health US, LLC20%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Enalapril and Hydrochlorothiazide is used (Medicaid data)

A general measure of how commonly Enalapril and Hydrochlorothiazide is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Enalapril and Hydrochlorothiazide is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

12,397
Medicaid prescriptions filled (Q1–Q4 2025)
$244,803 gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Enalapril and Hydrochlorothiazide prescribed? Of the 1,601 medications we measure, Enalapril and Hydrochlorothiazide ranks #890 by Medicaid prescriptions — more than 44% of them.

Where Enalapril and Hydrochlorothiazide ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #890 of 1,601
#885 Lonapegsomatropin-tcgd... 13,066 Rx #886 Mebendazole 13,051 Rx #887 Ferric Citrate 12,907 Rx #888 Cyclophosphamide 12,778 Rx #889 Imatinib 12,484 Rx #890 Enalapril and Hydrochl... 12,397 Rx #891 Doxorubicin 12,297 Rx #892 Sertaconazole Topical 12,283 Rx #893 Glatiramer Injection 12,218 Rx #894 Phytonadione 12,205 Rx #895 Amlodipine / Hydrochlo... 12,179 Rx

Utilization by Enalapril and Hydrochlorothiazide product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 10 mg / 25 mg oral tablet is the most-dispensed Enalapril and Hydrochlorothiazide product — about 63% of these Medicaid prescriptions.

enalapril maleate 10 MG / hydrochlorothiazide 25 MG Oral Tablet Most dispensed

7,763 Medicaid prescriptions (Q1–Q4 2025) 63% of Enalapril and Hydrochlorothiazide prescriptions shown $141,943 gross reimbursement (before rebates) ≈ $18 per prescription (gross)

Summed across the 1 of 18 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 858828

enalapril maleate 5 MG / hydrochlorothiazide 12.5 MG Oral Tablet

4,634 Medicaid prescriptions (Q1–Q4 2025) 37% of Enalapril and Hydrochlorothiazide prescriptions shown $102,860 gross reimbursement (before rebates) ≈ $22 per prescription (gross)

Summed across the 1 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 858824

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Enalapril and Hydrochlorothiazide, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 2 of 27 listed Enalapril and Hydrochlorothiazide NDCs with Medicaid activity.

Compare Enalapril and Hydrochlorothiazide products

A representative set of FDA-listed product records for Enalapril and Hydrochlorothiazide — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Strength Route Manufacturer / Labeler Category ⓘ Details
💊Tablet
ENALAPRIL MALEATE 10 mg/1; HYDROCHLOROTHIAZIDE 25 mg Oral Bausch Health US, LLC NDA View NDC →
ENALAPRIL MALEATE 5 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg Oral Dr. Reddy's Laboratories Limited ANDA View NDC →
ENALAPRIL MALEATE 10 mg/1; HYDROCHLOROTHIAZIDE 25 mg Oral Dr. Reddy's Laboratories Limited ANDA View NDC →
ENALAPRIL MALEATE 5 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg Oral Sun Pharmaceutical Industries, Inc. ANDA View NDC →
ENALAPRIL MALEATE 10 mg/1; HYDROCHLOROTHIAZIDE 25 mg Oral Sun Pharmaceutical Industries, Inc. ANDA View NDC →

Showing 5 of 5 products — FDA National Drug Code Directory. See every product, package size and price: browse all 5 Enalapril and Hydrochlorothiazide NDCs →

Enalapril and Hydrochlorothiazide recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Enalapril and Hydrochlorothiazide recalls since July 2021.

✅No Enalapril and Hydrochlorothiazide recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

💵 What Enalapril and Hydrochlorothiazide costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Tablet · Oral ENALAPRIL MALEATE 5 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg $0.170 per tablet NDC details & price history
Tablet · Oral 5; 12.5 mg/1; mg $0.170 per tablet NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Enalapril and Hydrochlorothiazide brand names

Enalapril and Hydrochlorothiazide is sold under one brand name in the FDA directory — Vaseretic. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Vaseretic

Who makes Enalapril and Hydrochlorothiazide: manufacturers and labelers

3 companies list Enalapril and Hydrochlorothiazide products with the FDA. By number of product records, the largest are Dr. Reddy's Laboratories Limited, Taro Pharmaceuticals U.S.A., Inc., Bausch Health US, LLC. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Dr. Reddy's Laboratories Limited 2 Taro Pharmaceuticals U.S.A., Inc. 2 Bausch Health US, LLC 1

Enalapril and Hydrochlorothiazide drug class (RxNorm)

Enalapril and Hydrochlorothiazide belongs to the Angiotensin Converting Enzyme Inhibitor class.

Pharmacologic class Angiotensin Converting Enzyme Inhibitor
Drug family (ATC) ACE inhibitors, plain
How it works Angiotensin-converting Enzyme Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Enalapril and Hydrochlorothiazide page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Aug 31, 2020
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Enalapril and Hydrochlorothiazide.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Enalapril and Hydrochlorothiazide after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
3
Finished products in the current FDA directory
5
Companies listing them (makers, repackagers, distributors)
3
FDA labeler codes behind them ⓘ
3
Linked representative label ⓘ
Bausch Health US LLC
Linked label effective
Aug 31, 2020
Composite sections available
20
Linked SPL Set ID
bf3007e2-8fcc-48de-8fd5-55e95033d62f
Linked SPL Document ID
b97cbaf1-3abe-4f23-b2a0-4ff43f8bf5cb
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Bausch Health US LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →