Medication interaction hub

What Supplements Interact with Enalapril Maleate, Hydrochlorothiazide?

Enalapril Maleate, Hydrochlorothiazide brand name: Vaseretic. Every interaction below applies to the brands too.

238 Interactions 11 Major 200 Moderate 27 Minor
Curated & coded by · Clinical Pharmacist · Updated September 25, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Enalapril Maleate, Hydrochlorothiazide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Enalapril Maleate, Hydrochlorothiazide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you take Vaseretic (enalapril with hydrochlorothiazide) for blood pressure, check this list carefully before adding any supplement; 11 of the 238 entries are rated major. Most run one of two ways: herbs that also drop blood pressure and can take it too low, or ones that raise it and fight the medicine. A smaller group stresses the kidneys, which both parts of this pill depend on to work safely.

Potassium cuts both ways here. The enalapril half keeps it in your body, so supplements can push levels too high, while a few herbs drain it alongside the diuretic. Calcium in larger doses can climb dangerously because the thiazide slows how quickly your kidneys clear it. Activated charcoal simply soaks up the medicine, so space the two well apart. Twenty entries also add sun sensitivity, and hydrochlorothiazide on its own already makes some people burn faster.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 200 Minor 27 No known interaction 1,214

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Enalapril Maleate, Hydrochlorothiazide: Top Interactions at a Glance

The Enalapril Maleate, Hydrochlorothiazide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 238 interacting ingredients — plus 1,214 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Enalapril Maleate, Hydrochlorothiazide Combinations Today

The Enalapril Maleate, Hydrochlorothiazide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Likely Potassium + Enalapril Maleate, Hydrochlorothiazidei

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.

Read the full interaction Minor Likelihood Unlikely Capsicum + Enalapril Maleate, Hydrochlorothiazidei

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.

Read the full interaction Moderate Likelihood Possible Niacin + Enalapril Maleate, Hydrochlorothiazidei

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Uzara + Enalapril Maleate, Hydrochlorothiazidei

Theoretically, concomitant use of potassium-depleting diuretics and uzara can increase the risk of cardiac glycoside toxicity due to potassium depletion.

Read the full interaction Moderate Likelihood Probable Calcium + Enalapril Maleate, Hydrochlorothiazidei

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.

Read the full interaction Minor Likelihood Possible Juniper + Enalapril Maleate, Hydrochlorothiazidei

Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Enalapril Maleate, Hydrochlorothiazide

All 1,452 ingredients in our database, ranked by severity — 238 with a Enalapril Maleate, Hydrochlorothiazide interaction on file and 1,214 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Enalapril Maleate, Hydrochlorothiazide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Potassium with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Using ACEIs with high doses of potassium increases the risk of hyperkalemia.

Full Potassium + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Capsicum with Enalapril Maleate, Hydrochlorothiazide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.

Full Capsicum + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Niacin with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.

Full Niacin + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Uzara with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and uzara can increase the risk of cardiac glycoside toxicity due to potassi...

Full Uzara + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Calcium with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.

Full Calcium + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Abuta with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking abuta with diuretic drugs might cause additive effects and increase the risk of adverse effects.

Full Abuta + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Adrafinil with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafinil might reduce the effects of antihypertensive drugs.

Full Adrafinil + Enalapril Maleate, Hydrochlorothiazide answer

Can you take African Wild Potato with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence shows that African wild potato extract inhibits OAT3.

Full African Wild Potato + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Agmatine with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.

Full Agmatine + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Alder Buckthorn with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Alder buckthorn has stimulant laxative effects.

Full Alder Buckthorn + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Alfalfa with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.

Full Alfalfa + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Algal Oil with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.

Full Algal Oil + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Aloe with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.

Full Aloe + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Andrographis with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.

Full Andrographis + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Angelica Archangelica with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Full Angelica Archangelica + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Apple Cider Vinegar with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.

Full Apple Cider Vinegar + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Aristolochia with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Aristolochia is nephrotoxic.

Full Aristolochia + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Arrach with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of arrach can increase risk of adverse effects, as unspecified Chenopodium species are associated with photos...

Full Arrach + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Artichoke with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.

Full Artichoke + Enalapril Maleate, Hydrochlorothiazide answer

Can you take Asafoetida with Enalapril Maleate, Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that asafoetida has hypotensive effects.

Full Asafoetida + Enalapril Maleate, Hydrochlorothiazide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Enalapril Maleate, Hydrochlorothiazide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Enalapril Maleate, Hydrochlorothiazide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Enalapril Maleate, Hydrochlorothiazide sits in 10 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Enalapril Maleate, Hydrochlorothiazide through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Enalapril Maleate, Hydrochlorothiazide through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Enalapril Maleate, Hydrochlorothiazide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Enalapril Maleate, Hydrochlorothiazide through this category.

Ace Inhibitors (Aceis) 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Enalapril Maleate, Hydrochlorothiazide through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Enalapril Maleate, Hydrochlorothiazide through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Enalapril Maleate, Hydrochlorothiazide through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Enalapril Maleate, Hydrochlorothiazide through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Enalapril Maleate, Hydrochlorothiazide through this category.

Sulfonamide Antibiotics 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Enalapril Maleate, Hydrochlorothiazide through this category.

About Enalapril Maleate, Hydrochlorothiazide

Enalapril and hydrochlorothiazide is a combination medicine used to treat high blood pressure (hypertension) in adults who need more than one medication to reach their blood pressure goal.

Generic name: Enalapril Maleate, Hydrochlorothiazide  ·  Brand name: Vaseretic.

See the full Enalapril and Hydrochlorothiazide drug information

Related: does Enalapril Maleate, Hydrochlorothiazide deplete any nutrients?

Enalapril Maleate, Hydrochlorothiazide has 7 reported nutrient associations in the research literature — see the Enalapril Maleate, Hydrochlorothiazide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Enalapril Maleate, Hydrochlorothiazide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Enalapril Maleate, Hydrochlorothiazide.

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Pharmacist Counseling Corner

Enalapril Maleate, Hydrochlorothiazide & Supplements: Common Questions

What supplements interact with Enalapril Maleate, Hydrochlorothiazide?
In our interaction database, 238 supplement and herbal ingredients have an interaction with Enalapril Maleate, Hydrochlorothiazide on file — 11 rated major, 200 moderate, and 27 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: American Hellebore, Para-aminobenzoic Acid (paba), Siberian Cocklebur.
Which Enalapril Maleate, Hydrochlorothiazide supplement interactions are the most serious?
The 11 major-rated combinations — led by American Hellebore, Para-aminobenzoic Acid (paba), Siberian Cocklebur, Tyramine and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Enalapril Maleate, Hydrochlorothiazide?
That depends entirely on which supplement. The honest answer for Enalapril Maleate, Hydrochlorothiazide is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Vaseretic have the same supplement interactions as Enalapril Maleate, Hydrochlorothiazide?
Yes — Vaseretic all contain Enalapril Maleate, Hydrochlorothiazide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Enalapril Maleate, Hydrochlorothiazide deplete any vitamins or nutrients?
It might — Enalapril Maleate, Hydrochlorothiazide has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Enalapril Maleate, Hydrochlorothiazide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Enalapril Maleate, Hydrochlorothiazide and my other medications?
This page covers Enalapril Maleate, Hydrochlorothiazide against supplements and herbal ingredients. Checking Enalapril Maleate, Hydrochlorothiazide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Enalapril and Hydrochlorothiazide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 25, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.