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Enalapril

Enalapril is an ACE inhibitor (a type of blood pressure and heart medicine) used to treat high blood pressure, heart failure, and a weakened heart pumping function that has not yet caused symptoms.

Brand names VasotecEpaned
Drug class Angiotensin Converting Enzyme Inhibitor
Rx Forms 2
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 82 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 5, 2026 🚨Recall on record · 2
Enalapril at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Enalapril, on the U.S. market since about 1985 and available generically, is an ACE inhibitor that relaxes blood vessels by blocking the enzyme that makes angiotensin II, and it is a standard first choice for high blood pressure, heart failure and a weakened heart not yet causing symptoms. Most people tolerate it well, and the effects they notice are mild tiredness or lightheadedness, mostly early on. Its boxed warning is for serious harm to a developing baby, so it should be stopped as soon as a pregnancy is found. Swelling of the face, lips, tongue or throat can start at any point in treatment and needs emergency help.

Clinical pearls

  • Skip potassium supplements and potassium-based salt substitutes unless your prescriber approves, because enalapril already nudges potassium up.
  • Never take it together with sacubitril/valsartan, and switching between the two needs a gap of at least 36 hours.
  • Expect periodic blood tests of kidney function and potassium, especially after starting or after a dose increase.
  • Severe stomach pain, with or without nausea or vomiting, can be swelling of the intestine from enalapril and needs prompt care.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Enalapril can cause injury and death to a developing baby if taken during pregnancy. Medicines like it act on the renin-angiotensin system and can reduce fetal kidney function, especially in the second and third trimesters. Potential effects include low amniotic fluid, lung and skull problems, kidney failure and death. If you become pregnant, contact your doctor right away. Enalapril should be stopped as soon as pregnancy is detected.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asTablet, Oral solution
Earliest FDA record1985
Companies listing it with the FDA31
FDA label last updatedMay 29, 2021
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide A plain-language walkthrough of Enalapril, written from its FDA label.

What Enalapril is used for

▾

Enalapril is an ACE inhibitor with several approved uses.

  • High blood pressure, to lower the risk of strokes and heart attacks.
  • Symptomatic heart failure, usually with diuretics and digitalis.
  • Asymptomatic left ventricular dysfunction, to slow progression to overt heart failure and reduce hospitalizations.
  • Oral solution products (including Epaned) are labeled for high blood pressure in adults and children older than one month.

How Enalapril works

▾

Enalapril is converted in the body to enalaprilat, which blocks angiotensin-converting enzyme (ACE). This lowers angiotensin II, a substance that narrows blood vessels, and reduces aldosterone, a hormone that makes the body hold salt and water.

The result is relaxed blood vessels and lower blood pressure. Aldosterone falls only slightly, which can nudge potassium up a little.

Enalapril dosage

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Enalapril is taken by mouth as a tablet or ready-to-use oral solution, once or twice daily depending on the condition. Doses are adjusted to your response and kidney function.

  • Tablets (such as Vasotec) are not affected by food.
  • Oral solution (such as Epaned) is for oral use only.
  • If you miss a dose, follow your prescriber’s and pharmacist’s advice.

Dosing details from the FDA-approved label

From the Enalapril prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Hypertension (patients not on diuretics)
    • Recommended initial dose is 5 mg once a day
    • Dosage adjusted according to blood pressure response
    • Usual dosage range is 10 to 40 mg per day administered in a single dose or two divided doses
    • If antihypertensive effect diminishes toward the end of the dosing interval with once daily dosing, an increase in dosage or twice daily administration should be considered
  • Hypertension (patients on a diuretic that cannot be discontinued)
    • Initial dose of 2.5 mg used under medical supervision for at least two hours and until blood pressure has stabilized for at least an additional hour
    • If possible, discontinue the diuretic for two to three days before beginning therapy
  • Hypertensive patients with renal impairment
    • Usual dose for creatinine clearance more than 30 mL/min (serum creatinine up to approximately 3 mg/dL)
    • For creatinine clearance less than or equal to 30 mL/min (serum creatinine more than or equal to 3 mg/dL) the first dose is 2.5 mg once daily
    • May be titrated upward until blood pressure is controlled
    • Maximum: 40 mg daily
    • Initial dose: normal renal function >80 mL/min 5 mg; mild impairment ≤80 >30 mL/min 5 mg; moderate to severe ≤30 mL/min 2.5 mg
  • Dialysis patients
    • 2.5 mg on dialysis days
    • Dosage on nondialysis days adjusted depending on the blood pressure response
  • Heart failure
    • Recommended initial dose is 2.5 mg
    • Recommended dosing range is 2.5 to 20 mg given twice a day
    • Titrated upward, as tolerated, over a period of a few days or weeks
    • Maximum: Maximum daily dose administered in clinical trials was 40 mg in divided doses
    • After the initial dose, observe under medical supervision for at least two hours and until blood pressure has stabilized for at least an additional hour; if possible reduce the dose of any concomitant diuretic
  • Asymptomatic left ventricular dysfunction
    • Started on 2.5 mg twice daily and titrated as tolerated to the targeted daily dose of 20 mg (in divided doses)
    • After the initial dose, observe under medical supervision for at least two hours and until blood pressure has stabilized for at least an additional hour
  • Heart failure with hyponatremia (serum sodium less than 130 mEq/L) or serum creatinine greater than 1.6 mg/dL
    • Initiate at 2.5 mg daily under close medical supervision
    • May be increased to 2.5 mg b.i.d., then 5 mg b.i.d. and higher as needed, usually at intervals of four days or more
    • Maximum: 40 mg daily
    • Increase only if there is not excessive hypotension or significant deterioration of renal function at the time of adjustment
  • Pediatric hypertensive patients
    • Usual recommended starting dose is 0.08 mg/kg (up to 5 mg) once daily
    • Adjusted according to blood pressure response
    • Maximum: Doses above 0.58 mg/kg (or in excess of 40 mg) have not been studied in pediatric patients
    • Not recommended in neonates and in pediatric patients with glomerular filtration rate less than 30 mL/min/1.73 m2
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION Hypertension In patients who are currently being treated with a diuretic, symptomatic hypotension occasionally may occur following the initial dose of enalapril maleate tablets. The diuretic should, if possible, be discontinued for two to three days before beginning therapy with enalapril maleate tablets to reduce the likelihood of hypotension (see WARNINGS, Hypotension ). If the patient's blood pressure is not controlled with enalapril maleate tablets alone, diuretic therapy may be resumed. If the diuretic cannot be discontinued an initial dose of 2.5 mg should be used under medical supervision for at least two hours and until blood pressure has stabilized for at least an additional hour (see WARNINGS, Hypotension and PRECAUTIONS, Drug Interactions ). The recommended initial dose in patients not on diuretics is 5 mg once a day. Dosage should be adjusted according to blood pressure response. The usual dosage range is 10 to 40 mg per day administered in a single dose or two divided doses. In some patients treated once daily, the antihypertensive effect may diminish toward the end of the dosing interval. In such patients, an increase in dosage or twice daily administration should be considered. If blood pressure is not controlled with enalapril maleate tablets alone, a diuretic may be added. Concomitant administration of enalapril maleate tablets with potassium supplements, potassium salt substitutes, or potassium-sparing diuretics may lead to increases of serum potassium (see PRECAUTIONS ). Dosage Adjustment in Hypertensive Patients with Renal Impairment The usual dose of enalapril is recommended for patients with a creatinine clearance more than 30 mL/min (serum creatinine of up to approximately 3 mg/dL). For patients with creatinine clearance less than or equal to 30 mL/min (serum creatinine more than or equal to 3 mg/dL), the first dose is 2.5 mg once daily. The dosage may be titrated upward until blood pressure is controlled or to a maximum of 40 mg daily. 1 See WARNINGS, Anaphylactoid Reactions During Membrane Exposure. 2 Dosage on nondialysis days should be adjusted depending on the blood pressure response.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Enalapril side effects

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Enalapril is generally well tolerated, and most side effects are mild and temporary.

Common side effects

  • Fatigue
  • Dizziness or lightheadedness from low blood pressure
  • Mildly raised potassium levels in the blood
  • Slightly higher potassium

When to get medical help

  • Swelling of the face, lips, tongue, throat or limbs, or trouble breathing: get emergency help, because this can be life-threatening.
  • Severe stomach pain, with or without nausea or vomiting, which can be a sign of intestinal swelling.
  • Yellowing of the skin or eyes (jaundice), which can signal rare liver problems. Tell your doctor right away.
  • Fainting or marked dizziness from very low blood pressure.
  • A pregnancy: tell your doctor right away.

Enalapril warnings and precautions

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  • Pregnancy: can harm or kill a developing baby.
  • Angioedema: swelling of the face, lips, tongue or throat can happen at any time and can be fatal.
  • Low blood pressure: more likely with heart failure, dialysis, diuretics or low fluid or salt.
  • Kidney function and potassium: may need monitoring.
  • Liver: rare serious liver injury has been reported.
  • White blood cells: a related ACE inhibitor has caused agranulocytosis. Periodic white blood cell checks may be considered in people with collagen vascular or kidney disease.

Enalapril interactions

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Several medicines and substances can clash with enalapril.

  • Sacubitril/valsartan and other neprilysin inhibitors: raise swelling risk and are contraindicated together.
  • Aliskiren: do not combine in people with diabetes.
  • ARBs or other ACE inhibitors: raise the risk of low blood pressure, high potassium and kidney problems.
  • Potassium supplements, salt substitutes and potassium-sparing diuretics: can raise potassium too high.
  • Diuretics: can cause a larger blood pressure drop after the first dose.
  • mTOR inhibitors: may raise angioedema risk.

Interactions listed in the FDA-approved label

From the Enalapril prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Neprilysin inhibitors: Patients taking concomitant neprilysin inhibitors may be at increased risk for angioedema.
  • Dual blockade of the renin-angiotensin system (angiotensin receptor blockers, ACE inhibitors, or aliskiren): Associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. In general, avoid combined use of RAS inhibitors; closely monitor blood pressure, renal function, and electrolytes.
  • Aliskiren: Dual RAS blockade is associated with increased risks of hypotension, hyperkalemia, and changes in renal function. Do not coadminister aliskiren with enalapril maleate tablets in patients with diabetes; avoid use in patients with renal impairment.
  • Potassium supplements, potassium salt substitutes, or potassium-sparing diuretics: Concomitant administration may lead to increases of serum potassium.
  • Diuretics: Symptomatic hypotension occasionally may occur following the initial dose in patients being treated with a diuretic. If possible, discontinue the diuretic for two to three days before beginning therapy; if it cannot be discontinued, start at 2.5 mg under medical supervision.
Read the label’s full interactions text

Drug Interactions Neprilysin Inhibitors Patients taking concomitant neprilysin inhibitors may be at increased risk for angioedema (see WARNINGS ). Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Most patients receiving the combination of two RAS inhibitors do not obtain any additional benefit compared to monotherapy. In general, avoid combined use of RAS inhibitors. Closely monitor blood pressure, renal function, and electrolytes in patients on enalapril maleate tablets and other agents that affect the RAS. Do not coadminister aliskiren with enalapril maleate tablets in patients with diabetes. Avoid use of aliskiren with enalapril maleate tablets in patients with renal impairment (GFR <60 mL/min). Hypotension — Patients on Diuretic Therapy Patients on diuretics and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with enalapril. The possibility of hypotensive effects with enalapril can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with enalapril. If it is necessary to continue the diuretic, provide close medical supervision after the initial dose for at least two hours and until blood pressure has stabilized for at least an additional hour (see WARNINGS, Hypotension and DOSAGE AND ADMINISTRATION ). Agents Causing Renin Release The antihypertensive effect of enalapril maleate tablets is augmented by antihypertensive agents that cause renin release (e.g., diuretics).

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿166 supplements and herbs with documented Enalapril interactions, ranked by severity Check Enalapril against a supplement or herb →

Before taking Enalapril

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  • Do not use it with a history of angioedema from an ACE inhibitor, or hereditary or idiopathic angioedema.
  • Tell your doctor if you are pregnant or planning pregnancy.
  • Tell your doctor about kidney disease, dialysis, liver problems or diabetes.
  • Tell your doctor if you are dehydrated or on diuretics.
  • Oral solution is not recommended in newborns or in children with significantly reduced kidney function.

Enalapril overdose

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Overdose data in humans are limited. The most likely effect is very low blood pressure, usually treated with an intravenous saline infusion. Enalaprilat can be removed by hemodialysis. Seek emergency help if you take too much.

What Enalapril does in the body

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Enalapril lowers blood pressure by reducing resistance in the arteries, with little change in heart rate. Effects begin about one hour after a dose and peak at four to six hours, and are maintained for at least 24 hours at recommended doses. Full effect can take several weeks. In heart failure, it improves heart output and exercise tolerance, and in a large trial it reduced hospitalizations for heart failure.

How your body processes Enalapril

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Enalapril is absorbed within about an hour and about 60% is absorbed. The body converts it to the more active enalaprilat, which peaks three to four hours later. The effective half-life of enalaprilat with repeated dosing is about 11 hours. It is cleared mainly by the kidneys, so levels build up when kidney function is low.

How to store Enalapril

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Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) . Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

166

Supplements & herbs that interact with Enalapril

166 supplements and herbal products have documented interactions with Enalapril in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 6
  • Moderate · 136
  • Minor · 24
ACTIVATED CHARCOAL Major AMERICAN HELLEBORE Major AMERICAN MISTLETOE Major ASARABACCA Major SIBERIAN COCKLEBUR Major TYRAMINE Major ADRAFINIL Moderate AGMATINE Moderate +158 more
Every supplement checked against Enalapril — ranked by severity The full interaction hub: 6 major · 136 moderate · 24 minor · every one linked to its full report. Check Enalapril against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

1

Nutrient depletion considerations

Enalapril has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

COENZYME Q10 Insufficient Evidence
See the full Enalapril nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Enalapril: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Enalapril — the kind of thing our pharmacy team would talk through with you at the counter.

What is enalapril for?

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It treats high blood pressure and heart failure. It is also used when the heart’s pumping function is weak but you don’t have symptoms yet, to slow progression to heart failure. Lower blood pressure reduces the risk of strokes and heart attacks.

How should I take it?

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Take it by mouth, as a tablet or oral solution, once or twice a day as prescribed. Food does not affect tablet absorption. Don’t change your dose on your own, and ask me if you miss one.

What side effects should I expect?

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Most people tolerate it well. You may feel tired or dizzy, especially when starting. Stand up slowly, and tell your doctor if dizziness is bothersome.

When should I get urgent help?

▾
Get emergency help for swelling of the face, lips, tongue or throat, or trouble breathing. Call your doctor for severe stomach pain, yellowing of your skin or eyes, or fainting.

Can I take it during pregnancy?

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No. It can seriously harm or even kill a developing baby. If you become pregnant or plan to, call your doctor right away.

Do I need to watch what else I take?

▾
Yes. Check with me before using potassium supplements, salt substitutes, water pills, or other blood pressure medicines. You must not combine it with sacubitril/valsartan, and aliskiren is not allowed if you have diabetes.

Is Enalapril available over the counter?

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No. Enalapril is a prescription medicine: every Enalapril product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Enalapril first available?

▾
The earliest FDA record we hold for Enalapril is from 1985: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Enalapril was first used.

Who makes Enalapril?

▾
31 companies currently list Enalapril products in the FDA's NDC Directory, including Bryant Ranch Prepack, A-S Medication Solutions, Remedyrepack Inc.. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Enalapril on HelloPharmacist

📊Enalapril supplement interactions166 checked — ranked by severity 🌿Drug & Supplement CheckerEnalapril vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Enalapril NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Enalapril Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Enalapril forms and strengths (how it comes)

Enalapril is available in 2 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Tablet

By mouth
Brands Vasotec
How this form is used
What it may be used for
  • Vasotec is used for high blood pressure.
  • Vasotec is used for symptomatic congestive heart failure, usually with diuretics and digitalis.
  • Vasotec is used for asymptomatic left ventricular dysfunction in clinically stable patients.
Important instructions
  • Vasotec can be taken once daily or divided into two doses a day.
  • If you take a diuretic, your doctor may pause it for a couple of days before starting Vasotec, or supervise the first dose.
  • Vasotec absorption is not influenced by food.
Available strengths 4 strengths
2.5 mg 5 mg 10 mg 20 mg
195 FDA-listed product records ⓘ

Oral solution

By mouth
Brands Epaned
How this form is used
What it may be used for
  • Epaned is used for high blood pressure in adults and children older than one month.
  • Epaned is used for symptomatic heart failure.
  • Epaned is used for asymptomatic left ventricular dysfunction.
Important instructions
  • Epaned is a ready-to-use solution for oral use only.
  • Epaned is not recommended in newborns (infants one month of age or younger).
  • Epaned dosing in children is based on body weight and adjusted to blood pressure response.
Available strengths 1 strength
1 mg/mL
15 FDA-listed product records ⓘ

Enalapril on the U.S. market: products, makers and brands

How Enalapril appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

31 companies list 106 Enalapril product records with the FDA, mostly as tablet, oral solution; the earliest marketing or approval year on record is 1985. Brand names on the directory include Vasotec, Epaned; the rest are generics.

2
Dose forms ⓘ
31
Labelers (makers, repackagers, distributors)
4
Brand names
106
FDA-listed product records ⓘ
1985
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (12) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack10%
A-S Medication Solutions8%
Remedyrepack Inc.6%
Northstar RxLLC5%
Amici Pharma, Inc4%
Bausch Health US LLC4%
Other makers63%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Enalapril is used (Medicaid data)

A general measure of how commonly Enalapril is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Enalapril is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

361,404
Medicaid prescriptions filled (Q1–Q4 2025)
$13.7M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Enalapril prescribed? Of the 1,601 medications we measure, Enalapril ranks #298 by Medicaid prescriptions — more than 81% of them.

Where Enalapril ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #298 of 1,601
#293 Cyclosporine Ophthalmi... 377,528 Rx #294 Finasteride 375,944 Rx #295 Neomycin, Polymyxin, a... 367,823 Rx #296 Hydromorphone 367,041 Rx #297 Calcitriol 366,263 Rx #298 Enalapril 361,404 Rx #299 Desmopressin 357,369 Rx #300 Aripiprazole Injection 354,838 Rx #301 Emtricitabine and Teno... 354,223 Rx #302 Emtricitabine / Tenofo... 354,223 Rx #303 Vortioxetine 354,075 Rx

Utilization by Enalapril product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 20 mg oral tablet is the most-dispensed Enalapril product — about 34% of these Medicaid prescriptions.

enalapril maleate 20 MG Oral Tablet Most dispensed

122,953 Medicaid prescriptions (Q1–Q4 2025) 34% of Enalapril prescriptions shown $1.9M gross reimbursement (before rebates) ≈ $15 per prescription (gross)

Summed across the 14 of 140 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 858810

enalapril maleate 10 MG Oral Tablet

87,155 Medicaid prescriptions (Q1–Q4 2025) 24% of Enalapril prescriptions shown $1.1M gross reimbursement (before rebates) ≈ $13 per prescription (gross)

Summed across the 14 of 154 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 858817

enalapril maleate 5 MG Oral Tablet

64,250 Medicaid prescriptions (Q1–Q4 2025) 18% of Enalapril prescriptions shown $785,730 gross reimbursement (before rebates) ≈ $12 per prescription (gross)

Summed across the 12 of 129 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 858813

enalapril maleate 1 MG/ML Oral Solution

47,571 Medicaid prescriptions (Q1–Q4 2025) 13% of Enalapril prescriptions shown $9.5M gross reimbursement (before rebates) ≈ $200 per prescription (gross)

Summed across the 8 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1435624

enalapril maleate 2.5 MG Oral Tablet

39,475 Medicaid prescriptions (Q1–Q4 2025) 11% of Enalapril prescriptions shown $428,479 gross reimbursement (before rebates) ≈ $11 per prescription (gross)

Summed across the 12 of 65 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 858804

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Enalapril, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 60 of 497 listed Enalapril NDCs with Medicaid activity.

Compare Enalapril products

A representative set of FDA-listed product records for Enalapril — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 103 of 106 products — FDA National Drug Code Directory. See every product, package size and price: browse all 106 Enalapril NDCs →

Enalapril recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list 2 Enalapril recalls since July 2021, covering 5 product listings. Both are still ongoing or began in the last six months. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Ongoing Class II Apr 23, 2026 · JB Chemicals and Pharmaceuticals Ltd
Failed Impurities/Degradation Specifications:Out of specification result occurred in Organic Impurities Test
  • Enalapril Maleate Tablets, USP, 20 mg, 1,000-count bottle, Rx only, Manufactured by: Unique Pharmaceutical Laboratories (A Div. of J.B. Chemicals & Pharmaceuticals Ltd.), Mumbai 400 030, India, Distr… Lots: Lot #: GEH25023, Expires: 6/30/2027 FDA record D-0520-2026 →
Ongoing Class II Mar 16, 2022 · Golden State Medical Supply Inc.
CGMP Deviations
  • Enalapril Maleate Tablets, USP; 20 mg; 90 tablets, NDC 60429-186-90; manufactured by Taro Pharmaceutical Industries, Ltd.; packaged by GSMS, Incorporated, CA. Lots: Lots: GS035031, GS035199, 20 mg; 90 tablets, Exp.: 03/2022; Lots: GS036495, GS036904, Exp.: 05/2022; Lots: GS037401, Exp.: 09/2022; Lots: GS037986, GS038359, GS039560, Exp.: 11/2022; Lot: GS041110, Exp.: 12/2022. (NDC: 60429-186-90). FDA record D-1180-2022 →
  • Enalapril Maleate Tablets, USP; 10 mg; 90 tablets, NDC 60429-185-90; manufactured by Taro Pharmaceutical Industries, Ltd.; packaged by GSMS, Incorporated, CA. Lots: Lots: GS027890, GS028177, GS028488, 10 mg; 90 tablets, Exp.: 04/2022; Lots: GS028847, GS028848, Exp.: 09/2022; GS029627, GS029862,GS030057, GS030481, GS030870, GS031060, GS031437, GS031438, GS033527, GS034231, Exp.: 10/2022; Lots: GS034810… FDA record D-1179-2022 →
  • Enalapril Maleate Tablets, USP; 5 mg; 90 tablets, NDC 60429-184-90; manufactured by Taro Pharmaceutical Industries, Ltd.; packaged by GSMS, Incorporated, CA. Lots: Lot: GS029041, GS029353, GS02986, 5 mg; 90 tablets, Exp.: 09/2022; Lot: GS030056, GS030869, GS033943, Exp.: 10/2022; Lots: GS034490, GS035197, Exp.:02/2023; Lots: GS035198, Exp.: 03/2023; Lots: GS035596, GS035947, GS036759, GS037400, Exp.:… FDA record D-1178-2022 →
  • Enalapril Maleate Tablets, USP; 2.5 mg; 90 tablets, NDC 60429-183-90; manufactured by Taro Pharmaceutical Industries, Ltd.; packaged by GSMS, Incorporated, CA, USA. Lots: Lots: GS028301, 2.5 mg; 90 tablets, Exp.: 06/2022; Lots: GS029973, GS029974, GS031436, GS031715, GS033191, GS033940, Exp. : 10/2022; Lot: GS034212, Exp.: 12/2022; Lot: GS035315, GS035945, GS036905, GS038038, GS039199, Exp.: 04/2023; Lot: G… FDA record D-1177-2022 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Enalapril RxCUI 3827 3 dose forms · 6 strengths
  1. Dose form (SCDF) Injectable Solution RxCUI 378288 No current FDA listing
    Clinical drug / strength (SCD) maleate 1.25 MG/ML RxCUI 858821
  2. Dose form (SCDF) Oral Solution RxCUI 1435623 In current FDA listings
    Clinical drug / strength (SCD) maleate 1 MG/ML RxCUI 1435624

Look up RxCUI 3827 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Enalapril costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Solution · Oral 1 mg/mL $0.795 per mL NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Enalapril brand names

Enalapril is sold under 2 brand names in the FDA directory — Vasotec, Epaned. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Vasotec Epaned

Who makes Enalapril: manufacturers and labelers

31 companies list Enalapril products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, A-S Medication Solutions, Remedyrepack Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Bryant Ranch Prepack 11 A-S Medication Solutions 9 Remedyrepack Inc. 6 Northstar RxLLC 5 Amici Pharma, Inc 4 Bausch Health US LLC 4 Chartwell RX, LLC 4 Golden State Medical Supply, Inc. 4 Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 4 Major Pharmaceuticals 4 Northwind Health Company, LLC 4 NuCare Pharmaceuticals,Inc. 4 Oceanside Pharmaceuticals 4 Preferred Pharmaceuticals Inc. 4 Rising Pharma Holdings, Inc. 4 ScieGen Pharmaceuticals, Inc. 4 Solco Healthcare US, LLC 4 Taro Pharmaceuticals U.S.A., Inc. 4 Coupler LLC 3 Legacy Pharmaceutical Packaging, LLC 3 PD-Rx Pharmaceuticals, Inc. 2 Proficient Rx LP 2 Amneal Pharmaceuticals NY LLC 1 Ascend Laboratories, LLC 1

…and 7 more on the FDA NDC directory.

Enalapril drug class (RxNorm)

Enalapril belongs to the Angiotensin Converting Enzyme Inhibitor class.

Pharmacologic class Angiotensin Converting Enzyme Inhibitor
Drug family (ATC) ACE inhibitors, plain
How it works Angiotensin-converting Enzyme Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Enalapril page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective May 29, 2021
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Enalapril.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Enalapril after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
82
Finished products in the current FDA directory
106
Companies listing them (makers, repackagers, distributors)
31
FDA labeler codes behind them ⓘ
34
Linked representative label ⓘ
Amneal Pharmaceuticals NY LLC
Linked label effective
May 29, 2021
Composite sections available
25
Linked SPL Set ID
7efed863-919d-458e-99e1-ce0cec95537a
Linked SPL Document ID
ddab86a7-99c5-4f3d-9bc9-bfd33b2886e4
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 1

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Amneal Pharmaceuticals NY LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →