Vortioxetine

Vortioxetine is used to treat depression in adults. Vortioxetine is in a class of medications called serotonin modulators. It works mainly by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.

Vortioxetine comes as a tablet to take by mouth. It is usually taken with or without food once a day. Take vortioxetine at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take vortioxetine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may adjust your dose of vortioxetine depending on how well you respond to treatment and whether you experience side effects. Be sure to talk to your doctor about how you are feeling during your treatment with vortioxetine.

It may take 2 to 4 weeks or longer before you feel the full benefit of vortioxetine. Continue to take vortioxetine even if you feel well. Do not stop taking vortioxetine without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking vortioxetine, you may experience withdrawal symptoms such as headache, mood changes, irritability, agitation, nausea, dizziness, burning, numbness, or tingling in the hands or feet, anxiety, confusion, sweating, shaking, frenzied or abnormally excited mood, ringing in the ears, tiredness, difficulty falling asleep or staying asleep. and seizures. Tell your doctor if you experience any of these symptoms while you are decreasing your dose of vortioxetine or soon after you stop taking vortioxetine.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking vortioxetine,

• tell your doctor and pharmacist if you are allergic to vortioxetine, any other medications, or any of the ingredients in vortioxetine tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

• tell your doctor if you are taking monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Emsam, Zelapar), and tranylcypromine (Parnate) or if you have stopped taking them within the past 2 weeks. Your doctor may tell you not to take vortioxetine. If you stop taking vortioxetine, you should wait at least 21 days before you start to take an MAO inhibitor.

• tell your doctor and pharmacist what other prescription and nonprescription medications, and vitamins, nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amphetamines such as amphetamine (in Adderall, in Mydayis), dextroamphetamine (Dexedrine, in Adderall), and methamphetamine (Desoxyn); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antidepressants ('mood elevators') such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline, and trimipramine; bupropion (Aplenzin, Contrave, Forfivo, Wellbutrin, Zyban); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); buspirone; carbamazepine (Carbatrol, Equetro, Tegretol, others); clopidogrel (Plavix); diuretics ('water pills'); fentanyl (Actiq, Duragesic, Fentora, Subsys); heparin; lithium (Lithobid); medications for mental illness; medications for migraine headaches such as almotriptan, eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); phenytoin (Dilantin, Phenytek); quinidine (in Nuedexta); rifampin (Rifadin, Rimactane); other selective serotonin-reuptake inhibitors such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); serotonin and norepinephrine reuptake inhibitors such as duloxetine (Cymbalta), desvenlafaxine (Pristiq), and venlafaxine (Effexor); and tramadol (Conzip, Qdola, Ulltram, in Ultracet). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor what herbal products and nutritional supplements you are taking, especially St. John's wort and tryptophan.

• tell your doctor if you have a low level of sodium in your blood, if you drink or have ever drunk large amounts of alcohol, and if you have or have ever had seizures, glaucoma (increased pressure in the eye that may cause loss of sight), or bleeding problems.

• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking vortioxetine, call your doctor. Vortioxetine may cause problems in newborns following delivery if it is taken during the last few months of pregnancy.

• if you are having surgery, including dental surgery, or a medical test that involves dyes, tell the doctor or dentist that you are taking vortioxetine.

• you should know that vortioxetine may affect your judgment, thinking, and movements. Do not drive a car or operate machinery until you know how this medication affects you.

• ask your doctor about the safe use of alcoholic beverages while you are taking vortioxetine.

• you should know that vortioxetine may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Vortioxetine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea

  • vomiting

  • diarrhea

  • constipation

  • gas

  • dry mouth

  • dizziness

  • unusual dreams

  • sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation

  • sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm

• Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately:

  • rash

  • hives

  • itching

  • swelling of the eyes, face, lips, tongue, or throat

  • hoarseness

  • difficulty breathing or swallowing

  • unusual bruising or bleeding

  • fever, sweating, confusion, fast or irregular heartbeat, severe muscle stiffness or twitching, agitation, hallucinations, loss of coordination, nausea, vomiting, or diarrhea

  • nosebleed

  • headache

  • difficulty concentrating

  • memory problems

  • confusion

  • weakness

  • unsteadiness

  • hallucinations

  • fainting

  • seizures

  • coma (loss of consciousness for a period of time)

• Vortioxetine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

• nausea

• dizziness

• diarrhea

• stomach pain

• itching

• sleepiness

• flushing

• agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

• seizures

Keep all appointments with your doctor.

Before having any laboratory test (especially those that involve methylene blue), tell your doctor and the laboratory personnel that you are taking vortioxetine.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Repaglinide	Repaglinide The metabolism of Vortioxetine can be decreased when combined with Repaglinide.
Montelukast	Montelukast The metabolism of Vortioxetine can be decreased when combined with Montelukast.
Leflunomide	Leflunomide The metabolism of Vortioxetine can be decreased when combined with Leflunomide.
Delavirdine	Delavirdine The metabolism of Vortioxetine can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Vortioxetine can be increased when combined with Nevirapine.
Atorvastatin	Atorvastatin The metabolism of Vortioxetine can be decreased when combined with Atorvastatin.
Dolasetron	Dolasetron The risk or severity of adverse effects can be increased when Dolasetron is combined with Vortioxetine.
Candesartan	Candesartan The metabolism of Vortioxetine can be decreased when combined with Candesartan.
Cilostazol	Cilostazol Cilostazol may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Clopidogrel	Clopidogrel The metabolism of Vortioxetine can be decreased when combined with Clopidogrel.
Diphenoxylate	Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Vortioxetine.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The metabolism of Vortioxetine can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Fenofibrate	Fenofibrate The metabolism of Vortioxetine can be decreased when combined with Fenofibrate.
Guanfacine	Guanfacine The risk or severity of adverse effects can be increased when Guanfacine is combined with Vortioxetine.
Magnesium Hydroxide	Magnesium Hydroxide Vortioxetine may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Methylergonovine	Methylergonovine Methylergometrine may increase the vasoconstricting activities of Vortioxetine.
Mycophenolate	Mycophenolate Mycophenolic acid may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Naratriptan	Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Vortioxetine.
Olsalazine	Olsalazine Olsalazine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Paregoric	Paregoric The metabolism of Vortioxetine can be decreased when combined with Morphine.
Penbutolol	Penbutolol The metabolism of Vortioxetine can be decreased when combined with Acebutolol.
Pentazocine	Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Vortioxetine.
Potassium	Potassium Potassium cation may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone	Prednisone The metabolism of Vortioxetine can be increased when combined with Prednisone.
Ranitidine	Ranitidine The metabolism of Vortioxetine can be decreased when combined with Ranitidine.
Reserpine	Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Vortioxetine.
Rizatriptan	Rizatriptan The risk or severity of adverse effects can be increased when Rizatriptan is combined with Vortioxetine.
Sumatriptan	Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Vortioxetine.
Tacrolimus	Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Vortioxetine.
Tizanidine	Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Vortioxetine.
Triamcinolone	Triamcinolone The metabolism of Vortioxetine can be increased when combined with Triamcinolone.
Zolmitriptan	Zolmitriptan The risk or severity of vasospastic reactions can be increased when Zolmitriptan is combined with Vortioxetine.
Ampicillin Injection	Ampicillin Injection Ampicillin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Doxycycline Injection	Doxycycline Injection Doxycycline may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Fluconazole Injection	Fluconazole Injection The metabolism of Vortioxetine can be decreased when combined with Fluconazole.
Foscarnet Injection	Foscarnet Injection Foscarnet may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Vortioxetine.
Levofloxacin Injection	Levofloxacin Injection Levofloxacin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Meperidine Injection	Meperidine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Vortioxetine.
Metoclopramide Injection	Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Vortioxetine.
Metronidazole Injection	Metronidazole Injection The metabolism of Vortioxetine can be decreased when combined with Metronidazole.
Morphine Injection	Morphine Injection The metabolism of Vortioxetine can be decreased when combined with Morphine.
Pamidronate Injection	Pamidronate Injection Pamidronic acid may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Vancomycin Injection	Vancomycin Injection Vortioxetine may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection	Zidovudine Injection The metabolism of Vortioxetine can be decreased when combined with Zidovudine.
Altretamine	Altretamine The metabolism of Vortioxetine can be decreased when combined with Amphetamine.
Cefuroxime	Cefuroxime Cefuroxime may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Cyclosporine	Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Vortioxetine.
Ondansetron	Ondansetron The risk or severity of adverse effects can be increased when Ondansetron is combined with Vortioxetine.
Granisetron	Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Vortioxetine.
Torsemide	Torsemide The metabolism of Vortioxetine can be decreased when combined with Torasemide.
Olanzapine	Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Vortioxetine.
Alosetron	Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Vortioxetine.
Entacapone	Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Vortioxetine.
Eprosartan	Eprosartan Vortioxetine may decrease the antihypertensive activities of Eprosartan.
Hydroxychloroquine	Hydroxychloroquine The metabolism of Vortioxetine can be decreased when combined with Hydroxychloroquine.
Meloxicam	Meloxicam Meloxicam may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Oxcarbazepine	Oxcarbazepine The metabolism of Vortioxetine can be increased when combined with Oxcarbazepine.
Pantoprazole	Pantoprazole The metabolism of Vortioxetine can be decreased when combined with Pantoprazole.
Telmisartan	Telmisartan The metabolism of Vortioxetine can be decreased when combined with Telmisartan.
Temozolomide	Temozolomide Temozolomide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Zaleplon	Zaleplon Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Anakinra	Anakinra The metabolism of Vortioxetine can be increased when combined with Anakinra.
Desloratadine	Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Vortioxetine.
Linezolid	Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Vortioxetine.
Trimipramine	Trimipramine The metabolism of Vortioxetine can be decreased when combined with Trimipramine.
Etanercept Injection	Etanercept Injection The metabolism of Vortioxetine can be increased when combined with Etanercept.
Glycopyrrolate	Glycopyrrolate Vortioxetine may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil	Modafinil The metabolism of Vortioxetine can be decreased when combined with Modafinil.
Perindopril	Perindopril Perindopril may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Tenofovir	Tenofovir Tenofovir may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Sirolimus	Sirolimus The metabolism of Sirolimus can be decreased when combined with Vortioxetine.
Dutasteride	Dutasteride The metabolism of Vortioxetine can be decreased when combined with Dutasteride.
Epinephrine Injection	Epinephrine Injection The metabolism of Vortioxetine can be decreased when combined with Epinephrine.
Eplerenone	Eplerenone Eplerenone may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram	Escitalopram The risk or severity of serotonin syndrome can be increased when Escitalopram is combined with Vortioxetine.
Olmesartan	Olmesartan Vortioxetine may decrease the antihypertensive activities of Olmesartan.
Zonisamide	Zonisamide The metabolism of Vortioxetine can be decreased when combined with Zonisamide.
Adalimumab Injection	Adalimumab Injection The metabolism of Vortioxetine can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The risk or severity of adverse effects can be increased when Aripiprazole is combined with Vortioxetine.
Atomoxetine	Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Vortioxetine.
Dexmethylphenidate	Dexmethylphenidate The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Vortioxetine.
Atazanavir	Atazanavir Atazanavir may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Almotriptan	Almotriptan The metabolism of Vortioxetine can be decreased when combined with Almotriptan.
Eletriptan	Eletriptan The metabolism of Vortioxetine can be increased when combined with Eletriptan.
Mefloquine	Mefloquine The metabolism of Vortioxetine can be decreased when combined with Mefloquine.
Rosuvastatin	Rosuvastatin The metabolism of Vortioxetine can be decreased when combined with Rosuvastatin.
Vardenafil	Vardenafil The metabolism of Vortioxetine can be decreased when combined with Vardenafil.
Aprepitant	Aprepitant The metabolism of Vortioxetine can be decreased when combined with Aprepitant.
Emtricitabine	Emtricitabine Emtricitabine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Memantine	Memantine The metabolism of Vortioxetine can be decreased when combined with Memantine.
Tegaserod	Tegaserod The metabolism of Vortioxetine can be decreased when combined with Tegaserod.
Tadalafil	Tadalafil Tadalafil may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Frovatriptan	Frovatriptan The risk or severity of adverse effects can be increased when Frovatriptan is combined with Vortioxetine.
Progesterone	Progesterone The metabolism of Vortioxetine can be decreased when combined with Progesterone.
Apomorphine Injection	Apomorphine Injection The risk or severity of hypotension can be increased when Apomorphine is combined with Vortioxetine.
Infliximab Injection	Infliximab Injection The metabolism of Vortioxetine can be increased when combined with Infliximab.
Oxandrolone	Oxandrolone The metabolism of Vortioxetine can be decreased when combined with Oxandrolone.
Protriptyline	Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Vortioxetine.
Rifaximin	Rifaximin The metabolism of Vortioxetine can be increased when combined with Rifaximin.
Duloxetine	Duloxetine The metabolism of Vortioxetine can be decreased when combined with Duloxetine.
Norethindrone	Norethindrone The metabolism of Vortioxetine can be decreased when combined with Norethisterone.
Tinidazole	Tinidazole Tinidazole may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Trospium	Trospium Vortioxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan	Bosentan The metabolism of Vortioxetine can be increased when combined with Bosentan.
Cefditoren	Cefditoren Cefdinir may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Cinacalcet	Cinacalcet The metabolism of Vortioxetine can be decreased when combined with Cinacalcet.
Cyanocobalamin Injection	Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Erlotinib	Erlotinib The metabolism of Vortioxetine can be decreased when combined with Erlotinib.
Eszopiclone	Eszopiclone The risk or severity of CNS depression can be increased when Vortioxetine is combined with Eszopiclone.
Ganciclovir	Ganciclovir Ganciclovir may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ribavirin	Ribavirin Ribavirin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Solifenacin	Solifenacin Vortioxetine may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir	Valganciclovir Valganciclovir may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Voriconazole	Voriconazole The metabolism of Vortioxetine can be decreased when combined with Voriconazole.
Adefovir	Adefovir Adefovir may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Dextroamphetamine	Dextroamphetamine The metabolism of Vortioxetine can be decreased when combined with Amphetamine.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The metabolism of Vortioxetine can be increased when combined with Peginterferon alfa-2b.
Sodium Oxybate	Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Isocarboxazid	Isocarboxazid The metabolism of Vortioxetine can be decreased when combined with Isocarboxazid.
Ramelteon	Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Vortioxetine.
Darifenacin	Darifenacin The metabolism of Darifenacin can be decreased when combined with Vortioxetine.
Fentanyl	Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Vortioxetine.
Pregabalin	Pregabalin The therapeutic efficacy of Vortioxetine can be increased when used in combination with Pregabalin.
Deferasirox	Deferasirox The metabolism of Vortioxetine can be decreased when combined with Deferasirox.
Phenylephrine	Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Vortioxetine.
Tipranavir	Tipranavir The metabolism of Tipranavir can be decreased when combined with Vortioxetine.
Felbamate	Felbamate The metabolism of Vortioxetine can be decreased when combined with Felbamate.
Ranolazine	Ranolazine The serum concentration of Vortioxetine can be increased when it is combined with Ranolazine.
Abatacept Injection	Abatacept Injection The metabolism of Vortioxetine can be increased when combined with Abatacept.
Rasagiline	Rasagiline The metabolism of Vortioxetine can be decreased when combined with Rasagiline.
Imatinib	Imatinib The metabolism of Vortioxetine can be decreased when combined with Imatinib.
Sitagliptin	Sitagliptin The metabolism of Vortioxetine can be decreased when combined with Sitagliptin.
Varenicline	Varenicline Varenicline may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Gefitinib	Gefitinib The metabolism of Vortioxetine can be decreased when combined with Gefitinib.
Albuterol	Albuterol Salbutamol may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Paliperidone	Paliperidone The risk or severity of adverse effects can be increased when Paliperidone is combined with Vortioxetine.
Bortezomib	Bortezomib The metabolism of Vortioxetine can be decreased when combined with Bortezomib.
Clofarabine Injection	Clofarabine Injection Clofarabine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Lubiprostone	Lubiprostone Lubiprostone may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Primaquine	Primaquine The metabolism of Vortioxetine can be decreased when combined with Primaquine.
Aliskiren	Aliskiren Vortioxetine may decrease the antihypertensive activities of Aliskiren.
Pemetrexed Injection	Pemetrexed Injection Vortioxetine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate	Dimenhydrinate The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Vortioxetine.
Lisdexamfetamine	Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Lisdexamfetamine is combined with Vortioxetine.
Nabilone	Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Sorafenib	Sorafenib The metabolism of Vortioxetine can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib The risk or severity of QTc prolongation and torsade de pointes can be increased when Sunitinib is combined with Vortioxetine.
Dronabinol	Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Lapatinib	Lapatinib The metabolism of Vortioxetine can be decreased when combined with Lapatinib.
Levocetirizine	Levocetirizine The risk or severity of adverse effects can be increased when Levocetirizine is combined with Vortioxetine.
Pegaptanib Injection	Pegaptanib Injection Pegaptanib may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Dasatinib	Dasatinib The metabolism of Vortioxetine can be decreased when combined with Dasatinib.
Mexiletine	Mexiletine The metabolism of Vortioxetine can be decreased when combined with Mexiletine.
Armodafinil	Armodafinil The metabolism of Vortioxetine can be decreased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection Azacitidine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Vortioxetine.
Lenalidomide	Lenalidomide Lenalidomide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Nilotinib	Nilotinib The metabolism of Vortioxetine can be decreased when combined with Nilotinib.
Bexarotene	Bexarotene The metabolism of Vortioxetine can be decreased when combined with Bexarotene.
Budesonide	Budesonide The metabolism of Vortioxetine can be increased when combined with Budesonide.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Vortioxetine can be decreased when combined with Chloramphenicol.
Desmopressin	Desmopressin Desmopressin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Vortioxetine.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Vortioxetine.
Doripenem Injection	Doripenem Injection Doripenem may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Etravirine	Etravirine The metabolism of Vortioxetine can be decreased when combined with Etravirine.
Arsenic Trioxide Injection	Arsenic Trioxide Injection Arsenic trioxide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Desvenlafaxine	Desvenlafaxine The risk or severity of adverse effects can be increased when Desvenlafaxine is combined with Vortioxetine.
Cevimeline	Cevimeline Cevimeline may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Nebivolol	Nebivolol The metabolism of Nebivolol can be decreased when combined with Vortioxetine.
Tretinoin	Tretinoin The metabolism of Vortioxetine can be decreased when combined with Tretinoin.
Pilocarpine	Pilocarpine The metabolism of Vortioxetine can be decreased when combined with Pilocarpine.
Flecainide	Flecainide The metabolism of Flecainide can be decreased when combined with Vortioxetine.
Certolizumab Injection	Certolizumab Injection The metabolism of Vortioxetine can be increased when combined with Certolizumab pegol.
Irinotecan Injection	Irinotecan Injection The metabolism of Vortioxetine can be decreased when combined with Irinotecan.
Daptomycin Injection	Daptomycin Injection Daptomycin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Praziquantel	Praziquantel The metabolism of Vortioxetine can be decreased when combined with Praziquantel.
Mitotane	Mitotane The metabolism of Vortioxetine can be increased when combined with Mitotane.
Methylnaltrexone Injection	Methylnaltrexone Injection Methylnaltrexone may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Rufinamide	Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Vortioxetine.
Midazolam	Midazolam The risk or severity of adverse effects can be increased when Midazolam is combined with Vortioxetine.
Naltrexone Injection	Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Vortioxetine.
Dexrazoxane Injection	Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Eltrombopag	Eltrombopag The metabolism of Vortioxetine can be decreased when combined with Eltrombopag.
Milnacipran	Milnacipran The risk or severity of adverse effects can be increased when Milnacipran is combined with Vortioxetine.
Dexlansoprazole	Dexlansoprazole The metabolism of Vortioxetine can be decreased when combined with Dexlansoprazole.
Plerixafor Injection	Plerixafor Injection Plerixafor may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Fesoterodine	Fesoterodine Fesoterodine may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Betaxolol	Betaxolol The metabolism of Vortioxetine can be decreased when combined with Betaxolol.
Iloperidone	Iloperidone The risk or severity of adverse effects can be increased when Iloperidone is combined with Vortioxetine.
Prasugrel	Prasugrel The metabolism of Vortioxetine can be decreased when combined with Prasugrel.
Lacosamide	Lacosamide The metabolism of Vortioxetine can be decreased when combined with Lacosamide.
Everolimus	Everolimus The metabolism of Vortioxetine can be decreased when combined with Everolimus.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone	Dronedarone The metabolism of Dronedarone can be decreased when combined with Vortioxetine.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Vortioxetine.
Pralatrexate Injection	Pralatrexate Injection Pralatrexate may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Palonosetron Injection	Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Vortioxetine.
Saxagliptin	Saxagliptin Saxagliptin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Telavancin Injection	Telavancin Injection Telavancin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Romidepsin Injection	Romidepsin Injection The metabolism of Vortioxetine can be decreased when combined with Romidepsin.
Tapentadol	Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Topotecan	Topotecan Topotecan may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Golimumab Injection	Golimumab Injection The metabolism of Vortioxetine can be increased when combined with Golimumab.
Pazopanib	Pazopanib The metabolism of Vortioxetine can be decreased when combined with Pazopanib.
Asenapine	Asenapine The risk or severity of adverse effects can be increased when Asenapine is combined with Vortioxetine.
Vigabatrin	Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Vortioxetine.
Pitavastatin	Pitavastatin The metabolism of Vortioxetine can be decreased when combined with Pitavastatin.
Albendazole	Albendazole The metabolism of Vortioxetine can be decreased when combined with Albendazole.
Levonorgestrel	Levonorgestrel The metabolism of Vortioxetine can be decreased when combined with Levonorgestrel.
Oxymorphone	Oxymorphone The risk or severity of adverse effects can be increased when Oxymorphone is combined with Vortioxetine.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Vortioxetine can be increased when combined with Tocilizumab.
Dalfampridine	Dalfampridine Dalfampridine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Vortioxetine.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Vortioxetine can be decreased when combined with Cabazitaxel.
Ceftaroline Injection	Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Lurasidone	Lurasidone The risk or severity of adverse effects can be increased when Lurasidone is combined with Vortioxetine.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Vortioxetine can be decreased when combined with Acetaminophen.
Vilazodone	Vilazodone The metabolism of Vortioxetine can be decreased when combined with Vilazodone.
Ipilimumab Injection	Ipilimumab Injection Ipilimumab may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Denileukin Diftitox Injection	Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Terbutaline Injection	Terbutaline Injection Terbutaline may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Roflumilast	Roflumilast Roflumilast may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Rilpivirine	Rilpivirine The metabolism of Vortioxetine can be decreased when combined with Rilpivirine.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Vortioxetine can be decreased when combined with Cyclophosphamide.
Abiraterone	Abiraterone The metabolism of Vortioxetine can be decreased when combined with Abiraterone.
Rivaroxaban	Rivaroxaban Rivaroxaban may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ticagrelor	Ticagrelor The metabolism of Vortioxetine can be decreased when combined with Ticagrelor.
Ruxolitinib	Ruxolitinib Ruxolitinib may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Clobazam	Clobazam The metabolism of Vortioxetine can be decreased when combined with Clobazam.
Vemurafenib	Vemurafenib The metabolism of Vortioxetine can be decreased when combined with Vemurafenib.
Vismodegib	Vismodegib The metabolism of Vortioxetine can be decreased when combined with Vismodegib.
Ivacaftor	Ivacaftor The metabolism of Vortioxetine can be decreased when combined with Ivacaftor.
Deferiprone	Deferiprone Deferiprone may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Axitinib	Axitinib The metabolism of Vortioxetine can be decreased when combined with Axitinib.
Crizotinib	Crizotinib The metabolism of Vortioxetine can be decreased when combined with Crizotinib.
Cabergoline	Cabergoline Cabergoline may increase the vasoconstricting activities of Vortioxetine.
Naloxone Injection	Naloxone Injection Naloxone may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ambrisentan	Ambrisentan The metabolism of Vortioxetine can be decreased when combined with Ambrisentan.
Fondaparinux Injection	Fondaparinux Injection Fondaparinux may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ezogabine	Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Vortioxetine.
Enzalutamide	Enzalutamide The metabolism of Vortioxetine can be increased when combined with Enzalutamide.
Mirabegron	Mirabegron The metabolism of Vortioxetine can be decreased when combined with Mirabegron.
Regorafenib	Regorafenib The metabolism of Vortioxetine can be decreased when combined with Regorafenib.
Bosutinib	Bosutinib The metabolism of Vortioxetine can be decreased when combined with Bosutinib.
Teriflunomide	Teriflunomide The metabolism of Vortioxetine can be decreased when combined with Teriflunomide.
Cabozantinib (thyroid cancer)	Cabozantinib (thyroid cancer) The metabolism of Vortioxetine can be decreased when combined with Cabozantinib.
Teduglutide Injection	Teduglutide Injection Teduglutide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Alogliptin	Alogliptin Alogliptin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ponatinib	Ponatinib The metabolism of Vortioxetine can be decreased when combined with Ponatinib.
Pomalidomide	Pomalidomide The risk or severity of adverse effects can be increased when Pomalidomide is combined with Vortioxetine.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Vortioxetine can be decreased when combined with Trastuzumab emtansine.
Apixaban	Apixaban The metabolism of Vortioxetine can be decreased when combined with Apixaban.
Canagliflozin	Canagliflozin Canagliflozin may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide	Methazolamide Methazolamide may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib	Dabrafenib The serum concentration of Vortioxetine can be decreased when it is combined with Dabrafenib.
Ospemifene	Ospemifene The metabolism of Vortioxetine can be decreased when combined with Ospemifene.
Trametinib	Trametinib The metabolism of Vortioxetine can be decreased when combined with Trametinib.
Levomilnacipran	Levomilnacipran The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Vortioxetine.
Ertapenem Injection	Ertapenem Injection Ertapenem may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Perampanel	Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Ibrutinib	Ibrutinib The metabolism of Vortioxetine can be decreased when combined with Ibrutinib.
Ketorolac Injection	Ketorolac Injection Ketorolac may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Sofosbuvir	Sofosbuvir Sofosbuvir may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Dapagliflozin	Dapagliflozin The metabolism of Vortioxetine can be decreased when combined with Dapagliflozin.
Apremilast	Apremilast The metabolism of Vortioxetine can be increased when combined with Apremilast.
Droxidopa	Droxidopa Vortioxetine may increase the hypertensive activities of Droxidopa.
Ceritinib	Ceritinib The metabolism of Vortioxetine can be decreased when combined with Ceritinib.
Siltuximab Injection	Siltuximab Injection The metabolism of Vortioxetine can be increased when combined with Siltuximab.
Eslicarbazepine	Eslicarbazepine The risk or severity of adverse effects can be increased when Vortioxetine is combined with Eslicarbazepine.
Testosterone Injection	Testosterone Injection The metabolism of Vortioxetine can be decreased when combined with Testosterone.
Oritavancin Injection	Oritavancin Injection The metabolism of Vortioxetine can be decreased when combined with Oritavancin.
Hydrocodone	Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Suvorexant	Suvorexant Vortioxetine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Edoxaban	Edoxaban Vortioxetine may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Olaparib	Olaparib The metabolism of Olaparib can be decreased when combined with Vortioxetine.
Methamphetamine	Methamphetamine The risk or severity of adverse effects can be increased when Metamfetamine is combined with Vortioxetine.
Tasimelteon	Tasimelteon The risk or severity of adverse effects can be increased when Vortioxetine is combined with Tasimelteon.
Riociguat	Riociguat The metabolism of Vortioxetine can be decreased when combined with Riociguat.
Secukinumab Injection	Secukinumab Injection The metabolism of Vortioxetine can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Vortioxetine.
Lenvatinib	Lenvatinib The metabolism of Vortioxetine can be decreased when combined with Lenvatinib.
Naloxegol	Naloxegol The metabolism of Vortioxetine can be decreased when combined with Naloxegol.
Panobinostat	Panobinostat The metabolism of Vortioxetine can be decreased when combined with Panobinostat.
Haloperidol Injection	Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Vortioxetine.
Amiloride	Amiloride Amiloride may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan	Macitentan Macitentan may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Flibanserin	Flibanserin The risk or severity of adverse effects can be increased when Flibanserin is combined with Vortioxetine.
Rolapitant	Rolapitant The metabolism of Vortioxetine can be decreased when combined with Rolapitant.
Daclatasvir	Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Vortioxetine.
Brexpiprazole	Brexpiprazole The risk or severity of adverse effects can be increased when Vortioxetine is combined with Brexpiprazole.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Vortioxetine.
Cariprazine	Cariprazine The risk or severity of adverse effects can be increased when Cariprazine is combined with Vortioxetine.
Penicillin G Procaine Injection	Penicillin G Procaine Injection Vortioxetine may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline	Eluxadoline The risk or severity of serotonin syndrome can be increased when Vortioxetine is combined with Eluxadoline.
Trabectedin Injection	Trabectedin Injection The metabolism of Vortioxetine can be decreased when combined with Trabectedin.
Ixazomib	Ixazomib Vortioxetine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rifapentine	Rifapentine The metabolism of Vortioxetine can be increased when combined with Rifapentine.
Lesinurad	Lesinurad Vortioxetine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Vortioxetine can be increased when combined with Dexamethasone.
Brivaracetam Injection	Brivaracetam Injection The metabolism of Vortioxetine can be decreased when combined with Brivaracetam.
Cobicistat	Cobicistat The metabolism of Vortioxetine can be decreased when combined with Cobicistat.
Midodrine	Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Vortioxetine.
Selexipag	Selexipag The metabolism of Selexipag can be decreased when combined with Vortioxetine.
Pimavanserin	Pimavanserin The risk or severity of adverse effects can be increased when Pimavanserin is combined with Vortioxetine.
Diphenhydramine Injection	Diphenhydramine Injection The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Vortioxetine.
Furosemide Injection	Furosemide Injection Furosemide may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib	Rucaparib The metabolism of Vortioxetine can be decreased when combined with Rucaparib.
Lixisenatide Injection	Lixisenatide Injection Vortioxetine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Brigatinib	Brigatinib The metabolism of Brigatinib can be decreased when combined with Vortioxetine.
Doxepin (Insomnia)	Doxepin (Insomnia) Doxepin may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Deutetrabenazine	Deutetrabenazine Vortioxetine may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine	Valbenazine Vortioxetine may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort	Deflazacort The metabolism of Vortioxetine can be increased when combined with Deflazacort.
Safinamide	Safinamide The metabolism of Vortioxetine can be decreased when combined with Safinamide.
Naldemedine	Naldemedine Vortioxetine may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin	Midostaurin The metabolism of Vortioxetine can be increased when combined with Midostaurin.
Enasidenib	Enasidenib The metabolism of Vortioxetine can be decreased when combined with Enasidenib.
Benznidazole	Benznidazole Vortioxetine may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection	Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Vortioxetine.
Delafloxacin	Delafloxacin Vortioxetine may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Acalabrutinib	Acalabrutinib The metabolism of Vortioxetine can be decreased when combined with Acalabrutinib.
Letermovir	Letermovir The metabolism of Vortioxetine can be decreased when combined with Letermovir.
Tetrabenazine	Tetrabenazine The metabolism of Vortioxetine can be decreased when combined with Tetrabenazine.
Ertugliflozin	Ertugliflozin Ertugliflozin may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection	Buprenorphine Injection Vortioxetine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide	Apalutamide The metabolism of Vortioxetine can be increased when combined with Apalutamide.
Avatrombopag	Avatrombopag The metabolism of Vortioxetine can be increased when combined with Avatrombopag.
Baricitinib	Baricitinib Vortioxetine may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine	Lofexidine The therapeutic efficacy of Vortioxetine can be increased when used in combination with Lofexidine.
Plazomicin Injection	Plazomicin Injection Vortioxetine may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat	Eliglustat The metabolism of Vortioxetine can be decreased when combined with Eliglustat.
Encorafenib	Encorafenib The metabolism of Encorafenib can be decreased when combined with Vortioxetine.
Elagolix	Elagolix The metabolism of Elagolix can be decreased when combined with Vortioxetine.
Doravirine	Doravirine The metabolism of Doravirine can be decreased when combined with Vortioxetine.
Tafenoquine	Tafenoquine The metabolism of Vortioxetine can be decreased when combined with Tafenoquine.
Cannabidiol	Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Vortioxetine.
Dacomitinib	Dacomitinib The metabolism of Vortioxetine can be decreased when combined with Dacomitinib.
Stiripentol	Stiripentol The metabolism of Vortioxetine can be decreased when combined with Stiripentol.
Gilteritinib	Gilteritinib The therapeutic efficacy of Vortioxetine can be decreased when used in combination with Gilteritinib.
Glasdegib	Glasdegib The metabolism of Glasdegib can be decreased when combined with Vortioxetine.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Vortioxetine.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Vortioxetine.
Rifamycin	Rifamycin The metabolism of Vortioxetine can be increased when combined with Rifamycin.
Prucalopride	Prucalopride Prucalopride may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Vortioxetine can be increased when combined with Emapalumab.
Siponimod	Siponimod The metabolism of Siponimod can be decreased when combined with Vortioxetine.
Acyclovir Ophthalmic	Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Erdafitinib	Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Vortioxetine.
Esomeprazole Injection	Esomeprazole Injection The metabolism of Vortioxetine can be decreased when combined with Esomeprazole.
Alpelisib	Alpelisib The serum concentration of Vortioxetine can be decreased when it is combined with Alpelisib.
Brexanolone Injection	Brexanolone Injection The risk or severity of adverse effects can be increased when Vortioxetine is combined with Brexanolone.
Solriamfetol	Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Vortioxetine.
Triclabendazole	Triclabendazole The metabolism of Vortioxetine can be decreased when combined with Triclabendazole.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Vortioxetine.
Pitolisant	Pitolisant The serum concentration of Vortioxetine can be decreased when it is combined with Pitolisant.
Fedratinib	Fedratinib The metabolism of Fedratinib can be decreased when combined with Vortioxetine.
Phenytoin Injection	Phenytoin Injection The metabolism of Vortioxetine can be increased when combined with Phenytoin.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Vortioxetine can be increased when combined with Fosphenytoin.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Vortioxetine.
Voxelotor	Voxelotor The metabolism of Voxelotor can be decreased when combined with Vortioxetine.
Avapritinib	Avapritinib The metabolism of Avapritinib can be decreased when combined with Vortioxetine.
Lumateperone	Lumateperone The risk or severity of adverse effects can be increased when Vortioxetine is combined with Lumateperone.
Lasmiditan	Lasmiditan The risk or severity of serotonin syndrome can be increased when Vortioxetine is combined with Lasmiditan.
Cenobamate	Cenobamate The serum concentration of Vortioxetine can be decreased when it is combined with Cenobamate.
Ozanimod	Ozanimod The metabolism of Ozanimod can be decreased when combined with Vortioxetine.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Vortioxetine.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Vortioxetine.
Selpercatinib	Selpercatinib The serum concentration of Selpercatinib can be increased when it is combined with Vortioxetine.
Lemborexant	Lemborexant The serum concentration of Vortioxetine can be decreased when it is combined with Lemborexant.
Fenfluramine	Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Vortioxetine.
Pralsetinib	Pralsetinib The metabolism of Vortioxetine can be decreased when combined with Pralsetinib.
Opicapone	Opicapone The metabolism of Vortioxetine can be decreased when combined with Opicapone.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Vortioxetine can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection	Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Vortioxetine is combined with Naxitamab.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine	Viloxazine The risk or severity of adverse effects can be increased when Vortioxetine is combined with Viloxazine.
Tobramycin Injection	Tobramycin Injection Tobramycin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Theophylline	Theophylline The metabolism of Vortioxetine can be decreased when combined with Theophylline.
Fenoprofen	Fenoprofen Fenoprofen may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Indomethacin	Indomethacin Indomethacin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Mefenamic Acid	Mefenamic Acid The metabolism of Vortioxetine can be decreased when combined with Mefenamic acid.
Naproxen	Naproxen Naproxen may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Tolmetin	Tolmetin Tolmetin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Sulindac	Sulindac Sulindac may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Trazodone	Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Vortioxetine.
Isotretinoin	Isotretinoin Isotretinoin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Sucralfate	Sucralfate Sucralfate may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Hydroxyurea	Hydroxyurea The metabolism of Vortioxetine can be decreased when combined with Hydroxyurea.
Floxuridine	Floxuridine The metabolism of Vortioxetine can be decreased when combined with Floxuridine.
Phenobarbital	Phenobarbital The metabolism of Vortioxetine can be increased when combined with Phenobarbital.
Metaxalone	Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Vortioxetine.
Methotrexate Injection	Methotrexate Injection Methotrexate may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Levorphanol	Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Vortioxetine.
Primidone	Primidone The metabolism of Vortioxetine can be increased when combined with Primidone.
Methsuximide	Methsuximide The metabolism of Vortioxetine can be decreased when combined with Methsuximide.
Diethylpropion	Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with Vortioxetine.
Chlorpromazine	Chlorpromazine The metabolism of Vortioxetine can be decreased when combined with Chlorpromazine.
Diazepam	Diazepam The risk or severity of adverse effects can be increased when Diazepam is combined with Vortioxetine.
Oxazepam	Oxazepam The risk or severity of adverse effects can be increased when Oxazepam is combined with Vortioxetine.
Flurazepam	Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Vortioxetine.
Clorazepate	Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Vortioxetine.
Lorazepam	Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Vortioxetine.
Phenoxybenzamine	Phenoxybenzamine The risk or severity of hypertension can be increased when Phenoxybenzamine is combined with Vortioxetine.
Carmustine	Carmustine Carmustine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Amantadine	Amantadine The risk or severity of serotonin syndrome can be increased when Amantadine is combined with Vortioxetine.
Codeine	Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Vortioxetine.
Meprobamate	Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Vortioxetine.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Vortioxetine.
Bromocriptine	Bromocriptine Bromocriptine may increase the vasoconstricting activities of Vortioxetine.
Metaproterenol	Metaproterenol The risk or severity of hypertension can be increased when Orciprenaline is combined with Vortioxetine.
Tranylcypromine	Tranylcypromine The metabolism of Vortioxetine can be decreased when combined with Tranylcypromine.
Phenelzine	Phenelzine The metabolism of Vortioxetine can be decreased when combined with Phenelzine.
Procarbazine	Procarbazine The metabolism of Vortioxetine can be decreased when combined with Procarbazine.
Ergoloid Mesylates	Ergoloid Mesylates Ergoloid mesylate may increase the vasoconstricting activities of Vortioxetine.
Tetracycline	Tetracycline Tetracycline may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Minocycline	Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Prochlorperazine	Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Vortioxetine.
Thioridazine	Thioridazine The metabolism of Vortioxetine can be decreased when combined with Thioridazine.
Trifluoperazine	Trifluoperazine The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Vortioxetine.
Bleomycin	Bleomycin Bleomycin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Dapsone	Dapsone The metabolism of Vortioxetine can be decreased when combined with Dapsone.
Sulfadiazine	Sulfadiazine The metabolism of Vortioxetine can be decreased when combined with Sulfadiazine.
Oxycodone	Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Vortioxetine.
Methadone	Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Vortioxetine.
Oxybutynin	Oxybutynin The metabolism of Vortioxetine can be decreased when combined with Oxybutynin.
Benztropine	Benztropine Benzatropine may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Maprotiline	Maprotiline The risk or severity of adverse effects can be increased when Maprotiline is combined with Vortioxetine.
Ibuprofen	Ibuprofen Ibuprofen may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Trihexyphenidyl	Trihexyphenidyl Vortioxetine may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine	Orphenadrine Vortioxetine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine	Perphenazine The risk or severity of adverse effects can be increased when Perphenazine is combined with Vortioxetine.
Azathioprine	Azathioprine Azathioprine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Fluphenazine	Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Vortioxetine.
Phentermine	Phentermine The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Vortioxetine.
Methylphenidate	Methylphenidate Methylphenidate may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Amoxapine	Amoxapine The metabolism of Amoxapine can be decreased when combined with Vortioxetine.
Sulfasalazine	Sulfasalazine Sulfasalazine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Hydrocortisone	Hydrocortisone The metabolism of Vortioxetine can be increased when combined with Hydrocortisone.
Doxorubicin	Doxorubicin The metabolism of Vortioxetine can be decreased when combined with Doxorubicin.
Phenazopyridine	Phenazopyridine Phenazopyridine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Carbamazepine	Carbamazepine The metabolism of Vortioxetine can be increased when combined with Carbamazepine.
Molindone	Molindone The risk or severity of adverse effects can be increased when Molindone is combined with Vortioxetine.
Methyldopa	Methyldopa Methyldopa may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Vortioxetine.
Prazosin	Prazosin Vortioxetine may decrease the antihypertensive activities of Prazosin.
Hydralazine	Hydralazine Hydralazine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Cimetidine	Cimetidine The metabolism of Vortioxetine can be decreased when combined with Cimetidine.
Gentamicin Injection	Gentamicin Injection Gentamicin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Warfarin	Warfarin The metabolism of Vortioxetine can be decreased when combined with Warfarin.
Clonazepam	Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Vortioxetine.
Loperamide	Loperamide The metabolism of Vortioxetine can be decreased when combined with Loperamide.
Promethazine	Promethazine The metabolism of Vortioxetine can be decreased when combined with Promethazine.
Meclofenamate	Meclofenamate Meclofenamic acid may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Daunorubicin	Daunorubicin The metabolism of Vortioxetine can be increased when combined with Daunorubicin.
Nitrofurantoin	Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Griseofulvin	Griseofulvin The metabolism of Vortioxetine can be increased when combined with Griseofulvin.
Digoxin	Digoxin Vortioxetine may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine	Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Vortioxetine.
Chloroquine	Chloroquine The metabolism of Vortioxetine can be decreased when combined with Chloroquine.
Quinine	Quinine The metabolism of Vortioxetine can be decreased when combined with Quinine.
Ethosuximide	Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Vortioxetine.
Triamterene	Triamterene Triamterene may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Sulfinpyrazone	Sulfinpyrazone The metabolism of Vortioxetine can be decreased when combined with Sulfinpyrazone.
Chlorothiazide	Chlorothiazide Chlorothiazide may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone	Chlorthalidone Chlorthalidone may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone	Metolazone Metolazone may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide	Isosorbide Isosorbide may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Clindamycin Injection	Clindamycin Injection The metabolism of Vortioxetine can be decreased when combined with Clindamycin.
Secobarbital	Secobarbital The metabolism of Vortioxetine can be increased when combined with Secobarbital.
Desipramine	Desipramine The metabolism of Vortioxetine can be decreased when combined with Desipramine.
Amitriptyline	Amitriptyline The metabolism of Vortioxetine can be decreased when combined with Amitriptyline.
Imipramine	Imipramine The metabolism of Vortioxetine can be decreased when combined with Imipramine.
Probenecid	Probenecid The metabolism of Vortioxetine can be decreased when combined with Probenecid.
Quinidine	Quinidine The metabolism of Vortioxetine can be decreased when combined with Quinidine.
Procainamide	Procainamide The metabolism of Procainamide can be decreased when combined with Vortioxetine.
Isoniazid	Isoniazid The metabolism of Vortioxetine can be decreased when combined with Isoniazid.
Pyrazinamide	Pyrazinamide Pyrazinamide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Rifampin	Rifampin The metabolism of Vortioxetine can be increased when combined with Rifampicin.
Disopyramide	Disopyramide Disopyramide may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Valproic Acid	Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Vortioxetine.
Tamoxifen	Tamoxifen The metabolism of Vortioxetine can be decreased when combined with Tamoxifen.
Butabarbital	Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Vortioxetine.
Levothyroxine	Levothyroxine The metabolism of Vortioxetine can be decreased when combined with Levothyroxine.
Liothyronine	Liothyronine Liothyronine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Methimazole	Methimazole The metabolism of Vortioxetine can be decreased when combined with Methimazole.
Chlorpropamide	Chlorpropamide Chlorpropamide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Tolbutamide	Tolbutamide The metabolism of Vortioxetine can be decreased when combined with Tolbutamide.
Tolazamide	Tolazamide Tolazamide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Dextromethorphan	Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Vortioxetine.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of CNS depression can be increased when Vortioxetine is combined with Cyclobenzaprine.
Niacin	Niacin The metabolism of Vortioxetine can be decreased when combined with Niacin.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Vortioxetine.
Doxylamine	Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Cyproheptadine	Cyproheptadine The risk or severity of adverse effects can be increased when Cyproheptadine is combined with Vortioxetine.
Clemastine	Clemastine The metabolism of Vortioxetine can be decreased when combined with Clemastine.
Chlorpheniramine	Chlorpheniramine The risk or severity of adverse effects can be increased when Chlorpheniramine is combined with Vortioxetine.
Brompheniramine	Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Vortioxetine.
Meclizine	Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Vortioxetine.
Ethambutol	Ethambutol Ethambutol may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Methyclothiazide	Methyclothiazide Methyclothiazide may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide	Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Dantrolene	Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Vortioxetine.
Chlorzoxazone	Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Vortioxetine.
Carisoprodol	Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Vortioxetine.
Methocarbamol	Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Vortioxetine.
Pyridoxine	Pyridoxine Pyridoxine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Folic Acid	Folic Acid Folic acid may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Disulfiram	Disulfiram The metabolism of Vortioxetine can be decreased when combined with Disulfiram.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The metabolism of Vortioxetine can be decreased when combined with Propranolol.
Minoxidil	Minoxidil Vortioxetine may decrease the antihypertensive activities of Minoxidil.
Pseudoephedrine	Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Pseudoephedrine is combined with Vortioxetine.
Nortriptyline	Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Vortioxetine.
Spironolactone	Spironolactone The metabolism of Vortioxetine can be decreased when combined with Spironolactone.
Amphotericin B Injection	Amphotericin B Injection Amphotericin B may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Phytonadione	Phytonadione Phylloquinone may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Amikacin Injection	Amikacin Injection Amikacin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Nadolol	Nadolol Nadolol may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Butorphanol Injection	Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Vortioxetine.
Nalbuphine Injection	Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Vortioxetine.
Allopurinol	Allopurinol Allopurinol may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Trimethobenzamide	Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Vortioxetine.
Flavoxate	Flavoxate Flavoxate may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Fluorouracil Injection	Fluorouracil Injection The metabolism of Vortioxetine can be decreased when combined with Fluorouracil.
Colchicine	Colchicine The metabolism of Vortioxetine can be decreased when combined with Colchicine.
Cefaclor	Cefaclor Cefaclor may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Cefadroxil	Cefadroxil Cefadroxil may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Cefazolin Injection	Cefazolin Injection Cefazolin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Cephalexin	Cephalexin Cephalexin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Cefoxitin Injection	Cefoxitin Injection Cefoxitin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Dacarbazine	Dacarbazine Dacarbazine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Acetazolamide	Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Vortioxetine.
Cefotaxime Injection	Cefotaxime Injection Cefotaxime may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Calcitonin Salmon Injection	Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ketoconazole	Ketoconazole The metabolism of Vortioxetine can be decreased when combined with Ketoconazole.
Pyrantel	Pyrantel The risk or severity of adverse effects can be increased when Vortioxetine is combined with Pyrantel.
Thiotepa Injection	Thiotepa Injection The metabolism of Vortioxetine can be decreased when combined with Thiotepa.
Vincristine Injection	Vincristine Injection The metabolism of Vortioxetine can be decreased when combined with Vincristine.
Captopril	Captopril Vortioxetine may decrease the antihypertensive activities of Captopril.
Isoxsuprine	Isoxsuprine The risk or severity of hypertension can be increased when Isoxsuprine is combined with Vortioxetine.
Vinblastine	Vinblastine The metabolism of Vortioxetine can be decreased when combined with Vinblastine.
Ethacrynic Acid	Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Colistimethate Injection	Colistimethate Injection Colistimethate may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Metoprolol	Metoprolol The metabolism of Vortioxetine can be decreased when combined with Metoprolol.
Hydroxyzine	Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Thiothixene	Thiothixene The risk or severity of adverse effects can be increased when Thiothixene is combined with Vortioxetine.
Aspirin	Aspirin Acetylsalicylic acid may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Salsalate	Salsalate Salsalate may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Alprazolam	Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Vortioxetine.
Temazepam	Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Vortioxetine.
Triazolam	Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Vortioxetine.
Dicyclomine	Dicyclomine Dicyclomine may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Hyoscyamine	Hyoscyamine Vortioxetine may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline	Propantheline Propantheline may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Trimethoprim	Trimethoprim The metabolism of Vortioxetine can be decreased when combined with Trimethoprim.
Diltiazem	Diltiazem The metabolism of Vortioxetine can be decreased when combined with Diltiazem.
Nifedipine	Nifedipine The metabolism of Vortioxetine can be decreased when combined with Nifedipine.
Timolol	Timolol The metabolism of Vortioxetine can be decreased when combined with Timolol.
Verapamil	Verapamil The metabolism of Vortioxetine can be decreased when combined with Verapamil.
Atenolol	Atenolol The metabolism of Vortioxetine can be decreased when combined with Atenolol.
Pindolol	Pindolol The risk or severity of adverse effects can be increased when Pindolol is combined with Vortioxetine.
Cisplatin Injection	Cisplatin Injection Vortioxetine may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal	Diflunisal Diflunisal may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Piroxicam	Piroxicam Piroxicam may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Bumetanide	Bumetanide Bumetanide may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide	Etoposide The metabolism of Vortioxetine can be decreased when combined with Etoposide.
Glyburide	Glyburide The metabolism of Vortioxetine can be decreased when combined with Glyburide.
Glipizide	Glipizide Glipizide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Indapamide	Indapamide Indapamide may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin	Amoxicillin Amoxicillin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Oxacillin Injection	Oxacillin Injection Oxacillin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Pentoxifylline	Pentoxifylline Pentoxifylline may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Pentamidine Injection	Pentamidine Injection Pentamidine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ceftriaxone Injection	Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Labetalol	Labetalol The metabolism of Vortioxetine can be decreased when combined with Labetalol.
Auranofin	Auranofin Auranofin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Leuprolide Injection	Leuprolide Injection Leuprolide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Gemfibrozil	Gemfibrozil The metabolism of Vortioxetine can be decreased when combined with Gemfibrozil.
Guanabenz	Guanabenz The risk or severity of hypertension can be increased when Guanabenz is combined with Vortioxetine.
Dipivefrin Ophthalmic	Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ceftazidime Injection	Ceftazidime Injection Ceftazidime may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ketoprofen	Ketoprofen Ketoprofen may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Cefotetan Injection	Cefotetan Injection Cefotetan may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Pimozide	Pimozide The metabolism of Vortioxetine can be decreased when combined with Pimozide.
Enalapril	Enalapril Vortioxetine may decrease the antihypertensive activities of Enalapril.
Flurbiprofen	Flurbiprofen Flurbiprofen may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Amiodarone	Amiodarone The metabolism of Vortioxetine can be decreased when combined with Amiodarone.
Aztreonam Injection	Aztreonam Injection Aztreonam may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Buspirone	Buspirone The risk or severity of serotonin syndrome can be increased when Buspirone is combined with Vortioxetine.
Lovastatin	Lovastatin The metabolism of Vortioxetine can be decreased when combined with Lovastatin.
Ciprofloxacin	Ciprofloxacin The metabolism of Vortioxetine can be decreased when combined with Ciprofloxacin.
Mesalamine	Mesalamine Mesalazine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Diclofenac	Diclofenac Diclofenac may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Fluoxetine	Fluoxetine The serum concentration of Vortioxetine can be increased when it is combined with Fluoxetine.
Nimodipine	Nimodipine Vortioxetine may decrease the antihypertensive activities of Nimodipine.
Clozapine	Clozapine The metabolism of Vortioxetine can be decreased when combined with Clozapine.
Estazolam	Estazolam The risk or severity of adverse effects can be increased when Estazolam is combined with Vortioxetine.
Idarubicin	Idarubicin The metabolism of Vortioxetine can be decreased when combined with Idarubicin.
Didanosine	Didanosine Didanosine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Pentostatin Injection	Pentostatin Injection Pentostatin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Clarithromycin	Clarithromycin The metabolism of Vortioxetine can be decreased when combined with Clarithromycin.
Benazepril	Benazepril Vortioxetine may decrease the antihypertensive activities of Benazepril.
Etodolac	Etodolac Etodolac may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Felodipine	Felodipine The metabolism of Vortioxetine can be decreased when combined with Felodipine.
Fosinopril	Fosinopril Fosinopril may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Nabumetone	Nabumetone Nabumetone may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Quinapril	Quinapril Vortioxetine may decrease the antihypertensive activities of Quinapril.
Ramipril	Ramipril Vortioxetine may decrease the antihypertensive activities of Ramipril.
Simvastatin	Simvastatin The metabolism of Vortioxetine can be decreased when combined with Simvastatin.
Amlodipine	Amlodipine Vortioxetine may decrease the antihypertensive activities of Amlodipine.
Teniposide Injection	Teniposide Injection The metabolism of Vortioxetine can be decreased when combined with Teniposide.
Itraconazole	Itraconazole The metabolism of Vortioxetine can be decreased when combined with Itraconazole.
Lisinopril	Lisinopril Lisinopril may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Oxaprozin	Oxaprozin Oxaprozin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Atovaquone	Atovaquone The metabolism of Vortioxetine can be decreased when combined with Atovaquone.
Rifabutin	Rifabutin The metabolism of Vortioxetine can be increased when combined with Rifabutin.
Sotalol	Sotalol The metabolism of Sotalol can be decreased when combined with Vortioxetine.
Bisoprolol	Bisoprolol Bisoprolol may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Zolpidem	Zolpidem Vortioxetine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin	Doxazosin The metabolism of Vortioxetine can be decreased when combined with Doxazosin.
Terazosin	Terazosin Vortioxetine may decrease the antihypertensive activities of Terazosin.
Isradipine	Isradipine Isradipine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Omeprazole	Omeprazole The metabolism of Vortioxetine can be decreased when combined with Omeprazole.
Cisapride	Cisapride The metabolism of Vortioxetine can be decreased when combined with Cisapride.
Gabapentin	Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Vortioxetine.
Fluvastatin	Fluvastatin The metabolism of Vortioxetine can be decreased when combined with Fluvastatin.
Venlafaxine	Venlafaxine The metabolism of Vortioxetine can be decreased when combined with Venlafaxine.
Fluvoxamine	Fluvoxamine The metabolism of Vortioxetine can be decreased when combined with Fluvoxamine.
Nefazodone	Nefazodone The risk or severity of adverse effects can be increased when Nefazodone is combined with Vortioxetine.
Lamotrigine	Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Vortioxetine.
Losartan	Losartan The metabolism of Vortioxetine can be decreased when combined with Losartan.
Valacyclovir	Valacyclovir Valaciclovir may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Tramadol	Tramadol The risk or severity of serotonin syndrome can be increased when Vortioxetine is combined with Tramadol.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Vortioxetine can be decreased when combined with Vinorelbine.
Carboplatin Injection	Carboplatin Injection Carboplatin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Moexipril	Moexipril Vortioxetine may decrease the antihypertensive activities of Moexipril.
Lansoprazole	Lansoprazole The metabolism of Vortioxetine can be decreased when combined with Lansoprazole.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Vortioxetine can be decreased when combined with Ifosfamide.
Nicardipine	Nicardipine The metabolism of Vortioxetine can be decreased when combined with Nicardipine.
Bupropion	Bupropion The risk or severity of adverse effects can be increased when Bupropion is combined with Vortioxetine.
Ticlopidine	Ticlopidine The metabolism of Vortioxetine can be decreased when combined with Ticlopidine.
Saquinavir	Saquinavir The metabolism of Vortioxetine can be decreased when combined with Saquinavir.
Metformin	Metformin Metformin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Nisoldipine	Nisoldipine Nisoldipine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Lamivudine	Lamivudine Lamivudine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Riluzole	Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Vortioxetine.
Acarbose	Acarbose Acarbose may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Glimepiride	Glimepiride The metabolism of Vortioxetine can be decreased when combined with Glimepiride.
Anastrozole	Anastrozole The metabolism of Vortioxetine can be decreased when combined with Anastrozole.
Gemcitabine Injection	Gemcitabine Injection Gemcitabine may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Indinavir	Indinavir The metabolism of Vortioxetine can be decreased when combined with Indinavir.
Ritonavir	Ritonavir The serum concentration of Vortioxetine can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Vortioxetine can be decreased when combined with Docetaxel.
Cidofovir Injection	Cidofovir Injection Cidofovir may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Meropenem Injection	Meropenem Injection Meropenem may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Clomipramine	Clomipramine The metabolism of Vortioxetine can be decreased when combined with Clomipramine.
Zafirlukast	Zafirlukast The metabolism of Vortioxetine can be decreased when combined with Zafirlukast.
Fosfomycin	Fosfomycin Fosfomycin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Mirtazapine	Mirtazapine Vortioxetine may increase the serotonergic activities of Mirtazapine.
Trandolapril	Trandolapril Vortioxetine may decrease the antihypertensive activities of Trandolapril.
Topiramate	Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Vortioxetine.
Zileuton	Zileuton The metabolism of Vortioxetine can be decreased when combined with Zileuton.
Valsartan	Valsartan The metabolism of Vortioxetine can be decreased when combined with Valsartan.
Pramipexole	Pramipexole Vortioxetine may increase the sedative activities of Pramipexole.
Donepezil	Donepezil The risk or severity of adverse effects can be increased when Donepezil is combined with Vortioxetine.
Nelfinavir	Nelfinavir The metabolism of Vortioxetine can be decreased when combined with Nelfinavir.
Azithromycin	Azithromycin The metabolism of Vortioxetine can be decreased when combined with Azithromycin.
Loratadine	Loratadine The metabolism of Vortioxetine can be decreased when combined with Loratadine.
Carvedilol	Carvedilol Vortioxetine may decrease the antihypertensive activities of Carvedilol.
Nilutamide	Nilutamide The metabolism of Vortioxetine can be decreased when combined with Nilutamide.
Flutamide	Flutamide Flutamide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Selegiline	Selegiline The metabolism of Vortioxetine can be decreased when combined with Selegiline.
Bicalutamide	Bicalutamide The metabolism of Vortioxetine can be decreased when combined with Bicalutamide.
Sertraline	Sertraline The metabolism of Vortioxetine can be decreased when combined with Sertraline.
Propafenone	Propafenone The metabolism of Vortioxetine can be decreased when combined with Propafenone.
Letrozole	Letrozole The metabolism of Vortioxetine can be decreased when combined with Letrozole.
Raloxifene	Raloxifene The metabolism of Vortioxetine can be decreased when combined with Raloxifene.
Irbesartan	Irbesartan The metabolism of Vortioxetine can be decreased when combined with Irbesartan.
Tamsulosin	Tamsulosin Tamsulosin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ropinirole	Ropinirole Vortioxetine may increase the sedative activities of Ropinirole.
Finasteride	Finasteride The metabolism of Vortioxetine can be decreased when combined with Finasteride.
Quetiapine	Quetiapine The risk or severity of adverse effects can be increased when Quetiapine is combined with Vortioxetine.
Cefepime Injection	Cefepime Injection Cefepime may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Cefprozil	Cefprozil Cefprozil may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Cefpodoxime	Cefpodoxime Cefpodoxime may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Cetirizine	Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Vortioxetine.
Paroxetine	Paroxetine The metabolism of Vortioxetine can be decreased when combined with Paroxetine.
Tolcapone	Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Vortioxetine.
Citalopram	Citalopram The risk or severity of adverse effects can be increased when Citalopram is combined with Vortioxetine.
Capecitabine	Capecitabine The metabolism of Vortioxetine can be decreased when combined with Capecitabine.
Efavirenz	Efavirenz The metabolism of Vortioxetine can be increased when combined with Efavirenz.
Abacavir	Abacavir Abacavir may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Sildenafil	Sildenafil The metabolism of Vortioxetine can be decreased when combined with Sildenafil.
Pioglitazone	Pioglitazone The metabolism of Vortioxetine can be decreased when combined with Pioglitazone.
Celecoxib	Celecoxib The metabolism of Vortioxetine can be decreased when combined with Celecoxib.
Rosiglitazone	Rosiglitazone The metabolism of Vortioxetine can be decreased when combined with Rosiglitazone.
Tolterodine	Tolterodine Tolterodine may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Thalidomide	Thalidomide Vortioxetine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir	Oseltamivir Oseltamivir may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Balsalazide	Balsalazide Balsalazide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Nateglinide	Nateglinide Nateglinide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Galantamine	Galantamine The metabolism of Vortioxetine can be decreased when combined with Galantamine.
Levetiracetam	Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Vortioxetine.
Rabeprazole	Rabeprazole The metabolism of Vortioxetine can be decreased when combined with Rabeprazole.
Terbinafine	Terbinafine The metabolism of Vortioxetine can be decreased when combined with Terbinafine.