Medication interaction hub

What Supplements Interact with Vortioxetine?

Vortioxetine brand names: Trintellix, Brintellix, Sehippy. Every interaction below applies to the brands too.

100 Interactions 2 Major 73 Moderate 25 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Vortioxetine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Vortioxetine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Vortioxetine (Trintellix) is an antidepressant that works through serotonin, which makes this a list to treat with real care. Two of the 100 ingredients on file rate major: lithium, which can add to the serotonin effect and raise the risk of serotonin syndrome (a dangerous excess of serotonin), and activated charcoal, which can soak up the dose before your body gets it. Understand those two first.

Most of the remaining entries follow two patterns. Roughly 60 involve CYP2D6, the liver enzyme that clears vortioxetine, so herbs like goldenseal that block it can push your blood level higher than intended. Another 20 add their own serotonin activity, 5-HTP among them. The other 98 split into 73 moderate and 25 minor, and fibers such as glucomannan can blunt absorption unless taken well apart from your pill.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 73 Minor 25 No known interaction 1,352

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Vortioxetine: Top Interactions at a Glance

The Vortioxetine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 100 interacting ingredients — plus 1,352 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Vortioxetine Combinations Today

The Vortioxetine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Ashwagandha + Vortioxetinei

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.

Read the full interaction Moderate Likelihood Possible L-tryptophan + Vortioxetinei

Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.

Read the full interaction Minor Likelihood Unlikely Valerian + Vortioxetinei

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.

Read the full interaction Moderate Likelihood Possible 5-htp + Vortioxetinei

Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.

Read the full interaction Minor Likelihood Possible Marshmallow + Vortioxetinei

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Read the full interaction Moderate Likelihood Possible Shiitake Mushroom + Vortioxetinei

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full interaction
The complete list

Every Supplement Checked Against Vortioxetine

All 1,452 ingredients in our database, ranked by severity — 100 with a Vortioxetine interaction on file and 1,352 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Vortioxetine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ashwagandha with Vortioxetine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.

Full Ashwagandha + Vortioxetine answer

Can you take L-tryptophan with Vortioxetine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.

Full L-tryptophan + Vortioxetine answer

Can you take Valerian with Vortioxetine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.

Full Valerian + Vortioxetine answer

Can you take 5-htp with Vortioxetine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.

Full 5-htp + Vortioxetine answer

Can you take Marshmallow with Vortioxetine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Vortioxetine answer

Can you take Slippery Elm with Vortioxetine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Vortioxetine answer

Can you take St. John's Wort with Vortioxetine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, St.

Full St. John's Wort + Vortioxetine answer

Can you take Terminalia with Vortioxetine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.

Full Terminalia + Vortioxetine answer

Can you take Tinospora Cordifolia with Vortioxetine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.

Full Tinospora Cordifolia + Vortioxetine answer

Can you take Tragacanth with Vortioxetine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Vortioxetine answer

Can you take Tree Turmeric with Vortioxetine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.

Full Tree Turmeric + Vortioxetine answer

Can you take White Pepper with Vortioxetine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that some constituents of white pepper inhibit cytochrome P450 2D6 (CYP2D6).

Full White Pepper + Vortioxetine answer

Can you take Yohimbe with Vortioxetine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.

Full Yohimbe + Vortioxetine answer

Can you take Thyroid Extract with Vortioxetine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Vortioxetine answer

Can you take 1,3-dmba with Vortioxetine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, 1,3-DMBA might modestly increase the levels of CYP2D6 substrates.

Full 1,3-dmba + Vortioxetine answer

Can you take Agar with Vortioxetine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Vortioxetine answer

Can you take Algin with Vortioxetine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Vortioxetine answer

Can you take Bitter Orange with Vortioxetine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, bitter orange might increase levels of drug metabolized by CYP2D6.

Full Bitter Orange + Vortioxetine answer

Can you take Black Psyllium with Vortioxetine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Vortioxetine answer

Can you take Blond Psyllium with Vortioxetine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Vortioxetine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Vortioxetine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Vortioxetine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Vortioxetine sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Vortioxetine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Vortioxetine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Vortioxetine through this category.

Cytochrome P450 2A6 (Cyp2A6) Substrates 5 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

5 of the supplement ingredients on this page reach Vortioxetine through this category.

Antidepressant Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Vortioxetine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Vortioxetine through this category.

About Vortioxetine

Vortioxetine is a serotonin modulator medication used to treat depression in adults.

Generic name: Vortioxetine  ·  Brand names: Trintellix, Brintellix, Sehippy.

See the full Vortioxetine drug information

Related: does Vortioxetine deplete any nutrients?

Vortioxetine has 2 reported nutrient associations in the research literature — see the Vortioxetine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Vortioxetine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Vortioxetine.

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Pharmacist Counseling Corner

Vortioxetine & Supplements: Common Questions

What supplements interact with Vortioxetine?
More than you might expect — 100 in total, though they are far from equal: 2 are rated major, 73 moderate, and 25 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Lithium, Ayahuasca.
Which Vortioxetine supplement interactions are the most serious?
Focus on the major group: Activated Charcoal and Lithium. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Vortioxetine?
Usually yes — most people on Vortioxetine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Trintellix have the same supplement interactions as Vortioxetine?
Yes — Trintellix, Brintellix, Sehippy all contain Vortioxetine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Vortioxetine deplete any vitamins or nutrients?
It might — Vortioxetine has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Vortioxetine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Vortioxetine and my other medications?
This page covers Vortioxetine against supplements and herbal ingredients. Checking Vortioxetine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Vortioxetine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.