Vortioxetine
68 interactions 5 explained in plain English
Also sold as:
Trintellix
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Metoclopramide Nasal Spray
Metoclopramide Injection
Linezolid Injection
Betrixaban
Fondaparinux
Palonosetron Injection
Contraindicated
Vortioxetine Linezolid Injection Zyvox Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Vortioxetine Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Vortioxetine Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome DetailsMajor
Vortioxetine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Vortioxetine Amitriptyline Elavil Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Vortioxetine Sertraline Explained Increased CYP2D6 substrate exposure and an increased risk of serotonin syndrome Details Vortioxetine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Vortioxetine Apixaban Eliquis Explained An increased risk of bleeding Details Vortioxetine Aspirin Acuprin® An increased risk of bleeding Details Vortioxetine Aspirin Rectal Aspirin An increased risk of bleeding Details Vortioxetine Betrixaban Bevyxxa® An increased risk of bleeding Details Vortioxetine Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Vortioxetine Anagrelide Agrylin An increased risk of bleeding Details Vortioxetine Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Vortioxetine Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Vortioxetine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Vortioxetine Clopidogrel Plavix An increased risk of bleeding Details Vortioxetine Dabigatran Pradaxa® An increased risk of bleeding Details Vortioxetine Dabigatran Etexilate An increased risk of bleeding Details Vortioxetine Dacomitinib Vizimpro Increased vortioxetine exposure Details Vortioxetine Dalteparin Injection Fragmin An increased risk of bleeding Details Vortioxetine Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Vortioxetine Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Vortioxetine Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Vortioxetine Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Vortioxetine Dipyridamole Permole® An increased risk of bleeding Details Vortioxetine Dolasetron Anzemet Increased risk of serotonin syndrome Details Vortioxetine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Vortioxetine Edoxaban Savaysa An increased risk of bleeding Details Vortioxetine Enoxaparin Lovenox An increased risk of bleeding Details Vortioxetine Enoxaparin Injection Lovenox An increased risk of bleeding Details Vortioxetine Epoprostenol Flolan An increased risk of bleeding Details Vortioxetine Etodolac Lodine An increased risk of bleeding Details Vortioxetine Fenoprofen Fenopron An increased risk of bleeding Details Vortioxetine Fentanyl Transdermal Patch Duragesic® An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Vortioxetine Flurbiprofen Ansaid An increased risk of bleeding Details Vortioxetine Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Vortioxetine Fondaparinux Arixtra An increased risk of bleeding Details Vortioxetine Fondaparinux Injection Arixtra An increased risk of bleeding Details Vortioxetine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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