Drug & supplement interaction

Black Mulberry + Vortioxetine

Vortioxetine brand names: Trintellix, Brintellix, Sehippy.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Black Mulberry and Vortioxetine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Black Mulberry and Vortioxetine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Vortioxetine and Black Mulberry in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Black Mulberry safety at a glance

Black Mulberry overall Use caution The fruit is safe as food, but concentrated supplement doses are less studied.
Pregnancy Use caution Eating the fruit as food is likely fine, but avoid concentrated extracts unless your doctor approves.
Breastfeeding Use caution Fruit as food is likely fine, but there is little safety data on supplement doses.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Vortioxetine and Black Mulberry? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Vortioxetine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Vortioxetine is filed under 6 classifications — including cytochrome p450 2a6 (cyp2a6) substrates, antidepressant drugs, serotonergic drugs. Black Mulberry has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and midazolam (versed) (moderate) — and none of Vortioxetine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Black Mulberry Does Interact With Other Medications

Black Mulberry has 87 moderate known drug interactions in our database — Vortioxetine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 87 No known interaction 2,743 (incl. Vortioxetine)
Taking anything else?

Check Another of Your Medications Against Black Mulberry

Covers the 2,830 medications we’ve checked against Black Mulberry. Pick one to open its full report.

What to actually watch for

What Black Mulberry Itself Has Been Linked To

This is not an interaction — nothing below involves Vortioxetine. It is the side-effect record for Black Mulberry on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Black Mulberry, this list is the first place to look.

  • A skin rash Additional detail

    “Topically, black mulberry leaf may cause contact dermatitis. A case of lichenoid contact dermatitis was reported in a 68-year-old male who came into contact with black mulberry leaves while picking black mulberries.”

    Black Mulberry · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 105799. Navarro-Triviño FJ, Jadczak P, Llamas-Molina JM, Ruiz-Villaverde R. Lichenoid contact dermatitis caused by Morus nigra L. Contact Dermatitis 2021;84(6):484-486.

Everything above comes from the Natural Medicines adverse-effect record for Black Mulberry — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Vortioxetine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Vortioxetine column appears here.

From our Q&A

Questions About Black Mulberry or Vortioxetine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Black Mulberry or Vortioxetine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Vortioxetine

This page covers Black Mulberry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Vortioxetine page lists 100 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Lithium (major), 1,3-dmaa (moderate), 5-htp (moderate) and Acacia Rigidula (moderate).

By severity: 2 major · 73 moderate · 25 minor.

From our pharmacist’s overview on the Vortioxetine page

“Vortioxetine (Trintellix) is an antidepressant that works through serotonin, which makes this a list to treat with real care. Two of the 100 ingredients on file rate major: lithium, which can add to the serotonin effect and raise the risk of serotonin syndrome (a dangerous excess of serotonin), and activated charcoal, which can soak up…”

Reviewed by 2 · Jul 18, 2026

Open the Vortioxetine interaction page

How much people look this up

Where Black Mulberry and Vortioxetine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Mulberry
Steady interest

#845 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Vortioxetine
Top 25%

#492 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Mulberry reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Black Mulberry and Vortioxetine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Black Mulberry

What is Black Mulberry?

Black Mulberry
  • General antioxidant support
  • Blood sugar support
  • Cholesterol and heart health
  • Digestive health
  • Cold and sore throat remedies (traditional)

Black mulberry is a nutritious fruit rich in antioxidants and vitamins, and it is generally safe to enjoy as a food. Some early research on its leaf and fruit extracts hints at benefits for blood sugar and cholesterol, but the evidence is still limited. Talk with your pharmacist or doctor before using concentrated extracts, especially if you have a health condition.

Morus nigra · Moraceae · Fruit (berries), leaves, and sometimes root bark · Fresh or dried fruit, juice, jam, tea, powder, and capsules or extracts

An interaction check asks whether these two react with each other — it does not ask whether Black Mulberry is a good idea for someone in your situation. Here is what our Black Mulberry record says about it on its own.

Black Mulberry: dosing

There is no official standardized dose for black mulberry supplements. The amount in products varies widely depending on whether the fruit, leaf, or an extract is used.If you use a commercial product, follow the directions on the label and do not take more than recommended. Eating the fresh or dried fruit as part of a normal diet does not require special dosing.

From our Black Mulberry monograph — the full record covers uses, side effects and every documented interaction.

Read the full Black Mulberry monograph & all interactions
Medication

About Vortioxetine

What Is Vortioxetine Used For?

Brand names: Trintellix, Brintellix, Sehippy

Trintellix (vortioxetine) is FDA-approved to treat major depressive disorder (MDD) in adults. MDD is more than ordinary sadness — it is a persistent low mood that interferes with daily life and requires medical treatment.

Trintellix is not approved for use in children or teenagers. If you or a family member are wondering about treatment for depression in someone under 18, talk with a healthcare provider about what options are studied and approved for that age group.

Most-Reported Side Effects for Vortioxetine

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 2,259 reports
Fatigue 1,212 reports
Headache 1,066 reports
Anxiety 1,039 reports
Vomiting 1,020 reports
See full Vortioxetine drug information
Keep checking

Other Drugs & Black Mulberry

Browse every other medication we’ve checked against Black Mulberry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
87Moderate
0Minor
2,742No known interaction
87 Moderate 2,742 No interaction
Moderate

87 interactions

Showing 60 of 87 moderate interactions — see all 87 on the Black Mulberry page.

No interaction 2,742 drugs checked — show the list

We also checked Black Mulberry against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,742 medications checked with no known interaction — see the full Black Mulberry list.

See the full Black Mulberry interactions page
See every supplement checked against Vortioxetine, ranked by severity
Evidence & sources

Black Mulberry References

The 5 references that drive our Black Mulberry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Kim, H., Yoon, Y. J., Shon, J. H., Cha, I. J., Shin, J. G., and Liu, K. H. Inhibitory effects of fruit juices on CYP3A activity. Drug Metab Dispos. 2006;34(4):521-523. PubMed
  3. Xu LJ, Yu MH, Huang CY, et al. Isoprenylated flavonoids from Morus nigra and their PPAR ? agonistic activities. Fitoterapia 2018;127:109-14. PubMed
  4. Momeni H, Salehi A, Absalan A, Akbari M. Hydro-alcoholic extract of Morus nigra reduces fasting blood glucose and HbA1c% in diabetic patients, probably via competitive and allosteric interaction with alpha-glucosidase enzyme; a clinical trial and in silic
  5. Navarro-Triviño FJ, Jadczak P, Llamas-Molina JM, Ruiz-Villaverde R. Lichenoid contact dermatitis caused by Morus nigra L. Contact Dermatitis 2021;84(6):484-486.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Black Mulberry and Vortioxetine Together: Common Questions

Is it safe to take Black Mulberry with Vortioxetine?
We do not list a known interaction between Black Mulberry and Vortioxetine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Black Mulberry and Vortioxetine combination checked?
Interactions in our licensed database are recorded against drug classes. Vortioxetine is filed under 6 classifications, and Black Mulberry has documented interactions with 2 drug classes — none of Vortioxetine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Black Mulberry interact with any other medications?
Yes. Black Mulberry has 87 documented drug interactions in our database — Vortioxetine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Vortioxetine interact with any supplements?
Yes. Vortioxetine has documented interactions with 100 supplements in our database — Black Mulberry is not one of them. The Vortioxetine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Black Mulberry monograph Uses, safety profile, and every drug interaction in one place Vortioxetine drug information The full plain-English guide to this medication Vortioxetine supplement interactions Every supplement checked against Vortioxetine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Vortioxetine and Black Mulberry?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.